{"id":16689,"date":"2024-09-27T19:24:11","date_gmt":"2024-09-27T17:24:11","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16689"},"modified":"2024-09-27T19:28:09","modified_gmt":"2024-09-27T17:28:09","slug":"journal-of-immunology","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/journal-of-immunology\/","title":{"rendered":"Journal of Immunology"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts is-layout-flow wp-block-latest-posts-is-layout-flow\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/15\/arid2-regulates-peripheral-b-cell-maturation-and-germinal-center-responses-in-vivo\/\">Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-15T17:56:50+02:00\" class=\"wp-block-latest-posts__post-date\">15 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag247. doi: 10.1093\/jimmun\/vkag247. ABSTRACT SWI\/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using &#8230; <a title=\"Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/15\/arid2-regulates-peripheral-b-cell-maturation-and-germinal-center-responses-in-vivo\/\" aria-label=\"Read more about Arid2 regulates peripheral B cell maturation and germinal-center responses in vivo\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/15\/scopolamine-ameliorates-psoriasis-by-blocking-m1-receptor-mediated-il-23-production-in-dendritic-cells\/\">Scopolamine ameliorates psoriasis by blocking M1 receptor-mediated IL-23 production in dendritic cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-15T17:56:49+02:00\" class=\"wp-block-latest-posts__post-date\">15 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag179. doi: 10.1093\/jimmun\/vkag179. ABSTRACT Psoriasis is a chronic inflammatory skin disease involving intricate neuroimmune crosstalk. However, the specific mechanisms and therapeutic targets remain elusive. In this study, a pilot clinical trial demonstrated that intravenous scopolamine, a muscarinic receptor antagonist, significantly ameliorated skin lesions in psoriasis patients. Consistently, scopolamine reduced inflammation in &#8230; <a title=\"Scopolamine ameliorates psoriasis by blocking M1 receptor-mediated IL-23 production in dendritic cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/15\/scopolamine-ameliorates-psoriasis-by-blocking-m1-receptor-mediated-il-23-production-in-dendritic-cells\/\" aria-label=\"Read more about Scopolamine ameliorates psoriasis by blocking M1 receptor-mediated IL-23 production in dendritic cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/14\/papaverine-ameliorates-psoriasis-like-skin-inflammation-by-regulating-immune-cell-differentiation-and-rage-s100a7-axis-in-an-imiquimod-induced-murine-model\/\">Papaverine ameliorates psoriasis-like skin inflammation by regulating immune cell differentiation and RAGE-S100A7 axis in an imiquimod-induced murine model<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-14T23:40:45+02:00\" class=\"wp-block-latest-posts__post-date\">14 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag233. doi: 10.1093\/jimmun\/vkag233. ABSTRACT Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting at least 2% of the global population. Papaverine, an alkaloid with known anti-inflammatory, anti-cancer, and RAGE-antagonistic properties, has not been previously evaluated for anti-psoriatic activity. This study investigated the protective effects and mechanisms of papaverine in an imiquimod &#8230; <a title=\"Papaverine ameliorates psoriasis-like skin inflammation by regulating immune cell differentiation and RAGE-S100A7 axis in an imiquimod-induced murine model\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/14\/papaverine-ameliorates-psoriasis-like-skin-inflammation-by-regulating-immune-cell-differentiation-and-rage-s100a7-axis-in-an-imiquimod-induced-murine-model\/\" aria-label=\"Read more about Papaverine ameliorates psoriasis-like skin inflammation by regulating immune cell differentiation and RAGE-S100A7 axis in an imiquimod-induced murine model\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/12\/selenium-serves-as-an-immunomodulator-adjunct-to-enhance-the-efficacy-of-anti-pd-1-therapy-in-non-small-cell-lung-cancer\/\">Selenium serves as an immunomodulator adjunct to enhance the efficacy of anti-PD-1 therapy in non-small cell lung cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-12T05:41:13+02:00\" class=\"wp-block-latest-posts__post-date\">12 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag241. doi: 10.1093\/jimmun\/vkag241. ABSTRACT The role of selenium in tumor progression remains controversial, and its mechanisms of action in the context of immunotherapy are poorly understood. In this study, our findings indicate that selenium supplementation did not alter immune parameters, induce organ damage under healthy conditions, or affect the growth of &#8230; <a title=\"Selenium serves as an immunomodulator adjunct to enhance the efficacy of anti-PD-1 therapy in non-small cell lung cancer\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/12\/selenium-serves-as-an-immunomodulator-adjunct-to-enhance-the-efficacy-of-anti-pd-1-therapy-in-non-small-cell-lung-cancer\/\" aria-label=\"Read more about Selenium serves as an immunomodulator adjunct to enhance the efficacy of anti-PD-1 therapy in non-small cell lung cancer\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/11\/virus-specific-memory-cd4-t-cells-sustain-long-term-numerical-and-functional-impairment-following-whole-body-irradiation\/\">Virus-specific memory CD4 T cells sustain long-term numerical and functional impairment following whole-body irradiation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-11T06:20:59+02:00\" class=\"wp-block-latest-posts__post-date\">11 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag244. doi: 10.1093\/jimmun\/vkag244. ABSTRACT The increasing demand for nuclear power and radiotherapy has expanded potential avenues for human exposure to whole-body irradiation (WBI), underscoring the need to understand its impact on immune cells. While prior studies have explored radiation-induced disruptions in immune homeostasis, the direct effect of WBI on pre-existing memory &#8230; <a title=\"Virus-specific memory CD4 T cells sustain long-term numerical and functional impairment following whole-body irradiation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/11\/virus-specific-memory-cd4-t-cells-sustain-long-term-numerical-and-functional-impairment-following-whole-body-irradiation\/\" aria-label=\"Read more about Virus-specific memory CD4 T cells sustain long-term numerical and functional impairment following whole-body irradiation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/09\/estrogen-receptor-beta-limits-t-cell-mediated-inflammation-to-maintain-immune-homeostasis\/\">Estrogen receptor beta limits T cell-mediated inflammation to maintain immune homeostasis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-09T05:43:32+02:00\" class=\"wp-block-latest-posts__post-date\">9 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag238. doi: 10.1093\/jimmun\/vkag238. ABSTRACT Many autoimmune diseases exhibit a female sex bias in prevalence and severity, yet the mechanisms for this remain unclear. 17\u03b2-estradiol (E2) is a steroid sex hormone with established immunomodulatory roles in CD4+ T cells, which express the nuclear estrogen receptors ER\u03b1 and ER\u03b2. Autoimmune disease patients exhibit &#8230; <a title=\"Estrogen receptor beta limits T cell-mediated inflammation to maintain immune homeostasis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/09\/estrogen-receptor-beta-limits-t-cell-mediated-inflammation-to-maintain-immune-homeostasis\/\" aria-label=\"Read more about Estrogen receptor beta limits T cell-mediated inflammation to maintain immune homeostasis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/02\/differential-responses-of-liver-versus-lymphoid-tissue-dc-to-small-extracellular-vesicles-generated-by-hepatic-ischemia-reperfusion-injury\/\">Differential responses of liver versus lymphoid tissue DC to small extracellular vesicles generated by hepatic ischemia-reperfusion injury<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-02T11:52:12+02:00\" class=\"wp-block-latest-posts__post-date\">2 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag224. doi: 10.1093\/jimmun\/vkag224. ABSTRACT Hepatic ischemia-reperfusion (I\/R) injury triggers release of small extracellular vesicles (sEVs) that can function as systemic conveyors of inflammatory signals. While sEV-mediated immune cell modulation has been studied extensively in vitro, knowledge is based largely on sEVs derived from cultured cells, rather than injured tissues. Consequently, the &#8230; <a title=\"Differential responses of liver versus lymphoid tissue DC to small extracellular vesicles generated by hepatic ischemia-reperfusion injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/02\/differential-responses-of-liver-versus-lymphoid-tissue-dc-to-small-extracellular-vesicles-generated-by-hepatic-ischemia-reperfusion-injury\/\" aria-label=\"Read more about Differential responses of liver versus lymphoid tissue DC to small extracellular vesicles generated by hepatic ischemia-reperfusion injury\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/01\/a-skin-kidney-neutrophil-axis-links-ultraviolet-exposure-to-renal-angiogenesis-and-tissue-remodeling-in-healthy-and-lupus-kidneys\/\">A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-09-01T23:37:18+02:00\" class=\"wp-block-latest-posts__post-date\">1 de September de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag178. doi: 10.1093\/jimmun\/vkag178. ABSTRACT Neutrophils have been implicated in mediating immune crosstalk between injured tissue and distal organs, either promoting local and distal inflammation or mediating tissue repair. Skin injury from ultraviolet (UV) light triggers neutrophil migration to the kidney, which may have implications for nephritis flares in systemic lupus erythematosus. &#8230; <a title=\"A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/09\/01\/a-skin-kidney-neutrophil-axis-links-ultraviolet-exposure-to-renal-angiogenesis-and-tissue-remodeling-in-healthy-and-lupus-kidneys\/\" aria-label=\"Read more about A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/29\/nanobodies-specific-for-v%ce%b211-enable-detection-and-noninvasive-imaging-of-antigen-specific-t-cells-in-vivo\/\">Nanobodies specific for V\u03b211 enable detection and noninvasive imaging of antigen-specific T cells in vivo<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-29T18:22:24+02:00\" class=\"wp-block-latest-posts__post-date\">29 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 29;215(9):vkag237. doi: 10.1093\/jimmun\/vkag237. ABSTRACT Through screening of a VHH phage display library constructed from an alpaca immunized with the recombinantly expressed murine myelin oligodendrocyte (MOG)-specific 2D2 T cell receptor (TCR), we identified nanobodies that reduced antigen-driven 2D2 T cell activation in vitro. Immunoblotting and staining confirmed TCR\u03b2 chain reactivity and V\u03b211-associated &#8230; <a title=\"Nanobodies specific for V\u03b211 enable detection and noninvasive imaging of antigen-specific T cells in vivo\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/29\/nanobodies-specific-for-v%ce%b211-enable-detection-and-noninvasive-imaging-of-antigen-specific-t-cells-in-vivo\/\" aria-label=\"Read more about Nanobodies specific for V\u03b211 enable detection and noninvasive imaging of antigen-specific T cells in vivo\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/24\/identification-of-an-fgd5-positive-subset-of-inkt1-cells-with-enhanced-cytotoxicity\/\">Identification of an Fgd5-positive subset of iNKT1 cells with enhanced cytotoxicity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-24T05:38:59+02:00\" class=\"wp-block-latest-posts__post-date\">24 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag199. doi: 10.1093\/jimmun\/vkag199. ABSTRACT Invariant natural killer T (iNKT) cells are unconventional \u0251\u03b2 T cells that respond to lipid-based antigens. They play a vital role in response to infections and are involved in diseases such as allergic asthma and cancer. Despite clear immunological roles across multiple diseases, remarkably few tools exist &#8230; <a title=\"Identification of an Fgd5-positive subset of iNKT1 cells with enhanced cytotoxicity\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/24\/identification-of-an-fgd5-positive-subset-of-inkt1-cells-with-enhanced-cytotoxicity\/\" aria-label=\"Read more about Identification of an Fgd5-positive subset of iNKT1 cells with enhanced cytotoxicity\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/24\/ace2-decoy-fc-fusions-and-bispecific-killer-engagers-require-fc-engagement-for-in-vivo-efficacy-against-sars-cov-2\/\">ACE2 decoy Fc-fusions and bispecific killer engagers require Fc engagement for in vivo efficacy against SARS-CoV-2<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-24T05:38:59+02:00\" class=\"wp-block-latest-posts__post-date\">24 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag235. doi: 10.1093\/jimmun\/vkag235. ABSTRACT