{"id":16689,"date":"2024-09-27T19:24:11","date_gmt":"2024-09-27T17:24:11","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16689"},"modified":"2024-09-27T19:28:09","modified_gmt":"2024-09-27T17:28:09","slug":"journal-of-immunology","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/journal-of-immunology\/","title":{"rendered":"Journal of Immunology"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/il-22-synergizes-with-il-17-to-promote-mucosal-inflammation-and-bone-loss\/\">IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-01T01:25:53+02:00\" class=\"wp-block-latest-posts__post-date\">1 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag186. doi: 10.1093\/jimmun\/vkag186. ABSTRACT Interleukin (IL)-22 mediates immune cell communication with nonhematopoietic cells and was shown to exert protective or destructive effects in different disease contexts. In the oral mucosal disease periodontitis, IL-22 has been associated with increased tissue destruction, although cause-and-effect evidence and the underlying mechanisms are lacking. Here, we &#8230; <a title=\"IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/il-22-synergizes-with-il-17-to-promote-mucosal-inflammation-and-bone-loss\/\" aria-label=\"Read more about IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/fc%ce%b3riii-blockade-prevents-anti-hla-mediated-platelet-clearance-in-a-humanized-murine-model-of-platelet-transfusion-refractoriness\/\">Fc\u03b3RIII blockade prevents anti-HLA-mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-08-01T01:25:53+02:00\" class=\"wp-block-latest-posts__post-date\">1 de August de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag195. doi: 10.1093\/jimmun\/vkag195. ABSTRACT Immune platelet transfusion refractoriness (iPTR) is a major complication in transfusion medicine. Although anti-HLA antibodies are recognized contributors, the mechanisms by which they drive platelet clearance remain incompletely defined. We examined sera from 18 patients with iPTR and found that anti-HLA antibodies induced uptake of human platelets &#8230; <a title=\"Fc\u03b3RIII blockade prevents anti-HLA-mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/08\/01\/fc%ce%b3riii-blockade-prevents-anti-hla-mediated-platelet-clearance-in-a-humanized-murine-model-of-platelet-transfusion-refractoriness\/\" aria-label=\"Read more about Fc\u03b3RIII blockade prevents anti-HLA-mediated platelet clearance in a humanized murine model of platelet transfusion refractoriness\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/rag1-based-time-stamp-tracing-of-t-cell-developmental-origins\/\">Rag1-based time-stamp tracing of T-cell developmental origins<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-31T13:17:06+02:00\" class=\"wp-block-latest-posts__post-date\">31 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag154. doi: 10.1093\/jimmun\/vkag154. ABSTRACT The postnatal T\u2011cell pool comprises cells at diverse developmental stages, complicating efforts to resolve T\u2011cell differentiation, maturation, and long\u2011term adaptation. To address this challenge, we developed Rag1\u2011mediated time-stamp tracing, a genetic strategy that enables time\u2011resolved tracking of T\u2011cell developmental origins. We validate the specificity and temporal resolution &#8230; <a title=\"Rag1-based time-stamp tracing of T-cell developmental origins\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/rag1-based-time-stamp-tracing-of-t-cell-developmental-origins\/\" aria-label=\"Read more about Rag1-based time-stamp tracing of T-cell developmental origins\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/gut-microbial-composition-modulates-endogenous-food-specific-cd4-t-cells-in-food-allergy\/\">Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-31T13:17:06+02:00\" class=\"wp-block-latest-posts__post-date\">31 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag172. doi: 10.1093\/jimmun\/vkag172. ABSTRACT The growing food allergy epidemic is thought to be related to changing environmental factors, particularly changes in the gut microbiome. While prior work has demonstrated that food allergy can be modulated by gut microbes, little is known about how food allergen-specific CD4+ T cells are affected by &#8230; <a title=\"Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/31\/gut-microbial-composition-modulates-endogenous-food-specific-cd4-t-cells-in-food-allergy\/\" aria-label=\"Read more about Gut microbial composition modulates endogenous food-specific CD4+ T cells in food