{"id":16689,"date":"2024-09-27T19:24:11","date_gmt":"2024-09-27T17:24:11","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16689"},"modified":"2024-09-27T19:28:09","modified_gmt":"2024-09-27T17:28:09","slug":"journal-of-immunology","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/journal-of-immunology\/","title":{"rendered":"Journal of Immunology"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/correction-to-abin2-function-is-required-to-suppress-dss-induced-colitis-by-a-tpl2-independent-mechanism\/\">Correction to: ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-16T19:41:51+02:00\" class=\"wp-block-latest-posts__post-date\">16 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag156. doi: 10.1093\/jimmun\/vkag156. NO ABSTRACT PMID:42300803 | DOI:10.1093\/jimmun\/vkag156<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/human-xirp1-is-a-new-podosome-protein-targeting-cytosolic-bacteria-as-part-of-the-ifn-%ce%b3-defense-program\/\">Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-\u03b3 defense program<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-16T07:23:14+02:00\" class=\"wp-block-latest-posts__post-date\">16 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag116. doi: 10.1093\/jimmun\/vkag116. ABSTRACT Interferon-gamma (IFN-\u03b3) is a powerful transactivating signal eliciting hundreds of IFN-stimulated genes (ISGs) in humans to help combat infection. Most ISGs remain uncharacterized, and here we searched for actin-binding candidates that could potentially target intracellular pathogens to block their spread or promote immune cell migration into infected &#8230; <a title=\"Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-\u03b3 defense program\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/human-xirp1-is-a-new-podosome-protein-targeting-cytosolic-bacteria-as-part-of-the-ifn-%ce%b3-defense-program\/\" aria-label=\"Read more about Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-\u03b3 defense program\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/reply-toward-a-more-translational-ss-ild-model-sex-differences-endpoints-and-b-cell-targets\/\">Reply: &#8220;Toward a more translational SS-ILD model: Sex differences, endpoints, and B cell targets&#8221;<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T19:04:57+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkaf379. doi: 10.1093\/jimmun\/vkaf379. NO ABSTRACT PMID:42295821 | DOI:10.1093\/jimmun\/vkaf379<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/congenital-cytomegalovirus-infection-drives-oligoclonal-expansion-of-cytotoxic-%ce%b3%ce%b4-t-cells-from-early-fetal-progenitors\/\">Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic \u03b3\u03b4 T cells from early fetal progenitors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T19:04:57+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag099. doi: 10.1093\/jimmun\/vkag099. ABSTRACT Gamma delta (\u03b3\u03b4) T cells emerge early during human gestation and are uniquely equipped to protect the fetus and infant following infection, due to their innate-like recognition of conserved molecular ligands. Following congenital cytomegalovirus infection (cCMV), V\u03b41 T cells have been shown to expand, differentiate, and upregulate &#8230; <a title=\"Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic \u03b3\u03b4 T cells from early fetal progenitors\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/congenital-cytomegalovirus-infection-drives-oligoclonal-expansion-of-cytotoxic-%ce%b3%ce%b4-t-cells-from-early-fetal-progenitors\/\" aria-label=\"Read more about Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic \u03b3\u03b4 T cells from early fetal progenitors\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/comment-on-toward-clinically-actionable-explainable-ai-in-pulmonary-arterial-hypertension-endpoints-calibration-and-external-validation\/\">Comment on &#8220;Toward clinically actionable explainable AI in pulmonary arterial hypertension: Endpoints, calibration, and external validation&#8221;<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T19:04:57+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkaf377. doi: 10.1093\/jimmun\/vkaf377. NO ABSTRACT PMID:42295822 | DOI:10.1093\/jimmun\/vkaf377<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/p120-catenin-enhances-macrophage-efferocytosis-and-facilitates-resolution-of-lung-inflammatory-injury\/\">p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T18:03:56+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag109. doi: 10.1093\/jimmun\/vkag109. ABSTRACT Defective resolution of inflammation following sepsis contributes to persistent immune dysfunction and increased morbidity and mortality worldwide. Efficient clearance of apoptotic polymorphonuclear neutrophils (PMNs) by macrophages, a process known as efferocytosis, is essential for resolving inflammation, promoting tissue repair, and restoring immune homeostasis; however, the molecular mechanisms &#8230; <a title=\"p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/p120-catenin-enhances-macrophage-efferocytosis-and-facilitates-resolution-of-lung-inflammatory-injury\/\" aria-label=\"Read more about p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/parenteral-vaccination-protects-against-mucosal-salmonella-infection-by-inducing-liver-tissue-resident-memory-cd4-t-cells\/\">Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T18:03:56+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag138. doi: 10.1093\/jimmun\/vkag138. ABSTRACT Salmonella enterica is a gastrointestinal pathogen that causes a variety of intestinal and systemic clinical disease. Vaccine development for systemic salmonellosis requires a deeper understanding of protective mechanisms and the relative contribution of mucosal and systemic host responses to bacterial elimination. Here, we examined the relative importance &#8230; <a title=\"Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/parenteral-vaccination-protects-against-mucosal-salmonella-infection-by-inducing-liver-tissue-resident-memory-cd4-t-cells\/\" aria-label=\"Read more about Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/a-novel-monocyte-derived-antigen-presenting-cell-t-regulatory-cell-axis-contributes-to-skin-wound-healing-and-is-impaired-in-diabetic-mice\/\">A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T18:03:55+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag128. doi: 10.1093\/jimmun\/vkag128. ABSTRACT Despite a vast literature on the role of macrophages in wound healing, the role of dermal monocyte (Mo)-derived antigen presenting cells (APC) has received scant attention. Using scRNAseq and flow cytometry, we identify a population of APC that is prominent in wounds of non-diabetic mice but is &#8230; <a title=\"A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/a-novel-monocyte-derived-antigen-presenting-cell-t-regulatory-cell-axis-contributes-to-skin-wound-healing-and-is-impaired-in-diabetic-mice\/\" aria-label=\"Read more about A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/13\/preselection-cd4cd8-thymocytes-modulate-tcr-responsiveness-following-tcr%ce%b2-selection\/\">Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCR\u03b2 selection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-13T06:48:35+02:00\" class=\"wp-block-latest-posts__post-date\">13 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag105. doi: 10.1093\/jimmun\/vkag105. ABSTRACT Modulation of T cell receptor (TCR) sensitivity during positive selection is critical to avoid negative selection and direct thymocytes into their appropriate lineage. Thymocytes just prior to positive selection (preselection) are highly responsive to low affinity self-ligands and are also actively rearranging their TCR\u03b1 locus as they &#8230; <a title=\"Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCR\u03b2 selection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/13\/preselection-cd4cd8-thymocytes-modulate-tcr-responsiveness-following-tcr%ce%b2-selection\/\" aria-label=\"Read more about Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCR\u03b2 selection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/variable-fab-domain-n-glycosylation-patterns-in-the-b-cell-receptor-repertoires-of-healthy-individuals-and-patients-with-rheumatoid-arthritis\/\">Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-11T12:00:49+02:00\" class=\"wp-block-latest-posts__post-date\">11 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag113. doi: 10.1093\/jimmun\/vkag113. ABSTRACT N-linked glycosylation (N-glyc) sites (N-X-S\/T, X\u2260P) can be introduced by somatic hypermutation in immunoglobulin Fab regions. In patients with rheumatoid arthritis (RA), anti-citrullinated protein antibodies have a striking overrepresentation of Fab N-glycosylation. To further explore this, we sequenced B cell receptors (BCRs) from peripheral blood of 13 &#8230; <a title=\"Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/variable-fab-domain-n-glycosylation-patterns-in-the-b-cell-receptor-repertoires-of-healthy-individuals-and-patients-with-rheumatoid-arthritis\/\" aria-label=\"Read more about Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/bach1-orchestrates-macrophage-state-transitions-to-coordinate-regenerative-inflammation\/\">BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-11T12:00:49+02:00\" class=\"wp-block-latest-posts__post-date\">11 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag101. doi: 10.1093\/jimmun\/vkag101. ABSTRACT Efficient tissue regeneration requires the precise coordination of inflammatory and regenerative programs, principally mediated by monocyte-derived macrophages. However, the transcriptional wiring and epigenomic processes behind complex macrophage subtype specification and transition between the different states are not known. Here we have identified the transcriptional repressor BACH1 as &#8230; <a title=\"BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/bach1-orchestrates-macrophage-state-transitions-to-coordinate-regenerative-inflammation\/\" aria-label=\"Read more about BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/crispri-screening-identifies-son-and-map4k1-as-regulators-of-type-iii-cytokine-expression-in-innate-lymphoid-cells\/\">CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-10T17:44:19+02:00\" class=\"wp-block-latest-posts__post-date\">10 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag110. doi: 10.1093\/jimmun\/vkag110. ABSTRACT The cytokines interleukin (IL)-22 and IL-17 are secreted by innate and adaptive immune cells to drive &#8220;type III&#8221; responses that protect against extracellular pathogens, promote mucosal barrier integrity, and foster microbiota homeostasis. However, dysregulation of IL-22 and\/or IL-17 contributes to autoimmunity, chronic inflammation, and malignancy. Thus, a &#8230; <a title=\"CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/crispri-screening-identifies-son-and-map4k1-as-regulators-of-type-iii-cytokine-expression-in-innate-lymphoid-cells\/\" aria-label=\"Read more about CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/cd7-drives-cd8-t-cell-exhaustion-during-chronic-viral-infection\/\">CD7 drives CD8 T cell exhaustion during chronic viral infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-09T01:49:31+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag091. doi: 10.1093\/jimmun\/vkag091. ABSTRACT Viral or tumor persistence is often associated with CD8 T cell &#8220;exhaustion,&#8221; a differentiation process characterized by co-inhibitory receptor upregulation and loss of effector function. Recent data show that &#8220;exhausted&#8221; T cells are a heterogenous population that includes a progenitor subset that transitions through an intermediate state &#8230; <a title=\"CD7 drives CD8 T cell exhaustion during chronic viral infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/cd7-drives-cd8-t-cell-exhaustion-during-chronic-viral-infection\/\" aria-label=\"Read more about CD7 drives CD8 T cell exhaustion during chronic viral infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation\/\">Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-09T01:49:31+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag074. doi: 10.1093\/jimmun\/vkag074. ABSTRACT Messenger RNA (mRNA) vaccines effectively induce protective immunity, but antigen-specific CD8+ T cell responses exhibit limited persistence. In this study, we aimed to assess CD8+ T cell responses following a third dose of the Pfizer BNT162b2 COVID-19 vaccine and identify factors contributing to their longevity. Using HLA &#8230; <a title=\"Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation\/\" aria-label=\"Read more about Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/sleep-interruption-aggravates-sepsis-by-rewiring-the-macrophage-immune-response\/\">Sleep interruption aggravates sepsis by rewiring the macrophage immune response<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T19:37:05+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag130. doi: 10.1093\/jimmun\/vkag130. ABSTRACT Sepsis is the leading cause of death in hospitals and is very common in intensive care units (ICUs). Sleep is frequently interrupted in the hospital setting, especially within the ICU. Patients who sleep poorly have worse outcomes, such as increased mortality and longer hospital stays; however, the &#8230; <a title=\"Sleep interruption aggravates sepsis by rewiring the macrophage immune response\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/sleep-interruption-aggravates-sepsis-by-rewiring-the-macrophage-immune-response\/\" aria-label=\"Read more about Sleep interruption aggravates sepsis by rewiring the macrophage immune response\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/fate-mapping-reveals-a-prenatal-to-neonatal-wave-of-ilc2s-with-a-history-of-cd3g-expression\/\">Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T07:15:44+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag124. doi: 10.1093\/jimmun\/vkag124. ABSTRACT Group 2 innate