SARS-CoV-2 has continued to evolve over time, necessitating the adaptation of vaccines to maintain efficacy. Monoclonal antibodies (mAbs) against SARS-CoV-2 were a key line of defense for unvaccinated or immunocompromised individuals. However, these mAbs are now ineffective against current SARS-CoV-2 variants. Here, we tested 3 aspects of &#8230; <a title=\"ACE2 decoy Fc-fusions and bispecific killer engagers require Fc engagement for in vivo efficacy against SARS-CoV-2\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/24\/ace2-decoy-fc-fusions-and-bispecific-killer-engagers-require-fc-engagement-for-in-vivo-efficacy-against-sars-cov-2\/\" aria-label=\"Read more about ACE2 decoy Fc-fusions and bispecific killer engagers require Fc engagement for in vivo efficacy against SARS-CoV-2\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/23\/invariant-chain-controls-hla-dq-folding-and-shapes-the-hla-class-ii-proxiome\/\">Invariant chain controls HLA-DQ folding and shapes the HLA class II proxiome<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-23T06:17:18+02:00\" class=\"wp-block-latest-posts__post-date\">23 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag201. doi: 10.1093\/jimmun\/vkag201. ABSTRACT The invariant chain (Ii) trimerizes in the endoplasmic reticulum and swiftly associates with nascent alpha and beta chains of major histocompatibility complex class II (MHCII) molecules. Ii was ascribed many roles pertaining to the antigen presentation capacity of MHCII molecules. The lack of Ii in knockout mice &#8230; <a title=\"Invariant chain controls HLA-DQ folding and shapes the HLA class II proxiome\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/23\/invariant-chain-controls-hla-dq-folding-and-shapes-the-hla-class-ii-proxiome\/\" aria-label=\"Read more about Invariant chain controls HLA-DQ folding and shapes the HLA class II proxiome\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/21\/kdm4a-promotes-microglial-pyroptosis-and-neuropathic-pain-via-the-meg3-smurf2-hes1-axis\/\">KDM4A promotes microglial pyroptosis and neuropathic pain via the MEG3\/SMURF2\/HES1 axis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-21T23:43:57+02:00\" class=\"wp-block-latest-posts__post-date\">21 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag223. doi: 10.1093\/jimmun\/vkag223. ABSTRACT Neuropathic pain (NP) is a refractory clinical disorder in which microglial pyroptosis plays a crucial role, yet the epigenetic regulation by lysine demethylase 4A (KDM4A) remains unclear. In this study, chronic constriction injury (CCI) rat models were established, and KDM4A was knocked down to evaluate its effects &#8230; <a title=\"KDM4A promotes microglial pyroptosis and neuropathic pain via the MEG3\/SMURF2\/HES1 axis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/21\/kdm4a-promotes-microglial-pyroptosis-and-neuropathic-pain-via-the-meg3-smurf2-hes1-axis\/\" aria-label=\"Read more about KDM4A promotes microglial pyroptosis and neuropathic pain via the MEG3\/SMURF2\/HES1 axis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/21\/age-related-changes-in-the-human-t-cell-receptor-alpha-repertoire-suggest-positive-selection-of-dual-specific-t-cells\/\">Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-21T17:40:16+02:00\" class=\"wp-block-latest-posts__post-date\">21 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag214. doi: 10.1093\/jimmun\/vkag214. ABSTRACT The human T cell receptor (TCR) repertoire is generated in the thymus through a process of recombination involving two gene loci, TRA and TRB, and the pairing of the resulting peptide chains. Because of the lack of allelic exclusion in TRA loci, it is possible for a &#8230; <a title=\"Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/21\/age-related-changes-in-the-human-t-cell-receptor-alpha-repertoire-suggest-positive-selection-of-dual-specific-t-cells\/\" aria-label=\"Read more about Age-related changes in the human T cell receptor alpha repertoire suggest positive selection of dual-specific T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/recombinant-sptrf-proteins-illustrate-putative-functions-of-native-sptrf-proteins-from-immune-response-to-resolution-in-sea-urchins\/\">Recombinant SpTrf proteins illustrate putative functions of native SpTrf proteins: from immune response to resolution in sea urchins<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-20T18:17:07+02:00\" class=\"wp-block-latest-posts__post-date\">20 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag213. doi: 10.1093\/jimmun\/vkag213. ABSTRACT The complex and sophisticated sea urchin innate immune system relies on conserved immune receptor and effector molecules plus the euechinoid-specific Transformer family. Native SpTransformer (natSpTrf) proteins in Strongylocentrotus purpuratus respond to immune challenge by augmenting phagocytosis of microbes. These proteins show significant sequence diversity both within and &#8230; <a title=\"Recombinant SpTrf proteins illustrate putative functions of native SpTrf proteins: from immune response to resolution in sea urchins\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/recombinant-sptrf-proteins-illustrate-putative-functions-of-native-sptrf-proteins-from-immune-response-to-resolution-in-sea-urchins\/\" aria-label=\"Read more about Recombinant SpTrf proteins illustrate putative functions of native SpTrf proteins: from immune response to resolution in sea urchins\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/cd55-downregulation-identifies-a-pathogenic-cd4-t-cell-axis-linked-to-p38-mapk-signaling-in-rheumatoid-arthritis\/\">CD55 downregulation identifies a pathogenic CD4+ T cell axis linked to p38 MAPK signaling in rheumatoid arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-20T12:07:15+02:00\" class=\"wp-block-latest-posts__post-date\">20 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag229. doi: 10.1093\/jimmun\/vkag229. ABSTRACT CD4+ T cell dysfunction plays a critical role in the pathogenesis of rheumatoid arthritis (RA). In this study, we investigated the expression, phenotypic characteristics, and potential clinical significance of CD55, a membrane-bound complement regulatory protein, in peripheral blood CD4+ T cells from RA patients. Flow cytometric analysis &#8230; <a title=\"CD55 downregulation identifies a pathogenic CD4+ T cell axis linked to p38 MAPK signaling in rheumatoid arthritis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/cd55-downregulation-identifies-a-pathogenic-cd4-t-cell-axis-linked-to-p38-mapk-signaling-in-rheumatoid-arthritis\/\" aria-label=\"Read more about CD55 downregulation identifies a pathogenic CD4+ T cell axis linked to p38 MAPK signaling in rheumatoid arthritis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/pd-l1-restrains-t-cell-immunity-in-nile-tilapia-by-suppressing-activation-induced-fatty-acid-synthesis\/\">PD-L1 restrains T-cell immunity in Nile tilapia by suppressing activation-induced fatty acid synthesis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-20T12:07:15+02:00\" class=\"wp-block-latest-posts__post-date\">20 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag236. doi: 10.1093\/jimmun\/vkag236. ABSTRACT The programmed death ligand 1\/programmed cell death 1 (PD-L1\/PD-1) serves as a critical immune checkpoint in T cell-mediated immune responses, playing a central role in maintaining peripheral immune tolerance and homeostasis. Although early vertebrates lack a PD-1 homolog and they retain PD-L1, the functional significance and regulatory &#8230; <a title=\"PD-L1 restrains T-cell immunity in Nile tilapia by suppressing activation-induced fatty acid synthesis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/20\/pd-l1-restrains-t-cell-immunity-in-nile-tilapia-by-suppressing-activation-induced-fatty-acid-synthesis\/\" aria-label=\"Read more about PD-L1 restrains T-cell immunity in Nile tilapia by suppressing activation-induced fatty acid synthesis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/18\/immunotherapy-of-malignant-melanoma-using-t-cell-activating-microbeads\/\">Immunotherapy of malignant melanoma using T cell-activating microbeads<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-18T19:16:01+02:00\" class=\"wp-block-latest-posts__post-date\">18 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag191. doi: 10.1093\/jimmun\/vkag191. ABSTRACT Metastatic disease is the prime cause of death from many malignancies. Due to the multiple different lesions and the increased aggressiveness of the cancer cells, metastatic disease is often difficult to treat. Here, the introduction of immune checkpoint blockers (ICBs) has greatly helped to improve patients&#8217; prognosis &#8230; <a title=\"Immunotherapy of malignant melanoma using T cell-activating microbeads\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/18\/immunotherapy-of-malignant-melanoma-using-t-cell-activating-microbeads\/\" aria-label=\"Read more about Immunotherapy of malignant melanoma using T cell-activating microbeads\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/18\/isotype-specific-antibody-secreting-plasma-cells-harbor-epigenetic-and-transcription-factor-architectures-defining-distinct-cell-lineages\/\">Isotype-specific antibody secreting plasma cells harbor epigenetic and transcription factor architectures defining distinct cell lineages<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-18T05:36:52+02:00\" class=\"wp-block-latest-posts__post-date\">18 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag231. doi: 10.1093\/jimmun\/vkag231. ABSTRACT Antibody-secreting cells (ASCs) are critical effectors of humoral immunity, wherein their distinct isotypes play specialized roles in pathogen defense. Despite studies defining the transcriptional programs of selected ASC isotypes, specific mechanisms underlying isotype-specific gene regulation are largely unaddressed. Here, we performed an integrated multiomics analysis (RNA sequencing, &#8230; <a title=\"Isotype-specific antibody secreting plasma cells harbor epigenetic and transcription factor architectures defining distinct cell lineages\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/18\/isotype-specific-antibody-secreting-plasma-cells-harbor-epigenetic-and-transcription-factor-architectures-defining-distinct-cell-lineages\/\" aria-label=\"Read more about Isotype-specific antibody secreting plasma cells harbor epigenetic and transcription factor architectures defining distinct cell lineages\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/15\/generation-and-characterization-of-a-novel-mhc-ii-tetramer-for-tracking-and-characterization-of-toxin-b-specific-cd4-t-cell-responses\/\">Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-15T05:51:11+02:00\" class=\"wp-block-latest-posts__post-date\">15 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag152. doi: 10.1093\/jimmun\/vkag152. ABSTRACT The gastrointestinal pathogen Clostridioides difficile is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two virulence factors, toxin A (TcdA) and toxin B (TcdB). Antibodies specific for TcdA and TcdB are correlated with protection from symptomatic recurrence; &#8230; <a title=\"Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/15\/generation-and-characterization-of-a-novel-mhc-ii-tetramer-for-tracking-and-characterization-of-toxin-b-specific-cd4-t-cell-responses\/\" aria-label=\"Read more about Generation and characterization of a novel MHC-II tetramer for tracking and characterization of toxin B-specific CD4+ T cell responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/deficiency-in-circulating-t-cells-in-four-core-genotypes-mice-with-sry-translocation\/\">Deficiency in circulating T cells in four core genotypes mice with Sry translocation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-14T06:31:41+02:00\" class=\"wp-block-latest-posts__post-date\">14 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag207. doi: 10.1093\/jimmun\/vkag207. ABSTRACT Sex differences exist in the immune responses to infections and in the prevalence and severity of autoimmune and allergic diseases. These sex differences may be caused by sex hormones and\/or variable inactivation of X chromosome genes. The 4 core genotypes mice allow for distinction between the effects &#8230; <a title=\"Deficiency in circulating T cells in four core genotypes mice with Sry translocation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/deficiency-in-circulating-t-cells-in-four-core-genotypes-mice-with-sry-translocation\/\" aria-label=\"Read more about Deficiency in circulating T cells in four core genotypes mice with Sry translocation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/semaphorin3e-is-a-novel-regulator-of-germinal-center-responses-in-a-mouse-model-of-allergic-asthma\/\">Semaphorin3E is a novel regulator of germinal center responses in a mouse model of allergic asthma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-14T03:27:33+02:00\" class=\"wp-block-latest-posts__post-date\">14 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag220. doi: 10.1093\/jimmun\/vkag220. ABSTRACT Little is