{"id":16684,"date":"2024-09-27T19:17:21","date_gmt":"2024-09-27T17:17:21","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16684"},"modified":"2024-09-27T19:17:56","modified_gmt":"2024-09-27T17:17:56","slug":"immunity","status":"publish","type":"page","link":"https:\/\/inmuno.es\/immunity\/","title":{"rendered":"Immunity"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts is-layout-flow wp-block-latest-posts-is-layout-flow\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00395-X?rss=yes\">The narrow path to CD8+ T cell recognition of mutant p53<\/a><div class=\"wp-block-latest-posts__post-author\">by Evan W. Newell<\/div><time datetime=\"2026-10-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Shared cancer driver mutations offer attractive targets for cancer immunotherapy, but their expression does not necessarily put them within the reach of a T cell response. In this issue of Immunity, Haratani et al. identify distinct barriers to the pro&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00389-4?rss=yes\">Astrocytes go into presenter mode<\/a><div class=\"wp-block-latest-posts__post-author\">by Lara Labarta-Bajo, Nicola J. Allen<\/div><time datetime=\"2026-10-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Astrocytes are glial cells important for neuronal health, but their functions in CNS immunopathology are less understood. In a recent issue of Nature, Lee et al. report that CD40 engagement and proinflammatory cytokines promote lipid droplet accumulati&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00393-6?rss=yes\">Regulatory B cells: Induced, inspired, and ready to soothe neuroinflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by Rylee J. Beam, Douglas S. Prado, Rebecca A. Elsner<\/div><time datetime=\"2026-10-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">B cells can promote or restrain inflammation, yet harnessing their regulatory functions has been limited by a lack of understanding of how to efficiently induce them. In this issue of Immunity, Manfroi et al. identify chemical compounds that efficientl&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00383-3?rss=yes\">The nerve rings twice<\/a><div class=\"wp-block-latest-posts__post-author\">by Kenji Kabashima<\/div><time datetime=\"2026-10-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">How does neural activity ignite skin inflammation? In this issue, Chen et al. show that one round of nociceptor activation builds a transient, chemokine CCL2-dependent dendritic cell-rich neighborhood, whereas a second round within the tested 3\u201312-h ra&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00396-1?rss=yes\">The matrix remembers<\/a><div class=\"wp-block-latest-posts__post-author\">by Agne Antanaviciute, Alison Simmons<\/div><time datetime=\"2026-10-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Inflammation can have lasting effects, but the mechanisms that drive these effects remain unclear. Adir and colleagues reveal that intestinal inflammation leaves a durable imprint in the extracellular matrix. This modified matrix redirects stem-cell fa&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00392-4?rss=yes\">Viral deISGylation holds the key to the metabolic kingdom<\/a><div class=\"wp-block-latest-posts__post-author\">by Byron Shue, Sonja M. Best<\/div><time datetime=\"2026-10-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The interferon-induced modification of cellular and viral proteins by ISG15 inhibits viral infection and is reversed by virus-encoded deISGylases, but the broad physiological impacts of this host-pathogen clash remain unclear. In this issue of Immunity&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00391-2?rss=yes\">Multidimensional view of immunotherapy<\/a><time datetime=\"2026-10-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The introduction of immune checkpoint blockade revolutionized cancer treatments. Since then, the field of immunotherapy has expanded exponentially, both in therapeutic innovations and applicable disease contexts. Investigators across disciplines discus&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00381-X?rss=yes\">Induced regulatory B cells stably expressing interleukin-10 reverse central nervous system autoimmunity by targeting myeloid cells<\/a><time datetime=\"2026-10-06T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Interleukin (IL)-10 produced by B cells has regulatory functions in disease contexts. Manfroi et al. report a strategy for the efficient generation of IL-10-producing B cells using a chemical compound identified through a high-throughput screen. Upon t&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00382-1?rss=yes\">Functional evaluation of TCR-pMHC pairs at scale allows in silico TCR reactivity prediction<\/a><time datetime=\"2026-10-01T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Messemaker et al. develop a TCR rapid assembly platform (T-RAP) and use it to generate a large high-quality dataset of functionally validated TCR-pMHC pairs. With the resulting validated TCR-pMHC dataset (TCRvdb), structure-based prediction of TCR-pMHC&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00384-5?rss=yes\">Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy<\/a><time datetime=\"2026-10-01T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de October de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Menzel, Zhou, et al. examine the impact of surgical removal of tumor-draining lymph node (tdLN) resection on anti-tumor immunity. They find that after tdLN resection, tumor antigen is rerouted to distant LNs, where it supports tumor-specific T cell res&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00399-7?rss=yes\">Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids<\/a><time datetime=\"2026-09-30T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 56, 1910\u20131926.e1\u2013e7; August 8, 2023)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00348-1?rss=yes\">Cancers modulate processing and presentation of p53 neoantigens to evade T cell detection<\/a><time datetime=\"2026-09-17T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mutations in TP53 occur early in malignant transformation and are generally present in all descendant tumor cells. Haratani et al. find a dearth of actionable neoantigens displayed in the cancer immunopeptidome and define various mechanisms whereby tum&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00380-8?rss=yes\">Effector differentiation by stem-like