allergy\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/t-cell-immunity-to-sars-cov-2-vaccination-in-inflammatory-bowel-disease-patients-treated-with-anti-cytokine-biologics\/\">T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-30T19:02:10+02:00\" class=\"wp-block-latest-posts__post-date\">30 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag173. doi: 10.1093\/jimmun\/vkag173. ABSTRACT Anti-TNF and anti-IL-12\/IL-23 are commonly used therapies for immune-mediated inflammatory diseases (IMIDs), including inflammatory bowel disease (IBD). Although several studies have shown intact T cell responses following 2 to 3 doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in biologics treated IMID patients, our group &#8230; <a title=\"T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/t-cell-immunity-to-sars-cov-2-vaccination-in-inflammatory-bowel-disease-patients-treated-with-anti-cytokine-biologics\/\" aria-label=\"Read more about T cell immunity to SARS-CoV-2 vaccination in inflammatory bowel disease patients treated with anti-cytokine biologics\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/lowering-cd40l-expression-in-murine-lupus-results-in-an-increase-in-disease-indicators-in-female-but-not-male-b6-mice\/\">Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-30T12:56:26+02:00\" class=\"wp-block-latest-posts__post-date\">30 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag205. doi: 10.1093\/jimmun\/vkag205. ABSTRACT Our laboratory has previously described a mouse model (CD40L\u03945) that produces 60% of wild-type CD40L due to a targeted deletion in an RNA binding site within the CD40L message. The CD40L\u03945 mutation, which destabilizes CD40L mRNA during T-cell activation, causes disrupted germinal center (GC) formation, leading to &#8230; <a title=\"Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/30\/lowering-cd40l-expression-in-murine-lupus-results-in-an-increase-in-disease-indicators-in-female-but-not-male-b6-mice\/\" aria-label=\"Read more about Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/cd8-t-cell-effector-programming-is-epigenetically-regulated-by-dusp2-through-baf-complex-driven-chromatin-remodeling\/\">CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T12:40:10+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag202. doi: 10.1093\/jimmun\/vkag202. ABSTRACT Effector gene expression in CD8+ T cells is tightly controlled at the epigenetic and transcriptional levels; however, crucial regulatory signals remain incompletely understood. In this study, we identify dual specificity phosphatase 2 (DUSP2) as a key epigenetic modulator of effector CD8+ T-cell state, by elucidating inhibition of &#8230; <a title=\"CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/cd8-t-cell-effector-programming-is-epigenetically-regulated-by-dusp2-through-baf-complex-driven-chromatin-remodeling\/\" aria-label=\"Read more about CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/nkp44-recognition-of-platelet-derived-growth-factor-d-enhances-the-cytolytic-activity-of-natural-killer-cells\/\">NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T12:40:10+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag204. doi: 10.1093\/jimmun\/vkag204. ABSTRACT Natural killer (NK) cells are cytotoxic innate lymphoid cells that play a critical role in tumor surveillance by releasing proinflammatory cytokines and cytotoxic granules. NKp44 is an activating receptor that promotes NK cell secretion of TNF and IFN-\u03b3 upon engaging platelet-derived growth factor D (PDGF-DD), a ligand &#8230; <a title=\"NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/nkp44-recognition-of-platelet-derived-growth-factor-d-enhances-the-cytolytic-activity-of-natural-killer-cells\/\" aria-label=\"Read more about NKp44 recognition of platelet-derived growth factor D enhances the cytolytic activity of natural killer cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/binding-of-death-receptor-3-dr3-to-intracellular-tradd-and-traf2-is-independent-of-its-natural-ligand-tl1a\/\">Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T12:40:10+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag194. doi: 10.1093\/jimmun\/vkag194. ABSTRACT The TNF\u2011like cytokine TL1A is a key regulator of immune responses through engagement of its receptor, death receptor 3 (DR3), and has emerged as a therapeutic target in inflammatory diseases. Prevailing models propose that TL1A binding initiates recruitment of adaptor proteins to DR3, leading to downstream signaling. &#8230; <a title=\"Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/binding-of-death-receptor-3-dr3-to-intracellular-tradd-and-traf2-is-independent-of-its-natural-ligand-tl1a\/\" aria-label=\"Read