{"id":16684,"date":"2024-09-27T19:17:21","date_gmt":"2024-09-27T17:17:21","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16684"},"modified":"2024-09-27T19:17:56","modified_gmt":"2024-09-27T17:17:56","slug":"immunity","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/immunity\/","title":{"rendered":"Immunity"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00269-4?rss=yes\">The lasting legacy of motherhood in the gut<\/a><div class=\"wp-block-latest-posts__post-author\">by Iker Ram\u00edrez Lape\u00f1a, Stephanie C. Ganal-Vonarburg<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">While pregnancy suppresses systemic immunity to tolerate the fetus, adaptations of the gut remain unclear. In a recent issue of Nature, Huang et al. show that reproduction increases intestinal eosinophils, shifting intestinal stem cell fate toward gobl&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00272-4?rss=yes\">Lung lipids license neutrophils to grease the gate<\/a><div class=\"wp-block-latest-posts__post-author\">by Maxwell Bannister, Mikala Egeblad<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Metabolic alterations and neutrophils define the pre-metastatic niche, but the mechanisms connecting them remain incompletely understood. In this issue of Immunity, Qian et al. show that endothelial-derived palmitate induces neutrophils to release lipo&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00266-9?rss=yes\">Danger fuels immune escape<\/a><div class=\"wp-block-latest-posts__post-author\">by Massimo Russo, Santiago Zelenay<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Extracellular ATP (eATP) is an immunogenic danger signal. In this issue of Immunity, Hu et al. report that in the tumor microenvironment, eATP signals through the receptor P2RY2 on cancer cells, triggering the COX-PGE2 pathway and thereby immune suppre&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00268-2?rss=yes\">CD4+ T cells persist with their Eomes<\/a><div class=\"wp-block-latest-posts__post-author\">by Abishek Vaidya, Alice O. Kamphorst<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Similar to CD8+ T cells, stem-like CD4+ T cells sustain responses to tumors, chronic infections, and inflammation. In this issue of Immunity, Wen et al. and Agesta et al. reveal EOMES as a critical regulator of stem-like CD4+ T cell maintenance and dif&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00265-7?rss=yes\">Good 4 u: A classic cytokine rejuvenates hematopoiesis<\/a><div class=\"wp-block-latest-posts__post-author\">by Kira L. Florczak, Steven J. Van Dyken<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Aging and chronic inflammation alter hematopoiesis, impacting the hematopoietic progenitor populations in the bone marrow. In this issue of Immunity, Yao et al. show that the canonical type 2 cytokine interleukin 4 reverses age-related hematopoietic an&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00267-0?rss=yes\">Philippe Bousso (1971\u20132026)<\/a><div class=\"wp-block-latest-posts__post-author\">by Matthew L. Albert, Ellen A. Robey<\/div><time datetime=\"2026-07-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In April of this year, our community lost one of its most brilliant and beloved members, Philippe Bousso. With his unique scientific vision, love of technical innovation, and his generous and kind spirit, Philippe touched many of our lives and gave us &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00253-0?rss=yes\">Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Recurrence is a major clinical challenge in hepatocellular carcinoma (HCC). Gu et al. examine human HCC samples to identify drivers of disease recurrence and find that inhibiting the cholesterol esterification enzyme SOAT1 impairs tumor redox resilienc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00260-8?rss=yes\">Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-02T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">2 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">West Nile virus and other neurotrophic arboviruses can cause life-threatening encephalitis. Lewy et al. identify a cross-organ immune circuit where viral pattern sensing in the skin potently counteracts viral encephalitis. Mechanistically, the establis&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00257-8?rss=yes\">Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-02T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">2 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Extracellular ATP (eATP) is associated with immune suppression in the tumor microenvironment (TME) via its metabolite adenosine. Hu et al. find that immunotherapy increases eATP within the TME and drives immune suppression through direct binding of the&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00255-4?rss=yes\">Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Aerobic glycolysis, a hallmark of cancer, preferentially converts pyruvate into lactate. Guo et al. demonstrate that tumor aerobic glycolysis drives lactate production through PKM2-mediated phosphorylation and activation of LDHA. Lactate directly binds&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00270-0?rss=yes\">Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-25T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">25 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 59, 458\u2013476.e1\u2013e13; February 10, 2026)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00230-X?rss=yes\">Antibody binding geometry and affinity control inhibitory hFc\u03b3RIIB receptor signaling<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-25T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">25 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Understanding Fc\u03b3R engagement and signaling is central to improving monoclonal antibody therapeutics. Using structural, biophysical, and cellular immunology approaches, Fisher et al. demonstrate how disparate off rates drive the agonism and antagonism &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00229-3?rss=yes\">The transcription factor Eomes drives a stemness program in CD4+ T cells that promotes anti-tumor immunity in response to immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-24T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The transcription factor Eomes orchestrates the differentiation and maintenance of an exhausted-like