intraepithelial \u03b3\u03b4 T cells is required for host defense against infection<\/a><time datetime=\"2026-09-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 59, 1\u201321.e1\u2013e7; March 10, 2026)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00347-X?rss=yes\">Chromatin triggers tissue-specific immunity in 3D<\/a><div class=\"wp-block-latest-posts__post-author\">by Joshua McKeever, Andrew S. Koh<\/div><time datetime=\"2026-09-08T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">8 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Antigenic and environmental stimuli sensed by innate and adaptive immune cells trigger cognate functions that allow the coordination of the appropriate immune response. In this issue of Immunity, Tzerpos et al. and Jay et al. demonstrate that chromatin&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00344-4?rss=yes\">Sensory nerves send lymphoid assembly up in smoke<\/a><div class=\"wp-block-latest-posts__post-author\">by Aditya Patil, Lloyd Bod<\/div><time datetime=\"2026-09-08T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">8 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Accumulating evidence implicates sensory neurons in tumor progression, but signals linking nociceptive activity to impaired antitumor immunity remain unclear. In a recent issue of Cell, Ho et al. show that nociceptor activation impedes TLS assembly thr&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00345-6?rss=yes\">Speedy delivery: EV-derived fungal antigens establish oral-gut Th17 crosstalk<\/a><div class=\"wp-block-latest-posts__post-author\">by Joanne E. Konkel, Sarah L. Gaffen<\/div><time datetime=\"2026-09-08T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">8 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Candida albicans induces Th17 cells, but their origins remain unresolved. In this issue of Immunity, Martini et al. show that the mouth is a reservoir for fungal Th17 cells that adopt pathogenic signatures in the gut during Crohn\u2019s disease.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00342-0?rss=yes\">Lending an ear to the lung<\/a><div class=\"wp-block-latest-posts__post-author\">by Bingpeng Yao, Xin Sun<\/div><time datetime=\"2026-09-08T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">8 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The unprecedented recent advancement in the field of interoception (sensing self) has introduced neuromodulation as a realistic treatment approach. Shibuya et al. identified an ear-to-lung reflex in which activation of auricular-innervating TRPV1+ vaga&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00351-1?rss=yes\">UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes<\/a><time datetime=\"2026-09-03T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 59, 2500\u20132514.e1\u2013e8; September 8, 2026)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00324-9?rss=yes\">A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection<\/a><time datetime=\"2026-08-28T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">28 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Autoantibodies (autoAbs) are linked to mortality and Long COVID, yet their cellular origins remain unclear. Yuan et al. identify a distinct B cell population (DN2 cells) as a key source of autoAbs during SARS-CoV-2 infection. These cells mirror lupus D&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00325-0?rss=yes\">Temporal analyses of immune responses in sepsis reveal asynchrony between clinical stage of illness and immune states<\/a><time datetime=\"2026-08-28T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">28 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Sepsis lacks effective therapeutic interventions. Fish et al. examine sepsis patients and identify three temporal immune states with distinct resistance, disease tolerance, and resilience program trajectories. Early and late immune responses do not ali&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00321-3?rss=yes\">Long-lasting extracellular matrix modifications reshape intestinal stem cell fate and promote chronic inflammation<\/a><time datetime=\"2026-08-26T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">26 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Whether inflammation leaves a lasting imprint on the intestinal stem cell (ISC) niche has remained unknown. Adir et al. find that persistent modified ECM (modECM) encodes inflammatory memory, reshapes Lgr5+ ISCs into wound-associated epithelia, and pro&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00322-5?rss=yes\">T cell fate is dictated by different antigen-presenting cells in response to dietary versus gut epithelial self-antigen<\/a><time datetime=\"2026-08-26T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">26 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mechanisms governing T cell responses to food or microbes have been characterized; however, whether they also regulate gut autoimmunity is unknown. Zhou et al. uncover that self-antigens depend on distinct subsets of antigen-presenting cells compared w&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00323-7?rss=yes\">Single-allele chromatin tracing reveals cytokine-dependent super-enhancer repositioning in CD4+ T cells<\/a><time datetime=\"2026-08-24T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cytokine cues reshape how chromatin folds to control immune gene activity. Jay et al. show that cytokine signals reposition the Ets1 super-enhancer toward the geometric center of the locus and sustain Ets1 expression required for helper T cell differen&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00318-3?rss=yes\">An inflammatory bowel disease-linked lncRNA suppresses transcription factor T-BET expression in T cells to limit intestinal inflammation<\/a><time datetime=\"2026-08-20T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The role of noncoding lncRNAs in human disease is difficult to ascertain. Yang-Fischer et al. identify lnc15 (2310015A10Rik\/ENSMUSG00000097729) as a cytoplasmic brake on intestinal inflammation. lnc15 expression is decreased in active human inflammator&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00319-5?rss=yes\">Metabolic inflammation, obesity, and cancer<\/a><time datetime=\"2026-08-20T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Ginhoux and colleagues review the mechanisms underlying the impact of obesity on cancer susceptibility, progression, and response to