known about the role of semaphorin 3E (Sema3E) in B cell responses and immunoglobulin regulation. Our recent data indicate that Sema3e knockout mice have significantly higher serum levels of total and allergen-specific IgE in allergic asthma, suggesting Sema3E&#8217;s crucial role in modulating the humoral response. &#8230; <a title=\"Semaphorin3E is a novel regulator of germinal center responses in a mouse model of allergic asthma\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/semaphorin3e-is-a-novel-regulator-of-germinal-center-responses-in-a-mouse-model-of-allergic-asthma\/\" aria-label=\"Read more about Semaphorin3E is a novel regulator of germinal center responses in a mouse model of allergic asthma\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/adipose-stem-cell-vesicles-reduce-bleomycin-induced-dermal-fibrosis-and-oxidative-stress-in-scleroderma-mice-via-circ-zfyve9\/\">Adipose stem cell vesicles reduce bleomycin-induced dermal fibrosis and oxidative stress in scleroderma mice via circ-Zfyve9<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-14T03:27:33+02:00\" class=\"wp-block-latest-posts__post-date\">14 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag219. doi: 10.1093\/jimmun\/vkag219. ABSTRACT Systemic sclerosis (SSc) is an autoimmune condition affecting several organs. It is identified by thickening of the dermis, connective tissue affected by collagen accumulation, and vascular injuries that induce hypoxia. The present study aimed to determine whether extracellular vesicles (EVs) from adipose-derived stem cells (ADSCs) attenuated bleomycin-induced &#8230; <a title=\"Adipose stem cell vesicles reduce bleomycin-induced dermal fibrosis and oxidative stress in scleroderma mice via circ-Zfyve9\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/adipose-stem-cell-vesicles-reduce-bleomycin-induced-dermal-fibrosis-and-oxidative-stress-in-scleroderma-mice-via-circ-zfyve9\/\" aria-label=\"Read more about Adipose stem cell vesicles reduce bleomycin-induced dermal fibrosis and oxidative stress in scleroderma mice via circ-Zfyve9\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/mir-221-5p-aggravates-sepsis-induced-myocardial-injury-by-targeting-neuropilin-1\/\">MiR-221-5p aggravates sepsis-induced myocardial injury by targeting neuropilin-1<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-14T03:27:33+02:00\" class=\"wp-block-latest-posts__post-date\">14 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag228. doi: 10.1093\/jimmun\/vkag228. ABSTRACT Sepsis-induced cardiac dysfunction is a primary contributor to mortality, and microRNAs (miRNAs) are recognized as crucial mediators in sepsis pathogenesis. This study aims to identify the key regulatory miRNAs involved in cardiac dysfunction stemming from sepsis. We developed a rat model of sepsis using cecal ligation and &#8230; <a title=\"MiR-221-5p aggravates sepsis-induced myocardial injury by targeting neuropilin-1\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/14\/mir-221-5p-aggravates-sepsis-induced-myocardial-injury-by-targeting-neuropilin-1\/\" aria-label=\"Read more about MiR-221-5p aggravates sepsis-induced myocardial injury by targeting neuropilin-1\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/13\/antigen-presentation-requirements-for-effective-cdc1-based-cancer-immunotherapy\/\">Antigen presentation requirements for effective cDC1-based cancer immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-13T19:19:58+02:00\" class=\"wp-block-latest-posts__post-date\">13 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag198. doi: 10.1093\/jimmun\/vkag198. ABSTRACT Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with murine cDC1s, generated in culture from bone marrow cells &#8230; <a title=\"Antigen presentation requirements for effective cDC1-based cancer immunotherapy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/13\/antigen-presentation-requirements-for-effective-cdc1-based-cancer-immunotherapy\/\" aria-label=\"Read more about Antigen presentation requirements for effective cDC1-based cancer immunotherapy\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/rapid-glycolytic-metabolism-underpins-mucosal-associated-invariant-t-cell-functional-responses-to-innate-cytokines\/\">Rapid glycolytic metabolism underpins mucosal-associated invariant T cell functional responses to innate cytokines<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-12T23:52:11+02:00\" class=\"wp-block-latest-posts__post-date\">12 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag212. doi: 10.1093\/jimmun\/vkag212. ABSTRACT Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that recognizes bacterial-derived antigens presented on MR1. Upon TCR triggering, MAIT cells respond rapidly, producing a range of effector molecules which facilitate host-protective responses in the context of microbial infections. In contrast, MAIT cell responses &#8230; <a title=\"Rapid glycolytic metabolism underpins mucosal-associated invariant T cell functional responses to innate cytokines\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/rapid-glycolytic-metabolism-underpins-mucosal-associated-invariant-t-cell-functional-responses-to-innate-cytokines\/\" aria-label=\"Read more about Rapid glycolytic metabolism underpins mucosal-associated invariant T cell functional responses to innate cytokines\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/unveiling-the-role-of-lysosomes-in-antigen-processing-and-presentation\/\">Unveiling the role of lysosomes in antigen processing and presentation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-12T23:52:11+02:00\" class=\"wp-block-latest-posts__post-date\">12 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag200. doi: 10.1093\/jimmun\/vkag200. ABSTRACT Lysosomes drive antigen proteolysis and peptide loading for major histocompatibility complex class II (MHCII) presentation in antigen-presenting cells (APCs), enabling activation of peptide-specific CD4+ T helper cells (CD4+ Th cells). Tight regulation of endocytic trafficking, protease activity, and peptide editing is required to generate stable peptide-MHCII complexes &#8230; <a title=\"Unveiling the role of lysosomes in antigen processing and presentation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/unveiling-the-role-of-lysosomes-in-antigen-processing-and-presentation\/\" aria-label=\"Read more about Unveiling the role of lysosomes in antigen processing and presentation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/innate-immune-reprogramming-of-chicken-macrophages-by-sodium-butyrate-enhances-reactive-oxygen-species-mediated-antimicrobial-responses-in-vitro\/\">Innate immune reprogramming of chicken macrophages by sodium butyrate enhances reactive oxygen species-mediated antimicrobial responses in vitro<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-12T17:38:17+02:00\" class=\"wp-block-latest-posts__post-date\">12 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag209. doi: 10.1093\/jimmun\/vkag209. ABSTRACT In the established model of classical trained immunity, metabolic and epigenetic hubs serve as central integrators of innate memory. While typically associated with proinflammatory reprogramming, the regulation of autophagy and cellular proteostasis remains essential for guiding macrophage differentiation and ensuring efficient pathogen clearance without excessive inflammation. In &#8230; <a title=\"Innate immune reprogramming of chicken macrophages by sodium butyrate enhances reactive oxygen species-mediated antimicrobial responses in vitro\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/innate-immune-reprogramming-of-chicken-macrophages-by-sodium-butyrate-enhances-reactive-oxygen-species-mediated-antimicrobial-responses-in-vitro\/\" aria-label=\"Read more about Innate immune reprogramming of chicken macrophages by sodium butyrate enhances reactive oxygen species-mediated antimicrobial responses in vitro\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/correction-to-p38-signaling-enhances-short-lived-effector-cell-differentiation-and-weakens-central-memory-cd8-t-cell-formation\/\">Correction to: p38 signaling enhances short-lived effector cell differentiation and weakens central memory CD8+ T-cell formation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-12T06:24:51+02:00\" class=\"wp-block-latest-posts__post-date\">12 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag221. doi: 10.1093\/jimmun\/vkag221. NO ABSTRACT PMID:42580673 | DOI:10.1093\/jimmun\/vkag221<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/trecing-down-the-source-naive-and-memory-t-cell-generation-in-dirty-mice-and-men\/\">TRECing down the source: naive and memory T cell generation in dirty mice and men<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-12T06:24:51+02:00\" class=\"wp-block-latest-posts__post-date\">12 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag216. doi: 10.1093\/jimmun\/vkag216. ABSTRACT Healthy aging relies on the maintenance of a diverse T cell pool. This diversity is ensured by balancing thymic output, differentiation of naive into memory T cells, T cell proliferation and cell death. For naive T cells, the balance of these processes differs between standard laboratory mice &#8230; <a title=\"TRECing down the source: naive and memory T cell generation in dirty mice and men\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/12\/trecing-down-the-source-naive-and-memory-t-cell-generation-in-dirty-mice-and-men\/\" aria-label=\"Read more about TRECing down the source: naive and memory T cell generation in dirty mice and men\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/11\/skullcapflavone-ii-alleviates-osteoarthritis-by-inhibiting-inflammation-and-ferroptosis-via-the-slc7a11-gpx4-signaling-pathway\/\">Skullcapflavone II alleviates osteoarthritis by inhibiting inflammation and ferroptosis via the SLC7A11\/GPX4 signaling pathway<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-11T00:50:10+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag230. doi: 10.1093\/jimmun\/vkag230. ABSTRACT Osteoarthritis (OA), the most prevalent degenerative joint disease, leads to significant disability in the elderly and is characterized by functional and structural deterioration of the knee joint. This study aimed to investigate the therapeutic potential of skullcapflavone II (SkII), a flavonoid known for its anti-inflammatory properties, in &#8230; <a title=\"Skullcapflavone II alleviates osteoarthritis by inhibiting inflammation and ferroptosis via the SLC7A11\/GPX4 signaling pathway\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/11\/skullcapflavone-ii-alleviates-osteoarthritis-by-inhibiting-inflammation-and-ferroptosis-via-the-slc7a11-gpx4-signaling-pathway\/\" aria-label=\"Read more about Skullcapflavone II alleviates osteoarthritis by inhibiting inflammation and ferroptosis via the SLC7A11\/GPX4 signaling pathway\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/11\/metabolic-crosstalk-between-c-myc-and-glutamine-utilization-sustains-igm-b-cell-immunity-in-teleosts\/\">Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-11T00:50:10+02:00\" class=\"wp-block-latest-posts__post-date\">11 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag227. doi: 10.1093\/jimmun\/vkag227. ABSTRACT B-cell responses rely on a tightly coordinated interplay between transcriptional programs and metabolic reprogramming. Upon activation, B cells remodel their metabolic profiles, with enhanced glutamine metabolism supporting biomass synthesis and proliferation. However, whether and how glutaminolysis underpins B-cell responses in early vertebrates remains largely unexplored. Here, using &#8230; <a title=\"Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/11\/metabolic-crosstalk-between-c-myc-and-glutamine-utilization-sustains-igm-b-cell-immunity-in-teleosts\/\" aria-label=\"Read more about Metabolic crosstalk between c-Myc and glutamine utilization sustains IgM+ B-cell immunity in teleosts\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/10\/the-cxcl10-cxcr3-axis-drives-actin-remodeling-to-recruit-cd4-t-cells-to-gut-epithelium-during-transmissible-gastroenteritis-virus-infection\/\">The CXCL10\/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-10T06:38:02+02:00\" class=\"wp-block-latest-posts__post-date\">10 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag222. doi: 10.1093\/jimmun\/vkag222. ABSTRACT The immune system initially protects hosts against viral pathogens, with chemokines guiding immune cell movement. However, their expression patterns and immune cell recruitment mechanisms during transmissible gastroenteritis virus (TGEV) infection are still not fully understood. Here, we identified a distinct chemokine expression profile in intestinal epithelial cells &#8230; <a title=\"The CXCL10\/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/10\/the-cxcl10-cxcr3-axis-drives-actin-remodeling-to-recruit-cd4-t-cells-to-gut-epithelium-during-transmissible-gastroenteritis-virus-infection\/\" aria-label=\"Read more about The CXCL10\/CXCR3 axis drives actin remodeling to recruit CD4+ T cells to gut