lymphoid cells (ILC2s) are thought to develop in the bone marrow and fetal liver. However, increasing evidence supports the presence of thymic ILC2s in mice and humans. In this study, we introduce a novel fate-mapping mouse model designed to track thymic ILC2s in peripheral &#8230; <a title=\"Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/fate-mapping-reveals-a-prenatal-to-neonatal-wave-of-ilc2s-with-a-history-of-cd3g-expression\/\" aria-label=\"Read more about Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/adjuvants-orchestrate-cross-organ-induction-of-mucosal-cd8-t-cell-immune-responses-in-respiratory-tracts\/\">Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T07:15:44+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag117. doi: 10.1093\/jimmun\/vkag117. ABSTRACT Mucosal immunity is paramount for combating respiratory infections, but conventional vaccination methods, such as intramuscular injection, often struggle to induce it. Although direct mucosal vaccination is effective, it carries an increased risk of respiratory adverse effects, making it particularly challenging for individuals with chronic respiratory diseases. Consequently, &#8230; <a title=\"Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/adjuvants-orchestrate-cross-organ-induction-of-mucosal-cd8-t-cell-immune-responses-in-respiratory-tracts\/\" aria-label=\"Read more about Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/ifitm1-differentially-regulates-antibacterial-immunity-and-immunopathology-but-is-dispensable-for-antiparasitic-responses\/\">IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T07:15:44+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag122. doi: 10.1093\/jimmun\/vkag122. ABSTRACT Interferon-induced transmembrane (IFITM) proteins underpin antiviral responses, yet their role in bacterial infections remains underexplored, particularly for parasites. We probed the role of IFITM1 in Mycobacterium tuberculosis (Mtb), Listeria monocytogenes (Lm), and Leishmania major infection using IFITM1 knockout mice. Notably, IFITM1 was upregulated in murine and human &#8230; <a title=\"IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/ifitm1-differentially-regulates-antibacterial-immunity-and-immunopathology-but-is-dispensable-for-antiparasitic-responses\/\" aria-label=\"Read more about IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/04\/pgrn-promotes-host-defense-against-b-thailandensis-induced-sepsis-by-augmenting-macrophage-antibacterial-capacity-via-jak1-stat3-pathway\/\">PGRN promotes host defense against B. thailandensis-induced sepsis by augmenting macrophage antibacterial capacity via JAK1-STAT3 pathway<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-04T13:25:18+02:00\" class=\"wp-block-latest-posts__post-date\">4 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag069. doi: 10.1093\/jimmun\/vkag069. ABSTRACT Burkholderia thailandensis (B. thailandensis) is an emerging pathogen. Although it has not yet caused large-scale outbreaks, severe infections can lead to sepsis. Currently, there are no effective treatment strategies available, highlighting the urgent need to develop novel therapies. Progranulin (PGRN) is a multifunctional protein with complex roles &#8230; <a title=\"PGRN promotes host defense against B. thailandensis-induced sepsis by augmenting macrophage antibacterial capacity via JAK1-STAT3 pathway\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/04\/pgrn-promotes-host-defense-against-b-thailandensis-induced-sepsis-by-augmenting-macrophage-antibacterial-capacity-via-jak1-stat3-pathway\/\" aria-label=\"Read more about PGRN promotes host defense against B. thailandensis-induced sepsis by augmenting macrophage antibacterial capacity via JAK1-STAT3 pathway\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/03\/correction-to-combinatorial-action-of-tgf%ce%b2-and-il-10-induces-monocyte-and-monocyte-derived-dendritic-cell-dysfunction-in-people-living-with-hiv-3717\/\">Correction to:\u00a0Combinatorial action of TGF\u03b2 and IL-10 induces monocyte and monocyte-derived dendritic cell dysfunction in people living with HIV 3717<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-03T06:45:23+02:00\" class=\"wp-block-latest-posts__post-date\">3 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag047. doi: 10.1093\/jimmun\/vkag047. NO ABSTRACT PMID:42229912 | DOI:10.1093\/jimmun\/vkag047<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/correction-to-hepatitis-c-virus-inhibits-dna-damage-repair-through-reactive-oxygen-and-nitrogen-species-and-by-interfering-with-the-atm-nbs1-mre11-rad50-dna-repair-pathway-in-monocytes-and-hepatocyte\/\">Correction to: Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1\/Mre11\/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-02T13:24:49+02:00\" class=\"wp-block-latest-posts__post-date\">2 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkaf166. doi: 10.1093\/jimmun\/vkaf166. NO ABSTRACT PMID:42226503 | DOI:10.1093\/jimmun\/vkaf166<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/pi3k%ce%b4-inhibition-alters-cd8-t-cell-differentiation-and-reprograms-the-tumor-microenvironment-following-adoptive-immunotherapy\/\">PI3K\u03b4 inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-30T07:14:14+02:00\" class=\"wp-block-latest-posts__post-date\">30 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag108. doi: 10.1093\/jimmun\/vkag108. ABSTRACT T cell exhaustion remains a significant barrier to effective adoptive cell therapy in solid tumors. Here, we demonstrate that in vitro treatment with the PI3K\u03b4 inhibitor CAL-101 generates T cells with enhanced stemness and metabolic fitness. These cells show increased mitochondrial dependence and spare respiratory capacity while &#8230; <a title=\"PI3K\u03b4 inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/pi3k%ce%b4-inhibition-alters-cd8-t-cell-differentiation-and-reprograms-the-tumor-microenvironment-following-adoptive-immunotherapy\/\" aria-label=\"Read more about PI3K\u03b4 inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/the-role-of-electroacupuncture-in-altering-lipoic-acid-metabolism-to-reduce-joint-inflammation-in-rheumatoid-arthritis-rats\/\">The role of electroacupuncture in altering lipoic acid metabolism to reduce joint inflammation in rheumatoid arthritis rats<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-30T07:14:14+02:00\" class=\"wp-block-latest-posts__post-date\">30 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag083. doi: 10.1093\/jimmun\/vkag083. ABSTRACT Rheumatoid arthritis (RA) is characterized by severe synovial inflammation and progressive joint destruction. This study evaluated the therapeutic effects of electroacupuncture (EA) in a rat model of RA and explored its potential association with lipoic acid (LA) metabolism. Collagen-induced arthritis (CIA) was established in rats, followed by &#8230; <a title=\"The role of electroacupuncture in altering lipoic acid metabolism to reduce joint inflammation in rheumatoid arthritis rats\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/the-role-of-electroacupuncture-in-altering-lipoic-acid-metabolism-to-reduce-joint-inflammation-in-rheumatoid-arthritis-rats\/\" aria-label=\"Read more about The role of electroacupuncture in altering lipoic acid metabolism to reduce joint inflammation in rheumatoid arthritis rats\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/29\/contributions-of-t-helper-9-cells-in-endometriosis-associated-inflammation-and-lesion-growth\/\">Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-29T22:08:28+02:00\" class=\"wp-block-latest-posts__post-date\">29 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag123. doi: 10.1093\/jimmun\/vkag123. ABSTRACT Endometriosis is an inflammatory gynecologic disease characterized by ectopic growth of endometrial-like tissue, resulting in pelvic pain and infertility. T-helper 9 (Th9) cells play a known role in various chronic inflammatory diseases. Despite parallels between endometriosis and Th9-driven diseases, their role in endometriosis has not been extensively &#8230; <a title=\"Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/29\/contributions-of-t-helper-9-cells-in-endometriosis-associated-inflammation-and-lesion-growth\/\" aria-label=\"Read more about Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/cns1-dependent-regulatory-t-cells-shape-recovery-from-acute-lung-injury\/\">CNS1-dependent regulatory T cells shape recovery from acute lung injury<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-28T01:23:53+02:00\" class=\"wp-block-latest-posts__post-date\">28 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag119. doi: 10.1093\/jimmun\/vkag119. ABSTRACT Regulatory T cells (Tregs) play a crucial role in mediating recovery from acute lung injury (ALI). However, the complex roles of functionally heterogeneous Treg subsets in the lung during the resolution of acute inflammation remain unclear. To investigate the role of peripherally induced Tregs, we utilized mice &#8230; <a title=\"CNS1-dependent regulatory T cells shape recovery from acute lung injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/cns1-dependent-regulatory-t-cells-shape-recovery-from-acute-lung-injury\/\" aria-label=\"Read more about CNS1-dependent regulatory T cells shape recovery from acute lung injury\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/27\/mir-378b-3p-promotes-porcine-reproductive-and-respiratory-syndrome-virus-replication-by-negatively-regulating-type-i-interferon-expression-via-targeting-ogt\/\">miR-378b-3p promotes porcine reproductive and respiratory syndrome virus replication by negatively regulating type I interferon expression via targeting OGT<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-27T00:03:16+02:00\" class=\"wp-block-latest-posts__post-date\">27 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag121. doi: 10.1093\/jimmun\/vkag121. ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viral pathogens for the swine industry. PRRSV has evolved diverse strategies to modulate the type I interferon (IFN-I) response during infections. Recently, it has become increasingly recognized that microRNAs (miRNAs) can contribute to &#8230; <a title=\"miR-378b-3p promotes porcine reproductive and respiratory syndrome virus replication by negatively regulating type I interferon expression via targeting OGT\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/27\/mir-378b-3p-promotes-porcine-reproductive-and-respiratory-syndrome-virus-replication-by-negatively-regulating-type-i-interferon-expression-via-targeting-ogt\/\" aria-label=\"Read more about miR-378b-3p promotes porcine reproductive and respiratory syndrome virus replication by negatively regulating type I interferon expression via targeting OGT\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/26\/pregnancy-induced-nk-cells-of-importance-to-gravidity-and-preeclampsia\/\">Pregnancy-induced NK cells of importance to gravidity and preeclampsia<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-26T00:37:20+02:00\" class=\"wp-block-latest-posts__post-date\">26 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag027. doi: 10.1093\/jimmun\/vkag027. ABSTRACT Immunological changes induced by a woman&#8217;s first pregnancy in controls and in cases of preeclampsia, which is more frequent and often a more severe complication in primigravid women, were investigated. Decidual natural killer (NK) cells are important for placentation and interact with HLA Ib molecules on extravillous &#8230; <a title=\"Pregnancy-induced NK cells of importance to gravidity and preeclampsia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/26\/pregnancy-induced-nk-cells-of-importance-to-gravidity-and-preeclampsia\/\" aria-label=\"Read more about Pregnancy-induced NK cells of importance to gravidity and preeclampsia\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/myeloid-cell-il-15-production-in-the-brain-supports-bystander-cd8-t-cell-neuropathic-immune-responses-following-virus-infection\/\">Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-25T19:28:30+02:00\" class=\"wp-block-latest-posts__post-date\">25 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag102. doi: 10.1093\/jimmun\/vkag102. ABSTRACT The central nervous system (CNS) includes a uniquely regulated immune response that supports homeostasis, response to injury, and response to pathogens. Recent work has shown that virus-associated immune responses in the CNS may contribute to neuronal injury and long-term outcomes such as neurocognitive decline. However, the fundamental &#8230; <a title=\"Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/myeloid-cell-il-15-production-in-the-brain-supports-bystander-cd8-t-cell-neuropathic-immune-responses-following-virus-infection\/\" aria-label=\"Read more about Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/myelin-antigen-specific-effector-cd8-t-cells-induce-chronic-cns-autoimmunity-in-a-cd4-t-cell-dependent-manner\/\">Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-25T19:28:30+02:00\" class=\"wp-block-latest-posts__post-date\">25 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag107. doi: 10.1093\/jimmun\/vkag107. ABSTRACT Both CD4+ and CD8+ T cells play critical roles in the immunopathogenesis of multiple sclerosis (MS). 