{"id":16684,"date":"2024-09-27T19:17:21","date_gmt":"2024-09-27T17:17:21","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16684"},"modified":"2024-09-27T19:17:56","modified_gmt":"2024-09-27T17:17:56","slug":"immunity","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/immunity\/","title":{"rendered":"Immunity"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00125-1?rss=yes\">Functions and features of circulating memory T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Stephen C. Jameson, Sara E. Hamilton<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Memory T (TMEM) cells are designated as either circulating (Tcircm) or tissue-resident (Trm) populations. In this review, Jameson and Hamilton examine the attributes of Tcircm cells and discuss the features and functional heterogeneity of distinct Tcir&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00120-2?rss=yes\">Spatial organization of tissue-resident memory T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Thomas N. Burn, Laura K. Mackay<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tissue-resident memory T (TRM) cells provide local, organ-specific immunity and are shaped by their position within these tissues. This review outlines how priming-associated programming, niche-level microenvironments, and local antigen exposure define&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00051-8?rss=yes\">Plasma cell ontogenies, functions, and lifespans<\/a><div class=\"wp-block-latest-posts__post-author\">by Colin A. Fields, Deepta Bhattacharya<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Although B cell development is a well-studied field, we are only beginning to appreciate the diversity and complexity of plasma cell formation and function. In this review, Fields and Bhattacharya discuss factors impacting plasma cell heterogeneity and&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00129-9?rss=yes\">A fast way to lose antibodies<\/a><div class=\"wp-block-latest-posts__post-author\">by Sheenam Verma, Oliver J. Harrison<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Long-lived plasma cells maintain antibody titers that sustain humoral immunity, yet the physiological cues regulating their persistence remain incompletely understood. In this issue of Immunity, Zhu et al. reveal that fasting-induced \u03b2-hydroxybutyrate &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00087-7?rss=yes\">Cellular memory of sub-lethal stress<\/a><div class=\"wp-block-latest-posts__post-author\">by Stephen W.G. Tait, Andrew Oberst<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Regulated cell death is critical for both homeostasis and the response to infection. In this perspective, Tait and Oberst discuss how sub-lethal activation of canonical cell death pathways has lasting impacts on cells and tissues. These near-death cell&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00126-3?rss=yes\">Universal vaccines? Only if your antibody genes agree<\/a><div class=\"wp-block-latest-posts__post-author\">by Vishal N. Rao, Camila H. Coelho<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Designing a universal influenza vaccine must address not only viral antigenic drift but also genetic variability in human antibody responses. In this issue of Immunity, two studies from the Karlsson-Hedestam lab (Corcoran et al. and Fischer et al.) int&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00077-4?rss=yes\">Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The immune system is a key contributor to organismal aging. Here, Ping et al. leverage single-cell multi-omics to construct a human immune aging clock, which pinpoints T cells as an aging nexus. RUNX1 orchestrates a transcriptional network that restrai&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00123-8?rss=yes\">Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Inducing broadly neutralizing antibodies (bnAbs) remains a challenge in HIV vaccine development. Mishra et al. show that an engineered germline-targeting HIV trimer, Q23-APEX-GT2, primes rare V2-apex bnAb precursors in humanized mice and outbred macaqu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00089-0?rss=yes\">Immunological memory to vaccines<\/a><div class=\"wp-block-latest-posts__post-author\">by Shane Crotty<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The generation of immune memory is at the crux of vaccine efficacy. Here, Crotty reviews the layers of adaptive immunity\u2014T cell, B cells, and antibodies\u2014and their integration to generate a holistic view of vaccine response. Common misconceptions and qu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00128-7?rss=yes\">PANoptosis fuels the fire of arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by Nagakannan Pandian, Thirumala-Devi Kanneganti<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Innate immune cell death is critical for host defense but drives inflammatory disease when dysregulated. In this issue of Immunity, Huang et al. report that the complement protein C1q activates macrophage mitochondrial SARM1 to deplete NAD+ and produce&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00127-5?rss=yes\">Two to tango: Microglia in glioblastoma invasion<\/a><div class=\"wp-block-latest-posts__post-author\">by Donn A. Van Deren, Malay Haldar<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">A lethal feature of glioblastoma is its ability to spread within the brain. In this issue of Immunity, Nebeling et al. use longitudinal three-photon imaging in an immunocompetent glioblastoma model to show that microglial responses at the far infiltrat&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00132-9?rss=yes\">Runx writes the ROR\u03b3t code for immune tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Chrysothemis C. Brown<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ROR\u03b3t is a key transcriptional regulator across diverse immune subsets. In this issue of Immunity, Fukui et al. show how Runx controls ROR\u03b3t expression during early development and link progenitor specification to the diversification of ROR\u03b3t+ innate i&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00124-X?rss=yes\">Training, memory, and tissue adaptation of NK cells and innate lymphoid cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Georg Gasteiger, Thomas Ossner, Christin