epithelium during transmissible gastroenteritis virus infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/iga-binding-characteristics-of-golden-hamster-and-ferret-fc%ce%b1-receptors\/\">IgA binding characteristics of golden hamster and ferret Fc\u03b1 receptors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-08T06:53:28+02:00\" class=\"wp-block-latest-posts__post-date\">8 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag218. doi: 10.1093\/jimmun\/vkag218. ABSTRACT Golden hamster (Mesocricetus auratus) and ferret (Mustela putorius furo) are important animal models in studies of human infectious disease. They are used widely to investigate pathogen-spreading mechanisms and host immunology to evaluate the safety and efficacy of small molecules, biologic drugs and vaccines. To this end, immunoglobulin &#8230; <a title=\"IgA binding characteristics of golden hamster and ferret Fc\u03b1 receptors\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/iga-binding-characteristics-of-golden-hamster-and-ferret-fc%ce%b1-receptors\/\" aria-label=\"Read more about IgA binding characteristics of golden hamster and ferret Fc\u03b1 receptors\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/delivery-of-extracellular-vesicle-associated-microrna-146a-regulates-human-monocyte-phenotype-and-function\/\">Delivery of extracellular vesicle-associated microRNA-146a regulates human monocyte phenotype and function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-08T06:53:28+02:00\" class=\"wp-block-latest-posts__post-date\">8 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag226. doi: 10.1093\/jimmun\/vkag226. ABSTRACT CCR2+ monocytes are recruited to sites of acute myocardial injury, where they play a critical role in clearing necrotic debris and replenishing the depleted resident macrophage population. Although this response is necessary for early tissue repair, prolonged activation of inflammatory pathways and persistent recruitment of CCR2+ monocytes &#8230; <a title=\"Delivery of extracellular vesicle-associated microRNA-146a regulates human monocyte phenotype and function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/delivery-of-extracellular-vesicle-associated-microrna-146a-regulates-human-monocyte-phenotype-and-function\/\" aria-label=\"Read more about Delivery of extracellular vesicle-associated microRNA-146a regulates human monocyte phenotype and function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/identifying-molecular-signatures-underpinning-treatment-responses-to-novel-therapeutics-influencing-covid-19-outcomes\/\">Identifying molecular signatures underpinning treatment responses to novel therapeutics influencing COVID-19 outcomes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-08T00:49:34+02:00\" class=\"wp-block-latest-posts__post-date\">8 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag189. doi: 10.1093\/jimmun\/vkag189. ABSTRACT COVID-19 continues to present ongoing global health challenges driven by diverse immune responses and heterogeneous clinical outcomes. The ACCORD trial evaluated 3 investigational treatments-bemcentinib, tozorakimab, and zilucoplan-in patients hospitalized with COVID-19, each of which has demonstrated clinical efficacy. To better understand their molecular mechanisms, we conducted a &#8230; <a title=\"Identifying molecular signatures underpinning treatment responses to novel therapeutics influencing COVID-19 outcomes\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/identifying-molecular-signatures-underpinning-treatment-responses-to-novel-therapeutics-influencing-covid-19-outcomes\/\" aria-label=\"Read more about Identifying molecular signatures underpinning treatment responses to novel therapeutics influencing COVID-19 outcomes\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/sorting-nexin-5-deficiency-impairs-mhc-class-ii-antigen-presentation-and-inflammatory-responses-during-tuberculosis\/\">Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-08T00:49:34+02:00\" class=\"wp-block-latest-posts__post-date\">8 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag217. doi: 10.1093\/jimmun\/vkag217. ABSTRACT Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, yet the host pathways that regulate antigen presentation and lung inflammation during Mycobacterium tuberculosis (Mtb) infection are incompletely defined. Sorting nexin 5 (SNX5) is a protein implicated in endosomal trafficking, antigen &#8230; <a title=\"Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/sorting-nexin-5-deficiency-impairs-mhc-class-ii-antigen-presentation-and-inflammatory-responses-during-tuberculosis\/\" aria-label=\"Read more about Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/enforcing-mtorc1-activity-in-therapeutic-cd4-t-cells-promotes-persistence-but-eventual-immune-exhaustion\/\">Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-08T00:49:34+02:00\" class=\"wp-block-latest-posts__post-date\">8 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag206. doi: 10.1093\/jimmun\/vkag206. ABSTRACT There is substantial interest in developing novel engineering strategies to promote the sustained metabolic fitness of therapeutic T cells. We previously showed that overexpression of RAS homologue enriched in brain (RHEB), a positive regulator of mammalian target of rapamycin complex 1 (mTORC1), promotes aerobic glycolysis and increases &#8230; <a title=\"Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/08\/enforcing-mtorc1-activity-in-therapeutic-cd4-t-cells-promotes-persistence-but-eventual-immune-exhaustion\/\" aria-label=\"Read more about Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/identification-of-a-regulatory-allosteric-site-in-arid5a-unveils-a-therapeutic-axis-for-systemic-inflammation\/\">Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-06T19:23:34+02:00\" class=\"wp-block-latest-posts__post-date\">6 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag215. doi: 10.1093\/jimmun\/vkag215. ABSTRACT Adenine-thymine (AT)-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) that post-transcriptionally stabilizes mRNAs encoding proinflammatory mediators, including Interleukin-6 (IL-6), thereby amplifying inflammation. However, structural basis and regulatory mechanisms of Arid5a function remain poorly defined. In this study, we identified and characterized a conserved allosteric &#8230; <a title=\"Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/identification-of-a-regulatory-allosteric-site-in-arid5a-unveils-a-therapeutic-axis-for-systemic-inflammation\/\" aria-label=\"Read more about Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/fluid-shear-stress-as-a-co-stimulatory-cue-to-enhance-t-cell-priming-and-restore-activation-in-cancer-patient-t-cells\/\">Fluid shear stress as a co-stimulatory cue to enhance T cell priming and restore activation in cancer patient T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-06T19:23:34+02:00\" class=\"wp-block-latest-posts__post-date\">6 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag166. doi: 10.1093\/jimmun\/vkag166. ABSTRACT Cancer patient-derived T cells often exhibit impaired activation and functional responsiveness due to chronic antigen exposure and therapy-induced immune dysregulation, limiting the efficacy of current immunotherapies. Mechanical forces, such as fluid shear stress (FSS), are emerging as critical regulators of immune cell activation, yet their role in &#8230; <a title=\"Fluid shear stress as a co-stimulatory cue to enhance T cell priming and restore activation in cancer patient T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/fluid-shear-stress-as-a-co-stimulatory-cue-to-enhance-t-cell-priming-and-restore-activation-in-cancer-patient-t-cells\/\" aria-label=\"Read more about Fluid shear stress as a co-stimulatory cue to enhance T cell priming and restore activation in cancer patient T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/elastase-and-myeloperoxidase-participate-in-neutrophil-extracellular-trap-release-stimulated-by-sars-cov-2\/\">Elastase and myeloperoxidase participate in neutrophil extracellular trap release stimulated by SARS-CoV-2<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-06T01:09:03+02:00\" class=\"wp-block-latest-posts__post-date\">6 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkaf313. doi: 10.1093\/jimmun\/vkaf313. ABSTRACT COVID-19 is a disease triggered by SARS-CoV-2 and some individuals develop a severe form that can progress to multiple organ failure. Neutrophils have been described as responsible for the release of neutrophil extracellular traps (NETs). The role of the elastase and myeloperoxidase (MPO) in NET release by &#8230; <a title=\"Elastase and myeloperoxidase participate in neutrophil extracellular trap release stimulated by SARS-CoV-2\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/elastase-and-myeloperoxidase-participate-in-neutrophil-extracellular-trap-release-stimulated-by-sars-cov-2\/\" aria-label=\"Read more about Elastase and myeloperoxidase participate in neutrophil extracellular trap release stimulated by SARS-CoV-2\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/il-17-driven-transcriptional-programs-in-muscle-fibroblasts-are-not-required-for-pathogenesis-in-murine-anti-histidyl-trna-synthetase-jo-1-myositis\/\">IL-17-driven transcriptional programs in muscle fibroblasts are not required for pathogenesis in murine anti-histidyl-tRNA synthetase (Jo-1) myositis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-06T00:08:38+02:00\" class=\"wp-block-latest-posts__post-date\">6 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag225. doi: 10.1093\/jimmun\/vkag225. ABSTRACT Idiopathic inflammatory myopathy (IIM) is a systemic autoimmune disease targeting muscle and extramuscular organs, but the molecular mechanisms driving IIM pathogenesis remain largely undefined. Muscle fibroblasts are central to orchestrating inflammation in myositis. Here, we investigated muscle fibroblast dynamics using a single-cell RNA sequencing approach in an &#8230; <a title=\"IL-17-driven transcriptional programs in muscle fibroblasts are not required for pathogenesis in murine anti-histidyl-tRNA synthetase (Jo-1) myositis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/06\/il-17-driven-transcriptional-programs-in-muscle-fibroblasts-are-not-required-for-pathogenesis-in-murine-anti-histidyl-trna-synthetase-jo-1-myositis\/\" aria-label=\"Read more about IL-17-driven transcriptional programs in muscle fibroblasts are not required for pathogenesis in murine anti-histidyl-tRNA synthetase (Jo-1) myositis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/04\/cd151-identifies-a-cytotoxic-cd4-t-cell-population-enriched-in-people-with-hiv-that-later-develop-cancer\/\">CD151 identifies a cytotoxic CD4 T cell population enriched in people with HIV that later develop cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-04T12:35:22+02:00\" class=\"wp-block-latest-posts__post-date\">4 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag208. doi: 10.1093\/jimmun\/vkag208. ABSTRACT People with HIV (PWH) exhibit persistent immune activation despite effective antiretroviral therapy, contributing to risk of non-AIDS-associated comorbidities such as cancer. Cell populations reflecting immune remodeling trajectories preceding malignancy are poorly characterized. Using peripheral blood mononuclear cells from an adult cohort (25-65 yr), we quantified the tetraspanin &#8230; <a title=\"CD151 identifies a cytotoxic CD4 T cell population enriched in people with HIV that later develop cancer\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/04\/cd151-identifies-a-cytotoxic-cd4-t-cell-population-enriched-in-people-with-hiv-that-later-develop-cancer\/\" aria-label=\"Read more about CD151 identifies a cytotoxic CD4 T cell population enriched in people with HIV that later develop cancer\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/04\/peptide-exchange-competent-class-i-mhc-molecules-produced-in-eukaryotic-cells-for-rapid-production-of-mhc-multimers\/\">Peptide exchange-competent class I MHC molecules produced in eukaryotic cells for rapid production of MHC multimers<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-04T12:35:22+02:00\" class=\"wp-block-latest-posts__post-date\">4 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Aug 4;215(8):vkag210. doi: 10.1093\/jimmun\/vkag210. ABSTRACT Class I MHC peptide (MHC-Ip) multimers are well-established reagents that detect antigen-specific T cells. The classical method for production of MHC-Ip multimers begins with the expression of MHC heavy chains (HCs) and \u03b22-microglobulin (\u03b22m) subunits as inclusion bodies in Escherichia coli and is followed by denaturant solubilization, &#8230; <a title=\"Peptide exchange-competent class I MHC molecules produced in eukaryotic cells for rapid production of MHC multimers\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/04\/peptide-exchange-competent-class-i-mhc-molecules-produced-in-eukaryotic-cells-for-rapid-production-of-mhc-multimers\/\" aria-label=\"Read more about Peptide exchange-competent class I MHC molecules produced in