1C6 T cell receptor transgenic (TcR-Tg) mice on the nonobese diabetic (NOD) background have a MOG[35-55] (myelin oligodendrocyte glycoprotein 35-55)-specific, major histocompatibility complex class II-restricted TcR that selects for both CD4+ &#8230; <a title=\"Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/myelin-antigen-specific-effector-cd8-t-cells-induce-chronic-cns-autoimmunity-in-a-cd4-t-cell-dependent-manner\/\" aria-label=\"Read more about Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/a-multiplexed-systems-based-approach-for-prediction-of-antibody-neutralization-breadth-for-soluble-human-receptors\/\">A multiplexed, systems-based approach for prediction of antibody neutralization breadth for soluble human receptors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-25T19:28:30+02:00\" class=\"wp-block-latest-posts__post-date\">25 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag106. doi: 10.1093\/jimmun\/vkag106. ABSTRACT For endemically circulating viruses, quantifying neutralization capacity of antibodies in a rapid and high-throughput manner is paramount given the ever-evolving targets of neutralization. Moreover, identifying features of an antibody response correlating with neutralization at the multivariate level can inform vaccine boosting strategies and next-generation monoclonal antibody therapies. &#8230; <a title=\"A multiplexed, systems-based approach for prediction of antibody neutralization breadth for soluble human receptors\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/a-multiplexed-systems-based-approach-for-prediction-of-antibody-neutralization-breadth-for-soluble-human-receptors\/\" aria-label=\"Read more about A multiplexed, systems-based approach for prediction of antibody neutralization breadth for soluble human receptors\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/preconditioning-determines-engraftment-and-therapeutic-efficacy-of-anti-cd19-car-t-cells-in-murine-lupus\/\">Preconditioning determines engraftment and therapeutic efficacy of anti-CD19 CAR-T cells in murine lupus<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-25T19:28:30+02:00\" class=\"wp-block-latest-posts__post-date\">25 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag112. doi: 10.1093\/jimmun\/vkag112. ABSTRACT Anti-CD19 chimeric antigen receptor (CAR) T cells have emerged as a promising therapeutic strategy for autoimmune diseases, including systemic lupus erythematosus. An unresolved question is how immunosuppressive preconditioning regimens influence CAR-T cell engraftment and therapeutic efficacy. In murine models, whole-body irradiation is required for optimal CAR-T cell &#8230; <a title=\"Preconditioning determines engraftment and therapeutic efficacy of anti-CD19 CAR-T cells in murine lupus\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/preconditioning-determines-engraftment-and-therapeutic-efficacy-of-anti-cd19-car-t-cells-in-murine-lupus\/\" aria-label=\"Read more about Preconditioning determines engraftment and therapeutic efficacy of anti-CD19 CAR-T cells in murine lupus\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/tuning-pi3k-striking-the-right-balance-for-optimal-cd8-t-cell-responses\/\">Tuning PI3K: striking the right balance for optimal CD8 T-cell responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-25T07:15:39+02:00\" class=\"wp-block-latest-posts__post-date\">25 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkaf296. doi: 10.1093\/jimmun\/vkaf296. ABSTRACT CD8 cytolytic T cells are key players in fighting viral infections and other intracellular pathogens. In response to signals from the TCR, costimulatory molecules, and cytokines, CD8 T cells differentiate into populations of cytolytic effectors that can efficiently kill infected and tumor cells, as well as memory &#8230; <a title=\"Tuning PI3K: striking the right balance for optimal CD8 T-cell responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/25\/tuning-pi3k-striking-the-right-balance-for-optimal-cd8-t-cell-responses\/\" aria-label=\"Read more about Tuning PI3K: striking the right balance for optimal CD8 T-cell responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/dectin-1-stalk-length-determines-binding-ability-immune-response-and-survival-in-a-mouse-model-of-coccidioidomycosis\/\">DECTIN-1 stalk length determines binding ability, immune response, and survival in a mouse model of coccidioidomycosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-22T18:54:00+02:00\" class=\"wp-block-latest-posts__post-date\">22 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag098. doi: 10.1093\/jimmun\/vkag098. ABSTRACT Coccidioidomycosis is a leading cause of pneumonia in the endemic area of the Sonora desert and the central valley of California. The causative agent are the fungi Coccidioides immitis and C. posadasii. While most infections ultimately resolve without treatment, some infections spread to the periphery and cause &#8230; <a title=\"DECTIN-1 stalk length determines binding ability, immune response, and survival in a mouse model of coccidioidomycosis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/dectin-1-stalk-length-determines-binding-ability-immune-response-and-survival-in-a-mouse-model-of-coccidioidomycosis\/\" aria-label=\"Read more about DECTIN-1 stalk length determines binding ability, immune response, and survival in a mouse model of coccidioidomycosis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/the-emerging-roles-of-nfil3-in-immunity\/\">The emerging roles of NFIL3 in immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-22T18:54:00+02:00\" class=\"wp-block-latest-posts__post-date\">22 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag103. doi: 10.1093\/jimmun\/vkag103. ABSTRACT NFIL3 (E4BP4) is a basic leucine zipper transcription factor best known for its roles in circadian regulation. It functions primarily as a transcriptional repressor through competitive DNA binding and the recruitment of histone-modifying complexes. More recently, NFIL3 has emerged as a critical regulator of immunity. It is &#8230; <a title=\"The emerging roles of NFIL3 in immunity\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/the-emerging-roles-of-nfil3-in-immunity\/\" aria-label=\"Read more about The emerging roles of NFIL3 in immunity\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/fc%ce%b3riiib-deficient-neutrophils-have-defects-in-ros-production-phagocytosis-and-actin-polymerization-following-stimulation-through-fc%ce%b3rs\/\">Fc\u03b3RIIIb-deficient neutrophils have defects in ROS production, phagocytosis, and actin polymerization following stimulation through Fc\u03b3Rs<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-22T18:54:00+02:00\" class=\"wp-block-latest-posts__post-date\">22 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag066. doi: 10.1093\/jimmun\/vkag066. ABSTRACT Neutrophils are crucial to innate immune responses to microbes. The engagement of opsonized pathogens by Fc gamma receptors (Fc\u03b3Rs) on neutrophil surfaces mediates multiple antimicrobial functions, including phagocytosis and the production of reactive oxygen species (ROS). Fc\u03b3RIIIb (CD16b) is the most abundant Fc\u03b3R on human neutrophils. This &#8230; <a title=\"Fc\u03b3RIIIb-deficient neutrophils have defects in ROS production, phagocytosis, and actin polymerization following stimulation through Fc\u03b3Rs\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/fc%ce%b3riiib-deficient-neutrophils-have-defects-in-ros-production-phagocytosis-and-actin-polymerization-following-stimulation-through-fc%ce%b3rs\/\" aria-label=\"Read more about Fc\u03b3RIIIb-deficient neutrophils have defects in ROS production, phagocytosis, and actin polymerization following stimulation through Fc\u03b3Rs\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/synergism-of-tnf-and-ifn%ce%b3-promotes-cell-death-but-tnf-drives-innate-immune-mediated-colitis-independent-of-ifn%ce%b3\/\">Synergism of TNF and IFN\u03b3 promotes cell death, but TNF drives innate immune-mediated colitis independent of IFN\u03b3<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-22T01:12:58+02:00\" class=\"wp-block-latest-posts__post-date\">22 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag111. doi: 10.1093\/jimmun\/vkag111. ABSTRACT The cause of inflammatory bowel disease (IBD) is not known, but both innate and adaptive immunity contribute to IBD pathogenesis. To better understand the contributions of innate immunity to IBD, we have generated a mouse model of IBD that occurs spontaneously in the absence of adaptive immunity. &#8230; <a title=\"Synergism of TNF and IFN\u03b3 promotes cell death, but TNF drives innate immune-mediated colitis independent of IFN\u03b3\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/22\/synergism-of-tnf-and-ifn%ce%b3-promotes-cell-death-but-tnf-drives-innate-immune-mediated-colitis-independent-of-ifn%ce%b3\/\" aria-label=\"Read more about Synergism of TNF and IFN\u03b3 promotes cell death, but TNF drives innate immune-mediated colitis independent of IFN\u03b3\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/pi3k-at-the-crossroads-choosing-b-cell-activation-or-tolerance\/\">PI3K at the crossroads: choosing B-cell activation or tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T18:46:36+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag002. doi: 10.1093\/jimmun\/vkag002. ABSTRACT Phosphoinositide 3-kinase (PI3K) mediates signaling downstream of many receptors expressed by B cells. Studies in both mice and humans have shown that PI3K plays a critical role in B-cell development, activation, and tolerance. Indeed the key role of PI3K in regulating activation versus tolerance is demonstrated by &#8230; <a title=\"PI3K at the crossroads: choosing B-cell activation or tolerance\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/pi3k-at-the-crossroads-choosing-b-cell-activation-or-tolerance\/\" aria-label=\"Read more about PI3K at the crossroads: choosing B-cell activation or tolerance\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/not-just-another-kinase-the-many-roles-of-pi3k-%ce%b4-in-adaptive-immunity\/\">Not just another kinase: the many roles of PI3K-\u03b4 in adaptive immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T18:46:36+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag071. doi: 10.1093\/jimmun\/vkag071. NO ABSTRACT PMID:42153523 | DOI:10.1093\/jimmun\/vkag071<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/from-the-gene-to-the-clinic-key-milestones-in-the-pi3k%ce%b4-journey\/\">From the gene to the clinic: Key milestones in the PI3K\u03b4 journey<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T18:46:36+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag075. doi: 10.1093\/jimmun\/vkag075. ABSTRACT Among the PI3K isoforms, PI3K\u03b4 has attracted particular attention from immunologists and hematologists. Despite earlier clinical setbacks, the PI3K\u03b4 field has recently re-emerged with renewed promise. Here, I highlight key milestones in the evolving understanding of PI3K\u03b4 signaling in immunity and cancer, and pivotal studies that have &#8230; <a title=\"From the gene to the clinic: Key milestones in the PI3K\u03b4 journey\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/from-the-gene-to-the-clinic-key-milestones-in-the-pi3k%ce%b4-journey\/\" aria-label=\"Read more about From the gene to the clinic: Key milestones in the PI3K\u03b4 journey\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/acidosis-enables-the-nlrp3-inflammasome-inhibiting-effects-of-%ce%b2-hydroxybutyrate-and-short-chain-carboxylic-acids\/\">Acidosis enables the NLRP3 inflammasome-inhibiting effects of \u03b2-hydroxybutyrate and short-chain carboxylic acids<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T18:46:36+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag085. doi: 10.1093\/jimmun\/vkag085. ABSTRACT NLRP3 inflammasome activation drives interleukin (IL)-1\u03b2 and IL-18 cleavage and secretion and induces pyroptosis. The ketone body \u03b2-hydroxybutyrate (BHB), produced during metabolic stress such as caloric insufficiency, has been reported to inhibit this pathway. However, the conditions that enable this effect, and whether it extends to other &#8230; <a title=\"Acidosis enables the NLRP3 inflammasome-inhibiting effects of \u03b2-hydroxybutyrate and short-chain carboxylic acids\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/acidosis-enables-the-nlrp3-inflammasome-inhibiting-effects-of-%ce%b2-hydroxybutyrate-and-short-chain-carboxylic-acids\/\" aria-label=\"Read more about Acidosis enables the NLRP3 inflammasome-inhibiting effects of \u03b2-hydroxybutyrate and short-chain carboxylic acids\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/nrp1-and-cd73-expressing-anergic-cd4-t-cells-are-progenitors-for-foxp3-treg-cell-differentiation-in-neonates\/\">NRP1 and CD73 expressing anergic CD4 T cells are progenitors for Foxp3 Treg cell differentiation in neonates<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T18:46:36+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag097. doi: 10.1093\/jimmun\/vkag097. ABSTRACT While the majority of self-reactive CD4+ T cells are deleted or become Foxp3+ regulatory T cells during thymic development, some self-reactive conventional Foxp3- T cells escape to the secondary lymphoid organs early in life. The induction of anergy in such potentially autoreactive T cells has been proposed &#8230; <a title=\"NRP1 and CD73 expressing anergic CD4 T cells are progenitors for Foxp3 Treg cell differentiation in neonates\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/nrp1-and-cd73-expressing-anergic-cd4-t-cells-are-progenitors-for-foxp3-treg-cell-differentiation-in-neonates\/\" aria-label=\"Read more about NRP1 and CD73 expressing anergic CD4 T cells are progenitors for Foxp3 Treg cell differentiation in neonates\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/the-nucleolar-protein-nop16-suppresses-tgf-%ce%b2-regulated-iga-class-switch-recombination-in-b-cells-by-regulating-aid-induction\/\">The nucleolar protein NOP16 suppresses TGF-\u03b2-regulated IgA class switch recombination in B cells by regulating AID induction<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T12:37:46+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag042. doi: 10.1093\/jimmun\/vkag042. ABSTRACT Nucleolar protein 16 (NOP16) has been increasingly implicated in promoting tumorigenesis and was recently identified as a novel epigenetic regulator. However, its physiological role in nonmalignant cells remains poorly understood. Although NOP16 is ubiquitously expressed across various tissues and cell types, we found it to be preferentially &#8230; <a title=\"The nucleolar protein NOP16 suppresses TGF-\u03b2-regulated IgA class switch recombination in B cells by regulating AID