therapy. They discuss how metabolic stress reprograms myeloid cells, particularly macrophages, driving chronic inflamma&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00320-1?rss=yes\">GPCR-G\u03b113 signaling regulates survival of intestinal intraepithelial CD8+ lymphocytes through migration to cytokine-rich niches<\/a><time datetime=\"2026-08-17T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The intestinal barrier harbors numerous intraepithelial lymphocytes (IELs) that promote tissue integrity and whose dysfunction contributes to disease. Earley et al. studied the G-protein coupled receptor signals regulating IEL movement and function and&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00316-X?rss=yes\">Canonical and noncanonical autophagy in immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by Vojo Deretic<\/div><time datetime=\"2026-08-17T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Recent studies have expanded the field of autophagy in immunity to include related but incompletely understood noncanonical autophagy processes. Deretic reviews these advancements in the context of immunity, offering a unifying framework for canonical &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00343-2?rss=yes\">Granzyme B Is Critical for T Cell Receptor-Induced Cell Death of Type 2 Helper T Cells<\/a><time datetime=\"2026-08-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 25, 237\u2013247; August 2006)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00317-1?rss=yes\">UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes<\/a><time datetime=\"2026-08-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">UVR-damaged melanocytes evade immune attack despite harboring many mutations. Lo et al. show that MITF, a transcriptional regulator crucial to melanocyte identity, directly induces the immune checkpoint molecule PD-L1. This intrinsic tolerance program &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00314-6?rss=yes\">Copy and paste: Humanizing IgH 155 kb at a time<\/a><div class=\"wp-block-latest-posts__post-author\">by Tianli Xiao, Richard A. Flavell<\/div><time datetime=\"2026-08-11T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Generating mice that express human antibodies is a lengthy and labor-intensive process. Knocking in human gene segments into mice has potential, but how large a gene segment can be knocked into a zygote? Nair et al. insert a 155-kb human VH locus direc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00312-2?rss=yes\">Peripheral vision: Treg cell induction in the gut<\/a><div class=\"wp-block-latest-posts__post-author\">by Taylor A. Graham, Peter A. Savage<\/div><time datetime=\"2026-08-11T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Some regulatory T (Treg) cells differentiate at peripheral sites in response to antigens derived from innocuous sources. In this issue of Immunity, Chi et al. examine an extensive array of T cell receptors with specificity for self, microbial, or dieta&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00315-8?rss=yes\">Different lysosomal insults, one microglial fate<\/a><div class=\"wp-block-latest-posts__post-author\">by Baiping Wang, Hui Zheng<\/div><time datetime=\"2026-08-11T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Genetic associations point to a connection between lysosomal function and neurodegeneration. In this issue of Immunity, Balak et al. and Tejwani et al. show that genetically distinct lysosomal insults converge on a shared MITF\/TFE-driven epigenetic pro&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00309-2?rss=yes\">The genesis of cutaneous neurogenic inflammation is a multi-step process requiring dendritic cell aggregation<\/a><time datetime=\"2026-08-11T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Neurogenic inflammation is an important component of cutaneous immunity, yet the mechanism remains incompletely defined. Chen et al. found that the neuropeptide substance P activates mast cell release of the chemokine CCL2 to form dermal aggregates of &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00311-0?rss=yes\">The cost of persistence: MEK and metabolic demand<\/a><div class=\"wp-block-latest-posts__post-author\">by Ewelina Sobierajska, Christopher B. Medina<\/div><time datetime=\"2026-08-11T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The metabolic mechanisms linking chronic TCR stimulation to T cell exhaustion remain incompletely understood. Mitra and colleagues show that sustained MEK signaling drives the bioenergetic demands of chronic activation to promote terminal exhaustion, w&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00313-4?rss=yes\">Coordinated transcriptional networks program organelle expansion and metabolic flows for high endothelial morphology and function<\/a><time datetime=\"2026-08-11T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">High endothelial venules require specialized morphology and PNAd expression to support lymphocyte homing; however, the transcriptional mechanisms coordinating these defining features have remained unclear. Bi et al. identify XBP1-dependent and CREB3L2-&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00306-7?rss=yes\">Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism<\/a><time datetime=\"2026-08-06T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">SARS-CoV-2 encodes a viral deISGylase called PLpro, but its physiological functions and direct substrates remain elusive. Using a deISGylation-activity-ablated recombinant SARS-CoV-2, Zhu et al. show that deISGylation activity is required for innate im&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00310-9?rss=yes\">Group 2 innate lymphoid cells activate myelin-reactive T cells to augment neuroinflammation<\/a><time datetime=\"2026-08-06T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The meninges play a key role in central nervous system (CNS) inflammation and autoimmunity, but the mechanisms remain unclear. Huang et al. find that group 2 innate lymphoid cells (ILC2s) accumulate in the dura during neuroinflammation, where they acti&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00278-5?rss=yes\">CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity<\/a><time datetime=\"2026-08-04T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Dendritic cells (DCs) can acquire distinct functional states. To examine how different DC states orchestrate anti-tumor immunity, Koufaki et al. develop mouse models to label and ablate CCR7+ DCs and