Th cell lineage that is transcriptionally and functionally distinct from conventional effector and memory Th subsets. This lineage is amplified by 4-1B&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00231-1?rss=yes\">Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-24T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CD4+ T helper cells are essential for adaptive immunity; however, factors governing their maintenance and function during chronic antigen exposure remain unclear. Wen et al. identify a precursor T cell population, dependent on TOX, EOMES, and MYB, that&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00224-4?rss=yes\">Analysis of West Nile disease convalescents identifies human monoclonal antibodies protective against West Nile and related orthoflaviviruses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-22T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">22 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">No specific prophylaxis or treatment exists for West Nile virus (WNV) or related orthoflavivirus infections. Cervantes Rinc\u00f3n et al. characterize human antibody responses to WNV and identify protective epitopes on the virus envelope protein. A potent m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00225-6?rss=yes\">Neutrophil regulation of immunotherapy for cancer is controlled by type II interferon<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Neutrophils have the capacity to both support and block tumor growth depending on their polarization state. Here, Pei et al. find that IFN-\u03b3 produced during immunotherapy induces PD-L1 expression by neutrophils with an aged phenotype that drives therap&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00216-5?rss=yes\">Immunoediting restricts clonal neoantigens in primary, treatment-naive human tumors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-11T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">11 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Borden et al. examine primary, treatment-naive squamous cell carcinoma (SCC) tumors to determine the impact of immunoediting. Comparison of SCC tumors from immunocompetent and immunosuppressed patients demonstrates immune-mediated sculpting of the tumo&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00215-3?rss=yes\">Astrocyte-microglia crosstalk unlocks Alzheimer\u2019s disease<\/a><div class=\"wp-block-latest-posts__post-author\">by Eunyoung Kim, Xinzhu Yu<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Altered astrocyte-microglia interactions have been implicated in the pathogenesis of Alzheimer\u2019s disease, but the underpinning mechanisms remain unclear. Zhang and colleagues show that astrocytic PAD2-mediated citrullination of vimentin activates micro&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00220-7?rss=yes\">Fibroblasts hold the key to TLS formation<\/a><div class=\"wp-block-latest-posts__post-author\">by Th\u00e9o Bouloudani, Catherine Saut\u00e8s-Fridman<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The presence of tertiary lymphoid structures (TLSs) associates with improved anti-tumor immunity, and as such, understanding why some tumors develop TLSs is of prime interest. In the current issue of Cancer Cell, Kirschstein et al. demonstrate that TGF&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00218-9?rss=yes\">Cholesterol metabolism in immune cells: From mechanisms to therapeutic opportunities<\/a><div class=\"wp-block-latest-posts__post-author\">by Mingyang Yin, Tao Liang, Yumeng Zhang, Guangchuan Wang, Wei Yang, Chenqi Xu<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cholesterol metabolism is an essential component of all immune cells. Xu and colleagues review the immunological functions of cholesterol metabolites and proteins and discuss how distinct cholesterol metabolic programs fulfil the metabolic and signalin&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00221-9?rss=yes\">Dendritic cells shape and sustain fibroblast niches<\/a><div class=\"wp-block-latest-posts__post-author\">by Spyridon Makris, Sophie E. Acton<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Fibroblasts are highly attuned for immune crosstalk within lymphoid tissues. In this issue of Immunity, Alouche et al. provide insight into how fibroblast immunoregulatory phenotypes are acquired and maintained, revealing that Ccl19hi fibroblastic reti&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00219-0?rss=yes\">Exhaustion in name only: CD8+ T cells drive lupus nephritis<\/a><div class=\"wp-block-latest-posts__post-author\">by Guillem Montamat-Garcia, Claudia Mauri<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Systemic lupus erythematosus is characterized by autoantibodies against nuclear antigens. In this issue of Immunity, Al Souz et al. report that kidney damage in lupus nephritis is sustained by stem-like CD8+ T cells that migrate from lymphoid tissues a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00217-7?rss=yes\">Guardian of two galaxies: Senescence-associated immune cells control disease tolerance and aging<\/a><div class=\"wp-block-latest-posts__post-author\">by Wolfgang Vivas, Sebastian Weis<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Preservation of host fitness is a common feature of longevity and immunity to infection. In this issue of Immunity, Triana-Martinez et al. reveal that p16High senescence-associated immune cells promote disease tolerance and healthy aging. Mechanistical&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00222-0?rss=yes\">Communicating science<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Research that is done but never shared does not make a sound. Science communication can take many forms and has many audiences, from research colleagues to the general public. Here, investigators discuss the importance of engaging in the dissemination &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00180-9?rss=yes\">Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging<\/a><div class=\"wp-block-latest-posts__post-author\">by Jingfei Yao, Yuting Wang, Yi Zhang<\/div><time datetime=\"2026-05-29T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Chronic inflammation and aging skew hematopoiesis toward myelopoiesis. Starting with a screen to identify signals capable of restoring lymphoid lineage commitment in HSPCs, Yao et al. find that exogenous interleukin 4 can