Friedrich<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immune experience can durably shape innate lymphocytes and their environments. Gasteiger and colleagues discuss how training, memory-like features, and dynamic niche interactions reprogram NK cells and ILCs to adapt their functions and tissue specializ&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00112-3?rss=yes\">Molecular and cellular bases of trained immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by Sarah J. Sun, Ra\u00fal Aguirre-Gamboa, Luis B. Barreiro<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In this review, Barreiro and colleagues synthesize molecular and cellular mechanisms of trained immunity across monocytes, tissue-resident macrophages, and HSPCs. They propose a unifying framework linking transcription factor activity, metabolic remode&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00122-6?rss=yes\">Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-02T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">2 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Regulatory T (Treg) cells are phenotypically stable in inflammatory settings. Maltez et al. report that \u03b1CD40 immunotherapy induced conversion of Treg cells into FoxP3\u2212Tbet+IFN-\u03b3+ \u201cExTreg\u201d cells within the tumor microenvironment. ExTreg cells exhibited&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00088-9?rss=yes\">Memory T cell aging and rejuvenation<\/a><div class=\"wp-block-latest-posts__post-author\">by Sarah Adamo, Joel G. Rurik, Claire E. Gustafson, Marcus Buggert<\/div><time datetime=\"2026-03-31T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">31 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Aging profoundly alters memory T cell immunity, reshaping diversity, differentiation, and function. Adamo et al. review how intrinsic aging programs, antigenic experience, and tissue context shape T cell responses and discuss emerging strategies to rec&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00121-4?rss=yes\">Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-31T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">31 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Infiltration of glioblastoma (GB) cells into the brain parenchyma and colonization of distant regions are associated with disease recurrence and therapy resistance. Using 3-photon intravital microscopy in an autochthonous GB model, Nebeling et al. iden&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00084-1?rss=yes\">High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Although long-term dietary effects on the immune system are well established, how short-term high-fat diet (HFD) alters intestinal immunity is less understood. Here, Torrico et al. show that within hours of initiating HFD, microbiota-driven inflammatio&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00113-5?rss=yes\">Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-26T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al. investigate influenza-specific antibodies to obtai&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00054-3?rss=yes\">A hierarchical Rorc(\u03b3t) cis-regulatory cascade orchestrates differentiation of ROR\u03b3t\u207a innate immune cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-24T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">24 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Transcription factor ROR\u03b3t is a central regulator of type 3 immunity, essential for host defense and tissue homeostasis. Fukui et al. identify a hierarchical CNS11-CNS9 enhancer cascade that governs ROR\u03b3t expression across innate lymphocytes and antige&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00047-6?rss=yes\">Ultra-high-throughput IGH genotyping of 25 global populations reveals population-biased allelic diversity and homozygous V and D gene deletions<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-16T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">16 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The genes that encode our antibodies display extensive variation between individuals. Corcoran et al. developed a high-throughput sequence-based method for identifying variations in antibody genes (ImmuneDiscover). This enabled the sequencing of 2,486 &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00079-8?rss=yes\">Big-eaters choking? Macrophages can\u2019t stomach microplastics<\/a><div class=\"wp-block-latest-posts__post-author\">by Luke A. Neufeld, Zhe Qi Liu, Tracy L. McGaha<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Microplastics are detectable in diverse human tissues, yet their biological impact remains unclear. In this issue of Immunity, Codo et al. dissect the mechanisms involved and find that polystyrene microplastics inhibit tissue-resident phagocyte clearan&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00078-6?rss=yes\">Out of many, IL-1<\/a><div class=\"wp-block-latest-posts__post-author\">by Jinsu Lee, Michael A. Wheeler<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al. identified a defined molecular and anatomical path&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00053-1?rss=yes\">Human anti-glycan reactivity emerges from B cells utilizing private gene rearrangements that are affinity maturated in germinal centers<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The human antibody repertoire is broadly reactive with carbohydrate antigens represented in the host\/self as well as the commensal microbiota. New et al. find that B cells reactive with the glycan constituent N-acetyl-glucosamine arise early in life an&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00076-2?rss=yes\">Antibody responses against bacterial glycans affinity mature and diversify in germinal centers<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Vaccines targeting bacterial glycans can elicit inconsistent and\/or poor protection in the young. Fryer, Pitt, et al. show that mucosal S. pyogenes infection triggers a glycan-specific B cell response that evolves with age and includes antibody class s&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00082-8?rss=yes\">Diversify and conquer: Antibody feedback in the germinal center<\/a><div class=\"wp-block-latest-posts__post-author\">by Amalie Grenov, Carola G. Vinuesa<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Pre-existing