find that this activation state is essential for tum&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00305-5?rss=yes\">CD163+ red pulp macrophages interact with marginal metallophilic macrophages during blood-stage malaria to maintain splenic architecture<\/a><time datetime=\"2026-08-04T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Splenic macrophages adapt to malaria through subset-specific remodeling and inter-macrophage communication. Using fate mapping, single-cell transcriptomics, and genetic perturbation, Mauel et al. show that red pulp macrophages (RPMs) and marginal metal&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00308-0?rss=yes\">Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF\/TFE transcription factors<\/a><time datetime=\"2026-08-03T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mutations in proteins with roles in lysosomal function, including progranulin, are linked with neurodegenerative diseases. Tejwani, Heffner, et al. demonstrate that lysosomal dysfunction is sufficient to drive epigenetic, transcriptional, and functiona&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00307-9?rss=yes\">Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases<\/a><time datetime=\"2026-08-03T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lysosomal dysfunction is associated with neurodegeneration. Balak et al. examine the cell-specific effects of lysosomal dysfunction in an MPS-IIIA (Sgsh\u2212\/\u2212) model and find that microglia are disproportionately affected. Mechanistically, the MITF\/TFE tr&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00280-3?rss=yes\">Butyrophilin-like 3 and 8 tetramers clamp V\u03b34V\u03b41 T cell receptors for antigen-independent activation<\/a><div class=\"wp-block-latest-posts__post-author\">by De Dong, Huiling Li, Yuwei Zhu, Zebin Lu, Junliang Zhu, Xinyu Tian, Zhiwei Huang<\/div><time datetime=\"2026-08-03T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BTNL3 and BTNL8 are butyrophilin-like receptors that selectively regulate intestinal V\u03b34+ T cells, yet the underlying activation mechanism has remained elusive. Dong et al. reveal that BTNL3-BTNL8 forms an antigen-independent tetramer that drives \u03b3\u03b4 TC&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00304-3?rss=yes\">The liver-secreted protein FGL1 restrains a subset of innate-like B cell responses via the receptor TACI<\/a><time datetime=\"2026-07-30T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Negative regulatory ligands have been underexplored for B cells. Su et al. identify fibrinogen-like protein 1 (FGL1) as a new inhibitory ligand for a transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) on a subset of &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00279-7?rss=yes\">Bile acids in cancer: From metabolism to immunomodulation<\/a><div class=\"wp-block-latest-posts__post-author\">by Qian Fang, Kai Markus Schneider<\/div><time datetime=\"2026-07-29T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Fang and Schneider review how bile acids connect host metabolism, microbial ecology, and tumor immunity. They present a spatial and cell-type-aware framework for bile acid immunomodulation and discuss therapeutic opportunities to remodel bile acid-immu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00276-1?rss=yes\">Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cells<\/a><time datetime=\"2026-07-28T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">28 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Adherent cells mimic the mechanical properties of their surroundings, becoming stiffer in more rigid environments and softer in more compliant ones. Elbanna et al. find that this environmentally induced stiffening response shapes metastatic site distri&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00277-3?rss=yes\">TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation<\/a><time datetime=\"2026-07-28T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">28 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Using CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation. They find that TCR identity encodes pTreg cell gener&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00275-X?rss=yes\">Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma<\/a><time datetime=\"2026-07-24T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">How brain-resident microglia regulate T cell immunity during glioma progression remains unclear. Qian et al. show that disease-associated microglia (DAMs) are not fixed suppressors but instead evolve with tumor stage. DAMs transition from antigen-prese&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00271-2?rss=yes\">Autophagy maintains high endothelial venule identity and function during inflammation<\/a><time datetime=\"2026-07-17T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">High endothelial venules (HEVs) facilitate lymphocyte entry into lymph nodes by displaying peripheral node addressin (PNAd), yet how PNAd is regulated remains poorly understood. Jacobs et al. reveal that autophagy preserves HEV identity and function by&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00273-6?rss=yes\">The transcription factor BACH1 couples chromatin priming and repression to enable macrophage plasticity and adaptation<\/a><time datetime=\"2026-07-17T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Macrophage plasticity and function involve precise regulation of transcriptional programs. Tzerpos et al. find that the transcription factor BACH1 establishes early chromatin accessibility while maintaining transcriptionally repressive states in naive &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00274-8?rss=yes\">Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING<\/a><time datetime=\"2026-07-17T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Innate immune recognition of bacteria is thought to center on cell-surface or endosomal pattern recognition receptors such as TLRs. Ragland et al. identify an intraphagosomal cyclic dinucleotide (CDN)-host transporter-STING axis, wherein cytoplasmic ST&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00256-6?rss=yes\">Activation of the auricular vagus nerve reflex suppresses airway inflammation<\/a><time datetime=\"2026-07-15T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">15 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Bioelectronic technologies are being deployed to treat many inflammatory conditions using transcutaneous