drive lymphoid differentiation&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00200-1?rss=yes\">A longitudinal atlas of human psoriatic skin reveals the mechanisms of anti-IL-23 therapy in disrupting the type 17 inflammatory circuit<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-28T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">28 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Patients with psoriasis show a durable clinical response to the anti-IL-23 biologic, risankizumab, even after treatment cessation. Here, Jiang et al. generate a longitudinal single-cell and spatial transcriptomics atlas of patients pre- and post-treatm&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00181-0?rss=yes\">Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-26T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">26 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lobel, Fonseca-Pereira, et al. demonstrate that dietary sulfur amino acids (Saa) enhance anti-tumor immunity in colon cancer. A high-Saa diet expands the bacterium Mucispirillum schaedleri, which activates a natural killer T cell-dendritic cell axis to&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00179-2?rss=yes\">Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-26T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">26 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">B cell infiltration in high-grade serous ovarian cancer associates with favorable prognosis. Nathan et al. show that tumor-draining lymph nodes in patients lack active germinal center responses and instead harbor quiescent tumor-reactive memory B cells&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00178-0?rss=yes\">The immunology of exercise: Mechanisms, mediators, and therapeutic opportunities<\/a><div class=\"wp-block-latest-posts__post-author\">by Catherine M. Phelps, Marlies Meisel<\/div><time datetime=\"2026-05-21T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">21 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Exercise is increasingly linked to improved immune function across diseases, yet the underlying mechanisms remain incompletely understood. Meisel et al. synthesize how acute exercise and sustained training reshape immune-cell trafficking and function t&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00177-9?rss=yes\">Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T17:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">T follicular helper 13 (Tfh13) cells are required for anaphylactic IgE responses, yet how these cells arise is unclear. Lee et al. show that allergen sensitization drives CCR8-dependent trafficking of ILC2s to lymph nodes, where they provide early IL-4&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00175-5?rss=yes\">Dietary soy shapes the microbiome to induce commensal-specific T follicular helper cells and IgA production<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Diet impacts gut microbes and, subsequently, host immunity, but our understanding of the mechanisms driving this axis remains incomplete. Hattori-Muroi, Maruta, Takahashi, et al. show that dietary soy promotes colonization of commensals that cooperativ&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00176-7?rss=yes\">Aged circulating CD8+ T cells and their secreted factors drive cognitive decline<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-14T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The role of non-infiltrating aged CD8+ T cells in brain function remains unclear. Sucharov et al. reveal that aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal of aged T cells, or their secreted factor granzyme K,&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00171-8?rss=yes\">Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-13T18:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">13 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">T follicular helper (Tfh) cells are essential for humoral immunity but can promote autoimmunity when dysregulated. Wang et al. identify a mevalonate pathway-dependent program in which GGPP supports Tfh cell differentiation by sustaining surface protein&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00172-X?rss=yes\">Daredevil human cDC2s tame wild TSLP to promote tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Abel Lopez Hernandez, Marc Dalod<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Under homeostatic conditions, murine dendritic cells (DCs) undergo a tolerogenic activation termed homeostatic maturation, preventing autoimmunity by inducing tolerance to innocuous antigens; whether this process occurs in humans is unknown. In this is&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00169-X?rss=yes\">A Kr\u00fcppel of factors regulate T cell residency and exhaustion<\/a><div class=\"wp-block-latest-posts__post-author\">by Dominic S. Albao, Shashank D. Nagaraja, Matthew E. Pipkin<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CD8+ T cells responding to chronic infections are functionally and spatially heterogeneous. In this issue of Immunity, Shen et al. and Geng et al. demonstrate that the transcription factors KLF2 and KLF3 have integrated but opposing roles in regulating&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00174-3?rss=yes\">Paving the road for CARs in pediatric autoimmune diseases<\/a><div class=\"wp-block-latest-posts__post-author\">by Mohamad Hamieh, Virginia Pascual<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Severe pediatric autoimmune diseases (AD) have limited therapeutic options. In a recent issue of Nature Medicine, Becilli et al. report a case series where CD19 CAR T cell treatment of pediatric AD patients induced rapid and durable remissions with man&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00170-6?rss=yes\">Rogue gut microbes derail memory<\/a><div class=\"wp-block-latest-posts__post-author\">by Dilara Hasavci, Thomas Blank<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The gut microbiome contributes to age-related cognitive decline, but signaling mechanisms remain unclear. In a recent issue of Nature, Cox et al. show that P. goldsteinii-derived fatty acids activate myeloid cells, thus inducing inflammation that disru&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00173-1?rss=yes\">ART Interrupted: Insights into ART-free HIV remission<\/a><div class=\"wp-block-latest-posts__post-author\">by