antibodies restrict naive B cell entry into germinal centers, but how antibody feedback shapes ongoing reactions is unclear. In this issue of Immunity, Barbulescu et al. and Yan et al. show that antigen binding by locally produced high-aff&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00081-6?rss=yes\">FLI-ing the script on NK cell persistence: Proteostasis as a limiting factor<\/a><div class=\"wp-block-latest-posts__post-author\">by Yi-Ju Chou, Stanley Ching-Cheng Huang<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Natural killer (NK) cells hold promise for cancer immunotherapy but show limited persistence in solid tumors. In this issue of Immunity, Ji et al. reveal that nutrient stress induces FLI1-mediated repression of pro-survival unfolded protein response pr&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00080-4?rss=yes\">Immune austerity: How the body balances its books when calories run low<\/a><div class=\"wp-block-latest-posts__post-author\">by Francesco Siracusa, Nicola Gagliani<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immune responses are energetically costly and must adapt to systemic nutrient availability. How immunity is reorganized to preserve host glucose during caloric restriction remains unclear. In this issue of Immunity, Menezes-Silva et al. show that dieta&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00046-4?rss=yes\">Resident tissue macrophages maintain intraocular pressure homeostasis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-09T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Intraocular pressure (IOP) is dysregulated in glaucoma, a leading cause of blindness. Immune contributions to IOP maintenance are poorly understood. Liu et al. reveal that long-lived resident tissue macrophages have a specialized role in IOP homeostasi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00090-7?rss=yes\">Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-06T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">6 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 58, 2320\u20132335.e1\u2013e9; September 9, 2025)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00040-3?rss=yes\">Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-06T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">6 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Rheumatoid joints contain macrophages with reparative potential, yet inflammation persists. Huang et al. demonstrate that these homeostatic macrophages lose their protective role by undergoing PANoptotic death. Mechanistically, C1q activates the mitoch&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00045-2?rss=yes\">HIF-1\u03b1+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-06T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">6 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and temporal distribution of lung HIF-1\u03b1-active CD4\u207a T cells&#8230;.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00033-6?rss=yes\">MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-26T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Resident macrophage maturation and tissue-specific identity depend on transcriptional programming, yet how conserved regulators universally drive these programs remains unresolved across tissues. Vanneste et al. identify MafB as a key transcriptional r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00074-9?rss=yes\">Immunity in Alzheimer\u2019s disease: From mechanisms to therapies<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaoying Chen, David M. Holtzman, Marco Colonna<\/div><time datetime=\"2026-02-26T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Alzheimer\u2019s disease (AD) is driven by dynamic interactions between innate and adaptive immunity. Colonna, Chen, and Holtzman review recent advances in the genetic and mechanistic understanding of how microglia and T cells shape AD progression, and disc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00085-3?rss=yes\">Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-26T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 58, 2524\u20132540.e1\u2013e5; October 14, 2025)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00070-1?rss=yes\">A longitudinal study of children identifies antibody Fc-mediated functions and antigen targets of immunity to Plasmodium vivax malaria<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-26T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Understanding immunity against Plasmodium vivax, a leading cause of malaria, will accelerate development of vaccines, which are currently lagging. Opi et al. identify important mechanisms and target antigens of protective P. vivax immunity in children,&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00048-8?rss=yes\">B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-26T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Using a dual-recombinase fate-mapping system to trace late-entry invader B cells in germinal centers, Zhou et al. show that across vaccination and influenza infection, invaders preferentially generate memory B cells, whose antibodies target subdominant&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00052-X?rss=yes\">HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV-vectored immunotherapy in humanized mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-25T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">25 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Broadly neutralizing antibodies are promising therapeutics for ending the HIV pandemic; however, their clinical efficacy is undermined by viral escape. Galvez, Nitido, et al. could drive the therapeutic outcomes of vectored immunotherapy in humanized m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00043-9?rss=yes\">Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-25T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">25 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Neuroimmune interactions shape host responses to infection, but the molecular role of sensory neurons during viral infection remains unclear. Roger et al. show that HSV-1-activated sensory neurons produce substance P and TAFA4, which act in a tissue-sp&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00027-0?rss=yes\">Effector differentiation by stem-like intraepithelial \u03b3\u03b4 T cells is required for host defense against infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-25T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">25 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\u03b3\u03b4IELs are essential for intestinal homeostasis, but how their differentiation and cytotoxic function are regulated remains unclear. Xie et al. demonstrate two functionally distinct \u03b3\u03b4IEL subsets, CD160+TCF1+BCL6+ stem-like and GZMB+BLIMP1+ effector-li&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00029-4?rss=yes\">Antibody-mediated feedback modulates interclonal competition in the germinal center<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-24T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">24 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Antibodies generated by prior immune responses regulate B cell responses upon recall immunization. Barbulescu et al. examine whether antibodies produced by an ongoing immune response influence the outcomes of contemporaneous germinal centers (GCs) and &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00030-0?rss=yes\">Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-24T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">24 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Microplastics pose a substantial threat to human health, but their effect on phagocytosis is unknown. Codo et al. find that polystyrene microplastics accumulate in different types of tissue-resident phagocytes, disrupting homeostatic clearance of apopt&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00003-8?rss=yes\">Fasting impairs humoral immunological memory by \u03b2-hydroxybutyrate-mediated depletion of plasma cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-23T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">23 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Vaccine-induced long-lived plasma cells protect the host by secreting neutralizing antibodies, yet the mechanism regulating their lifespan remains unclear. Here, Zhu et al. reveal that fasting depletes long-lived plasma cells and thus impairs humoral i&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00031-2?rss=yes\">Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-20T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">20 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Emotional stress worsens atopic dermatitis and its overall burden, yet the underlying mechanisms remain unclear. Xie et al. reveal that anxiety amplifies atopic dermatitis through sympathetic nervous system activation. Sympathetic release of norepineph&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00035-X?rss=yes\">The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-18T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">18 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tumor-infiltrating NK cells are often dysfunctional. Ji et al. show that the solid tumor microenvironment metabolome drives proteostasis imbalance and dysfunction in tumor-infiltrating NK cells and demonstrate that deletion of Fli1, a transcriptional r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00573-4?rss=yes\">Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-16T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">16 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 promotes the formation of positively curved membrane r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00032-4?rss=yes\">Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-13T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">13 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Feedback from circulating antibodies can shape initiating immune responses. Yan et al. examine ongoing germinal center (GC) responses upon immunization with an mRNA-LNP-encoded membrane-bound immunogen displaying three conserved HIV-1 envelope epitopes&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00561-8?rss=yes\">Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-10T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Powerful interferon (IFN)-I-producing capacity distinguishes plasmacytoid dendritic cells (pDCs) from related innate cells. Adams et al. find that, during pDC development, the locus encoding IFN-I genes acquires a unique intranuclear localization and c&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00041-5?rss=yes\">Doping cDC1s for tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Victor Bosteels, Sophie Janssens<\/div><time datetime=\"2026-02-10T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. p&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00044-0?rss=yes\">TCRAFT: A Rosetta Stone for T cell receptors<\/a><div class=\"wp-block-latest-posts__post-author\">by Christopher A. Polera, Alex M. Jaeger<\/div><time datetime=\"2026-02-10T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Defining the antigen specificity of T cell receptors (TCRs) remains a significant barrier to understanding adaptive immunity in various pathologies. In this issue of Immunity, Gaglione et al. report the development of TCRAFT, a novel platform that enab&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00042-7?rss=yes\">Shedding light on interventions for brain aging<\/a><div class=\"wp-block-latest-posts__post-author\">by Juan Zhang, Qiang Liu<\/div><time datetime=\"2026-02-10T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immunotherapeutic approaches to brain aging remain largely preclinical and in early translational stages, and they have focused mostly on modulating innate immunity. In this issue of Immunity, Negredo et al. identify T cells bearing exhaustion-like sig&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00039-7?rss=yes\">Cystine fuels ILC2s to survive lung inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by Yuchao Jing, Jie Zhou<\/div><time datetime=\"2026-02-10T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tissue inflammation introduces unique, and often harsh, environments for immune cells. During allergic airway inflammation, pathogenic ILC2s proliferate robustly and drive pathology, but how do they overcome the nutrient-depleted environment? In this i&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00028-2?rss=yes\">Microglia makeover: On-demand control panel revamp<\/a><div class=\"wp-block-latest-posts__post-author\">by