more about Binding of death receptor 3 (DR3) to intracellular TRADD and TRAF2 is independent of its natural ligand, TL1A\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/distinct-kinetic-features-of-innate-and-adaptive-responses-in-influenza-a-versus-influenza-b-infected-mice\/\">Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B-infected mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-29T01:30:02+02:00\" class=\"wp-block-latest-posts__post-date\">29 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag196. doi: 10.1093\/jimmun\/vkag196. ABSTRACT Influenza B infection is an important source of morbidity and mortality, especially in vulnerable populations such as children. Improved vaccines and antiviral therapeutics are hindered by gaps in knowledge about influenza B viruses (IBVs). We examined the immune responses in the lung, at the kinetic interface between &#8230; <a title=\"Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B-infected mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/29\/distinct-kinetic-features-of-innate-and-adaptive-responses-in-influenza-a-versus-influenza-b-infected-mice\/\" aria-label=\"Read more about Distinct kinetic features of innate and adaptive responses in influenza A versus influenza B-infected mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/split-immunomodulatory-impact-of-leptin-on-human-myeloid-cells-key-role-of-ido1-in-counteracting-the-immunostimulatory-effect-of-leptin\/\">Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-27T19:06:48+02:00\" class=\"wp-block-latest-posts__post-date\">27 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag211. doi: 10.1093\/jimmun\/vkag211. ABSTRACT Obesity increases cancer incidence and aggressiveness but is paradoxically associated with improved response to immunotherapy. Here, we show that intratumoral levels of leptin (LEP), a factor contributing to the development of obesity, predict improved outcomes of breast and liver cancers. In contrast, these levels of LEP are &#8230; <a title=\"Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/split-immunomodulatory-impact-of-leptin-on-human-myeloid-cells-key-role-of-ido1-in-counteracting-the-immunostimulatory-effect-of-leptin\/\" aria-label=\"Read more about Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/nad-depletion-links-metabolic-stress-to-drive-innate-immune-priming-and-selectively-control-panoptosis\/\">NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-27T19:06:48+02:00\" class=\"wp-block-latest-posts__post-date\">27 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag203. doi: 10.1093\/jimmun\/vkag203. ABSTRACT The innate immune system can detect infection, tissue damage, and other homeostatic disruptions to initiate an immune response, drive inflammation, and promote programmed cell death. While these responses can be beneficial in host defense, aberrant activation of inflammatory, lytic cell death pathways can be pathogenic. Emerging evidence &#8230; <a title=\"NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/27\/nad-depletion-links-metabolic-stress-to-drive-innate-immune-priming-and-selectively-control-panoptosis\/\" aria-label=\"Read more about NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/immunosuppressive-effects-of-voclosporin-in-inflammatory-bowel-disease-through-targeted-inhibition-of-slp-76-and-metabolic-reprogramming\/\">Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-26T06:23:35+02:00\" class=\"wp-block-latest-posts__post-date\">26 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag175. doi: 10.1093\/jimmun\/vkag175. ABSTRACT The adaptor protein SLP-76 plays a critical role in T-cell receptor signaling and immune activation, yet its relevance in inflammatory bowel disease (IBD) remains unclear. Although calcineurin inhibitors such as cyclosporine A (CsA) are used in severe ulcerative colitis, voclosporin (VCS), a novel calcineurin inhibitor approved for &#8230; <a title=\"Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/immunosuppressive-effects-of-voclosporin-in-inflammatory-bowel-disease-through-targeted-inhibition-of-slp-76-and-metabolic-reprogramming\/\" aria-label=\"Read more about Immunosuppressive effects of voclosporin in inflammatory bowel disease through targeted inhibition of SLP-76 and metabolic reprogramming\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/platelets-are-essential-for-survival-of-respiratory-restricted-viral-infection\/\">Platelets are essential for survival of respiratory-restricted viral infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-26T06:23:35+02:00\" class=\"wp-block-latest-posts__post-date\">26 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag197. doi: 10.1093\/jimmun\/vkag197. ABSTRACT Platelets are small, anucleate cells derived from megakaryocytes and are known for their essential role in hemostasis. Over the past decade, they have also emerged as important immune modulators, able to affect viral replication and leukocyte behavior. Most studies on platelets and viral infections have been focused &#8230; <a title=\"Platelets are essential for survival of respiratory-restricted viral infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/26\/platelets-are-essential-for-survival-of-respiratory-restricted-viral-infection\/\" aria-label=\"Read more about Platelets are essential for survival of respiratory-restricted viral infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/donor-cell-gata3-is-critical-for-gut-pathogenic-t-cell-effector-function-and-intestinal-eosinophilia-after-hematopoietic-cell-transplantation\/\">Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-25T07:02:05+02:00\" class=\"wp-block-latest-posts__post-date\">25 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag190. doi: 10.1093\/jimmun\/vkag190. ABSTRACT Hematopoietic cell transplantation (HCT) is a curative immunotherapy for hematologic malignancies such as acute myeloid leukemia, primarily through graft-versus-tumor (GVT) effects mediated by donor T cells. However, up to 60% of recipients develop graft-versus-host disease (GVHD), with intestinal involvement being a major contributor to morbidity and mortality. &#8230; <a title=\"Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/donor-cell-gata3-is-critical-for-gut-pathogenic-t-cell-effector-function-and-intestinal-eosinophilia-after-hematopoietic-cell-transplantation\/\" aria-label=\"Read more about Donor cell GATA3 is critical for gut pathogenic T cell effector function and intestinal eosinophilia after hematopoietic cell transplantation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/phylogenetic-analysis-of-amino-acid-sequences-indicates-a-central-role-of-transmembrane-domain-structural-elements-in-mhc-class-ii-function\/\">Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-25T00:59:15+02:00\" class=\"wp-block-latest-posts__post-date\">25 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag192. doi: 10.1093\/jimmun\/vkag192. ABSTRACT Human leukocyte antigen class II genes are highly polymorphic. This raises the question of how polymorphisms are distributed across the entirety of the class II molecule and how this distribution affects function. We performed a comprehensive analysis of amino acid variability across the entire class II molecule, &#8230; <a title=\"Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/25\/phylogenetic-analysis-of-amino-acid-sequences-indicates-a-central-role-of-transmembrane-domain-structural-elements-in-mhc-class-ii-function\/\" aria-label=\"Read more about Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/23\/kaempferols-potential-in-targeting-il-17-mediated-inflammatory-pathways-for-colorectal-cancer-treatment\/\">Kaempferol&#8217;s potential in targeting IL-17-mediated inflammatory pathways for colorectal cancer treatment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-23T12:30:36+02:00\" class=\"wp-block-latest-posts__post-date\">23 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag176. doi: 10.1093\/jimmun\/vkag176. ABSTRACT Colorectal cancer (CRC) is a leading malignancy with limited treatment options at advanced stages. Interleukin (IL)-17 signaling promotes tumor progression and immune evasion. Kaempferol, a natural flavonol, has anti-inflammatory and antitumor effects, but its role in modulating IL-17 pathways in CRC is unclear. We used an immunocompetent &#8230; <a title=\"Kaempferol&#8217;s potential in targeting IL-17-mediated inflammatory pathways for colorectal cancer treatment\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/23\/kaempferols-potential-in-targeting-il-17-mediated-inflammatory-pathways-for-colorectal-cancer-treatment\/\" aria-label=\"Read more about Kaempferol&#8217;s potential in targeting IL-17-mediated inflammatory pathways for colorectal cancer treatment\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/22\/unconventional-functions-of-natural-killer-cells-in-homeostasis-and-disease\/\">Unconventional functions of natural killer cells in homeostasis and disease<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-22T01:10:30+02:00\" class=\"wp-block-latest-posts__post-date\">22 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag148. doi: 