Ramon A. Lujan, Eli A. Boritz<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Defining correlates of HIV rebound upon antiretroviral therapy (ART) interruption can advance HIV cure research. In this issue of Immunity, Ma et al. analyze immunophenotypes and transcriptomes from multiple clinical trials, linking T and NK cell subse&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00168-8?rss=yes\">CD8+ T cells turn resilient under stress<\/a><div class=\"wp-block-latest-posts__post-author\">by Daniele C. Nascimento, Luciana Berod<\/div><time datetime=\"2026-05-12T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tumors present metabolic challenges for T cells. In this issue of Immunity, Scaglione et al. show that CD8+ T cells adapt to nutrient stress through biosynthetic plasticity, coupling translational reprioritization to metabolic reprogramming, preserving&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00214-1?rss=yes\">Interleukin-17-Producing \u03b3\u03b4 T Cells Originate from SOX13+ Progenitors that Are Independent of \u03b3\u03b4TCR Signaling<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-08T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">8 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 49, 857\u2013872.e1\u2013e5; November 20, 2018)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00167-6?rss=yes\">Spatiotemporal analysis reveals distinct inflammatory programs underlying chronic colitis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Fransson, Sorini, et al. build a multi-model, longitudinal transcriptomic atlas of experimental chronic colitis, integrating bulk, single-cell, and spatial data. They reveal shared inflammatory programs, epithelial antigen presentation, and dynamic neu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00138-X?rss=yes\">NK cell dysfunction and interferon-\u03b3 production underlie autoinflammation in mevalonate kinase deficiency<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-30T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The mechanisms linking defective protein prenylation to systemic inflammation in mevalonate kinase deficiency remain unclear. Munoz et al. reveal that mice and humans with MKD have defective NK cells, with impaired granule trafficking, reduced cytotoxi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00144-5?rss=yes\">Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-29T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CD8+ T cells must retain functional resilience as they traverse diverse environments. Scaglione et al. reveal how the integrated stress response enables CD8+ T cells to engage alternate biosynthetic modes under environmental stress that prevent dysfunc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00143-3?rss=yes\">Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-29T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Ulezko Antonova et al. examine plasmacytoid dendritic cells (pDCs) in lymphoid tissues from infancy to adulthood and identify a cycling population of pDCs in fetal and infant lymphoid organs that is found only in the bone marrow in adults. pDCs in sepa&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00140-8?rss=yes\">Kr\u00fcppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Geng et al. identify KLF2 as a central regulator of CX3CR1+ effector-like exhausted CD8+ T cells during chronic infection. KLF2 is uniquely expressed and both necessary and sufficient for this state. Disrupting the KLF2-dependent program enhances viral&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00141-X?rss=yes\">An SPP1-SOCS1 pathway constrains interferon responses in tumor-associated macrophages and shapes an immunosuppressive tumor microenvironment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tumor-associated macrophages (TAMs) can limit anti-tumor immunity. Sun et al. find that SPP1+ TAMs are enriched in tumors across cancer types and associated with resistance to immune checkpoint blockade. Mechanistically, SPP1 interacts with TRIM21 to l&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00142-1?rss=yes\">Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology<\/a><div class=\"wp-block-latest-posts__post-author\">by Daniel B. Graham, Ramnik J. Xavier<\/div><time datetime=\"2026-04-27T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Advancements in human genetics have catalyzed rapid discovery in immunology. Graham and Xavier review how functional genomics and chemical biology have joined forces to uncover mechanisms of mucosal immunity and the pathophysiology of inflammatory bowe&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00139-1?rss=yes\">Pharmacologic glycoengineering of Fc\u03b3 receptor IIIa enhances force-resistant IgG-Fc\u03b3R interactions and anti-tumor antibody efficacy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T18:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Therapeutic monoclonal antibodies are central to cancer treatment but often show incomplete efficacy. Cheng et al. demonstrate that transient host-cell glycoengineering to reduce N-glycan trimming strengthens IgG-Fc\u03b3RIIIa bond resilience under vascular&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00137-8?rss=yes\">Palmitic acid reprograms neutrophils to compromise vascular integrity and promote breast cancer lung metastasis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T18:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Pre-metastatic niche formation is a pivotal driver of breast cancer lung metastasis; however, the mechanisms underlying changes in vascular endothelial permeability remain unclear. Qian et al. demonstrate that triple-negative breast cancer-induced palm&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00136-6?rss=yes\">Modular double-stranded DNA recognition defines specificity of the exonuclease TREX1 in cGAS-STING control<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">TREX1, but not other DEDDh exonucleases, restrains cGAS-STING activation by cytosolic DNA. Zhu et al. examine the basis for this specificity and define a modular double-stranded DNA (dsDNA)-recognition architecture within TREX1 comprising R128, a subst&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00134-2?rss=yes\">Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-23T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">23 