eukaryotic cells for rapid production of MHC multimers\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/il-22-synergizes-with-il-17-to-promote-mucosal-inflammation-and-bone-loss\/\">IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-01T01:25:53+02:00\" class=\"wp-block-latest-posts__post-date\">1 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag186. doi: 10.1093\/jimmun\/vkag186. ABSTRACT Interleukin (IL)-22 mediates immune cell communication with nonhematopoietic cells and was shown to exert protective or destructive effects in different disease contexts. In the oral mucosal disease periodontitis, IL-22 has been associated with increased tissue destruction, although cause-and-effect evidence and the underlying mechanisms are lacking. Here, we &#8230; <a title=\"IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/il-22-synergizes-with-il-17-to-promote-mucosal-inflammation-and-bone-loss\/\" aria-label=\"Read more about IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/fc%ce%b3riii-blockade-prevents-anti-hla-mediated-platelet-clearance-in-a-humanized-murine-model-of-platelet-transfusion-refractoriness\/\">Fc\u03b3RIII blockade prevents anti-HLA-mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-01T01:25:53+02:00\" class=\"wp-block-latest-posts__post-date\">1 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag195. doi: 10.1093\/jimmun\/vkag195. ABSTRACT Immune platelet transfusion refractoriness (iPTR) is a major complication in transfusion medicine. Although anti-HLA antibodies are recognized contributors, the mechanisms by which they drive platelet clearance remain incompletely defined. We examined sera from 18 patients with iPTR and found that anti-HLA antibodies induced uptake of human platelets &#8230; <a title=\"Fc\u03b3RIII blockade prevents anti-HLA-mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/fc%ce%b3riii-blockade-prevents-anti-hla-mediated-platelet-clearance-in-a-humanized-murine-model-of-platelet-transfusion-refractoriness\/\" aria-label=\"Read more about Fc\u03b3RIII blockade prevents anti-HLA-mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/rag1-based-time-stamp-tracing-of-t-cell-developmental-origins\/\">Rag1-based time-stamp tracing of T-cell developmental origins<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-31T13:17:06+02:00\" class=\"wp-block-latest-posts__post-date\">31 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag154. doi: 10.1093\/jimmun\/vkag154. ABSTRACT The postnatal T\u2011cell pool comprises cells at diverse developmental stages, complicating efforts to resolve T\u2011cell differentiation, maturation, and long\u2011term adaptation. To address this challenge, we developed Rag1\u2011mediated time-stamp tracing, a genetic strategy that enables time\u2011resolved tracking of T\u2011cell developmental origins. We validate the specificity and temporal resolution &#8230; <a title=\"Rag1-based time-stamp tracing of T-cell developmental origins\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/rag1-based-time-stamp-tracing-of-t-cell-developmental-origins\/\" aria-label=\"Read more about Rag1-based time-stamp tracing of T-cell developmental origins\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/gut-microbial-composition-modulates-endogenous-food-specific-cd4-t-cells-in-food-allergy\/\">Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-31T13:17:06+02:00\" class=\"wp-block-latest-posts__post-date\">31 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag172. doi: 10.1093\/jimmun\/vkag172. ABSTRACT The growing food allergy epidemic is thought to be related to changing environmental factors, particularly changes in the gut microbiome. While prior work has demonstrated that food allergy can be modulated by gut microbes, little is known about how food allergen-specific CD4+ T cells are affected by &#8230; <a title=\"Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/gut-microbial-composition-modulates-endogenous-food-specific-cd4-t-cells-in-food-allergy\/\" aria-label=\"Read more about Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/t-cell-immunity-to-sars-cov-2-vaccination-in-inflammatory-bowel-disease-patients-treated-with-anti-cytokine-biologics\/\">T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-30T19:02:10+02:00\" class=\"wp-block-latest-posts__post-date\">30 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag173. doi: 10.1093\/jimmun\/vkag173. ABSTRACT Anti-TNF and anti-IL-12\/IL-23 are commonly used therapies for immune-mediated inflammatory diseases (IMIDs), including inflammatory bowel disease (IBD). Although several studies have shown intact T cell responses following 2 to 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in biologics treated IMID patients, our group &#8230; <a title=\"T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/t-cell-immunity-to-sars-cov-2-vaccination-in-inflammatory-bowel-disease-patients-treated-with-anti-cytokine-biologics\/\" aria-label=\"Read more about T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/lowering-cd40l-expression-in-murine-lupus-results-in-an-increase-in-disease-indicators-in-female-but-not-male-b6-mice\/\">Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-30T12:56:26+02:00\" class=\"wp-block-latest-posts__post-date\">30 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag205. doi: 10.1093\/jimmun\/vkag205. ABSTRACT Our laboratory has previously described a mouse model (CD40L\u03945) that produces 60% of wild-type CD40L due to a targeted deletion in an RNA binding site within the CD40L message. The CD40L\u03945 mutation, which destabilizes CD40L mRNA during T-cell activation, causes disrupted germinal center (GC) formation, leading to &#8230; <a title=\"Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/lowering-cd40l-expression-in-murine-lupus-results-in-an-increase-in-disease-indicators-in-female-but-not-male-b6-mice\/\" aria-label=\"Read more about Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/cd8-t-cell-effector-programming-is-epigenetically-regulated-by-dusp2-through-baf-complex-driven-chromatin-remodeling\/\">CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T12:40:10+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag202. doi: 10.1093\/jimmun\/vkag202. ABSTRACT Effector gene expression in CD8+ T cells is tightly controlled at the epigenetic and transcriptional levels; however, crucial regulatory signals remain incompletely understood. In this study, we identify dual specificity phosphatase 2 (DUSP2) as a key epigenetic modulator of effector CD8+ T-cell state, by elucidating inhibition of &#8230; <a title=\"CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/cd8-t-cell-effector-programming-is-epigenetically-regulated-by-dusp2-through-baf-complex-driven-chromatin-remodeling\/\" aria-label=\"Read more about CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/nkp44-recognition-of-platelet-derived-growth-factor-d-enhances-the-cytolytic-activity-of-natural-killer-cells\/\">NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T12:40:10+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag204. doi: 10.1093\/jimmun\/vkag204. ABSTRACT Natural killer (NK) cells are cytotoxic innate lymphoid cells that play a critical role in tumor surveillance by releasing proinflammatory cytokines and cytotoxic granules. NKp44 is an activating receptor that promotes NK cell secretion of TNF and IFN-\u03b3 upon engaging platelet-derived growth factor D (PDGF-DD), a ligand &#8230; <a title=\"NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/nkp44-recognition-of-platelet-derived-growth-factor-d-enhances-the-cytolytic-activity-of-natural-killer-cells\/\" aria-label=\"Read more about NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/binding-of-death-receptor-3-dr3-to-intracellular-tradd-and-traf2-is-independent-of-its-natural-ligand-tl1a\/\">Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T12:40:10+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag194. doi: 10.1093\/jimmun\/vkag194. ABSTRACT The TNF\u2011like cytokine TL1A is a key regulator of immune responses through engagement of its receptor, death receptor 3 (DR3), and has emerged as a therapeutic target in inflammatory diseases. Prevailing models propose that TL1A binding initiates recruitment of adaptor proteins to DR3, leading to downstream signaling. &#8230; <a title=\"Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/binding-of-death-receptor-3-dr3-to-intracellular-tradd-and-traf2-is-independent-of-its-natural-ligand-tl1a\/\" aria-label=\"Read more about Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/distinct-kinetic-features-of-innate-and-adaptive-responses-in-influenza-a-versus-influenza-b-infected-mice\/\">Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B-infected mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T01:30:02+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag196. doi: 10.1093\/jimmun\/vkag196. ABSTRACT Influenza B infection is an important source of morbidity and mortality, especially in vulnerable populations such as children. Improved vaccines and antiviral therapeutics are hindered by gaps in knowledge about influenza B viruses (IBVs). We examined the immune responses in the lung, at the kinetic interface between &#8230; <a title=\"Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B-infected mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/distinct-kinetic-features-of-innate-and-adaptive-responses-in-influenza-a-versus-influenza-b-infected-mice\/\" aria-label=\"Read more about Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B-infected mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/split-immunomodulatory-impact-of-leptin-on-human-myeloid-cells-key-role-of-ido1-in-counteracting-the-immunostimulatory-effect-of-leptin\/\">Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-27T19:06:48+02:00\" class=\"wp-block-latest-posts__post-date\">27 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag211. doi: 10.1093\/jimmun\/vkag211. ABSTRACT Obesity increases cancer incidence and aggressiveness but is paradoxically associated with improved response to immunotherapy. Here, we show that intratumoral levels of leptin (LEP), a factor contributing to the development of obesity, predict improved outcomes of breast and liver cancers. In contrast, these levels of LEP are &#8230; <a title=\"Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/split-immunomodulatory-impact-of-leptin-on-human-myeloid-cells-key-role-of-ido1-in-counteracting-the-immunostimulatory-effect-of-leptin\/\" aria-label=\"Read more about Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/nad-depletion-links-metabolic-stress-to-drive-innate-immune-priming-and-selectively-control-panoptosis\/\">NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-27T19:06:48+02:00\" class=\"wp-block-latest-posts__post-date\">27 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag203. doi: 10.1093\/jimmun\/vkag203. ABSTRACT The innate immune system can detect infection, tissue damage, and other homeostatic disruptions to initiate an immune response, drive inflammation, and promote programmed cell death. While these responses can be beneficial in host defense, aberrant activation of inflammatory, lytic cell death pathways can be pathogenic. Emerging evidence &#8230; <a title=\"NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/nad-depletion-links-metabolic-stress-to-drive-innate-immune-priming-and-selectively-control-panoptosis\/\" aria-label=\"Read more about NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/immunosuppressive-effects-of-voclosporin-in-inflammatory-bowel-disease-through-targeted-inhibition-of-slp-76-and-metabolic-reprogramming\/\">Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-26T06:23:35+02:00\" class=\"wp-block-latest-posts__post-date\">26 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag175. doi: 10.1093\/jimmun\/vkag175. ABSTRACT The adaptor protein SLP-76 plays a critical role in T-cell receptor signaling and immune activation, yet its relevance in inflammatory bowel disease (IBD) remains unclear. Although calcineurin inhibitors such as cyclosporine A (CsA) are used in severe ulcerative colitis, voclosporin (VCS), a novel calcineurin inhibitor approved for &#8230; <a title=\"Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/immunosuppressive-effects-of-voclosporin-in-inflammatory-bowel-disease-through-targeted-inhibition-of-slp-76-and-metabolic-reprogramming\/\" aria-label=\"Read more about Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/platelets-are-essential-for-survival-of-respiratory-restricted-viral-infection\/\">Platelets are essential for survival of respiratory-restricted viral infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-26T06:23:35+02:00\" class=\"wp-block-latest-posts__post-date\">26 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag197. doi: 10.1093\/jimmun\/vkag197. ABSTRACT Platelets are small, anucleate cells derived from megakaryocytes and are known for their essential role in hemostasis. Over the past decade, they have also emerged as important immune modulators, able to affect viral replication and leukocyte