Takahiro Masuda<\/div><time datetime=\"2026-02-10T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Microglia display remarkable plasticity, with their cellular states evolving in response to developmental stage, regional context, and environmental or pathological stimuli. In this issue of Immunity, Hamagami et al. demonstrate that adaptive reconfigu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00002-6?rss=yes\">Hormonal rewiring of immunity during dietary restriction ensures host defense and systemic glucose conservation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">When food availability is reduced, it is unclear how the host adapts to support glucose-demanding immune processes while preventing hypoglycemia. Here, Menezes-Silva, Jeong, et al. demonstrate that glucocorticoids (GCs) maintain immune homeostasis, and&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00567-9?rss=yes\">Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-09T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Respiratory infection and cardiovascular disease risk are tightly intertwined clinically, but the mechanisms of this relationship are largely unknown. Here, Downey et al. reveal how influenza traffics to the heart from the lung largely within pro-DC3s,&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00036-1?rss=yes\">Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer\u2019s disease risk factors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-02T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">2 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The function of the Alzheimer\u2019s disease (AD) risk gene INPP5D in microglia remains unclear. Xie et al. identify INPP5D as a direct regulator of RIPK1 kinase, known to be implicated in mediating neuroinflammation. They show that INPP5D deficiency in agi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00004-X?rss=yes\">Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-30T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">30 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Adaptive programming in lymphocytes during infection depends on when\u2014not just whether\u2014they sense antigen and proinflammatory cytokines such as IL-12. Grassmann et al. reveal that AP-1\/STAT4 cooperation links signal timing to lymphocyte fate, tuning CD8&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00034-8?rss=yes\">Meningeal B cells: Emerging players at the brain border<\/a><div class=\"wp-block-latest-posts__post-author\">by Dianyu Chen, Heping Xu<\/div><time datetime=\"2026-01-30T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">30 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Meningeal B cells are increasingly recognized as active players at the brain border. Chen and Xu review recent advances in understanding their heterogeneity, developmental origins, spatial organization, and diverse functions in health and disease, and &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00569-2?rss=yes\">Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-30T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">30 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The recent transmission of highly pathogenic avian influenza A virus H5N1 from cattle to humans underscores its pandemic risk. Daniel, Ullrich, et al. reveal that H5-naive individuals possess low but detectable H5-reactive and neutralizing IgG antibodi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00038-5?rss=yes\">Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-30T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">30 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immune cells populate the old brain, but whether they can be specifically targeted to improve brain function in older individuals remains unclear. Navarro Negredo et al. dissect how aging impacts brain immune activity and show that targeting immune cel&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00037-3?rss=yes\">B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-30T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">30 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">B cells transiently increase interleukin (IL)-2 receptor expression upon activation. Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis that promotes the differentiation of CD25+ age-associated B cells toward a regula&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00005-1?rss=yes\">Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-29T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">29 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Dhariwala et al. demonstrate that commensal microbes recruit classical monocytes to neonatal skin. Disrupting this interaction triggers aberrant IL-17 secretion from cutaneous T lymphocytes, heightening risk of skin inflammation. IL-1 signaling in skin&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00001-4?rss=yes\">Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-28T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">28 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mapping TCRs to antigens at scale presents a major challenge. Gaglione et al. develop an approach to rapidly synthesize and screen thousands of TCRs, enabling broad TCR-antigen screening. Examining T cell specificity in vitiligo uncovers autoreactive T&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00566-7?rss=yes\">A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-28T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">28 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cytosolic nucleic acid sensors contribute to pathogenic and autoinflammatory inflammation; however, little is known about the metabolic adaptations that they induce. Dunphy et al. find that these pathways induce type I interferon-dependent metabolic ch&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00572-2?rss=yes\">Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-26T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tumor-associated macrophages (TAMs) enhance cancer progression by driving angiogenesis, extracellular matrix remodeling, and immune suppression, yet their impact on nerve growth is unclear. Dolci and colleagues show that TAMs directly stimulate neurite&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00565-5?rss=yes\">Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiu Zhong, Ya Su, Zhiwei Zhou, Yuqiu Sun, Yanjie Hou, Feng Shao, Jingjin Ding<\/div><time datetime=\"2026-01-26T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In cellular immunity, cytotoxic lymphocytes-derived granzyme A (GZMA) targets the pore-forming protein GSDMB in target cells to confer pyroptotic killing, but how GZMA specifically recognizes and cleaves GSDMB is unknown. Zhong et al. demonstrate that &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00564-3?rss=yes\">Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-22T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">22 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The incidence of colorectal cancer (CRC) is elevated in individuals with inflammatory bowel disease. Pires et al. find that the cytokine TL1A stimulates production of GM-CSF by ILC3s, which triggers emergency granulopoiesis and neutrophil recruitment a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00563-1?rss=yes\">Commensal-derived trehalose monocorynomycolate triggers \u03b3\u03b4 T cell-driven protective ocular barrier immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-19T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">19 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Commensal microbes shape host immunity at barrier tissues and promote resistance to infection. Xu et al. identify a commensal Corynebacterium-derived lipid that activates IL-17\u207a \u03b3\u03b4 T cells via T cell receptor and IL-1 signaling, enhancing barrier defen&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00562-X?rss=yes\">To the nines: IL-9 boosts T cell function<\/a><div class=\"wp-block-latest-posts__post-author\">by Elizabeth Wickman, Maksim Mamonkin<\/div><time datetime=\"2026-01-13T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IL-9 is canonically associated with anti-helminth and allergic immunity. However, in this issue of Immunity, Jiang et al. and Castelli et al. demonstrate how integrating IL-9 signaling in T cells enhances their persistence and anti-tumor function in so&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00571-0?rss=yes\">Not aIL Treg-mediated suppress10n is equal<\/a><div class=\"wp-block-latest-posts__post-author\">by David E.J. Klawon, Tyler Jacks<\/div><time datetime=\"2026-01-13T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Regulatory T (Treg) cells suppress immune responses and are considered a major barrier to productive anti-tumor immunity. In this issue of Immunity, Huang et al. report that interleukin (IL)-10-producing Treg cells restrain tumor growth by suppressing &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00560-6?rss=yes\">A head start: Bone channels shape meningeal immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by Jasmin Herz, Jonathan Kipnis<\/div><time datetime=\"2026-01-13T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immune cells from the skull marrow reach the meninges through bone channels. In this issue of Immunity, Eme-Scolan and colleagues show that these channels form neonatally and can be remodeled to alter immune access to the brain\u2019s borders. Their work su&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00559-X?rss=yes\">IRF4 sends alveolar macrophages spiraling into an identity crisis during type 2 immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by Anika Hutton, Hernandez Moura Silva<\/div><time datetime=\"2026-01-13T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">A long-standing debate in the field asks whether resident tissue macrophages are terminally differentiated or remain capable of changing their fate and function during inflammation. In this issue of Immunity, Verwaerde et al. uncover an IRF4-driven cir&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00570-9?rss=yes\">Primitive macrophages take a road less traveled<\/a><div class=\"wp-block-latest-posts__post-author\">by Jessie Axsom, F. Chris Bennett<\/div><time datetime=\"2026-01-13T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Ontogeny is a crucial determinant of macrophage function, but it remains unclear how a shared set of transcription factors generate distinct transcriptional programs across macrophage lineages. In this issue of Immunity, Chen et al. discover a transcri&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00568-0?rss=yes\">Change and flow<\/a><div class=\"wp-block-latest-posts__post-author\">by Fabiola V. Rivas<\/div><time datetime=\"2026-01-13T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The water you touch in a river is the last of that which has passed and the first of that which is coming. Thus it is with time present.\u2014Leonardo da Vinci<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00525-4?rss=yes\">State-specific enhancer landscapes govern microglial plasticity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-07T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">7 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Microglia adopt diverse states throughout life. Whether these represent fixed lineages or reversible plasticity remains unclear. Hamagami and Kapadia et al. show that reactive microglia switch states through reprogramming of histone modifications at st&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00527-8?rss=yes\">Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-05T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">5 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Contemporary immunology research commonly utilizes detailed analyses of immunoglobulin sequences; however, IG immunogenetics remain understudied in rhesus macaques (RMs). Peres et al. combine IG genomic and repertoire sequencing of &gt;100 RMs to provide &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00523-0?rss=yes\">Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-31T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">31 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lucas et al. evaluate the interferon-gamma (IFN-\u03b3) signature against toxicity and efficacy in four neoadjuvant melanoma immunotherapy regimens. IFN-\u03b3-high scores associated with overall favorable efficacy but increased toxicity when anti-CTLA-4 was add&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00526-6?rss=yes\">From host to population: Bridging the viral immuno-evolutionary