induction\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/the-nucleolar-protein-nop16-suppresses-tgf-%ce%b2-regulated-iga-class-switch-recombination-in-b-cells-by-regulating-aid-induction\/\" aria-label=\"Read more about The nucleolar protein NOP16 suppresses TGF-\u03b2-regulated IgA class switch recombination in B cells by regulating AID induction\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/highly-focused-human-cd8-t-cell-response-in-the-lower-airways-during-acute-influenza-infection\/\">Highly focused human CD8+ T-cell response in the lower airways during acute influenza infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T12:37:46+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag068. doi: 10.1093\/jimmun\/vkag068. ABSTRACT Lung tissue-resident CD8+ T cells facilitate viral clearance and protective immunity to influenza viruses in animal models. Their role during acute human infection is not clear. Here we use bronchoalveolar lavage samples collected from human subjects naturally infected with influenza B virus to show that influenza-specific CD8+ &#8230; <a title=\"Highly focused human CD8+ T-cell response in the lower airways during acute influenza infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/highly-focused-human-cd8-t-cell-response-in-the-lower-airways-during-acute-influenza-infection\/\" aria-label=\"Read more about Highly focused human CD8+ T-cell response in the lower airways during acute influenza infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/longitudinal-multiomic-and-spatial-transcriptomic-profiling-of-lupus-nephritis-progression-in-a-murine-model\/\">Longitudinal multiomic and spatial transcriptomic profiling of lupus nephritis progression in a murine model<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T12:37:46+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag100. doi: 10.1093\/jimmun\/vkag100. ABSTRACT Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus, is characterized by progressive renal inflammation and tissue injury. To define molecular mechanisms underlying LN progression, we analyzed temporal and spatial transcriptomic profiles in kidneys of lupus-prone New Zealand Black\/White F1 mice at 10, 20, and 30 &#8230; <a title=\"Longitudinal multiomic and spatial transcriptomic profiling of lupus nephritis progression in a murine model\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/longitudinal-multiomic-and-spatial-transcriptomic-profiling-of-lupus-nephritis-progression-in-a-murine-model\/\" aria-label=\"Read more about Longitudinal multiomic and spatial transcriptomic profiling of lupus nephritis progression in a murine model\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/tgf%ce%b2-primes-alveolar-like-macrophages-to-induce-type-i-ifn-following-tlr2-activation\/\">TGF\u03b2 primes alveolar-like macrophages to induce type I IFN following TLR2 activation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-19T12:37:46+02:00\" class=\"wp-block-latest-posts__post-date\">19 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag090. doi: 10.1093\/jimmun\/vkag090. ABSTRACT Alveolar macrophages (AMs) are key mediators of lung function and are potential targets for therapies during respiratory infections. TGF\u03b2 is an important regulator of AM differentiation and maintenance, but how TGF\u03b2 directly modulates the innate immune responses of AMs remains unclear. This shortcoming prevents effective targeting of &#8230; <a title=\"TGF\u03b2 primes alveolar-like macrophages to induce type I IFN following TLR2 activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/19\/tgf%ce%b2-primes-alveolar-like-macrophages-to-induce-type-i-ifn-following-tlr2-activation\/\" aria-label=\"Read more about TGF\u03b2 primes alveolar-like macrophages to induce type I IFN following TLR2 activation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/18\/site-specific-methylation-of-a-tlr1-promoter-snp-impedes-creb-binding-to-impair-antibacterial-immunity-in-grass-carp\/\">Site-specific methylation of a TLR1 promoter SNP impedes CREB binding to impair antibacterial immunity in grass carp<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-18T13:05:38+02:00\" class=\"wp-block-latest-posts__post-date\">18 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag065. doi: 10.1093\/jimmun\/vkag065. ABSTRACT As the most abundantly farmed freshwater fish species, grass carp (Ctenopharyngodon idella) faces a serious threat from Aeromonas hydrophila infection, underscoring the critical need to understand the genetic basis of disease resistance for selective breeding. This study deciphered the functional association and mechanism between polymorphisms in the &#8230; <a title=\"Site-specific methylation of a TLR1 promoter SNP impedes CREB binding to impair antibacterial immunity in grass carp\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/18\/site-specific-methylation-of-a-tlr1-promoter-snp-impedes-creb-binding-to-impair-antibacterial-immunity-in-grass-carp\/\" aria-label=\"Read more about Site-specific methylation of a TLR1 promoter SNP impedes CREB binding to impair antibacterial immunity in grass carp\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/ndrg3-is-essential-for-sustaining-antigen-driven-t-cell-responses-by-protecting-against-restimulation-induced-cell-death\/\">NDRG3 is essential for sustaining antigen-driven T cell responses by protecting against restimulation-induced cell death<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-15T12:37:53+02:00\" class=\"wp-block-latest-posts__post-date\">15 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag070. doi: 10.1093\/jimmun\/vkag070. ABSTRACT During the response to infections and pathogenic challenges, T cells must expand profoundly and be resilient to repetitive restimulation to clear the ongoing assault and protect the host. This process of prolific expansion is tightly regulated to quickly provide a robust pool of pathogen-fighting T cells, yet &#8230; <a title=\"NDRG3 is essential for sustaining antigen-driven T cell responses by protecting against restimulation-induced cell death\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/ndrg3-is-essential-for-sustaining-antigen-driven-t-cell-responses-by-protecting-against-restimulation-induced-cell-death\/\" aria-label=\"Read more about NDRG3 is essential for sustaining antigen-driven T cell responses by protecting against restimulation-induced cell death\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/ets1-represses-blimp1-to-promote-germinal-center-t-follicular-helper-cell-differentiation-during-viral-infection\/\">Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-15T12:37:53+02:00\" class=\"wp-block-latest-posts__post-date\">15 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag096. doi: 10.1093\/jimmun\/vkag096. ABSTRACT Following acute viral infection, na\u00efve CD4+ T cells differentiate into T helper 1 (Th1) and T follicular helper (Tfh) cells. The transcription factor Ets1 represses Tfh cell formation and function following protein immunization; however, whether Ets1 regulates Tfh differentiation in viral infection is unclear. Here, we demonstrate &#8230; <a title=\"Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/15\/ets1-represses-blimp1-to-promote-germinal-center-t-follicular-helper-cell-differentiation-during-viral-infection\/\" aria-label=\"Read more about Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/14\/combined-cyclosporine-a-and-urolithin-a-therapy-ameliorates-murine-lupus-nephritis\/\">Combined cyclosporine A and urolithin A therapy ameliorates murine lupus nephritis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-14T13:10:28+02:00\" class=\"wp-block-latest-posts__post-date\">14 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag087. doi: 10.1093\/jimmun\/vkag087. ABSTRACT Monotherapies for lupus nephritis (LN) often fail to fully control the disease&#8217;s hallmark, renal inflammation and immune complex deposition. This study investigates a novel combination therapeutic strategy using urolithin A (UA), a multifaceted anti-inflammatory and antioxidant agent, with cyclosporine A (CsA), an established immunosuppressant. The combination therapy&#8217;s &#8230; <a title=\"Combined cyclosporine A and urolithin A therapy ameliorates murine lupus nephritis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/14\/combined-cyclosporine-a-and-urolithin-a-therapy-ameliorates-murine-lupus-nephritis\/\" aria-label=\"Read more about Combined cyclosporine A and urolithin A therapy ameliorates murine lupus nephritis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/12\/the-subset-of-m1-paired-mhc-class-ii-conformers-is-critical-for-cd4-t-cell-activation\/\">The subset of M1-paired MHC class II conformers is critical for CD4+ T cell activation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-12T19:18:12+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag093. doi: 10.1093\/jimmun\/vkag093. ABSTRACT Major histocompatibility complex class II molecules present exogenous antigen-derived peptide to CD4+ T cells leading to T cell activation as well as signaling into the antigen-presenting cell. Class II is an \u03b1\u03b2 heterodimer that forms 2 distinct conformers via differential pairing of transmembrane domain GxxxG motifs (i.e. &#8230; <a title=\"The subset of M1-paired MHC class II conformers is critical for CD4+ T cell activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/12\/the-subset-of-m1-paired-mhc-class-ii-conformers-is-critical-for-cd4-t-cell-activation\/\" aria-label=\"Read more about The subset of M1-paired MHC class II conformers is critical for CD4+ T cell activation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/12\/serpine1-regulates-th17-cell-differentiation-and-exacerbates-imq-induced-skin-inflammation\/\">Serpine1 regulates Th17 cell differentiation and exacerbates IMQ-induced skin inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-12T19:18:12+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag076. doi: 10.1093\/jimmun\/vkag076. ABSTRACT A large body of evidence indicates that Th17 cells play essential roles in mucosal immune responses and trigger autoimmune diseases, including multiple sclerosis, inflammatory bowel disease, and psoriasis. Targeting Th17 cells holds promise for therapeutic innovation. While the core cytokine signaling networks driving Th17 differentiation have been &#8230; <a title=\"Serpine1 regulates Th17 cell differentiation and exacerbates IMQ-induced skin inflammation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/12\/serpine1-regulates-th17-cell-differentiation-and-exacerbates-imq-induced-skin-inflammation\/\" aria-label=\"Read more about Serpine1 regulates Th17 cell differentiation and exacerbates IMQ-induced skin inflammation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/12\/cellular-composition-of-tissue-resident-monocyte-lineage-cells-reveals-transcriptional-heterogeneity-during-inflammatory-arthritis\/\">Cellular composition of tissue-resident monocyte-lineage cells reveals transcriptional heterogeneity during inflammatory arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-12T19:18:12+02:00\" class=\"wp-block-latest-posts__post-date\">12 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag077. doi: 10.1093\/jimmun\/vkag077. ABSTRACT Tissue-resident monocyte-lineage cells (TRMCs) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis. However, the precise identities and origins of TRMC subpopulations remain unclear. Here, we characterize the ontogeny of TRMCs, which are comprised of bone &#8230; <a title=\"Cellular composition of tissue-resident monocyte-lineage cells reveals transcriptional heterogeneity during inflammatory arthritis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/12\/cellular-composition-of-tissue-resident-monocyte-lineage-cells-reveals-transcriptional-heterogeneity-during-inflammatory-arthritis\/\" aria-label=\"Read more about Cellular composition of tissue-resident monocyte-lineage cells reveals transcriptional heterogeneity during inflammatory arthritis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/thymus-engraftment-and-developmental-progression-of-adoptively-transferred-progenitor-t-cells-are-affected-by-host-conditioning\/\">Thymus engraftment and developmental progression of adoptively transferred progenitor T cells are affected by host conditioning<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-08T18:35:17+02:00\" class=\"wp-block-latest-posts__post-date\">8 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag086. doi: 10.1093\/jimmun\/vkag086. ABSTRACT Hematopoietic stem cell transplantation as treatment for patients with leukemia relies on chemotherapy and\/or irradiation-based conditioning regimens to prevent graft rejection and cancer relapse. Despite advances in radiotherapy, total body irradiation for myeloablative conditioning is associated with dose and temporal heterogeneity, and how these variables impact thymus &#8230; <a title=\"Thymus engraftment and developmental progression of adoptively transferred progenitor T cells are affected by host conditioning\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/thymus-engraftment-and-developmental-progression-of-adoptively-transferred-progenitor-t-cells-are-affected-by-host-conditioning\/\" aria-label=\"Read more about Thymus engraftment and developmental progression of adoptively transferred progenitor T cells are affected by host conditioning\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/integrins-in-engraftment-of-ex-vivo-generated-plasma-cells\/\">Integrins in engraftment of ex vivo generated plasma cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-08T01:15:59+02:00\" class=\"wp-block-latest-posts__post-date\">8 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag084. doi: 10.1093\/jimmun\/vkag084. ABSTRACT Plasma cells (PCs) are terminally differentiated B cells that are long-lived and have high rates of protein secretion. Because of these features, ex vivo generated PCs are being developed as therapeutics for long-term protein delivery. Here, we used proteomics and flow cytometry-based