10.1093\/jimmun\/vkag148. ABSTRACT NK cells are classically defined by their rapid cytotoxicity against tumor cells and infected cells and by early inflammatory cytokine production. However, unconventional roles for NK cells as regulators of immunity and tissue homeostasis have recently been uncovered. Beyond their classical roles, NK cells can orchestrate leukocyte &#8230; <a title=\"Unconventional functions of natural killer cells in homeostasis and disease\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/22\/unconventional-functions-of-natural-killer-cells-in-homeostasis-and-disease\/\" aria-label=\"Read more about Unconventional functions of natural killer cells in homeostasis and disease\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/toll-like-receptor-responses-are-shaped-by-distinct-mapk-activation-profiles\/\">Toll-like receptor responses are shaped by distinct MAPK activation profiles<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-21T12:49:16+02:00\" class=\"wp-block-latest-posts__post-date\">21 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag180. doi: 10.1093\/jimmun\/vkag180. ABSTRACT Toll-like receptors (TLRs) are key sensors of infection and injury, and are critical inducers of inflammation. TLR-induced activation of the NF-\u03baB and MAPK pathways promotes the secretion of mediators of inflammation such as cytokines and chemokines. Control of cytokine production is critically important, as unnecessary inflammatory responses &#8230; <a title=\"Toll-like receptor responses are shaped by distinct MAPK activation profiles\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/toll-like-receptor-responses-are-shaped-by-distinct-mapk-activation-profiles\/\" aria-label=\"Read more about Toll-like receptor responses are shaped by distinct MAPK activation profiles\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/cd153-promotes-b-cell-responses-to-immunization-in-aged-mice\/\">CD153 promotes B-cell responses to immunization in aged mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-21T12:49:16+02:00\" class=\"wp-block-latest-posts__post-date\">21 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag188. doi: 10.1093\/jimmun\/vkag188. ABSTRACT We and others have described homeostatic dysregulation of the CD4+ memory T-cell compartment with age. To gain greater insights into this dysregulation, we performed comprehensive single-cell genomic analysis of endogenous memory CD4+ T cells from young and aged mice. This analysis revealed 16 populations, composed of Th1, &#8230; <a title=\"CD153 promotes B-cell responses to immunization in aged mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/cd153-promotes-b-cell-responses-to-immunization-in-aged-mice\/\" aria-label=\"Read more about CD153 promotes B-cell responses to immunization in aged mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/fluorescence-tracking-cd8-t-cells-from-tumor-draining-lymph-nodes-to-irradiated-tumors-and-their-activation-in-the-tumor-environment\/\">Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag142. doi: 10.1093\/jimmun\/vkag142. ABSTRACT Radiation is an effective site-specific cytotoxic therapy for cancer cells. In preclinical models, CD8 T cells are essential for optimum tumor control by radiation therapy, yet CD8 T cells are radiosensitive and depleted within the treatment field. Irradiated tumors can be refilled with T cells that were &#8230; <a title=\"Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/fluorescence-tracking-cd8-t-cells-from-tumor-draining-lymph-nodes-to-irradiated-tumors-and-their-activation-in-the-tumor-environment\/\" aria-label=\"Read more about Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/single-cell-analysis-of-ovarian-immune-cells-reveals-dynamic-changes-in-nk-and-b-cell-populations-after-ovarian-stimulation\/\">Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag153. doi: 10.1093\/jimmun\/vkag153. ABSTRACT The mammalian ovary is the dynamic end-organ of the hypothalamic-pituitary-ovarian axis. In this coordinated system, ovarian cells undergo continuous cycles of apoptosis, proliferation, and differentiation. These changes parallel fluctuations in ovarian hormones such as estradiol; however, the ovarian immune microenvironment during high- and low-estradiol states remains incompletely &#8230; <a title=\"Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/single-cell-analysis-of-ovarian-immune-cells-reveals-dynamic-changes-in-nk-and-b-cell-populations-after-ovarian-stimulation\/\" aria-label=\"Read more about Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/the-transcription-factor-srebp2-supports-the-activation-and-homeostasis-of-cd4-foxp3-regulatory-t-cells\/\">The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag181. doi: 10.1093\/jimmun\/vkag181. ABSTRACT Periodic activation of regulatory T cells (Tregs) is necessary to restrict autoreactive T cells and maintain immune homeostasis. IL-2-STAT5 signaling instructs several metabolic processes underlying Treg activation, including the mevalonate pathway, which is crucial for optimal Treg responses. However, direct links between IL-2-STAT5, mevalonate, and Treg function &#8230; <a title=\"The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/the-transcription-factor-srebp2-supports-the-activation-and-homeostasis-of-cd4-foxp3-regulatory-t-cells\/\" aria-label=\"Read more about The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/pari-deficiency-leads-to-increased-somatic-hypermutation\/\">PARI deficiency leads to increased somatic hypermutation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag031. doi: 10.1093\/jimmun\/vkag031. ABSTRACT Somatic hypermutation of immunoglobulin (Ig) genes in germinal center B cells is based on the introduction of DNA lesions by activation-induced cytidine deaminase (AID), followed by lesion processing by multiple error-prone DNA repair pathways. Error-free DNA repair by homologous recombination (HR) is required for the repair of &#8230; <a title=\"PARI deficiency leads to increased somatic hypermutation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/pari-deficiency-leads-to-increased-somatic-hypermutation\/\" aria-label=\"Read more about PARI deficiency leads to increased somatic hypermutation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/t-cell-mir-155-regulates-the-response-to-tumor-specific-mrna-vaccines-in-a-murine-model-of-acute-myeloid-leukemia\/\">T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag184. doi: 10.1093\/jimmun\/vkag184. ABSTRACT Acute myeloid leukemia (AML) is a malignant clonal expansion of myeloid progenitor cells that impedes normal hematopoiesis and culminates in bone marrow failure and death. The development of chemoresistant disease in response to first-line chemotherapies is common and indicates a need for new therapies. Tumor-specific mRNA vaccines &#8230; <a title=\"T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/t-cell-mir-155-regulates-the-response-to-tumor-specific-mrna-vaccines-in-a-murine-model-of-acute-myeloid-leukemia\/\" aria-label=\"Read more about T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/mtecs-and-b-cells-form-a-thymic-microniche-associated-with-b-cell-licensing\/\">mTECs and B cells form a thymic microniche associated with B-cell licensing<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag185. doi: 10.1093\/jimmun\/vkag185. ABSTRACT Thymic B cells rely on T cells and type-III IFN (IFN-\u03bb) signaling for class switch recombination and effective licensing as APCs, a process essential for their role in establishing central T-cell tolerance. IFN-\u03bb is produced exclusively by a subset of medullary thymic epithelial cells (mTECs); however, the &#8230; <a title=\"mTECs and B cells form a thymic microniche associated with B-cell licensing\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/mtecs-and-b-cells-form-a-thymic-microniche-associated-with-b-cell-licensing\/\" aria-label=\"Read more about mTECs and B cells form a thymic microniche associated with B-cell licensing\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/hidden-effects-of-polymyxin-b-its-role-in-activating-tlr2-mediated-inflammatory-responses\/\">Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag193. doi: 10.1093\/jimmun\/vkag193. ABSTRACT Polymyxins are cyclic cationic lipopeptide antibiotics that disrupt both the outer and inner membranes of Gram-negative bacteria. They also bind to bacterial lipopolysaccharides (LPSs), thereby inhibiting LPS recognition by Toll-like receptor 4 (TLR4) and preventing macrophage activation. However, the immunomodulatory effects of polymyxin B during infection, in &#8230; <a title=\"Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/hidden-effects-of-polymyxin-b-its-role-in-activating-tlr2-mediated-inflammatory-responses\/\" aria-label=\"Read more about Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/systemic-and-lung-resident-memory-elicited-by-oc43-coronavirus-infection-in-mice\/\">Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-16T01:34:42+02:00\" class=\"wp-block-latest-posts__post-date\">16 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag182. doi: 10.1093\/jimmun\/vkag182. ABSTRACT Endemic coronaviruses