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Specialized fibroblastic reticular cell (FRC) subsets in lymph nodes orchestrate the compartmentalization that guides immune cell migration, interaction, and function. Alouche et al. examine the signals governing FRC differentiation and identify a Notc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00135-4?rss=yes\">MAIT cells egress the thymus at several maturation stages with selective capacity to seed different tissues<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-22T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">22 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">MAIT cells acquire effector-memory and tissue-residency programs in the thymus. Paiva et al. demonstrate that MAIT cells can be selected by epithelial cells and egress the thymus at several developmental stages with subset-specific tissue tropisms and &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00133-0?rss=yes\">Organ injury in systemic autoimmunity is mediated by stem-like CD8+ T cells arising from tissue-draining lymph nodes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Loss of B cell tolerance, autoantibody production, and immune complex deposition are hallmarks of systemic lupus erythematosus. Al Souz et al. find that kidney-infiltrating CD8+ T cells differentiate from stem-like precursors in renal lymph nodes and c&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00130-5?rss=yes\">Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-16T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">16 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Intestinal microbiota can have both local and systemic effects on immunity and inflammation. Here, Yu et al. find that intestinal dysbiosis exacerbates atopic dermatitis pathology. Shifts in microbial abundances lead to elevated systemic levels of micr&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00131-7?rss=yes\">Skin inflammation and itch response are independently regulated by distinct nociceptor subsets<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-15T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">15 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Using scRNA-seq of skin-innervating neurons, Voisin et al. show that skin-projecting nociceptor subpopulations differentially integrate the inflammatory response during allergic contact dermatitis. Although peptidergic TRPV1+ neurons control neutrophil&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00125-1?rss=yes\">Functions and features of circulating memory T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Stephen C. Jameson, Sara E. Hamilton<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Memory T (TMEM) cells are designated as either circulating (Tcircm) or tissue-resident (Trm) populations. In this review, Jameson and Hamilton examine the attributes of Tcircm cells and discuss the features and functional heterogeneity of distinct Tcir&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00120-2?rss=yes\">Spatial organization of tissue-resident memory T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Thomas N. Burn, Laura K. Mackay<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tissue-resident memory T (TRM) cells provide local, organ-specific immunity and are shaped by their position within these tissues. This review outlines how priming-associated programming, niche-level microenvironments, and local antigen exposure define&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00051-8?rss=yes\">Plasma cell ontogenies, functions, and lifespans<\/a><div class=\"wp-block-latest-posts__post-author\">by Colin A. Fields, Deepta Bhattacharya<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Although B cell development is a well-studied field, we are only beginning to appreciate the diversity and complexity of plasma cell formation and function. In this review, Fields and Bhattacharya discuss factors impacting plasma cell heterogeneity and&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00129-9?rss=yes\">A fast way to lose antibodies<\/a><div class=\"wp-block-latest-posts__post-author\">by Sheenam Verma, Oliver J. Harrison<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Long-lived plasma cells maintain antibody titers that sustain humoral immunity, yet the physiological cues regulating their persistence remain incompletely understood. In this issue of Immunity, Zhu et al. reveal that fasting-induced \u03b2-hydroxybutyrate &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00087-7?rss=yes\">Cellular memory of sub-lethal stress<\/a><div class=\"wp-block-latest-posts__post-author\">by Stephen W.G. Tait, Andrew Oberst<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Regulated cell death is critical for both homeostasis and the response to infection. In this perspective, Tait and Oberst discuss how sub-lethal activation of canonical cell death pathways has lasting impacts on cells and tissues. These near-death cell&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00126-3?rss=yes\">Universal vaccines? Only if your antibody genes agree<\/a><div class=\"wp-block-latest-posts__post-author\">by Vishal N. Rao, Camila H. Coelho<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Designing a universal influenza vaccine must address not only viral antigenic drift but also genetic variability in human antibody responses. In this issue of Immunity, two studies from the Karlsson-Hedestam lab (Corcoran et al. and Fischer et al.) int&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00077-4?rss=yes\">Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The immune system is a key contributor to organismal aging. Here, Ping et al. leverage single-cell multi-omics to construct a human immune aging clock, which pinpoints T cells as an aging nexus. RUNX1 orchestrates a transcriptional network that restrai&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00123-8?rss=yes\">Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Inducing broadly neutralizing antibodies (bnAbs) remains a challenge in HIV vaccine development. Mishra et al. show that an engineered germline-targeting HIV trimer, Q23-APEX-GT2, primes rare V2-apex bnAb precursors in humanized mice and outbred macaqu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00089-0?rss=yes\">Immunological memory to vaccines<\/a><div class=\"wp-block-latest-posts__post-author\">by Shane