auricular nerve stimulation. Shibuya et al. employ viral tracing, chemogenetics, and optogenetics to unveil a sensory skin-lung vagal reflex that s&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00264-5?rss=yes\">Antigen-restricted Candida albicans Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation<\/a><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Martini, Hofmann, et al. identify C. albicans-specific Th17 cells targeting fungal EV proteins that predominantly reside in the human oral mucosa at homeostasis. However, these oral-residing cells exhibit TCR overlap with gut Th17 cells. During intesti&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00269-4?rss=yes\">The lasting legacy of motherhood in the gut<\/a><div class=\"wp-block-latest-posts__post-author\">by Iker Ram\u00edrez Lape\u00f1a, Stephanie C. Ganal-Vonarburg<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">While pregnancy suppresses systemic immunity to tolerate the fetus, adaptations of the gut remain unclear. In a recent issue of Nature, Huang et al. show that reproduction increases intestinal eosinophils, shifting intestinal stem cell fate toward gobl&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00272-4?rss=yes\">Lung lipids license neutrophils to grease the gate<\/a><div class=\"wp-block-latest-posts__post-author\">by Maxwell Bannister, Mikala Egeblad<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Metabolic alterations and neutrophils define the pre-metastatic niche, but the mechanisms connecting them remain incompletely understood. In this issue of Immunity, Qian et al. show that endothelial-derived palmitate induces neutrophils to release lipo&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00266-9?rss=yes\">Danger fuels immune escape<\/a><div class=\"wp-block-latest-posts__post-author\">by Massimo Russo, Santiago Zelenay<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Extracellular ATP (eATP) is an immunogenic danger signal. In this issue of Immunity, Hu et al. report that in the tumor microenvironment, eATP signals through the receptor P2RY2 on cancer cells, triggering the COX-PGE2 pathway and thereby immune suppre&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00268-2?rss=yes\">CD4+ T cells persist with their Eomes<\/a><div class=\"wp-block-latest-posts__post-author\">by Abishek Vaidya, Alice O. Kamphorst<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Similar to CD8+ T cells, stem-like CD4+ T cells sustain responses to tumors, chronic infections, and inflammation. In this issue of Immunity, Wen et al. and Agesta et al. reveal EOMES as a critical regulator of stem-like CD4+ T cell maintenance and dif&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00265-7?rss=yes\">Good 4 u: A classic cytokine rejuvenates hematopoiesis<\/a><div class=\"wp-block-latest-posts__post-author\">by Kira L. Florczak, Steven J. Van Dyken<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Aging and chronic inflammation alter hematopoiesis, impacting the hematopoietic progenitor populations in the bone marrow. In this issue of Immunity, Yao et al. show that the canonical type 2 cytokine interleukin 4 reverses age-related hematopoietic an&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00267-0?rss=yes\">Philippe Bousso (1971\u20132026)<\/a><div class=\"wp-block-latest-posts__post-author\">by Matthew L. Albert, Ellen A. Robey<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In April of this year, our community lost one of its most brilliant and beloved members, Philippe Bousso. With his unique scientific vision, love of technical innovation, and his generous and kind spirit, Philippe touched many of our lives and gave us &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00261-X?rss=yes\">Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity<\/a><time datetime=\"2026-07-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Precise control of cytosolic nucleic acid sensing is essential for immune homeostasis, yet endogenous metabolites that regulate both DNA and RNA sensing remain unidentified. Wang et al. identify FAD as a natural brake restraining both DNA- and RNA-trig&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00263-3?rss=yes\">MEK-dependent bioenergetic demand drives terminal CD8+ T cell exhaustion<\/a><time datetime=\"2026-07-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mitra et al. examine how chronic antigen stimulation of CD8+ T cells leads to this metabolic dysfunction and find that MEK-driven ATP demand drives terminal T cell exhaustion by supporting protein synthesis at the expense of NAD+-dependent proliferatio&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00262-1?rss=yes\">Nasal immunity in respiratory viral infection, transmission, and protection<\/a><div class=\"wp-block-latest-posts__post-author\">by Samuel W. Kazer, Jaclyn M.L. Walsh, Lillian J. Juttukonda, Jose Ordovas-Montanes<\/div><time datetime=\"2026-07-13T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The nasal mucosa is a key decision point during respiratory viral infection. Here, Kazer et al. review new understanding of how local host cell subsets respond during viral infection and how this knowledge may enable tissue-scale protection through muc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00259-1?rss=yes\">CRISPR-mediated precise large fragment insertion in zygotes enables rapid generation of humanized immunoglobulin heavy-chain mice<\/a><time datetime=\"2026-07-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Current CRISPR-Cas9 methods are restricted to small genomic edits. Nair et al. report the rapid generation of knock-in mice expressing human immunoglobulin (Ig) by precise deletion of the 2.4-Mb murine Ig heavy-chain locus and insertion of a 155-kb hum&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00258-X?rss=yes\">Transcription factor BHLHE40 expression in group 3 innate lymphoid cells and ROR\u03b3t\u207a antigen-presenting cells coordinates intestinal immunity<\/a><time datetime=\"2026-07-07T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">7 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The ability to maintain tolerance at mucosal barrier surfaces is critical for immune homeostasis. Yang et al. identify Bhlhe40 as a central regulator linking innate and adaptive intestinal immunity. By coordinating ILC3 effector responses with ROR\u03b3t\u207a a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00253-0?rss=yes\">Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience<\/a><time