IgA expressed by glomerular mesangial cells is involved in the pathogenesis of IgA nephropathy
BackgroundThe widely accepted “multi-hit hypothesis” of IgAN pathogenesis was challenged, as efficient depletion of CD20+ B cells failed to reduce serum galactose-deficient IgA1 (Gd-IgA1) or proteinuria in IgAN patients. Our group has discovered glomer…