Crotty<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The generation of immune memory is at the crux of vaccine efficacy. Here, Crotty reviews the layers of adaptive immunity\u2014T cell, B cells, and antibodies\u2014and their integration to generate a holistic view of vaccine response. Common misconceptions and qu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00128-7?rss=yes\">PANoptosis fuels the fire of arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by Nagakannan Pandian, Thirumala-Devi Kanneganti<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Innate immune cell death is critical for host defense but drives inflammatory disease when dysregulated. In this issue of Immunity, Huang et al. report that the complement protein C1q activates macrophage mitochondrial SARM1 to deplete NAD+ and produce&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00127-5?rss=yes\">Two to tango: Microglia in glioblastoma invasion<\/a><div class=\"wp-block-latest-posts__post-author\">by Donn A. Van Deren, Malay Haldar<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">A lethal feature of glioblastoma is its ability to spread within the brain. In this issue of Immunity, Nebeling et al. use longitudinal three-photon imaging in an immunocompetent glioblastoma model to show that microglial responses at the far infiltrat&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00132-9?rss=yes\">Runx writes the ROR\u03b3t code for immune tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Chrysothemis C. Brown<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ROR\u03b3t is a key transcriptional regulator across diverse immune subsets. In this issue of Immunity, Fukui et al. show how Runx controls ROR\u03b3t expression during early development and link progenitor specification to the diversification of ROR\u03b3t+ innate i&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00124-X?rss=yes\">Training, memory, and tissue adaptation of NK cells and innate lymphoid cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Georg Gasteiger, Thomas Ossner, Christin Friedrich<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immune experience can durably shape innate lymphocytes and their environments. Gasteiger and colleagues discuss how training, memory-like features, and dynamic niche interactions reprogram NK cells and ILCs to adapt their functions and tissue specializ&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00112-3?rss=yes\">Molecular and cellular bases of trained immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by Sarah J. Sun, Ra\u00fal Aguirre-Gamboa, Luis B. Barreiro<\/div><time datetime=\"2026-04-14T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In this review, Barreiro and colleagues synthesize molecular and cellular mechanisms of trained immunity across monocytes, tissue-resident macrophages, and HSPCs. They propose a unifying framework linking transcription factor activity, metabolic remode&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00118-4?rss=yes\">Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-09T15:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">9 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In Alzheimer\u2019s disease (AD), glial crosstalk surrounding amyloid-\u03b2 (A\u03b2) plaques establishes a self-reinforcing inflammatory circuit; however, its underlying mechanisms are incompletely understood. Zhang et al. find that astrocytic PAD2 citrullinates vi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00075-0?rss=yes\">Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-08T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">8 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Vendramin et al. identify nonsense-mediated mRNA decay (NMD) as a central constraint on tumor antigenicity. Inhibiting the NMD kinase SMG1 stabilizes aberrant NMD-targeted transcripts and reveals a previously inaccessible class of non-canonical, non-mu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00122-6?rss=yes\">Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-02T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">2 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Regulatory T (Treg) cells are phenotypically stable in inflammatory settings. Maltez et al. report that \u03b1CD40 immunotherapy induced conversion of Treg cells into FoxP3\u2212Tbet+IFN-\u03b3+ \u201cExTreg\u201d cells within the tumor microenvironment. ExTreg cells exhibited&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00114-7?rss=yes\">Distinct tissue niches contribute to prostate tissue-resident memory CD8+ T cell differentiation and heterogeneity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-01T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The prostate is an important exocrine gland and barrier tissue of the male reproductive system, yet prostate Trm cells remain uncharted. Takehara et al. utilize functional genetics and single-cell and spatial transcriptomics to identify the molecular r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00119-6?rss=yes\">Acute and chronic infections drive distinct trajectories in human memory CD4+ T cell formation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-01T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Different clinical courses of HCV infection shape CD4+ T cell immunity. Reinscheid et al. show that a stem-like subset of CD4+ T cells arising during chronic infection is maintained after successful antiviral therapy and establishes long-term memory th&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00117-2?rss=yes\">Multiplexed antigen panel analysis identifies B cell phenotype and receptor genetic contributions to antibody breadth<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-01T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Antibody responses following primary SARS-CoV-2 infection or mRNA vaccination are well described, but B cell phenotypes, receptor genetics, and antigen factors that determine initial viral variant binding breadth are less established. Wirz et al. find &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00088-9?rss=yes\">Memory T cell aging and rejuvenation<\/a><div class=\"wp-block-latest-posts__post-author\">by Sarah Adamo, Joel G. Rurik, Claire E. Gustafson, Marcus Buggert<\/div><time datetime=\"2026-03-31T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">31 