datetime=\"2026-07-03T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Recurrence is a major clinical challenge in hepatocellular carcinoma (HCC). Gu et al. examine human HCC samples to identify drivers of disease recurrence and find that inhibiting the cholesterol esterification enzyme SOAT1 impairs tumor redox resilienc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00260-8?rss=yes\">Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing<\/a><time datetime=\"2026-07-02T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">2 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">West Nile virus and other neurotrophic arboviruses can cause life-threatening encephalitis. Lewy et al. identify a cross-organ immune circuit where viral pattern sensing in the skin potently counteracts viral encephalitis. Mechanistically, the establis&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00254-2?rss=yes\">B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection<\/a><time datetime=\"2026-07-02T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">2 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Extrinsic factors that support CD8+ T cell responses during chronic viral infection are incompletely defined. Gago da Gra\u00e7a et al. identify a crucial role for B cells in triggering type I interferon production, thereby promoting T cell effector formati&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00257-8?rss=yes\">Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors<\/a><time datetime=\"2026-07-02T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">2 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Extracellular ATP (eATP) is associated with immune suppression in the tumor microenvironment (TME) via its metabolite adenosine. Hu et al. find that immunotherapy increases eATP within the TME and drives immune suppression through direct binding of the&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00255-4?rss=yes\">Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion<\/a><time datetime=\"2026-06-30T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Aerobic glycolysis, a hallmark of cancer, preferentially converts pyruvate into lactate. Guo et al. demonstrate that tumor aerobic glycolysis drives lactate production through PKM2-mediated phosphorylation and activation of LDHA. Lactate directly binds&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00270-0?rss=yes\">Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition<\/a><time datetime=\"2026-06-25T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">25 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 59, 458\u2013476.e1\u2013e13; February 10, 2026)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00230-X?rss=yes\">Antibody binding geometry and affinity control inhibitory hFc\u03b3RIIB receptor signaling<\/a><time datetime=\"2026-06-25T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">25 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Understanding Fc\u03b3R engagement and signaling is central to improving monoclonal antibody therapeutics. Using structural, biophysical, and cellular immunology approaches, Fisher et al. demonstrate how disparate off rates drive the agonism and antagonism &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00229-3?rss=yes\">The transcription factor Eomes drives a stemness program in CD4+ T cells that promotes anti-tumor immunity in response to immunotherapy<\/a><time datetime=\"2026-06-24T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The transcription factor Eomes orchestrates the differentiation and maintenance of an exhausted-like Th cell lineage that is transcriptionally and functionally distinct from conventional effector and memory Th subsets. This lineage is amplified by 4-1B&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00231-1?rss=yes\">Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection<\/a><time datetime=\"2026-06-24T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CD4+ T helper cells are essential for adaptive immunity; however, factors governing their maintenance and function during chronic antigen exposure remain unclear. Wen et al. identify a precursor T cell population, dependent on TOX, EOMES, and MYB, that&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00228-1?rss=yes\">Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes<\/a><time datetime=\"2026-06-23T16:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">23 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lymph nodes initiate protective T cell responses to Mycobacterium tuberculosis yet also serve as sites of chronic infection. Shamskhou et al. shed light on this paradox by showing a shift from early dendritic cell-driven Th1 cell priming to monocyte-de&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00224-4?rss=yes\">Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses<\/a><time datetime=\"2026-06-22T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">22 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">No specific prophylaxis or treatment exists for West Nile virus (WNV) or related orthoflavivirus infections. Cervantes Rinc\u00f3n et al. characterize human antibody responses to WNV and identify protective epitopes on the virus envelope protein. A potent m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00225-6?rss=yes\">Neutrophil regulation of immunotherapy for cancer is controlled by type II interferon<\/a><time datetime=\"2026-06-15T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Neutrophils have the capacity to both support and block tumor growth depending on their polarization state. Here, Pei et al. find that IFN-\u03b3 produced during immunotherapy induces PD-L1 expression by neutrophils with an aged phenotype that drives therap&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00223-2?rss=yes\">Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection<\/a><time datetime=\"2026-06-12T18:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The mechanisms by which anti-RIPR antibodies inhibit parasite invasion are poorly understood. Williams et al. analyze monoclonal antibodies against the Plasmodium falciparum blood-stage protein RIPR and reveal that combinations of non-neutralizing anti&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00227-X?rss=yes\">Interleukin 23 promotes a pro-inflammatory Th17 cell state by stabilizing ROR\u03b3t and suppressing glucocorticoid receptor activity<\/a><time