approaches to comprehensively interrogate the &#8230; <a title=\"Integrins in engraftment of ex vivo generated plasma cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/integrins-in-engraftment-of-ex-vivo-generated-plasma-cells\/\" aria-label=\"Read more about Integrins in engraftment of ex vivo generated plasma cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/07\/role-of-ca2-activated-kca3-1-potassium-channel-in-car-t-cell-effector-function\/\">Role of Ca2+-activated KCa3.1 potassium channel in CAR T cell effector function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-07T13:06:13+02:00\" class=\"wp-block-latest-posts__post-date\">7 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag078. doi: 10.1093\/jimmun\/vkag078. ABSTRACT Genetically modified chimeric antigen receptor (CAR) T cells eliminate tumors by recognizing specific antigens on the cell surface. T cell ion channels (e.g. Kv1.3, KCa3.1) influence activation, proliferation, and effector functions such as target cell killing, through the regulation of Ca2+ signaling. We showed that CAR-expressing cells &#8230; <a title=\"Role of Ca2+-activated KCa3.1 potassium channel in CAR T cell effector function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/07\/role-of-ca2-activated-kca3-1-potassium-channel-in-car-t-cell-effector-function\/\" aria-label=\"Read more about Role of Ca2+-activated KCa3.1 potassium channel in CAR T cell effector function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/07\/an-overview-of-human-inflammasomes-activation-and-regulation\/\">An overview of human inflammasomes: Activation and regulation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-07T13:06:13+02:00\" class=\"wp-block-latest-posts__post-date\">7 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag081. doi: 10.1093\/jimmun\/vkag081. ABSTRACT The innate immune system has evolved as the primary response mechanism against microbial infections, tissue damage, and cellular stress. Signals that disrupt homeostasis are sensed by pattern recognition receptors and initiate innate immune responses to restore homeostasis. Some intracellular pattern recognition receptors belonging to the Nod-like receptor, &#8230; <a title=\"An overview of human inflammasomes: Activation and regulation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/07\/an-overview-of-human-inflammasomes-activation-and-regulation\/\" aria-label=\"Read more about An overview of human inflammasomes: Activation and regulation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/07\/glut1-mediated-glucose-flux-constrains-autoreactive-but-not-foreign-antigen-specific-b-cell-responses\/\">GLUT1-mediated glucose flux constrains autoreactive but not foreign antigen-specific B-cell responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-07T13:06:12+02:00\" class=\"wp-block-latest-posts__post-date\">7 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag092. doi: 10.1093\/jimmun\/vkag092. ABSTRACT Emerging evidence from lupus-prone mice and patients with systemic lupus erythematosus implicates enhanced glycolysis in lymphocytes as a driver of disease. We previously showed that the pharmacologic blockade of glycolysis reduced the production of autoantibodies without affecting antibodies induced by immunization to a foreign protein. Here we &#8230; <a title=\"GLUT1-mediated glucose flux constrains autoreactive but not foreign antigen-specific B-cell responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/07\/glut1-mediated-glucose-flux-constrains-autoreactive-but-not-foreign-antigen-specific-b-cell-responses\/\" aria-label=\"Read more about GLUT1-mediated glucose flux constrains autoreactive but not foreign antigen-specific B-cell responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/the-influence-of-nuclear-antigen-form-on-complement-activation-by-systemic-lupus-erythematosus-antinuclear-antibody-immune-complexes-determined-by-a-novel-immunocapture-assay\/\">The influence of nuclear antigen form on complement activation by systemic lupus erythematosus antinuclear antibody immune complexes determined by a novel immunocapture assay<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-29T18:46:59+02:00\" class=\"wp-block-latest-posts__post-date\">29 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag088. doi: 10.1093\/jimmun\/vkag088. ABSTRACT Systemic lupus erythematosus (SLE) is a systemic autoimmune disease in which immune complexes (ICs) consisting of antinuclear autoantibodies (ANAs) and nuclear antigens induce complement activation and contribute to disease pathogenesis. The impact of antigen form on ICs formation and subsequent complement activation is not well understood. To &#8230; <a title=\"The influence of nuclear antigen form on complement activation by systemic lupus erythematosus antinuclear antibody immune complexes determined by a novel immunocapture assay\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/the-influence-of-nuclear-antigen-form-on-complement-activation-by-systemic-lupus-erythematosus-antinuclear-antibody-immune-complexes-determined-by-a-novel-immunocapture-assay\/\" aria-label=\"Read more about The influence of nuclear antigen form on complement activation by systemic lupus erythematosus antinuclear antibody immune complexes determined by a novel immunocapture assay\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/lactate-conditioning-reprograms-mucosal-associated-invariant-t-cell-metabolism-boosting-effector-function\/\">Lactate conditioning reprograms mucosal-associated invariant T cell metabolism boosting effector function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-29T18:46:59+02:00\" class=\"wp-block-latest-posts__post-date\">29 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag073. doi: 10.1093\/jimmun\/vkag073. ABSTRACT Mucosal-associated invariant T (MAIT) cells are unconventional T cells, which upon activation can display potent cytotoxic and cytokine-producing capabilities. Together, these features make MAIT cells promising candidates for cancer immunotherapy. In this study, we show that MAIT cells can be efficiently amplified in vitro, and these amplified &#8230; <a title=\"Lactate conditioning reprograms mucosal-associated invariant T cell metabolism boosting effector function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/lactate-conditioning-reprograms-mucosal-associated-invariant-t-cell-metabolism-boosting-effector-function\/\" aria-label=\"Read more about Lactate conditioning reprograms mucosal-associated invariant T cell metabolism boosting effector function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/the-autoantibody-%ce%b21-aa-contributes-to-n-ofq-exacerbated-ventricular-arrhythmias-following-acute-myocardial-ischemia\/\">The autoantibody \u03b21-AA contributes to N\/OFQ-exacerbated ventricular arrhythmias following acute myocardial ischemia<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-29T18:46:59+02:00\" class=\"wp-block-latest-posts__post-date\">29 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag072. doi: 10.1093\/jimmun\/vkag072. ABSTRACT Ventricular arrhythmias are a primary cause of sudden cardiac death after acute myocardial infarction (AMI). Both \u03b21-adrenergic autoantibodies (\u03b21-AA) and nociceptin\/orphanin FQ (N\/OFQ) are implicated in AMI, but their potential interaction in ischemic arrhythmogenesis remains unclear. This study investigated the interplay between N\/OFQ and \u03b21-AA and the &#8230; <a title=\"The autoantibody \u03b21-AA contributes to N\/OFQ-exacerbated ventricular arrhythmias following acute myocardial ischemia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/29\/the-autoantibody-%ce%b21-aa-contributes-to-n-ofq-exacerbated-ventricular-arrhythmias-following-acute-myocardial-ischemia\/\" aria-label=\"Read more about The autoantibody \u03b21-AA contributes to N\/OFQ-exacerbated ventricular arrhythmias following acute myocardial ischemia\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/cynet-a-network-analysis-framework-for-high-dimensional-system-level-analyses-of-the-functional-immunome\/\">CyNET-a network analysis framework for high dimensional, system level analyses of the functional immunome<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-28T01:12:27+02:00\" class=\"wp-block-latest-posts__post-date\">28 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag064. doi: 10.1093\/jimmun\/vkag064. ABSTRACT The immune system is a complex &#8220;network of networks,&#8221; where interactions between various immune cell subsets determine immune competence and influence disease onset or control. These interactions dictate whether the body remains in a healthy state or develops pathological conditions. Traditional statistical methods largely ignore these interactions &#8230; <a title=\"CyNET-a network analysis framework for high dimensional, system level analyses of the functional immunome\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/cynet-a-network-analysis-framework-for-high-dimensional-system-level-analyses-of-the-functional-immunome\/\" aria-label=\"Read more about CyNET-a network analysis framework for high dimensional, system level analyses of the functional immunome\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/different-clinical-forms-of-plasmodium-vivax-infection-result-in-unique-t-cell-epitope-specific-immune-responses\/\">Different clinical forms of Plasmodium vivax infection result in unique T cell epitope-specific immune responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-28T01:12:27+02:00\" class=\"wp-block-latest-posts__post-date\">28 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkaf335. doi: 10.1093\/jimmun\/vkaf335. ABSTRACT Malaria remains a significant public health concern despite a steady decline in symptomatic cases. In Brazil, endemic regions are primarily concentrated in the Amazon region, where most cases are attributed to Plasmodium vivax. Although malaria does not confer long-term sterilizing immunity, clinical immunity is achieved, leading to &#8230; <a title=\"Different clinical forms of Plasmodium vivax infection result in unique T cell epitope-specific immune responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/different-clinical-forms-of-plasmodium-vivax-infection-result-in-unique-t-cell-epitope-specific-immune-responses\/\" aria-label=\"Read more about Different clinical forms of Plasmodium vivax infection result in unique T cell epitope-specific immune responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/deficiency-of-microrna-10a-in-cd4-t-cells-protects-against-intestinal-infection-through-mitochondrial-oxidation-il-22-pathway\/\">Deficiency of microRNA-10a in CD4+ T cells protects against intestinal infection through mitochondrial oxidation-IL-22 pathway<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-28T01:12:27+02:00\" class=\"wp-block-latest-posts__post-date\">28 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag089. doi: 10.1093\/jimmun\/vkag089. ABSTRACT Interleukin 22 (IL-22) produced by CD4+ T cells plays an important role in regulating intestinal immune responses during inflammation and infection, but the mechanisms controlling IL-22 expression in T cells remain incompletely understood. MicroRNA-10a (miR-10a) is known to regulate CD4+ T-cell function, but its role in IL-22 &#8230; <a title=\"Deficiency of microRNA-10a in CD4+ T cells protects against intestinal infection through mitochondrial oxidation-IL-22 pathway\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/deficiency-of-microrna-10a-in-cd4-t-cells-protects-against-intestinal-infection-through-mitochondrial-oxidation-il-22-pathway\/\" aria-label=\"Read more about Deficiency of microRNA-10a in CD4+ T cells protects against intestinal infection through mitochondrial oxidation-IL-22 pathway\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/evaluation-of-salmonella-paratyphi-specific-antibody-quantity-and-function-after-vaccination-and-controlled-human-infection\/\">Evaluation of Salmonella Paratyphi specific antibody quantity and function after vaccination and controlled human infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-28T01:12:27+02:00\" class=\"wp-block-latest-posts__post-date\">28 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag044. doi: 10.1093\/jimmun\/vkag044. ABSTRACT Salmonella Paratyphi A is a major cause of paratyphoid fever. Despite growing global concern, knowledge of S. Paratyphi A immunity remains limited, and no licensed vaccine exists. In a controlled human infection model (CHIM) homologous S. Paratyphi A rechallenge showed a non-significant reduction in risk of acute &#8230; <a title=\"Evaluation of Salmonella Paratyphi specific antibody quantity and function after vaccination and controlled human infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/evaluation-of-salmonella-paratyphi-specific-antibody-quantity-and-function-after-vaccination-and-controlled-human-infection\/\" aria-label=\"Read more about Evaluation of Salmonella Paratyphi specific antibody quantity and function after vaccination and controlled human infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/single-cell-analysis-identifies-cpt1a-associated-metabolic-remodeling-in-human-nk-cells-during-covid-19\/\">Single-cell analysis identifies CPT1a-associated metabolic remodeling in human NK cells during COVID-19<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-28T01:12:27+02:00\" class=\"wp-block-latest-posts__post-date\">28 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag036. doi: 10.1093\/jimmun\/vkag036. ABSTRACT Natural killer (NK) cells are critical for early antiviral immunity, yet their metabolic regulation during acute human viral infection remains incompletely understood. We analyzed NK cell activation and metabolic reprogramming in 47 vaccinated individuals with mild breakthrough SARS-CoV-2 infection and 20 matched healthy control subjects. COVID-19 patients &#8230; <a title=\"Single-cell analysis identifies CPT1a-associated metabolic remodeling in human NK cells during