circulate seasonally and, while typically mild, can produce robust inflammation and severe pneumonia. Immunological memory to coronaviruses can be cross-reactive for multiple coronaviruses including OC43 and SARS-CoV-2. In this study, we used mouse models to investigate immune responses elicited by pulmonary infection with OC43. OC43 &#8230; <a title=\"Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/systemic-and-lung-resident-memory-elicited-by-oc43-coronavirus-infection-in-mice\/\" aria-label=\"Read more about Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/a-novel-v%ce%b41-engager-targeting-cd19-enhances-human-v%ce%b41-%ce%b3%ce%b4-t-cell-responses-against-cll-and-cd19-hematological-malignancies\/\">A novel V\u03b41 engager targeting CD19 enhances human V\u03b41 \u03b3\u03b4 T cell responses against CLL and CD19+ hematological malignancies<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-16T01:34:42+02:00\" class=\"wp-block-latest-posts__post-date\">16 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag167. doi: 10.1093\/jimmun\/vkag167. ABSTRACT \u03b3\u03b4 T cells are associated with favorable outcomes in many cancers likely through a mechanism of stress-directed cytotoxicity and antitumor cytokine production. V\u03b41 \u03b3\u03b4 T cells are especially promising for immunotherapy due to their broad stress recognition and resistance to activation-induced cell death. Here, we generate a &#8230; <a title=\"A novel V\u03b41 engager targeting CD19 enhances human V\u03b41 \u03b3\u03b4 T cell responses against CLL and CD19+ hematological malignancies\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/16\/a-novel-v%ce%b41-engager-targeting-cd19-enhances-human-v%ce%b41-%ce%b3%ce%b4-t-cell-responses-against-cll-and-cd19-hematological-malignancies\/\" aria-label=\"Read more about A novel V\u03b41 engager targeting CD19 enhances human V\u03b41 \u03b3\u03b4 T cell responses against CLL and CD19+ hematological malignancies\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/14\/whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens\/\">Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-14T06:46:47+02:00\" class=\"wp-block-latest-posts__post-date\">14 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag174. doi: 10.1093\/jimmun\/vkag174. ABSTRACT Whole-body irradiation (WBI) consistently induces radiation-associated lymphopenia, a complication linked to poor prognosis and reduced overall survival. Understanding the quantitative and qualitative changes in na\u00efve CD4 T cells after WBI is critical because these cells play key roles in both host defense and the propagation of autoimmunity. &#8230; <a title=\"Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/14\/whole-body-irradiation-causes-long-term-impairments-in-the-maintenance-and-function-of-naive-cd4-t-cells-specific-for-self-and-non-self-antigens\/\" aria-label=\"Read more about Whole-body irradiation causes long-term impairments in the maintenance and function of na\u00efve CD4 T cells specific for self- and non-self-antigens\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/the-discovery-and-roles-of-type-2-innate-lymphoid-cells\/\">The discovery and roles of type 2 innate lymphoid cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-12T20:18:13+02:00\" class=\"wp-block-latest-posts__post-date\">12 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag104. doi: 10.1093\/jimmun\/vkag104. NO ABSTRACT PMID:42437361 | DOI:10.1093\/jimmun\/vkag104<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/long-term-survivors-of-melanoma-after-anti-pd-1-therapy-demonstrate-on-treatment-increase-in-abundance-of-4-1bb-cd4-t-cells-in-blood\/\">Long-term survivors of melanoma after anti-PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-12T07:06:55+02:00\" class=\"wp-block-latest-posts__post-date\">12 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag171. doi: 10.1093\/jimmun\/vkag171. ABSTRACT Anti-PD-1 monotherapy has shown a significant survival benefit for patients with advanced-stage melanoma. In this study, we explored whether long-term clinical benefit is determined by abundance or changes in such abundances of CD4 and CD8 T-cell subsets in blood. Peripheral blood mononuclear cells from 58 patients with &#8230; <a title=\"Long-term survivors of melanoma after anti-PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/long-term-survivors-of-melanoma-after-anti-pd-1-therapy-demonstrate-on-treatment-increase-in-abundance-of-4-1bb-cd4-t-cells-in-blood\/\" aria-label=\"Read more about Long-term survivors of melanoma after anti-PD-1 therapy demonstrate