behavior. Most studies on platelets and viral infections have been focused &#8230; <a title=\"Platelets are essential for survival of respiratory-restricted viral infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/platelets-are-essential-for-survival-of-respiratory-restricted-viral-infection\/\" aria-label=\"Read more about Platelets are essential for survival of respiratory-restricted viral infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/donor-cell-gata3-is-critical-for-gut-pathogenic-t-cell-effector-function-and-intestinal-eosinophilia-after-hematopoietic-cell-transplantation\/\">Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-25T07:02:05+02:00\" class=\"wp-block-latest-posts__post-date\">25 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag190. doi: 10.1093\/jimmun\/vkag190. ABSTRACT Hematopoietic cell transplantation (HCT) is a curative immunotherapy for hematologic malignancies such as acute myeloid leukemia, primarily through graft-versus-tumor (GVT) effects mediated by donor T cells. However, up to 60% of recipients develop graft-versus-host disease (GVHD), with intestinal involvement being a major contributor to morbidity and mortality. &#8230; <a title=\"Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/donor-cell-gata3-is-critical-for-gut-pathogenic-t-cell-effector-function-and-intestinal-eosinophilia-after-hematopoietic-cell-transplantation\/\" aria-label=\"Read more about Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/phylogenetic-analysis-of-amino-acid-sequences-indicates-a-central-role-of-transmembrane-domain-structural-elements-in-mhc-class-ii-function\/\">Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-25T00:59:15+02:00\" class=\"wp-block-latest-posts__post-date\">25 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag192. doi: 10.1093\/jimmun\/vkag192. ABSTRACT Human leukocyte antigen class II genes are highly polymorphic. This raises the question of how polymorphisms are distributed across the entirety of the class II molecule and how this distribution affects function. We performed a comprehensive analysis of amino acid variability across the entire class II molecule, &#8230; <a title=\"Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/phylogenetic-analysis-of-amino-acid-sequences-indicates-a-central-role-of-transmembrane-domain-structural-elements-in-mhc-class-ii-function\/\" aria-label=\"Read more about Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/23\/kaempferols-potential-in-targeting-il-17-mediated-inflammatory-pathways-for-colorectal-cancer-treatment\/\">Kaempferol&#8217;s potential in targeting IL-17-mediated inflammatory pathways for colorectal cancer treatment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-23T12:30:36+02:00\" class=\"wp-block-latest-posts__post-date\">23 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag176. doi: 10.1093\/jimmun\/vkag176. ABSTRACT Colorectal cancer (CRC) is a leading malignancy with limited treatment options at advanced stages. Interleukin (IL)-17 signaling promotes tumor progression and immune evasion. Kaempferol, a natural flavonol, has anti-inflammatory and antitumor effects, but its role in modulating IL-17 pathways in CRC is unclear. We used an immunocompetent &#8230; <a title=\"Kaempferol&#8217;s potential in targeting IL-17-mediated inflammatory pathways for colorectal cancer treatment\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/23\/kaempferols-potential-in-targeting-il-17-mediated-inflammatory-pathways-for-colorectal-cancer-treatment\/\" aria-label=\"Read more about Kaempferol&#8217;s potential in targeting IL-17-mediated inflammatory pathways for colorectal cancer treatment\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/22\/unconventional-functions-of-natural-killer-cells-in-homeostasis-and-disease\/\">Unconventional functions of natural killer cells in homeostasis and disease<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-22T01:10:30+02:00\" class=\"wp-block-latest-posts__post-date\">22 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag148. doi: 10.1093\/jimmun\/vkag148. ABSTRACT NK cells are classically defined by their rapid cytotoxicity against tumor cells and infected cells and by early inflammatory cytokine production. However, unconventional roles for NK cells as regulators of immunity and tissue homeostasis have recently been uncovered. Beyond their classical roles, NK cells can orchestrate leukocyte &#8230; <a title=\"Unconventional functions of natural killer cells in homeostasis and disease\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/22\/unconventional-functions-of-natural-killer-cells-in-homeostasis-and-disease\/\" aria-label=\"Read more about Unconventional functions of natural killer cells in homeostasis and disease\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/toll-like-receptor-responses-are-shaped-by-distinct-mapk-activation-profiles\/\">Toll-like receptor responses are shaped by distinct MAPK activation profiles<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-21T12:49:16+02:00\" class=\"wp-block-latest-posts__post-date\">21 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag180. doi: 10.1093\/jimmun\/vkag180. ABSTRACT Toll-like receptors (TLRs) are key sensors of infection and injury, and are critical inducers of inflammation. TLR-induced activation of the NF-\u03baB and MAPK pathways promotes the secretion of mediators of inflammation such as cytokines and chemokines. Control of cytokine production is critically important, as unnecessary inflammatory responses &#8230; <a title=\"Toll-like receptor responses are shaped by distinct MAPK activation profiles\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/toll-like-receptor-responses-are-shaped-by-distinct-mapk-activation-profiles\/\" aria-label=\"Read more about Toll-like receptor responses are shaped by distinct MAPK activation profiles\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/cd153-promotes-b-cell-responses-to-immunization-in-aged-mice\/\">CD153 promotes B-cell responses to immunization in aged mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-21T12:49:16+02:00\" class=\"wp-block-latest-posts__post-date\">21 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag188. doi: 10.1093\/jimmun\/vkag188. ABSTRACT We and others have described homeostatic dysregulation of the CD4+ memory T-cell compartment with age. To gain greater insights into this dysregulation, we performed comprehensive single-cell genomic analysis of endogenous memory CD4+ T cells from young and aged mice. This analysis revealed 16 populations, composed of Th1, &#8230; <a title=\"CD153 promotes B-cell responses to immunization in aged mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/cd153-promotes-b-cell-responses-to-immunization-in-aged-mice\/\" aria-label=\"Read more about CD153 promotes B-cell responses to immunization in aged mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/fluorescence-tracking-cd8-t-cells-from-tumor-draining-lymph-nodes-to-irradiated-tumors-and-their-activation-in-the-tumor-environment\/\">Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag142. doi: 10.1093\/jimmun\/vkag142. ABSTRACT Radiation is an effective site-specific cytotoxic therapy for cancer cells. In preclinical models, CD8 T cells are essential for optimum tumor control by radiation therapy, yet CD8 T cells are radiosensitive and depleted within the treatment field. Irradiated tumors can be refilled with T cells that were &#8230; <a title=\"Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/fluorescence-tracking-cd8-t-cells-from-tumor-draining-lymph-nodes-to-irradiated-tumors-and-their-activation-in-the-tumor-environment\/\" aria-label=\"Read more about Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/single-cell-analysis-of-ovarian-immune-cells-reveals-dynamic-changes-in-nk-and-b-cell-populations-after-ovarian-stimulation\/\">Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag153. doi: 10.1093\/jimmun\/vkag153. ABSTRACT The mammalian ovary is the dynamic end-organ of the hypothalamic-pituitary-ovarian axis. In this coordinated system, ovarian cells undergo continuous cycles of apoptosis, proliferation, and differentiation. These changes parallel fluctuations in ovarian hormones such as estradiol; however, the ovarian immune microenvironment during high- and low-estradiol states remains incompletely &#8230; <a title=\"Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/single-cell-analysis-of-ovarian-immune-cells-reveals-dynamic-changes-in-nk-and-b-cell-populations-after-ovarian-stimulation\/\" aria-label=\"Read more about Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/the-transcription-factor-srebp2-supports-the-activation-and-homeostasis-of-cd4-foxp3-regulatory-t-cells\/\">The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag181. doi: 10.1093\/jimmun\/vkag181. ABSTRACT Periodic activation of regulatory T cells (Tregs) is necessary to restrict autoreactive T cells and maintain immune homeostasis. IL-2-STAT5 signaling instructs several metabolic processes underlying Treg activation, including the mevalonate pathway, which is crucial for optimal Treg responses. However, direct links between IL-2-STAT5, mevalonate, and Treg function &#8230; <a title=\"The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/the-transcription-factor-srebp2-supports-the-activation-and-homeostasis-of-cd4-foxp3-regulatory-t-cells\/\" aria-label=\"Read more about The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/pari-deficiency-leads-to-increased-somatic-hypermutation\/\">PARI deficiency leads to increased somatic hypermutation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag031. doi: 10.1093\/jimmun\/vkag031. ABSTRACT Somatic hypermutation of immunoglobulin (Ig) genes in germinal center B cells is based on the introduction of DNA lesions by activation-induced cytidine deaminase (AID), followed by lesion processing by multiple error-prone DNA repair pathways. Error-free DNA repair by homologous recombination (HR) is required for the repair of &#8230; <a title=\"PARI deficiency leads to increased somatic hypermutation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/pari-deficiency-leads-to-increased-somatic-hypermutation\/\" aria-label=\"Read more about PARI deficiency leads to increased somatic hypermutation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/t-cell-mir-155-regulates-the-response-to-tumor-specific-mrna-vaccines-in-a-murine-model-of-acute-myeloid-leukemia\/\">T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag184. doi: 10.1093\/jimmun\/vkag184. ABSTRACT Acute myeloid leukemia (AML) is a malignant clonal expansion of myeloid progenitor cells that impedes normal hematopoiesis and culminates in bone marrow failure and death. The development of chemoresistant disease in response to first-line chemotherapies is common and indicates a need for new therapies. Tumor-specific mRNA vaccines &#8230; <a title=\"T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/t-cell-mir-155-regulates-the-response-to-tumor-specific-mrna-vaccines-in-a-murine-model-of-acute-myeloid-leukemia\/\" aria-label=\"Read more about T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/mtecs-and-b-cells-form-a-thymic-microniche-associated-with-b-cell-licensing\/\">mTECs and B cells form a thymic microniche associated with B-cell licensing<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag185. doi: 10.1093\/jimmun\/vkag185. ABSTRACT Thymic B cells rely on T cells and type-III IFN (IFN-\u03bb) signaling for class switch recombination and effective licensing as APCs, a process essential for their role in establishing central T-cell tolerance. IFN-\u03bb is produced exclusively by a subset of medullary thymic epithelial cells (mTECs); however, the &#8230; <a title=\"mTECs and B cells form a thymic microniche associated with B-cell licensing\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/mtecs-and-b-cells-form-a-thymic-microniche-associated-with-b-cell-licensing\/\" aria-label=\"Read more about mTECs and B cells form a thymic microniche associated with B-cell licensing\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/hidden-effects-of-polymyxin-b-its-role-in-activating-tlr2-mediated-inflammatory-responses\/\">Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag193. doi: 10.1093\/jimmun\/vkag193. ABSTRACT Polymyxins are cyclic cationic lipopeptide antibiotics that disrupt both the outer and inner membranes of Gram-negative bacteria. They also bind to bacterial lipopolysaccharides (LPSs), thereby inhibiting LPS recognition by Toll-like receptor 4 (TLR4) and preventing macrophage activation. However, the immunomodulatory effects of polymyxin B during infection, in &#8230; <a title=\"Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/hidden-effects-of-polymyxin-b-its-role-in-activating-tlr2-mediated-inflammatory-responses\/\" aria-label=\"Read more about Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/systemic-and-lung-resident-memory-elicited-by-oc43-coronavirus-infection-in-mice\/\">Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-16T01:34:42+02:00\" class=\"wp-block-latest-posts__post-date\">16 