gap<\/a><div class=\"wp-block-latest-posts__post-author\">by Hassan Jamaleddine, Bryan T. Grenfell, Andrea L. Graham, Judith N. Mandl<\/div><time datetime=\"2025-12-30T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">30 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mandl and colleagues describe an important gap in our understanding of how antiviral immune mechanisms in individual hosts alter the evolutionary trajectories of viruses as they spread through populations. They propose that bold new experimental system&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00521-7?rss=yes\">Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-29T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">29 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Skull marrow communicates with the meninges through bone channels, yet their formation and regulation remain poorly understood. Eme-Scolan et al. show that these channels undergo active remodeling during the neonatal period and can be reshaped by modul&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00524-2?rss=yes\">Transcription factor Maf promotes expression of repressor Zeb2 to drive microglia development in primitive hematopoiesis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-26T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">How distinct hematopoietic waves generate specialized macrophage lineages remains unclear. Chen et al. identify separate transcriptional pathways controlling macrophage development during primitive versus definitive hematopoiesis and identify Maf and J&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00522-9?rss=yes\">Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-19T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">19 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CCR7+ dendritic cells (DCs) are pivotal for antitumor immunity. Zitti, Duval et al. find that intratumoral CCR7+ DCs form perivascular hubs dependent on CCL19-CCR7 signaling. Regulatory T cells (Tregs) restrain immune function within these hubs, and bo&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00516-3?rss=yes\">Opposing functions of distinct regulatory T cell subsets in colorectal cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-15T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">15 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Huang et al. study the heterogeneity of regulatory T (Treg) cells in a genetic model of colorectal cancer (CRC) and find that interleukin (IL)-10\u2212 Treg cells promote tumor progression, whereas IL-10+ Treg cells restrain tumor growth by suppressing IL-1&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00517-5?rss=yes\">Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-11T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">11 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Monocyte-derived macrophages are highly plastic, whereas tissue-resident macrophages resist inflammatory reprogramming. Verwaerde et al. show that tissue-resident alveolar macrophages can be reprogrammed during type 2 pulmonary immune responses by acti&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00520-5?rss=yes\">Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-10T17:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immune cells must modulate their metabolism to adapt to tissue constraints. Wientjens et al. show that allergen-induced ILC2s and Th2 cells require cysteine-driven glutathione synthesis to prevent ferroptosis and support lipid metabolism. This redox ba&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00511-4?rss=yes\">The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaoxue Li, Wenhua Liang, Weifang Wang, Eilon Sherman, Keling Huang, Feng Wang<\/div><time datetime=\"2025-12-09T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Blocking pathogenic T cell migration is crucial for treating autoimmune diseases. Li et al. reveal SUB1 as a gatekeeper of CD4+ T cell infiltration in autoimmunity. TCR-induced SUB1 drives Rac-dependent cytoskeletal remodeling via DOCK2 transcriptional&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00518-7?rss=yes\">Memories are I(F)N-credibly protective<\/a><div class=\"wp-block-latest-posts__post-author\">by Brydie R. Huckestein, Paul G. Thomas<\/div><time datetime=\"2025-12-09T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lung-resident memory CD8+ T cells coordinate rapid antiviral defense mechanisms across lung compartments to quicky limit viral replication and spread. In this issue of Immunity, Mattingly et al. demonstrate the importance of CD8+ Trm cell-derived inter&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00510-2?rss=yes\">Skin deep: Unconventional autophagy eats away TNF-driven skin inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by Ying Feng, Francis Ka-Ming Chan<\/div><time datetime=\"2025-12-09T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tumor necrosis factor (TNF), type I interferons (IFNs), and autophagy are important biological processes, but their interactions in inflammation have not been explored. In this issue of Immunity, Priem et al. reveal that ATG9A-mediated autophagy curbs &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00514-X?rss=yes\">A surprising link: TET2 clonal hematopoiesis boosts immune checkpoint therapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Qiang Dong, Chengcheng Jin<\/div><time datetime=\"2025-12-09T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">TET2 mutations can drive clonal hematopoiesis (CH), but their impact on tumor immunity remains unresolved. Recently in Cancer Cell, Herbrich et al. reported that TET2-mutant CH reprograms tumor-associated macrophages to enhance antigen presentation and&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00513-8?rss=yes\">The history and promise of Treg cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Christophe Benoist, Dario A.A. Vignali, Richard A. Flavell, Diane Mathis<\/div><time datetime=\"2025-12-09T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The seminal discoveries that established the role of regulatory T cells in immunological tolerance were recognized by this year\u2019s Nobel Prize in Physiology or Medicine. Benoist and colleagues discuss the unfolding of the Treg story, the players involve&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00504-7?rss=yes\">Shape-shifting