SPHK1-mediated M2 macrophage polarization drives TGF-β1-dependent thrombus fibrosis
Background and objectiveVenous thrombus fibrosis contributes to post-thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (CTEPH). M2 macrophages promote fibrosis via TGF-β1 secretion. This study investigates whether sphingosine …