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Aging profoundly alters memory T cell immunity, reshaping diversity, differentiation, and function. Adamo et al. review how intrinsic aging programs, antigenic experience, and tissue context shape T cell responses and discuss emerging strategies to rec&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00121-4?rss=yes\">Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-31T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">31 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Infiltration of glioblastoma (GB) cells into the brain parenchyma and colonization of distant regions are associated with disease recurrence and therapy resistance. Using 3-photon intravital microscopy in an autochthonous GB model, Nebeling et al. iden&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00084-1?rss=yes\">High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Although long-term dietary effects on the immune system are well established, how short-term high-fat diet (HFD) alters intestinal immunity is less understood. Here, Torrico et al. show that within hours of initiating HFD, microbiota-driven inflammatio&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00116-0?rss=yes\">Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">How Foxp3 establishes the epigenetic and transcriptional identity of regulatory T (Treg) cells remains unclear. Murakami et al. demonstrate that Foxp3 cooperates with the AP-1 transcription factor BATF to directly promote chromatin accessibility and ge&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00115-9?rss=yes\">Perinatal infection elicits clonally restricted T follicular helper cell responses that drive antibody-mediated viral control<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T14:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Perinatally acquired persistent viral infections are thought to result in T cell tolerance. Martin et al. show that neonatally LCMV-infected mice mount virus-specific Tfh cell responses that are transcriptionally normal but clonally restricted. These r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00086-5?rss=yes\">NF-\u03baB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-27T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">27 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Aging is accompanied by significant changes to the immune system. Allen et al. demonstrate that age-related NF-\u03baB activation in fibroblasts remodels the lung resident immune system and promotes the emergence of pro-inflammatory Gzmk+ T cells. This work&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00092-0?rss=yes\">Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-27T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">27 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Stanbery et al. show that ILC2s are largely dispensable, but tuft cells remain essential for helminth clearance during secondary infection. Tuft cells are not required for Th2 priming. Instead, tuft cell effectors directly activate memory Th2 cells in &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00091-9?rss=yes\">Kr\u00fcppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-27T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">27 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">During chronic viral infection, CD8+ T cell exhaustion is closely linked to altered migration and tissue residency. Shen et al. identify a reciprocal KLF2-KLF3 transcriptional circuit that controls cellular localization and show that enforcing T cell m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00083-X?rss=yes\">p16High immune cells control disease tolerance as a defense and health span-extending strategy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-26T15:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cellular senescence is traditionally linked to aging and tissue dysfunction, yet whether beneficial p16High cells can protect against acute lethal stress remains unknown. Triana-Martinez et al. demonstrate that the BNT162b2 mRNA vaccine exerts strong p&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00113-5?rss=yes\">Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-26T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Variation in antibody genetics, as illustrated in the accompanying paper by Corcoran et al., can present a challenge to the development of population-wide protective vaccines. Fischer, Corcoran, et al. investigate influenza-specific antibodies to obtai&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00054-3?rss=yes\">A hierarchical Rorc(\u03b3t) cis-regulatory cascade orchestrates differentiation of ROR\u03b3t\u207a innate immune cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-24T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">24 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Transcription factor ROR\u03b3t is a central regulator of type 3 immunity, essential for host defense and tissue homeostasis. Fukui et al. identify a hierarchical CNS11-CNS9 enhancer cascade that governs ROR\u03b3t expression across innate lymphocytes and antige&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00049-X?rss=yes\">Multiomic analysis of ART-interruption cohorts identifies cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-20T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">20 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">To identify factors that can mediate post-ART HIV control, Ma et al. performed \u201comics\u201d on PBMCs from PWH from 4 analytical treatment interruption cohorts. NK and T cell features were identified, and the top two genes in CD4+ T cells predicting delayed &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00047-6?rss=yes\">Ultra-high-throughput IGH genotyping of 25 global populations reveals population-biased allelic diversity and homozygous V and D gene deletions<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-16T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">16 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The genes that encode our antibodies display extensive variation between individuals. Corcoran et al. developed a high-throughput sequence-based method for identifying variations in antibody genes (ImmuneDiscover). This enabled the sequencing of 2,486 &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00079-8?rss=yes\">Big-eaters