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag182. doi: 10.1093\/jimmun\/vkag182. ABSTRACT Endemic coronaviruses circulate seasonally and, while typically mild, can produce robust inflammation and severe pneumonia. Immunological memory to coronaviruses can be cross-reactive for multiple coronaviruses including OC43 and SARS-CoV-2. In this study, we used mouse models to investigate immune responses elicited by pulmonary infection with OC43. OC43 &#8230; <a title=\"Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/systemic-and-lung-resident-memory-elicited-by-oc43-coronavirus-infection-in-mice\/\" aria-label=\"Read more about Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/a-novel-v%ce%b41-engager-targeting-cd19-enhances-human-v%ce%b41-%ce%b3%ce%b4-t-cell-responses-against-cll-and-cd19-hematological-malignancies\/\">A novel V\u03b41 engager targeting CD19 enhances human V\u03b41 \u03b3\u03b4 T cell responses against CLL and CD19+ hematological malignancies<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-16T01:34:42+02:00\" class=\"wp-block-latest-posts__post-date\">16 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag167. doi: 10.1093\/jimmun\/vkag167. ABSTRACT \u03b3\u03b4 T cells are associated with favorable outcomes in many cancers likely through a mechanism of stress-directed cytotoxicity and antitumor cytokine production. V\u03b41 \u03b3\u03b4 T cells are especially promising for immunotherapy due to their broad stress recognition and resistance to activation-induced cell death. Here, we generate a &#8230; <a title=\"A novel V\u03b41 engager targeting CD19 enhances human V\u03b41 \u03b3\u03b4 T cell responses against CLL and CD19+ hematological malignancies\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/a-novel-v%ce%b41-engager-targeting-cd19-enhances-human-v%ce%b41-%ce%b3%ce%b4-t-cell-responses-against-cll-and-cd19-hematological-malignancies\/\" aria-label=\"Read more about A novel V\u03b41 engager targeting CD19 enhances human V\u03b41 \u03b3\u03b4 T cell responses against CLL and CD19+ hematological malignancies\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/14\/whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens\/\">Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-14T06:46:47+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag174. doi: 10.1093\/jimmun\/vkag174. ABSTRACT Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the quantitative and qualitative changes in na\u00efve CD4 T cells after WBI is critical because these cells play key roles in both host defense and the propagation of autoimmunity. &#8230; <a title=\"Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/14\/whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens\/\" aria-label=\"Read more about Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/the-discovery-and-roles-of-type-2-innate-lymphoid-cells\/\">The discovery and roles of type 2 innate lymphoid cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-12T20:18:13+02:00\" class=\"wp-block-latest-posts__post-date\">12 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag104. doi: 10.1093\/jimmun\/vkag104. NO ABSTRACT PMID:42437361 | DOI:10.1093\/jimmun\/vkag104<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/long-term-survivors-of-melanoma-after-anti-pd-1-therapy-demonstrate-on-treatment-increase-in-abundance-of-4-1bb-cd4-t-cells-in-blood\/\">Long-term survivors of melanoma after anti-PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-12T07:06:55+02:00\" class=\"wp-block-latest-posts__post-date\">12 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag171. doi: 10.1093\/jimmun\/vkag171. ABSTRACT Anti-PD-1 monotherapy has shown a significant survival benefit for patients with advanced-stage melanoma. In this study, we explored whether long-term clinical benefit is determined by abundance or changes in such abundances of CD4 and CD8 T-cell subsets in blood. Peripheral blood mononuclear cells from 58 patients with &#8230; <a title=\"Long-term survivors of melanoma after anti-PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/long-term-survivors-of-melanoma-after-anti-pd-1-therapy-demonstrate-on-treatment-increase-in-abundance-of-4-1bb-cd4-t-cells-in-blood\/\" aria-label=\"Read more about Long-term survivors of melanoma after anti-PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis\/\">Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-12T07:06:55+02:00\" class=\"wp-block-latest-posts__post-date\">12 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag163. doi: 10.1093\/jimmun\/vkag163. ABSTRACT Success of B cell depletion therapy in multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system, places B cells and their functions center stage in efforts to fully understand pathogenesis. Historically, MS animal models of experimental autoimmune encephalomyelitis have featured B cell-independent disease driven &#8230; <a title=\"Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis\/\" aria-label=\"Read more about Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/11\/cd22-is-upregulated-and-displays-suppressive-properties-on-cd4-t-cells-upon-a-persistent-virus-infection\/\">CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-11T12:51:59+02:00\" class=\"wp-block-latest-posts__post-date\">11 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag183. doi: 10.1093\/jimmun\/vkag183. ABSTRACT Chronic viral infections evade or suppress host immunity, posing risks to global human health. However, the underlying mechanisms of viral immune suppression are incompletely defined. Previously, we have demonstrated that sphingosine kinase 2 (SphK2) represses CD4+ T-cell immunity during lymphocytic choriomeningitis virus (LCMV) Clone 13 (Cl 13) &#8230; <a title=\"CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/11\/cd22-is-upregulated-and-displays-suppressive-properties-on-cd4-t-cells-upon-a-persistent-virus-infection\/\" aria-label=\"Read more about CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/10\/a-mutation-in-ptpn6-associated-to-emphysema-alters-b-lymphocyte-biology-in-humans-and-mice\/\">A mutation in PTPN6 associated to emphysema alters B-lymphocyte biology in humans and mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-10T13:31:59+02:00\" class=\"wp-block-latest-posts__post-date\">10 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag162. doi: 10.1093\/jimmun\/vkag162. ABSTRACT Our group discovered a mutation in a French-Canadian family causing a severe and early-onset form of emphysema. The heterozygote mutation located in the PTPN6 gene causes an alanine to threonine switch near the catalytic site of SHP-1, leading to a reduction of its enzymatic activity. In this &#8230; <a title=\"A mutation in PTPN6 associated to emphysema alters B-lymphocyte biology in humans and mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/10\/a-mutation-in-ptpn6-associated-to-emphysema-alters-b-lymphocyte-biology-in-humans-and-mice\/\" aria-label=\"Read more about A mutation in PTPN6 associated to emphysema alters B-lymphocyte biology in humans and mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/staphylococcus-aureus-superantigens-drive-a-concentration-dependent-neutrophilic-or-eosinophilic-pulmonary-inflammation-in-mouse-models-of-cystic-fibrosis\/\">Staphylococcus aureus superantigens drive a concentration-dependent neutrophilic or eosinophilic pulmonary inflammation in mouse models of cystic fibrosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-09T07:07:17+02:00\" class=\"wp-block-latest-posts__post-date\">9 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag155. doi: 10.1093\/jimmun\/vkag155. ABSTRACT Staphylococcus aureus (SA), the most common cystic fibrosis (CF) respiratory pathogen, is uniquely capable of producing superantigen (SAg) exotoxins, which are recognized as the most potent activators of the immune system and inducers of inflammation. Although a high frequency of CF SA isolates can produce SA-SAgs, their &#8230; <a title=\"Staphylococcus aureus superantigens drive a concentration-dependent neutrophilic or eosinophilic pulmonary inflammation in mouse models of cystic fibrosis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/staphylococcus-aureus-superantigens-drive-a-concentration-dependent-neutrophilic-or-eosinophilic-pulmonary-inflammation-in-mouse-models-of-cystic-fibrosis\/\" aria-label=\"Read more about Staphylococcus aureus superantigens drive a concentration-dependent neutrophilic or eosinophilic pulmonary inflammation in mouse models of cystic fibrosis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury\/\">Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-09T07:07:17+02:00\" class=\"wp-block-latest-posts__post-date\">9 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag140. doi: 10.1093\/jimmun\/vkag140. ABSTRACT Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen species (ROS). Mechanistically, AKT activation &#8230; <a title=\"Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury\/\" aria-label=\"Read more about Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection\/\">Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-09T07:07:17+02:00\" class=\"wp-block-latest-posts__post-date\">9 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag164. doi: 10.1093\/jimmun\/vkag164. ABSTRACT Memory CD8 T cells respond rapidly upon antigen re-encounter and are considered advantageous for protective immunity. However, they undergo a swift decline under chronic antigen stimulation. In this study, we found that memory CD8 T cells&#8217; heightened activation sensitivity promotes terminal differentiation and impairs the formation of &#8230; <a title=\"Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection\/\" aria-label=\"Read more about Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/inflammatory-genital-strain-of-chlamydia-trachomatis-elicits-a-th17-immune-response\/\">Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-08T08:50:39+02:00\" class=\"wp-block-latest-posts__post-date\">8 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag177. doi: 10.1093\/jimmun\/vkag177. ABSTRACT In humans, infection with Chlamydia trachomatis can result in chronic infection with severe reproductive consequences. The immune response elicited by natural infection fails to protect against reinfection and can contribute to tissue inflammation and damage. CD4+ T cells are key mediators of protection against C. trachomatis. However, &#8230; <a title=\"Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/inflammatory-genital-strain-of-chlamydia-trachomatis-elicits-a-th17-immune-response\/\" aria-label=\"Read more about Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/epigenetic-control-of-p53-activity-in-regulatory-t-cells-maintains-their-identity-to-prevent-inflammation\/\">Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-08T08:50:38+02:00\" class=\"wp-block-latest-posts__post-date\">8 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag145. doi: 10.1093\/jimmun\/vkag145. ABSTRACT Regulatory T cells (Tregs) are critical guardians of immune homeostasis that must operate in diverse and often inflammatory conditions. However, the mechanisms that Tregs use to maintain their stability and function, especially in response to the stresses of distinct microenvironments, remain incompletely understood. Previous work identified the &#8230; <a title=\"Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/epigenetic-control-of-p53-activity-in-regulatory-t-cells-maintains-their-identity-to-prevent-inflammation\/\" aria-label=\"Read more about Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/07\/the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen\/\">The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-07T01:23:27+02:00\" class=\"wp-block-latest-posts__post-date\">7 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag115. doi: 10.1093\/jimmun\/vkag115. ABSTRACT Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the &#8230; <a title=\"The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/07\/the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen\/\" aria-label=\"Read more about The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/05\/optineurin-restrains-il-17-associated-neuroinflammation-in-trigeminal-ganglia-to-preserve-sensory-function-after-ocular-hsv-1-infection\/\">Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-05T06:47:56+02:00\" class=\"wp-block-latest-posts__post-date\">5 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag161. doi: 10.1093\/jimmun\/vkag161. ABSTRACT Neurotrophic keratitis (NK) arises when trigeminal sensory dysfunction reduces corneal sensation and compromises epithelial maintenance. Herpes simplex virus type 1 (HSV-1) establishes latency in the trigeminal ganglion (TG) and is a common trigger of acquired NK, yet the host programs that determine whether inflamed ganglia recover or &#8230; <a title=\"Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/05\/optineurin-restrains-il-17-associated-neuroinflammation-in-trigeminal-ganglia-to-preserve-sensory-function-after-ocular-hsv-1-infection\/\" aria-label=\"Read