COVID-19\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/28\/single-cell-analysis-identifies-cpt1a-associated-metabolic-remodeling-in-human-nk-cells-during-covid-19\/\" aria-label=\"Read more about Single-cell analysis identifies CPT1a-associated metabolic remodeling in human NK cells during COVID-19\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/targeting-the-il-6-il-17-amplifier-loop-in-fibroblasts-insights-from-chronic-antibody-mediated-rejection-in-kidney-transplant-patients\/\">Targeting the IL-6\/IL-17 amplifier loop in fibroblasts: insights from chronic antibody-mediated rejection in kidney transplant patients<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T00:51:21+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag057. doi: 10.1093\/jimmun\/vkag057. ABSTRACT Chronic antibody-mediated kidney rejection (CABMR) is a major cause of chronic allograft injury. Fibroblasts have been implicated in mediating this injury through activation of the IL-6 amplifier loop (IL-6 + IL-17), driven by the NF-\u03baB and STAT3 signaling pathways. This study investigated the activation of the IL-6 &#8230; <a title=\"Targeting the IL-6\/IL-17 amplifier loop in fibroblasts: insights from chronic antibody-mediated rejection in kidney transplant patients\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/targeting-the-il-6-il-17-amplifier-loop-in-fibroblasts-insights-from-chronic-antibody-mediated-rejection-in-kidney-transplant-patients\/\" aria-label=\"Read more about Targeting the IL-6\/IL-17 amplifier loop in fibroblasts: insights from chronic antibody-mediated rejection in kidney transplant patients\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/25\/ligation-of-tlr2-but-not-of-tlr4-or-other-toll-like-receptors-induces-neutrophil-extracellular-trap-formation-in-humans\/\">Ligation of TLR2, but not of TLR4 or other Toll-like receptors, induces neutrophil extracellular trap formation in humans<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-25T01:07:04+02:00\" class=\"wp-block-latest-posts__post-date\">25 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag079. doi: 10.1093\/jimmun\/vkag079. ABSTRACT Neutrophils are usually the first cells recruited to sites of injury or infection where they mount antimicrobial responses, including the release of neutrophil extracellular traps (NETs). Toll-like receptors play a major role in the recognition of pathogen-associated molecular patterns and all but TLR3 are expressed in neutrophils. &#8230; <a title=\"Ligation of TLR2, but not of TLR4 or other Toll-like receptors, induces neutrophil extracellular trap formation in humans\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/25\/ligation-of-tlr2-but-not-of-tlr4-or-other-toll-like-receptors-induces-neutrophil-extracellular-trap-formation-in-humans\/\" aria-label=\"Read more about Ligation of TLR2, but not of TLR4 or other Toll-like receptors, induces neutrophil extracellular trap formation in humans\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/25\/e-cadherin-expression-promotes-tumor-growth-via-klrg1-dependent-pathways\/\">E-cadherin expression promotes tumor growth via KLRG1-dependent pathways<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-25T01:07:04+02:00\" class=\"wp-block-latest-posts__post-date\">25 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag046. doi: 10.1093\/jimmun\/vkag046. ABSTRACT Transformed cells frequently adapt to immune pressure by modulating expression of ligands for PD-1 and CTLA-4. Despite the success of therapies targeting these interactions, only a minority of patients experience a clinical response, highlighting the critical need for alternative targets. Prior work from our group showed that &#8230; <a title=\"E-cadherin expression promotes tumor growth via KLRG1-dependent pathways\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/25\/e-cadherin-expression-promotes-tumor-growth-via-klrg1-dependent-pathways\/\" aria-label=\"Read more about E-cadherin expression promotes tumor growth via KLRG1-dependent pathways\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/control-of-antibody-class-switch-recombination-by-quantitative-integration-of-antigen-signaling\/\">Control of antibody class switch recombination by quantitative integration of antigen signaling<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T12:56:13+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag048. doi: 10.1093\/jimmun\/vkag048. ABSTRACT Immunoglobulin class switch recombination by B lymphocytes requires the simultaneous expression of activation-induced cytidine deaminase (AID) and noncoding germline transcripts (GLT). Expression of both components is controllable through cytokine signalling and arise through stochastic mechanisms linked to cell division that can be predicted in mathematical models. Here &#8230; <a title=\"Control of antibody class switch recombination by quantitative integration of antigen signaling\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/control-of-antibody-class-switch-recombination-by-quantitative-integration-of-antigen-signaling\/\" aria-label=\"Read more about Control of antibody class switch recombination by quantitative integration of antigen signaling\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/the-seminal-effect-of-one-two-ifngr1-genetic-punch-from-30-years-ago\/\">The seminal effect of one-two IFNGR1 genetic punch from 30 years ago<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T12:56:12+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkaf356. doi: 10.1093\/jimmun\/vkaf356. NO ABSTRACT PMID:42027188 | DOI:10.1093\/jimmun\/vkaf356<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/zeb2-orchestrates-a-transcriptional-program-to-safeguard-the-integrity-of-human-cd4-th1-effector-memory-cells\/\">ZEB2 orchestrates a transcriptional program to safeguard the integrity of human CD4+ Th1 effector memory cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T12:56:12+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag043. doi: 10.1093\/jimmun\/vkag043. ABSTRACT CD4+ Th1 cells migrate to sites of inflammation, where they are indispensable for eliminating intracellular pathogens. The lineage-defining transcription factor T-bet establishes the T-helper 1 (Th1) transcriptional program, directing IFN-\u03b3 to drive effector responses and inducing subordinate transcription factors to shape the Th1 phenotype. Aberrant Th1 cell &#8230; <a title=\"ZEB2 orchestrates a transcriptional program to safeguard the integrity of human CD4+ Th1 effector memory cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/zeb2-orchestrates-a-transcriptional-program-to-safeguard-the-integrity-of-human-cd4-th1-effector-memory-cells\/\" aria-label=\"Read more about ZEB2 orchestrates a transcriptional program to safeguard the integrity of human CD4+ Th1 effector memory cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/march2-mediates-k27-linked-polyubiquitination-of-il-2-receptor-%ce%b1-to-negatively-regulate-t-cell-proliferation\/\">MARCH2 mediates K27-Linked polyubiquitination of IL-2 receptor \u03b1 to negatively regulate T cell proliferation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T12:56:12+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag045. doi: 10.1093\/jimmun\/vkag045. ABSTRACT Interleukin 2 (IL-2) is a cytokine secreted by activated T cells that plays a central role in T cell proliferation and differentiation. In this study, we identified MARCH2, an E3 ubiquitin ligase of the MARCH family, as a negative regulator of IL-2 receptor alpha (IL-2R\u03b1). MARCH2 interacts &#8230; <a title=\"MARCH2 mediates K27-Linked polyubiquitination of IL-2 receptor \u03b1 to negatively regulate T cell proliferation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/march2-mediates-k27-linked-polyubiquitination-of-il-2-receptor-%ce%b1-to-negatively-regulate-t-cell-proliferation\/\" aria-label=\"Read more about MARCH2 mediates K27-Linked polyubiquitination of IL-2 receptor \u03b1 to negatively regulate T cell proliferation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/syk-inhibition-limits-autoimmunity-and-abnormal-b-cell-phenotype-and-function-in-mice-with-b-cell-specific-traf3-deficiency\/\">Syk inhibition limits autoimmunity and abnormal B cell phenotype and function in mice with B cell-specific TRAF3 deficiency<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-24T12:56:12+02:00\" class=\"wp-block-latest-posts__post-date\">24 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag049. doi: 10.1093\/jimmun\/vkag049. ABSTRACT Autoimmune disorders reduce quality of life and lifespan and can increase B cell lymphoma risk. The adaptor protein TRAF3 regulates B cell survival, activation, and differentiation by restraining signaling through Toll-like receptors, tumor necrosis factor (TNF) receptor superfamily members, and the B cell antigen receptor-pathways linked to &#8230; <a title=\"Syk inhibition limits autoimmunity and abnormal B cell phenotype and function in mice with B cell-specific TRAF3 deficiency\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/24\/syk-inhibition-limits-autoimmunity-and-abnormal-b-cell-phenotype-and-function-in-mice-with-b-cell-specific-traf3-deficiency\/\" aria-label=\"Read more about Syk inhibition limits autoimmunity and abnormal B cell phenotype and function in mice with B cell-specific TRAF3 deficiency\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/caspase-8-mediates-e-coli-induced-cell-death-and-innate-immune-responses\/\">Caspase-8 mediates E. coli-induced cell death and innate immune responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-23T07:23:55+02:00\" class=\"wp-block-latest-posts__post-date\">23 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag037. doi: 10.1093\/jimmun\/vkag037. ABSTRACT Escherichia coli (E. coli) is a leading cause of invasive bacterial infections in humans. Pathogenic E. coli is not only the major etiological agent of enteric\/diarrheal disease and urinary tract infections, but also among the most common causes of sepsis and meningitis. Caspase-8 is known to regulate &#8230; <a title=\"Caspase-8 mediates E. coli-induced cell death and innate immune responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/caspase-8-mediates-e-coli-induced-cell-death-and-innate-immune-responses\/\" aria-label=\"Read more about Caspase-8 mediates E. coli-induced cell death and innate immune responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/riemerella-anatipestifer-omp85-a-bama-family-outer-membrane-protein-enhances-virulence-through-recruiting-host-complement-regulator-vitronectin-to-mediate-complement-evasion\/\">Riemerella anatipestifer OMP85, a BamA family outer membrane protein, enhances virulence through recruiting host complement regulator vitronectin to mediate complement evasion<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-23T07:23:55+02:00\" class=\"wp-block-latest-posts__post-date\">23 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag041. doi: 10.1093\/jimmun\/vkag041. ABSTRACT Riemerella anatipestifer infection causes septicemia and polyserositis in poultry, leading to serious economic losses to the global poultry industry. The ability to break through the host complement defense barrier is an important characteristic of R. anatipestifer. However, the underlying mechanisms are still not well understood at present. &#8230; <a title=\"Riemerella anatipestifer OMP85, a BamA family outer membrane protein, enhances virulence through recruiting host complement regulator vitronectin to mediate complement evasion\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/riemerella-anatipestifer-omp85-a-bama-family-outer-membrane-protein-enhances-virulence-through-recruiting-host-complement-regulator-vitronectin-to-mediate-complement-evasion\/\" aria-label=\"Read more about Riemerella anatipestifer OMP85, a BamA family outer membrane protein, enhances virulence through recruiting host complement regulator vitronectin to mediate complement evasion\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/redox-index-and-capacity-analysis-rica-reveals-nad-biology-changes-in-t-cell-responses-in-vitro-and-ex-vivo\/\">Redox index and capacity analysis (RICA) reveals NAD biology changes in T cell responses in vitro and ex vivo<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-23T07:23:55+02:00\" class=\"wp-block-latest-posts__post-date\">23 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag035. doi: 10.1093\/jimmun\/vkag035. ABSTRACT The importance of NAD metabolism in T cell differentiation and function has gained attention in recent years. However, technical limitations impede the specific interrogation of NAD dynamics in living immune cells. In this report, we present the redox index and capacity analysis (RICA) assay, a novel technique &#8230; <a title=\"Redox index and capacity analysis (RICA) reveals NAD biology changes in T cell responses in vitro and ex vivo\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/redox-index-and-capacity-analysis-rica-reveals-nad-biology-changes-in-t-cell-responses-in-vitro-and-ex-vivo\/\" aria-label=\"Read more about Redox index and capacity analysis (RICA) reveals NAD biology changes in T cell responses in vitro and ex vivo\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/cx3cr1-regulates-the-immune-microenvironment-in-the-placenta\/\">CX3CR1 regulates the immune microenvironment in the placenta<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-23T07:23:55+02:00\" class=\"wp-block-latest-posts__post-date\">23 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkaf371. doi: 10.1093\/jimmun\/vkaf371. ABSTRACT The immune environment at the maternal-fetal interface is highly regulated and changes depending on the stage of pregnancy. Any dysregulation or imbalance of the pro- and anti-inflammatory stages can disrupt placental development and can lead to various obstetric disorders, such as miscarriage, preterm birth, and preeclampsia. Several &#8230; <a title=\"CX3CR1 regulates the immune microenvironment in the placenta\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/23\/cx3cr1-regulates-the-immune-microenvironment-in-the-placenta\/\" aria-label=\"Read