choking? Macrophages can\u2019t stomach microplastics<\/a><div class=\"wp-block-latest-posts__post-author\">by Luke A. Neufeld, Zhe Qi Liu, Tracy L. McGaha<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Microplastics are detectable in diverse human tissues, yet their biological impact remains unclear. In this issue of Immunity, Codo et al. dissect the mechanisms involved and find that polystyrene microplastics inhibit tissue-resident phagocyte clearan&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00078-6?rss=yes\">Out of many, IL-1<\/a><div class=\"wp-block-latest-posts__post-author\">by Jinsu Lee, Michael A. Wheeler<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Sick animals often show reduced social engagement, a form of adaptive behavioral distancing thought to limit pathogen transmission beyond the infected individual. In a recent issue of Cell, Yang et al. identified a defined molecular and anatomical path&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00053-1?rss=yes\">Human anti-glycan reactivity emerges from B cells utilizing private gene rearrangements that are affinity maturated in germinal centers<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The human antibody repertoire is broadly reactive with carbohydrate antigens represented in the host\/self as well as the commensal microbiota. New et al. find that B cells reactive with the glycan constituent N-acetyl-glucosamine arise early in life an&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00076-2?rss=yes\">Antibody responses against bacterial glycans affinity mature and diversify in germinal centers<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Vaccines targeting bacterial glycans can elicit inconsistent and\/or poor protection in the young. Fryer, Pitt, et al. show that mucosal S. pyogenes infection triggers a glycan-specific B cell response that evolves with age and includes antibody class s&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00082-8?rss=yes\">Diversify and conquer: Antibody feedback in the germinal center<\/a><div class=\"wp-block-latest-posts__post-author\">by Amalie Grenov, Carola G. Vinuesa<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Pre-existing antibodies restrict naive B cell entry into germinal centers, but how antibody feedback shapes ongoing reactions is unclear. In this issue of Immunity, Barbulescu et al. and Yan et al. show that antigen binding by locally produced high-aff&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00081-6?rss=yes\">FLI-ing the script on NK cell persistence: Proteostasis as a limiting factor<\/a><div class=\"wp-block-latest-posts__post-author\">by Yi-Ju Chou, Stanley Ching-Cheng Huang<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Natural killer (NK) cells hold promise for cancer immunotherapy but show limited persistence in solid tumors. In this issue of Immunity, Ji et al. reveal that nutrient stress induces FLI1-mediated repression of pro-survival unfolded protein response pr&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00080-4?rss=yes\">Immune austerity: How the body balances its books when calories run low<\/a><div class=\"wp-block-latest-posts__post-author\">by Francesco Siracusa, Nicola Gagliani<\/div><time datetime=\"2026-03-10T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">10 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immune responses are energetically costly and must adapt to systemic nutrient availability. How immunity is reorganized to preserve host glucose during caloric restriction remains unclear. In this issue of Immunity, Menezes-Silva et al. show that dieta&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00046-4?rss=yes\">Resident tissue macrophages maintain intraocular pressure homeostasis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-09T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">9 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Intraocular pressure (IOP) is dysregulated in glaucoma, a leading cause of blindness. Immune contributions to IOP maintenance are poorly understood. Liu et al. reveal that long-lived resident tissue macrophages have a specialized role in IOP homeostasi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00090-7?rss=yes\">Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-06T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">6 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">(Immunity 58, 2320\u20132335.e1\u2013e9; September 9, 2025)<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00040-3?rss=yes\">Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-06T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">6 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Rheumatoid joints contain macrophages with reparative potential, yet inflammation persists. Huang et al. demonstrate that these homeostatic macrophages lose their protective role by undergoing PANoptotic death. Mechanistically, C1q activates the mitoch&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00045-2?rss=yes\">HIF-1\u03b1+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-06T14:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">6 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and temporal distribution of lung HIF-1\u03b1-active CD4\u207a T cells&#8230;.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00033-6?rss=yes\">MafB is a conserved transcriptional regulator of macrophage development and functional identity across tissues and species<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-26T16:00:00+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Resident macrophage maturation and tissue-specific identity depend on transcriptional programming, yet how conserved regulators universally drive these programs remains unresolved across tissues. Vanneste et al. identify MafB as a key transcriptional r&#8230;<\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":16685,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16684","page","type-page","status-publish","has-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16684"}],"version-history":[{"count":2,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16684\/revisions"}],"predecessor-version":[{"id":16687,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16684\/revisions\/16687"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media\/16685"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}