more about Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/04\/crystal-structure-and-immune-single-cell-atlas-provide-insights-into-the-functional-divergence-of-type-i-ifns-in-fish\/\">Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-04T01:21:05+02:00\" class=\"wp-block-latest-posts__post-date\">4 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag131. doi: 10.1093\/jimmun\/vkag131. ABSTRACT Type I interferons (IFNs) are central antiviral cytokines in vertebrates, yet the mechanisms underlying their functional diversification in early vertebrates remain unclear. Teleost fish, whose IFN repertoires expanded through whole-genome duplication, provide a powerful model to address this question. Here, we systematically characterize grass carp (Ctenopharyngodon idella) &#8230; <a title=\"Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/04\/crystal-structure-and-immune-single-cell-atlas-provide-insights-into-the-functional-divergence-of-type-i-ifns-in-fish\/\" aria-label=\"Read more about Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs\/\">Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag136. doi: 10.1093\/jimmun\/vkag136. ABSTRACT Foxp3+ regulatory T cells (Tregs) are capable suppressors of aberrant self-reactivity. However, how differences in affinity and specificity may support Treg function compared with autoimmune T cell function remains unresolved. In this study, we analyzed the T cell receptor (TCR) repertoires of the regulatory and effector T &#8230; <a title=\"Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs\/\" aria-label=\"Read more about Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/ftr85-negatively-regulates-type-i-ifn-antiviral-signaling-pathway-by-promoting-k48-linked-polyubiquitination-of-irf3\/\">FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag132. doi: 10.1093\/jimmun\/vkag132. ABSTRACT The finTRIM (FTR) subfamily, a group of fish-specific tripartite motif proteins, has arisen through gene duplication events specific to particular genera or species. However, the regulatory mechanisms of FTR in antiviral immune response remains largely unknown. In the present study, we identified a fish novel tripartite motif &#8230; <a title=\"FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/ftr85-negatively-regulates-type-i-ifn-antiviral-signaling-pathway-by-promoting-k48-linked-polyubiquitination-of-irf3\/\" aria-label=\"Read more about FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/an-mr1-specific-nanobody-capable-of-blocking-mr1t-cell-activation\/\">An MR1-specific nanobody capable of blocking MR1T cell activation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag094. doi: 10.1093\/jimmun\/vkag094. ABSTRACT MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that MR1 plays a role in microbial infection, inflammation, and tumor immunity. The antigens it presents include metabolites of microbial and self-origin as well as small-molecule &#8230; <a title=\"An MR1-specific nanobody capable of blocking MR1T cell activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/an-mr1-specific-nanobody-capable-of-blocking-mr1t-cell-activation\/\" aria-label=\"Read more about An MR1-specific nanobody capable of blocking MR1T cell activation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/tgf-%ce%b2-controls-developmental-fate-and-functional-identity-of-thymic-%ce%b3%ce%b4-t-cells\/\">TGF-\u03b2 controls developmental fate and functional identity of thymic \u03b3\u03b4 T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag134. doi: 10.1093\/jimmun\/vkag134. ABSTRACT Gamma delta (\u03b3\u03b4) T cells undergo a distinct developmental pathway within the thymus, where transforming growth factor \u03b2 (TGF-\u03b2) exerts pivotal regulatory influence. However, the precise mechanistic contributions of TGF-\u03b2 to \u03b3\u03b4 T cells differentiation and functional maturation remain incompletely understood. Here, we show that TGF-\u03b2 regulates &#8230; <a title=\"TGF-\u03b2 controls developmental fate and functional identity of thymic \u03b3\u03b4 T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/tgf-%ce%b2-controls-developmental-fate-and-functional-identity-of-thymic-%ce%b3%ce%b4-t-cells\/\" aria-label=\"Read more about TGF-\u03b2 controls developmental fate and functional identity of thymic \u03b3\u03b4 T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/complement-c3-deficiency-increases-the-effector-and-cytotoxic-functions-of-nk-cells-and-suppresses-tumor-growth\/\">Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag157. doi: 10.1093\/jimmun\/vkag157. ABSTRACT The complement system and natural killer (NK) cells play crucial roles in tumor growth and metastasis. The role of the complement system in affecting the phenotype and anti-tumor function of NK cells remains poorly understood. Using the B16F10 mouse melanoma model, we demonstrated that NK cells from &#8230; <a title=\"Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/complement-c3-deficiency-increases-the-effector-and-cytotoxic-functions-of-nk-cells-and-suppresses-tumor-growth\/\" aria-label=\"Read more about Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/01\/getting-on-your-last-nerve-ifns-and-resistance-to-infection\/\">Getting on your last nerve: IFNs and resistance to infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-01T01:27:57+02:00\" class=\"wp-block-latest-posts__post-date\">1 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag169. doi: 10.1093\/jimmun\/vkag169. ABSTRACT Interferons (IFNs) affect almost all nucleated cells and induce transcriptional events that are associated with control of intracellular infections as well as regulatory pathways that influence inflammatory processes. How different hematopoietic and non-hematopoietic cell types interpret these signals is a reflection of cellular context and function. For &#8230; <a title=\"Getting on your last nerve: IFNs and resistance to infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/01\/getting-on-your-last-nerve-ifns-and-resistance-to-infection\/\" aria-label=\"Read more about Getting on your last nerve: IFNs and resistance to infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/antigen-presenting-cancer-associated-fibroblasts-in-murine-pancreatic-tumors-differentially-regulate-t-cell-phenotype-and-function\/\">Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T07:07:53+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag165. doi: 10.1093\/jimmun\/vkag165. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) in which cancer-associated fibroblasts (CAFs) play pivotal roles in shaping therapeutic responses. Among these, MHC-II-expressing antigen-presenting CAFs (apCAFs) modulate CD4 T-cell activity, yet their contribution to the antitumor immune response remains unclear. Using tumor clones &#8230; <a title=\"Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/antigen-presenting-cancer-associated-fibroblasts-in-murine-pancreatic-tumors-differentially-regulate-t-cell-phenotype-and-function\/\" aria-label=\"Read more about Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/mhc-class-ii-on-melanoma-cells-regulates-the-anti-tumor-t-cell-response\/\">MHC class II on melanoma cells regulates the anti-tumor T cell response<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:28+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag158. doi: 10.1093\/jimmun\/vkag158. ABSTRACT In human melanoma, tumor cell-specific MHC class II expression is associated with improved response to programmed death 1 and programmed death-ligand 1 blockade; yet the direct effect of melanoma cell-specific MHC class II expression on anti-melanoma T cell responses remains largely unknown. In the clinically relevant Yale &#8230; <a title=\"MHC class II on melanoma cells regulates the anti-tumor T cell response\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/mhc-class-ii-on-melanoma-cells-regulates-the-anti-tumor-t-cell-response\/\" aria-label=\"Read more about MHC class II on melanoma cells regulates the anti-tumor T cell response\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/enpp1-dependent-usp2-ubiquitination-governs-sqstm1-mediated-autophagy-dependent-ferroptosis-in-trophoblast-cells-and-exacerbates-placental-dysfunction-in-gestational-diabetes-mellitus\/\">ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:28+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag127. doi: 10.1093\/jimmun\/vkag127. ABSTRACT Downregulation of ectonucleotide pyrophosphatase\/phosphodiesterase 1 (ENPP1) has been implicated in autophagic cell death. However, how ENPP1 regulates the interplay between autophagy and ferroptosis to maintain trophoblast homeostasis in the context of gestational diabetes mellitus (GDM) remains unclear. To determine ENPP1&#8217;s role in autophagy-dependent ferroptosis and its contribution &#8230; <a title=\"ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/enpp1-dependent-usp2-ubiquitination-governs-sqstm1-mediated-autophagy-dependent-ferroptosis-in-trophoblast-cells-and-exacerbates-placental-dysfunction-in-gestational-diabetes-mellitus\/\" aria-label=\"Read more about ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/er-stress-amplifies-inflammation-via-a-dual-mechanism-involving-i%ce%bab%ce%b6-xbp1s-synergism-and-regnase-1-degradation\/\">ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T01:03:23+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag151. doi: 10.1093\/jimmun\/vkag151. ABSTRACT Inflammatory diseases arise from complex interactions between immune signaling and cellular stress. Although endoplasmic reticulum (ER) stress is a key modulator of immunity, the mechanisms by which it promotes inflammatory pathology remain incompletely understood. Notably, ER stress-induced NF-\u03baB activation alone is insufficient to account for robust IL-6 &#8230; <a title=\"ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/er-stress-amplifies-inflammation-via-a-dual-mechanism-involving-i%ce%bab%ce%b6-xbp1s-synergism-and-regnase-1-degradation\/\" aria-label=\"Read more about ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/the-v158f-polymorphism-in-human-fc%ce%b3riiia-cd16a-defines-opposing-receptor-responses-when-interacting-with-soluble-immune-complexes\/\">The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag160. doi: 10.1093\/jimmun\/vkag160. ABSTRACT The V158F polymorphism found in the human Fc receptor CD16a (also known as Fc\u03b3RIIIa) is thought to influence autoimmune disorders and responses to IgG-based therapies. V158F is known to influence the IgG affinity, and thereby triggering of the CD16a receptor expressed on various immune cells. In contrast &#8230; <a title=\"The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/the-v158f-polymorphism-in-human-fc%ce%b3riiia-cd16a-defines-opposing-receptor-responses-when-interacting-with-soluble-immune-complexes\/\" aria-label=\"Read more about The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/foxp1-controls-fezf2-dependent-gene-expression-mimetic-mtec-diversity-and-thymic-central-tolerance\/\">Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag168. doi: 10.1093\/jimmun\/vkag168. ABSTRACT Forkhead Box P1 (Foxp1) is a transcription factor critical for the proper development of multiple tissues. While Foxp1 has a well-described role in regulating adaptive immunity through modulation of T and B cells, a function in medullary thymic epithelial cells (mTECs) has not been reported. Here we &#8230; <a title=\"Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/foxp1-controls-fezf2-dependent-gene-expression-mimetic-mtec-diversity-and-thymic-central-tolerance\/\" aria-label=\"Read more about Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/mapk-activated-protein-kinase-2-orchestrates-memory-t-cell-inflation-in-cytomegalovirus-infection\/\">MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag170. doi: 10.1093\/jimmun\/vkag170. ABSTRACT Memory T-cell inflation is a distinctive immunological phenomenon observed during persistent viral infections such as cytomegalovirus (CMV). Unlike conventional memory T-cell responses, which contract after infection resolution, a subset of CMV-specific T cells undergoes a progressive and sustained expansion, termed &#8220;inflation&#8221;, which is thought to be critical &#8230; <a title=\"MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/mapk-activated-protein-kinase-2-orchestrates-memory-t-cell-inflation-in-cytomegalovirus-infection\/\" aria-label=\"Read more about MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection\">Read more<\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":16690,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16689","page","type-page","status-publish","has-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16689"}],"version-history":[{"count":1,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689\/revisions"}],"predecessor-version":[{"id":16691,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689\/revisions\/16691"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media\/16690"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}