datetime=\"2026-06-12T16:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">How IL-23 drives an inflammatory Th17 cell state is poorly understood. Yang et al. identify two coordinated mechanisms specific to IL-23R signaling: the recruitment of CHD1 to stabilize ROR\u03b3t expression and function and the blockade of glucocorticoid r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00226-8?rss=yes\">A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains a homeostatic Th17 cell state<\/a><time datetime=\"2026-06-12T16:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Th17 cells can either preserve homeostasis or drive inflammation in tissues; however, the mechanisms that maintain homeostatic phenotypes are not well defined. Yang et al. uncover a cell-intrinsic glucocorticoid circuit and the underlying gene network &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00216-5?rss=yes\">Immunoediting restricts clonal neoantigens in primary, treatment-naive human tumors<\/a><time datetime=\"2026-06-11T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Borden et al. examine primary, treatment-naive squamous cell carcinoma (SCC) tumors to determine the impact of immunoediting. Comparison of SCC tumors from immunocompetent and immunosuppressed patients demonstrates immune-mediated sculpting of the tumo&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00215-3?rss=yes\">Astrocyte-microglia crosstalk unlocks Alzheimer\u2019s disease<\/a><div class=\"wp-block-latest-posts__post-author\">by Eunyoung Kim, Xinzhu Yu<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Altered astrocyte-microglia interactions have been implicated in the pathogenesis of Alzheimer\u2019s disease, but the underpinning mechanisms remain unclear. Zhang and colleagues show that astrocytic PAD2-mediated citrullination of vimentin activates micro&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00220-7?rss=yes\">Fibroblasts hold the key to TLS formation<\/a><div class=\"wp-block-latest-posts__post-author\">by Th\u00e9o Bouloudani, Catherine Saut\u00e8s-Fridman<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The presence of tertiary lymphoid structures (TLSs) associates with improved anti-tumor immunity, and as such, understanding why some tumors develop TLSs is of prime interest. In the current issue of Cancer Cell, Kirschstein et al. demonstrate that TGF&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00218-9?rss=yes\">Cholesterol metabolism in immune cells: From mechanisms to therapeutic opportunities<\/a><div class=\"wp-block-latest-posts__post-author\">by Mingyang Yin, Tao Liang, Yumeng Zhang, Guangchuan Wang, Wei Yang, Chenqi Xu<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cholesterol metabolism is an essential component of all immune cells. Xu and colleagues review the immunological functions of cholesterol metabolites and proteins and discuss how distinct cholesterol metabolic programs fulfil the metabolic and signalin&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00221-9?rss=yes\">Dendritic cells shape and sustain fibroblast niches<\/a><div class=\"wp-block-latest-posts__post-author\">by Spyridon Makris, Sophie E. Acton<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Fibroblasts are highly attuned for immune crosstalk within lymphoid tissues. In this issue of Immunity, Alouche et al. provide insight into how fibroblast immunoregulatory phenotypes are acquired and maintained, revealing that Ccl19hi fibroblastic reti&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00219-0?rss=yes\">Exhaustion in name only: CD8+ T cells drive lupus nephritis<\/a><div class=\"wp-block-latest-posts__post-author\">by Guillem Montamat-Garcia, Claudia Mauri<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Systemic lupus erythematosus is characterized by autoantibodies against nuclear antigens. In this issue of Immunity, Al Souz et al. report that kidney damage in lupus nephritis is sustained by stem-like CD8+ T cells that migrate from lymphoid tissues a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00217-7?rss=yes\">Guardian of two galaxies: Senescence-associated immune cells control disease tolerance and aging<\/a><div class=\"wp-block-latest-posts__post-author\">by Wolfgang Vivas, Sebastian Weis<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Preservation of host fitness is a common feature of longevity and immunity to infection. In this issue of Immunity, Triana-Martinez et al. reveal that p16High senescence-associated immune cells promote disease tolerance and healthy aging. Mechanistical&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00222-0?rss=yes\">Communicating science<\/a><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Research that is done but never shared does not make a sound. Science communication can take many forms and has many audiences, from research colleagues to the general public. Here, investigators discuss the importance of engaging in the dissemination &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00180-9?rss=yes\">Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging<\/a><div class=\"wp-block-latest-posts__post-author\">by Jingfei Yao, Yuting Wang, Yi Zhang<\/div><time datetime=\"2026-05-29T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Chronic inflammation and aging skew hematopoiesis toward myelopoiesis. Starting with a screen to identify signals capable of restoring lymphoid lineage commitment in HSPCs, Yao et al. find that exogenous interleukin 4 can drive lymphoid differentiation&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00200-1?rss=yes\">A longitudinal atlas of human psoriatic skin reveals the mechanisms of anti-IL-23 therapy in disrupting the type 17 inflammatory circuit<\/a><time datetime=\"2026-05-28T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">28 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Patients with psoriasis show a durable clinical response to the anti-IL-23 biologic, risankizumab, even after treatment cessation. Here, Jiang et al. generate a longitudinal single-cell and spatial transcriptomics atlas of patients pre- and post-treatm&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00181-0?rss=yes\">Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit<\/a><time datetime=\"2026-05-26T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">26 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lobel, Fonseca-Pereira, et al. demonstrate that dietary sulfur amino acids (Saa) enhance anti-tumor immunity in colon cancer. A high-Saa diet