more about CX3CR1 regulates the immune microenvironment in the placenta\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/immunological-evaluation-of-vaccines-to-prevent-chlamydia-trachomatis-infection-using-the-human-in-vitro-mimic-system\/\">Immunological evaluation of vaccines to prevent Chlamydia trachomatis infection using the human in vitro MIMIC system<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-22T13:03:46+02:00\" class=\"wp-block-latest-posts__post-date\">22 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag080. doi: 10.1093\/jimmun\/vkag080. ABSTRACT The Modular Immune In vitro Construct (MIMIC) system is an established laboratory-based methodology that reproduces in vitro the human in vivo T-cell immune response. In this study, we utilized the MIMIC system to establish a dendritic cell and CD4+ T-cell co-culture model that recapitulates T helper cell &#8230; <a title=\"Immunological evaluation of vaccines to prevent Chlamydia trachomatis infection using the human in vitro MIMIC system\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/immunological-evaluation-of-vaccines-to-prevent-chlamydia-trachomatis-infection-using-the-human-in-vitro-mimic-system\/\" aria-label=\"Read more about Immunological evaluation of vaccines to prevent Chlamydia trachomatis infection using the human in vitro MIMIC system\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/ischemia-free-liver-transplantation-alleviates-liver-transplant-injury-caused-by-cd69cd103-cd8t-cells-by-regulating-hif-2%ce%b1-expression\/\">Ischemia-free liver transplantation alleviates liver transplant injury caused by CD69+CD103-CD8+T cells by regulating HIF-2\u03b1 expression<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-22T13:03:46+02:00\" class=\"wp-block-latest-posts__post-date\">22 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag005. doi: 10.1093\/jimmun\/vkag005. ABSTRACT In this study, we investigate the mechanisms by which ischemia-free liver transplantation (IFLT) mitigates ischemia-reperfusion injury (IRI) and identify key therapeutic targets. Clinical data from 200 patients were collected to evaluate perioperative recovery and overall outcomes. Liver tissues were obtained from donors at the preprocurement, end-of-preservation, and &#8230; <a title=\"Ischemia-free liver transplantation alleviates liver transplant injury caused by CD69+CD103-CD8+T cells by regulating HIF-2\u03b1 expression\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/ischemia-free-liver-transplantation-alleviates-liver-transplant-injury-caused-by-cd69cd103-cd8t-cells-by-regulating-hif-2%ce%b1-expression\/\" aria-label=\"Read more about Ischemia-free liver transplantation alleviates liver transplant injury caused by CD69+CD103-CD8+T cells by regulating HIF-2\u03b1 expression\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/cd19-expression-associates-with-polyfunctionality-and-altered-secretion-dynamics-in-individual-activated-human-b-cells\/\">CD19 expression associates with polyfunctionality and altered secretion dynamics in individual activated human B cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-22T13:03:45+02:00\" class=\"wp-block-latest-posts__post-date\">22 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag063. doi: 10.1093\/jimmun\/vkag063. ABSTRACT The concept of polyfunctional secretion, the ability of cells to secrete multiple, functionally distinct proteins, has received increased attention for B cells as they have been described to secrete both antibodies and cytokines. However, the functional analysis of B cells was mostly performed in bulk, and consequently, &#8230; <a title=\"CD19 expression associates with polyfunctionality and altered secretion dynamics in individual activated human B cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/22\/cd19-expression-associates-with-polyfunctionality-and-altered-secretion-dynamics-in-individual-activated-human-b-cells\/\" aria-label=\"Read more about CD19 expression associates with polyfunctionality and altered secretion dynamics in individual activated human B cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/transcriptional-programming-of-early-forming-memory-b-cells-arises-independently-of-cognate-cd4-t-cell-interactions\/\">Transcriptional programming of early-forming memory B cells arises independently of cognate CD4+ T-cell interactions<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:26+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag054. doi: 10.1093\/jimmun\/vkag054. ABSTRACT Memory B cells (MBCs) are an integral part of the humoral immune response with the capacity to both reseed germinal center reactions and rapidly form antibody-secreting plasma cells (ASCs) upon secondary antigen encounter. MBCs arise via both T cell-dependent and -independent routes and while CD4+ T cells &#8230; <a title=\"Transcriptional programming of early-forming memory B cells arises independently of cognate CD4+ T-cell interactions\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/transcriptional-programming-of-early-forming-memory-b-cells-arises-independently-of-cognate-cd4-t-cell-interactions\/\" aria-label=\"Read more about Transcriptional programming of early-forming memory B cells arises independently of cognate CD4+ T-cell interactions\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/dab2ip-modulates-intestinal-inflammation-by-enhancing-ilc3-function-in-the-gut\/\">DAB2IP modulates intestinal inflammation by enhancing ILC3 function in the gut<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:26+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag050. doi: 10.1093\/jimmun\/vkag050. ABSTRACT Group 3 innate lymphoid cells (ILC3s) preserve intestinal barrier integrity by producing IL-22 and IL-17A, yet the molecular mechanisms that maintain these cytokines during inflammation are incompletely defined. Here, we identify DAB2IP as a cell-intrinsic regulator of ILC3 effector function. In human inflammatory bowel disease mucosa, DAB2IP &#8230; <a title=\"DAB2IP modulates intestinal inflammation by enhancing ILC3 function in the gut\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/dab2ip-modulates-intestinal-inflammation-by-enhancing-ilc3-function-in-the-gut\/\" aria-label=\"Read more about DAB2IP modulates intestinal inflammation by enhancing ILC3 function in the gut\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/loss-of-the-actin-remodeling-protein-flightless-1-impairs-cd8-and-regulatory-t-cell-function\/\">Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:26+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag019. doi: 10.1093\/jimmun\/vkag019. ABSTRACT T cell immunity depends on the precise coordination of signaling networks with actin cytoskeleton remodeling, yet the molecular regulators of these processes remain incompletely defined. Flightless-1 (FLII) is a gelsolin-family actin regulator with unique leucine-rich repeats that can couple cytoskeletal dynamics to diverse signaling pathways. Here, using &#8230; <a title=\"Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/loss-of-the-actin-remodeling-protein-flightless-1-impairs-cd8-and-regulatory-t-cell-function\/\" aria-label=\"Read more about Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/irci-2025-bridges-global-expertise-to-accelerate-progress-in-cancer-and-infection-immunology\/\">IRCI-2025 bridges global expertise to accelerate progress in cancer and infection immunology<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:26+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag011. doi: 10.1093\/jimmun\/vkag011. ABSTRACT At the heart of Lyon, France, two leading institutes, the Centre International de Recherche en Infectiologie and the Cancer Research Center of Lyon, have built strong immunology programs since their establishment in the early 2010s. Their collaborative spirit led to the creation of the Immune Responses in &#8230; <a title=\"IRCI-2025 bridges global expertise to accelerate progress in cancer and infection immunology\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/irci-2025-bridges-global-expertise-to-accelerate-progress-in-cancer-and-infection-immunology\/\" aria-label=\"Read more about IRCI-2025 bridges global expertise to accelerate progress in cancer and infection immunology\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/hif-1%ce%b1-impairs-nk-cell-differentiation-maturation-and-cytotoxicity-in-myelodysplastic-syndrome-via-jak1-stat5-socs2-pathway\/\">HIF-1\u03b1 impairs NK cell differentiation-maturation and cytotoxicity in myelodysplastic syndrome via JAK1\/STAT5\/SOCS2 pathway<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:25+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag059. doi: 10.1093\/jimmun\/vkag059. ABSTRACT Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid neoplasms characterized by treatment difficulties and a propensity to progress to acute myeloid leukemia. Impaired natural killer (NK) cell surveillance is a hallmark of MDS, yet the underlying molecular mechanisms remain poorly understood. This study aims to elucidate &#8230; <a title=\"HIF-1\u03b1 impairs NK cell differentiation-maturation and cytotoxicity in myelodysplastic syndrome via JAK1\/STAT5\/SOCS2 pathway\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/hif-1%ce%b1-impairs-nk-cell-differentiation-maturation-and-cytotoxicity-in-myelodysplastic-syndrome-via-jak1-stat5-socs2-pathway\/\" aria-label=\"Read more about HIF-1\u03b1 impairs NK cell differentiation-maturation and cytotoxicity in myelodysplastic syndrome via JAK1\/STAT5\/SOCS2 pathway\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/the-dual-role-of-peritoneal-cavity-b-cells-in-the-activation-of-antitumor-t-cells\/\">The dual role of peritoneal cavity B cells in the activation of antitumor T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:25+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag058. doi: 10.1093\/jimmun\/vkag058. ABSTRACT Peritoneal cavity (PerC) B cells can be classified into distinct subpopulations; however, their differential antigen-presenting capabilities and roles in antitumor immune responses remain largely unexplored. This study aimed to elucidate the properties of PerC B cell subpopulations in antitumor immune responses by using ovalbumin (OVA) peptides as &#8230; <a title=\"The dual role of peritoneal cavity B cells in the activation of antitumor T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/the-dual-role-of-peritoneal-cavity-b-cells-in-the-activation-of-antitumor-t-cells\/\" aria-label=\"Read more about The dual role of peritoneal cavity B cells in the activation of antitumor T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/genomic-organization-of-the-tcr%ce%b1-locus-and-essential-roles-of-%ce%b1%ce%b2-t-cells-in-antibacterial-immunity-in-nile-tilapia\/\">Genomic organization of the TCR\u03b1 locus and essential roles of \u03b1\u03b2 T cells in antibacterial immunity in Nile tilapia<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:25+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag038. doi: 10.1093\/jimmun\/vkag038. ABSTRACT T cells utilize diverse T cell receptors (TCRs) to recognize antigenic peptides and mediate adaptive immunity. However, the organization and function of \u03b1\u03b2 T cells in early vertebrates remain poorly understood. Here, we systematically characterized the TCR\u03b1 locus and \u03b1\u03b2 T cell responses in Nile tilapia (Oreochromis &#8230; <a title=\"Genomic organization of the TCR\u03b1 locus and essential roles of \u03b1\u03b2 T cells in antibacterial immunity in Nile tilapia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/genomic-organization-of-the-tcr%ce%b1-locus-and-essential-roles-of-%ce%b1%ce%b2-t-cells-in-antibacterial-immunity-in-nile-tilapia\/\" aria-label=\"Read more about Genomic organization of the TCR\u03b1 locus and essential roles of \u03b1\u03b2 T cells in antibacterial immunity in Nile tilapia\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/pim1-kinase-regulated-cellular-metabolism-sustains-differentiation-and-function-of-effector-cd8-t-cells-during-chronic-viral-infection\/\">PIM1 kinase-regulated cellular metabolism sustains differentiation and function of effector CD8+ T cells during chronic viral infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:25+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag062. doi: 10.1093\/jimmun\/vkag062. ABSTRACT CD8+ T-cell differentiation during chronic viral infection is supported by metabolic reprogramming to meet distinct bioenergetic demands. Early effector CD8+ T-cell differentiation and function are supported by the PI3K-Akt-mTOR pathway, while the differentiation of late exhausted CD8+ T cells remains incompletely understood. We first characterized the metabolic &#8230; <a title=\"PIM1 kinase-regulated cellular metabolism sustains differentiation and function of effector CD8+ T cells during chronic viral infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/pim1-kinase-regulated-cellular-metabolism-sustains-differentiation-and-function-of-effector-cd8-t-cells-during-chronic-viral-infection\/\" aria-label=\"Read more about PIM1 kinase-regulated cellular metabolism sustains differentiation and function of effector CD8+ T cells during chronic viral infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/non-ligand-binding-tlr20-2-and-dsrna-binding-tlr20-3-form-heterodimer-for-synergistic-antiviral-response-in-grass-carp\/\">Non-ligand-binding TLR20.2 and dsRNA-binding TLR20.3 form heterodimer for synergistic antiviral response in grass carp<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T19:23:25+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag040. doi: 10.1093\/jimmun\/vkag040. ABSTRACT TLR20 is a teleost-specific TLR member. However, its species distribution, biological function, and underlying mechanism remain largely unknown. In this study, we systematically retrieved the TLR20 species distribution and found only a few teleosts contain different TLR20 variants, especially