Trends Immunol. 2026 Mar 2:S1471-4906(26)00014-1. doi: 10.1016/j.it.2026.01.011. Online ahead of print.
ABSTRACT
During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of key EVT ligands, promotes placentation, tolerance, and immunity.
PMID:41771720 | DOI:10.1016/j.it.2026.01.011