expands the bacterium Mucispirillum schaedleri, which activates a natural killer T cell-dendritic cell axis to&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00179-2?rss=yes\">Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells<\/a><time datetime=\"2026-05-26T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">26 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">B cell infiltration in high-grade serous ovarian cancer associates with favorable prognosis. Nathan et al. show that tumor-draining lymph nodes in patients lack active germinal center responses and instead harbor quiescent tumor-reactive memory B cells&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00178-0?rss=yes\">The immunology of exercise: Mechanisms, mediators, and therapeutic opportunities<\/a><div class=\"wp-block-latest-posts__post-author\">by Catherine M. Phelps, Marlies Meisel<\/div><time datetime=\"2026-05-21T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">21 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Exercise is increasingly linked to improved immune function across diseases, yet the underlying mechanisms remain incompletely understood. Meisel et al. synthesize how acute exercise and sustained training reshape immune-cell trafficking and function t&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00177-9?rss=yes\">Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation<\/a><time datetime=\"2026-05-19T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">T follicular helper 13 (Tfh13) cells are required for anaphylactic IgE responses, yet how these cells arise is unclear. Lee et al. show that allergen sensitization drives CCR8-dependent trafficking of ILC2s to lymph nodes, where they provide early IL-4&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00175-5?rss=yes\">Dietary soy shapes the microbiome to induce commensal-specific T follicular helper cells and IgA production<\/a><time datetime=\"2026-05-19T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Diet impacts gut microbes and, subsequently, host immunity, but our understanding of the mechanisms driving this axis remains incomplete. Hattori-Muroi, Maruta, Takahashi, et al. show that dietary soy promotes colonization of commensals that cooperativ&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00176-7?rss=yes\">Aged circulating CD8+ T cells and their secreted factors drive cognitive decline<\/a><time datetime=\"2026-05-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The role of non-infiltrating aged CD8+ T cells in brain function remains unclear. Sucharov et al. reveal that aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal of aged T cells, or their secreted factor granzyme K,&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00171-8?rss=yes\">Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity<\/a><time datetime=\"2026-05-13T18:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">T follicular helper (Tfh) cells are essential for humoral immunity but can promote autoimmunity when dysregulated. Wang et al. identify a mevalonate pathway-dependent program in which GGPP supports Tfh cell differentiation by sustaining surface protein&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00172-X?rss=yes\">Daredevil human cDC2s tame wild TSLP to promote tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Abel Lopez Hernandez, Marc Dalod<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Under homeostatic conditions, murine dendritic cells (DCs) undergo a tolerogenic activation termed homeostatic maturation, preventing autoimmunity by inducing tolerance to innocuous antigens; whether this process occurs in humans is unknown. In this is&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00169-X?rss=yes\">A Kr\u00fcppel of factors regulate T cell residency and exhaustion<\/a><div class=\"wp-block-latest-posts__post-author\">by Dominic S. Albao, Shashank D. Nagaraja, Matthew E. Pipkin<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CD8+ T cells responding to chronic infections are functionally and spatially heterogeneous. In this issue of Immunity, Shen et al. and Geng et al. demonstrate that the transcription factors KLF2 and KLF3 have integrated but opposing roles in regulating&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00174-3?rss=yes\">Paving the road for CARs in pediatric autoimmune diseases<\/a><div class=\"wp-block-latest-posts__post-author\">by Mohamad Hamieh, Virginia Pascual<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Severe pediatric autoimmune diseases (AD) have limited therapeutic options. In a recent issue of Nature Medicine, Becilli et al. report a case series where CD19 CAR T cell treatment of pediatric AD patients induced rapid and durable remissions with man&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00170-6?rss=yes\">Rogue gut microbes derail memory<\/a><div class=\"wp-block-latest-posts__post-author\">by Dilara Hasavci, Thomas Blank<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The gut microbiome contributes to age-related cognitive decline, but signaling mechanisms remain unclear. In a recent issue of Nature, Cox et al. show that P. goldsteinii-derived fatty acids activate myeloid cells, thus inducing inflammation that disru&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00173-1?rss=yes\">ART Interrupted: Insights into ART-free HIV remission<\/a><div class=\"wp-block-latest-posts__post-author\">by Ramon A. Lujan, Eli A. Boritz<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Defining correlates of HIV rebound upon antiretroviral therapy (ART) interruption can advance HIV cure research. In this issue of Immunity, Ma et al. analyze immunophenotypes and transcriptomes from multiple clinical trials, linking T and NK cell subse&#8230;<\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":16685,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16684","page","type-page","status-publish","has-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/pages\/16684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/comments?post=16684"}],"version-history":[{"count":2,"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/pages\/16684\/revisions"}],"predecessor-version":[{"id":16687,"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/pages\/16684\/revisions\/16687"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/media\/16685"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/wp-json\/wp\/v2\/media?parent=16684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}