in Cyprinidae. Subsequently, we employed an economically important &#8230; <a title=\"Non-ligand-binding TLR20.2 and dsRNA-binding TLR20.3 form heterodimer for synergistic antiviral response in grass carp\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/non-ligand-binding-tlr20-2-and-dsrna-binding-tlr20-3-form-heterodimer-for-synergistic-antiviral-response-in-grass-carp\/\" aria-label=\"Read more about Non-ligand-binding TLR20.2 and dsRNA-binding TLR20.3 form heterodimer for synergistic antiviral response in grass carp\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/igf2bp2-condensates-stabilize-dok3-to-negatively-regulate-inflammatory-responses\/\">IGF2BP2 condensates stabilize DOK3 to negatively regulate inflammatory responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-20T03:12:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag067. doi: 10.1093\/jimmun\/vkag067. ABSTRACT Negative regulators are crucial for maintaining immune homeostasis, yet the complexities of their regulatory mechanisms are not fully elucidated. In this study, we reveal that IGF2BP2, an m6A reader protein, orchestrates the formation of phase-separated condensates dependent on G3BP1, acting as a pivotal negative regulator of bacterial-induced &#8230; <a title=\"IGF2BP2 condensates stabilize DOK3 to negatively regulate inflammatory responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/20\/igf2bp2-condensates-stabilize-dok3-to-negatively-regulate-inflammatory-responses\/\" aria-label=\"Read more about IGF2BP2 condensates stabilize DOK3 to negatively regulate inflammatory responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/19\/leveraging-a-naturally-occurring-igm-autoantibody-to-target-diabetogenic-t-cells-a-precision-medicine-approach-to-type-1-diabetes\/\">Leveraging a naturally occurring IgM autoantibody to target diabetogenic T cells: a precision medicine approach to type 1 diabetes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-19T19:08:14+02:00\" class=\"wp-block-latest-posts__post-date\">19 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag056. doi: 10.1093\/jimmun\/vkag056. ABSTRACT Current immunotherapies for autoimmune diseases lack sufficient specificity and often compromise protective immunity, underscoring the need for precision-based approaches. Here, we identify x-mAb, a germline-encoded IgM autoantibody derived from dual-expresser lymphocytes of patients with type 1 diabetes (T1D), as a potent agent for precision immunotherapy. In the &#8230; <a title=\"Leveraging a naturally occurring IgM autoantibody to target diabetogenic T cells: a precision medicine approach to type 1 diabetes\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/19\/leveraging-a-naturally-occurring-igm-autoantibody-to-target-diabetogenic-t-cells-a-precision-medicine-approach-to-type-1-diabetes\/\" aria-label=\"Read more about Leveraging a naturally occurring IgM autoantibody to target diabetogenic T cells: a precision medicine approach to type 1 diabetes\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/morphomapping-identifies-redox-dependent-control-of-netotic-states-in-primed-neutrophils\/\">MorphoMapping identifies redox-dependent control of NETotic states in primed neutrophils<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-16T19:09:57+02:00\" class=\"wp-block-latest-posts__post-date\">16 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag061. doi: 10.1093\/jimmun\/vkag061. ABSTRACT Neutrophils rapidly deploy phagocytosis, degranulation, and neutrophil extracellular trap (NET) formation to control infections, yet exaggerated NET formation contributes to tissue injury in inflammatory disease. Because NETosis is tightly linked to the cellular redox environment, we developed MorphoMapping, an imaging flow cytometry-based pipeline that resolves neutrophil morphotypes &#8230; <a title=\"MorphoMapping identifies redox-dependent control of NETotic states in primed neutrophils\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/morphomapping-identifies-redox-dependent-control-of-netotic-states-in-primed-neutrophils\/\" aria-label=\"Read more about MorphoMapping identifies redox-dependent control of NETotic states in primed neutrophils\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/mir-449b-5p-from-adipose-derived-mesenchymal-stem-cell-derived-exosomes-targets-igf1r-to-alleviate-airway-inflammation-and-improve-airway-smooth-muscle-cell-dysfunction-in-children-with-asthma\/\">miR-449b-5p from adipose-derived mesenchymal stem cell-derived exosomes targets IGF1R to alleviate airway inflammation and improve airway smooth muscle cell dysfunction in children with asthma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-16T19:09:57+02:00\" class=\"wp-block-latest-posts__post-date\">16 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkaf376. doi: 10.1093\/jimmun\/vkaf376. ABSTRACT This study investigated the protective effect of miR-449b-5p from adipose-derived mesenchymal stem cell-derived exosomes (ADSC-Exos) targeting type 1 insulin-like growth factor receptor (IGF1R) on airway smooth muscle cells (ASMCs) and further investigated its mechanism of action. ADSC-Exos were isolated and characterized. Cellular uptake of ADSC-Exos by ASMCs &#8230; <a title=\"miR-449b-5p from adipose-derived mesenchymal stem cell-derived exosomes targets IGF1R to alleviate airway inflammation and improve airway smooth muscle cell dysfunction in children with asthma\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/mir-449b-5p-from-adipose-derived-mesenchymal-stem-cell-derived-exosomes-targets-igf1r-to-alleviate-airway-inflammation-and-improve-airway-smooth-muscle-cell-dysfunction-in-children-with-asthma\/\" aria-label=\"Read more about miR-449b-5p from adipose-derived mesenchymal stem cell-derived exosomes targets IGF1R to alleviate airway inflammation and improve airway smooth muscle cell dysfunction in children with asthma\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/il-33-promotes-transcriptional-and-metabolic-adaptations-of-tissue-resident-th2-cells\/\">IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-16T19:09:57+02:00\" class=\"wp-block-latest-posts__post-date\">16 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag028. doi: 10.1093\/jimmun\/vkag028. ABSTRACT The polarization of naive CD4+ T cells into Th2 cells is initiated in lymphoid organs and completed as the cells become tissue resident, where they express ST2, the receptor for the alarmin interleukin (IL)-33, which may be a key signal for tissue integration. Cellular metabolic requirements associated &#8230; <a title=\"IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/il-33-promotes-transcriptional-and-metabolic-adaptations-of-tissue-resident-th2-cells\/\" aria-label=\"Read more about IL-33 promotes transcriptional and metabolic adaptations of tissue-resident Th2 cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/cd8-t-cells-contribute-to-arterial-aging-in-mice\/\">CD8+ T cells contribute to arterial aging in mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-16T19:09:57+02:00\" class=\"wp-block-latest-posts__post-date\">16 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag060. doi: 10.1093\/jimmun\/vkag060. ABSTRACT We have previously reported that T cells accumulate in the arteries of old mice and mechanistically contribute to the development of age-related arterial dysfunction. However, the specific T cell subtype that is the primary contributor to arterial aging is unknown. There is substantial evidence that CD8+ T &#8230; <a title=\"CD8+ T cells contribute to arterial aging in mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/16\/cd8-t-cells-contribute-to-arterial-aging-in-mice\/\" aria-label=\"Read more about CD8+ T cells contribute to arterial aging in mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/15\/modulation-of-rhesus-macaque-killer-cell-immunoglobulin-like-receptor-mhc-i-interactions-by-simian-immunodeficiency-virus-peptides\/\">Modulation of rhesus macaque killer cell immunoglobulin-like receptor-MHC I interactions by simian immunodeficiency virus peptides<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-15T20:51:25+02:00\" class=\"wp-block-latest-posts__post-date\">15 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag053. doi: 10.1093\/jimmun\/vkag053. ABSTRACT Natural killer (NK) cells are key effectors of innate immunity and contribute to early control of viral infections. Their activity is regulated in part by interactions between killer cell immunoglobulin-like receptors (KIRs) on NK cells and major histocompatibility complex class I (MHC I) molecules on target cells. &#8230; <a title=\"Modulation of rhesus macaque killer cell immunoglobulin-like receptor-MHC I interactions by simian immunodeficiency virus peptides\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/15\/modulation-of-rhesus-macaque-killer-cell-immunoglobulin-like-receptor-mhc-i-interactions-by-simian-immunodeficiency-virus-peptides\/\" aria-label=\"Read more about Modulation of rhesus macaque killer cell immunoglobulin-like receptor-MHC I interactions by simian immunodeficiency virus peptides\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/15\/folate-receptor-beta-drives-nlrp3-inflammasome-activation-and-pyroptosis-in-macrophages-independent-of-folate-binding\/\">Folate receptor beta drives NLRP3 inflammasome activation and pyroptosis in macrophages independent of folate binding<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-15T20:51:25+02:00\" class=\"wp-block-latest-posts__post-date\">15 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkag051. doi: 10.1093\/jimmun\/vkag051. ABSTRACT Folate receptor beta (FR\u03b2), encoded by FOLR2, is selectively expressed in monocytes and macrophages, yet its function in innate immune signaling remains poorly defined. Here, we identify FR\u03b2 as a novel regulator of NLRP3 inflammasome activation and pyroptosis in human THP-1 macrophages. Using CRISPR\/Cas9-mediated gene deletion, we &#8230; <a title=\"Folate receptor beta drives NLRP3 inflammasome activation and pyroptosis in macrophages independent of folate binding\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/15\/folate-receptor-beta-drives-nlrp3-inflammasome-activation-and-pyroptosis-in-macrophages-independent-of-folate-binding\/\" aria-label=\"Read more about Folate receptor beta drives NLRP3 inflammasome activation and pyroptosis in macrophages independent of folate binding\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/15\/identifying-the-master-regulator-bcl6-and-its-archrival-blimp1-for-t-follicular-helper-lineage-differentiation\/\">Identifying the master regulator Bcl6 and its archrival Blimp1 for T follicular helper lineage differentiation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-15T20:51:25+02:00\" class=\"wp-block-latest-posts__post-date\">15 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Apr 15;215(4):vkaf357. doi: 10.1093\/jimmun\/vkaf357. NO ABSTRACT PMID:41984501 | DOI:10.1093\/jimmun\/vkaf357<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/effectiveness-and-immunogenicity-of-a-nanoemulsion-protein-subunit-vaccine-against-pseudomonas-aeruginosa-investigation-in-diet-induced-obese-mice\/\">Effectiveness and immunogenicity of a nanoemulsion protein subunit vaccine against Pseudomonas aeruginosa: investigation in diet-induced obese mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-14T07:19:09+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Mar 17;215(3):vkag052. doi: 10.1093\/jimmun\/vkag052. ABSTRACT Pseudomonas aeruginosa (Pa) is an opportunistic pathogen threatening individuals with obesity, a condition associated with chronic meta-inflammation and altered immunity. In this study, we evaluate the immunogenicity and protective efficacy of a nanoemulsion-based subunit vaccine (L-PaF\/ME\/BECC) targeting Pa in a diet-induced obese mouse model. Mice fed a &#8230; <a title=\"Effectiveness and immunogenicity of a nanoemulsion protein subunit vaccine against Pseudomonas aeruginosa: investigation in diet-induced obese mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/effectiveness-and-immunogenicity-of-a-nanoemulsion-protein-subunit-vaccine-against-pseudomonas-aeruginosa-investigation-in-diet-induced-obese-mice\/\" aria-label=\"Read more about Effectiveness and immunogenicity of a nanoemulsion protein subunit vaccine against Pseudomonas aeruginosa: investigation in diet-induced obese mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/01\/basal-phosphorylation-of-ship1-by-lyn-suppresses-proinflammatory-signaling-in-the-absence-of-a-phagocytic-synapse\/\">Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-01T06:54:47+02:00\" class=\"wp-block-latest-posts__post-date\">1 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Mar 17;215(3):vkaf372. doi: 10.1093\/jimmun\/vkaf372. ABSTRACT Microscale engagement of the hemi-immunoreceptor tyrosine-based activation motif-containing receptor Dectin-1 by fungal particles activates Src-family kinases (SFKs) and Syk, drives second-messenger generation, and induces downstream Erk and Akt signaling and proinflammatory responses in macrophages. To avoid inappropriate activation in the absence of a pathogenic threat, macrophages restrict &#8230; <a title=\"Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/01\/basal-phosphorylation-of-ship1-by-lyn-suppresses-proinflammatory-signaling-in-the-absence-of-a-phagocytic-synapse\/\" aria-label=\"Read more about Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse\">Read more<\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":16690,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16689","page","type-page","status-publish","has-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16689"}],"version-history":[{"count":1,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689\/revisions"}],"predecessor-version":[{"id":16691,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689\/revisions\/16691"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media\/16690"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}