Hot−yet−suppressed under PD−1 blockade: an RMP–NRF2–PD−L1 axis associated with a reduced proportional response in hepatocellular carcinoma
Immune checkpoint blockade (ICB) provides therapeutic benefits to a subset of patients with hepatocellular carcinoma (HCC); however, reliable predictors of treatment efficacy remain scarce. This study investigates whether RPB5-mediating protein (RMP) f…