microglia respond to neuronal hyperexcitability<\/a><div class=\"wp-block-latest-posts__post-author\">by Clara Alice Musi, Diego Gomez-Nicola<\/div><time datetime=\"2025-12-09T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The initial responses of microglia to neuronal stress or altered network activity are poorly characterized. Xie and colleagues show that during TDP-43-related neurodegeneration, microglia detect early neuronal hyperactivity and transition into a distin&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00519-9?rss=yes\">Intestinal plasma cells get in formation<\/a><div class=\"wp-block-latest-posts__post-author\">by Gabrielle R. Berman, Carla R. Nowosad<\/div><time datetime=\"2025-12-09T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IgA plasma cells are the most abundant antibody-secreting reservoir in the body, yet details of their origin and behavior remain elusive. In this issue of Immunity, Simons et al. and Siniscalco et al. offer insights into IgA plasma cell dynamics during&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00503-5?rss=yes\">A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-08T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">8 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Systemic rotavirus infection poses a significant health challenge in neonates, but its underlying pathogenesis remains unclear. Xu et al. demonstrate that hepcidin-iron dysregulation in hepatic macrophages, particularly TREM2+ macrophages and Kupffer c&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00506-0?rss=yes\">A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-05T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">5 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">While the phospholipid PI4P is implicated in STING activation, its molecular mechanism has remained elusive. Han et al. reveal that PI4P cooperates with the transmembrane agonist GNE-6468 to activate the STING immune response, highlighting its therapeu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00508-4?rss=yes\">A host-centric view of the microbiota metabolome<\/a><div class=\"wp-block-latest-posts__post-author\">by Takahiro Yamada, Noah W. Palm<\/div><time datetime=\"2025-12-02T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">2 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our current understanding of microbial-host communication is largely based on context-dependent examples and anecdotes. Yamada and Palm present a teleological framework that organizes microbial metabolites based on their impacts on the host. These fund&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00507-2?rss=yes\">Clonal persistence dominates homeostatic intestinal IgA responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-01T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">1 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Gut plasma cells secrete IgA, which prevents infections, neutralizes toxins, and regulates the gut microbiota. Simons et al. demonstrate that stable IgA production results not from the persistence of individual plasma cells but rather a continuous dyna&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00509-6?rss=yes\">Quantifying the waning of humoral immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-28T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">28 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Memory is a central feature of the adaptive immunity. Saha et al. quantitatively model humoral memory and find that the pattern of waning of antibodies is better described by a power-law model rather than models with exponential waning. Their findings &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00479-0?rss=yes\">Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-26T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Human T cell responses are often studied using blood, yet most T cells reside in tissues. By comparing T cell receptor repertoires from millions of T cells from autologous tonsils and blood, Sureshchandra et al. demonstrate limited clonal, phenotypic, &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00505-9?rss=yes\">Human lung CD8+ tissue-resident memory T cell-derived interferon-\u03b3 orchestrates subset-specific antiviral programming in airway epithelial cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-26T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mattingly et al. use human lung cells to show that virus-specific CD8+ tissue-resident memory T cells trigger epithelial antiviral defenses via IFN\u03b3. This early protective response varies by epithelial subset, restricts influenza infection, and highlig&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00466-2?rss=yes\">Topography of the HLA-A protein enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-24T00:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">24 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Donor-specific antibodies against mismatched HLA proteins cause allograft failure, but the structural epitopes recognized by these antibodies are not well defined. Killian et al. identify immunodominant HLA-A\u221701:01 epitopes that are localized specifica&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(25)00475-3?rss=yes\">IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing antitumor efficacy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-21T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">21 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Castelli et al. show that incorporating interleukin-9 (IL-9) signaling reprograms chimeric antigen receptor (CAR) T cells to expand, persist, and resist dysfunction in solid tumors. This strategy improves antitumor activity at lower doses, suggesting a&#8230;<\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":16685,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16684","page","type-page","status-publish","has-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16684"}],"version-history":[{"count":2,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16684\/revisions"}],"predecessor-version":[{"id":16687,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16684\/revisions\/16687"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media\/16685"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}