on-treatment increase in abundance of 4-1BB+ CD4 T cells in blood\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis\/\">Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-12T07:06:55+02:00\" class=\"wp-block-latest-posts__post-date\">12 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag163. doi: 10.1093\/jimmun\/vkag163. ABSTRACT Success of B cell depletion therapy in multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system, places B cells and their functions center stage in efforts to fully understand pathogenesis. Historically, MS animal models of experimental autoimmune encephalomyelitis have featured B cell-independent disease driven &#8230; <a title=\"Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/12\/modeling-pathogenic-b-cell-function-in-experimental-autoimmune-encephalomyelitis\/\" aria-label=\"Read more about Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/11\/cd22-is-upregulated-and-displays-suppressive-properties-on-cd4-t-cells-upon-a-persistent-virus-infection\/\">CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-11T12:51:59+02:00\" class=\"wp-block-latest-posts__post-date\">11 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag183. doi: 10.1093\/jimmun\/vkag183. ABSTRACT Chronic viral infections evade or suppress host immunity, posing risks to global human health. However, the underlying mechanisms of viral immune suppression are incompletely defined. Previously, we have demonstrated that sphingosine kinase 2 (SphK2) represses CD4+ T-cell immunity during lymphocytic choriomeningitis virus (LCMV) Clone 13 (Cl 13) &#8230; <a title=\"CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/11\/cd22-is-upregulated-and-displays-suppressive-properties-on-cd4-t-cells-upon-a-persistent-virus-infection\/\" aria-label=\"Read more about CD22 is upregulated and displays suppressive properties on CD4+ T cells upon a persistent virus infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/10\/a-mutation-in-ptpn6-associated-to-emphysema-alters-b-lymphocyte-biology-in-humans-and-mice\/\">A mutation in PTPN6 associated to emphysema alters B-lymphocyte biology in humans and mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-10T13:31:59+02:00\" class=\"wp-block-latest-posts__post-date\">10 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag162. doi: 10.1093\/jimmun\/vkag162. ABSTRACT Our group discovered a mutation in a French-Canadian family causing a severe and early-onset form of emphysema. The heterozygote mutation located in the PTPN6 gene causes an alanine to threonine switch near the catalytic site of SHP-1, leading to a reduction of its enzymatic activity. In this &#8230; <a title=\"A mutation in PTPN6 associated to emphysema alters B-lymphocyte biology in humans and mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/10\/a-mutation-in-ptpn6-associated-to-emphysema-alters-b-lymphocyte-biology-in-humans-and-mice\/\" aria-label=\"Read more about A mutation in PTPN6 associated to emphysema alters B-lymphocyte biology in humans and mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/staphylococcus-aureus-superantigens-drive-a-concentration-dependent-neutrophilic-or-eosinophilic-pulmonary-inflammation-in-mouse-models-of-cystic-fibrosis\/\">Staphylococcus aureus superantigens drive a concentration-dependent neutrophilic or eosinophilic pulmonary inflammation in mouse models of cystic fibrosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-09T07:07:17+02:00\" class=\"wp-block-latest-posts__post-date\">9 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag155. doi: 10.1093\/jimmun\/vkag155. ABSTRACT Staphylococcus aureus (SA), the most common cystic fibrosis (CF) respiratory pathogen, is uniquely capable of producing superantigen (SAg) exotoxins, which are recognized as the most potent activators of the immune system and inducers of inflammation. Although a high frequency of CF SA isolates can produce SA-SAgs, their &#8230; <a title=\"Staphylococcus aureus superantigens drive a concentration-dependent neutrophilic or eosinophilic pulmonary inflammation in mouse models of cystic fibrosis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/staphylococcus-aureus-superantigens-drive-a-concentration-dependent-neutrophilic-or-eosinophilic-pulmonary-inflammation-in-mouse-models-of-cystic-fibrosis\/\" aria-label=\"Read more about Staphylococcus aureus superantigens drive a concentration-dependent neutrophilic or eosinophilic pulmonary inflammation in mouse models of cystic fibrosis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury\/\">Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-09T07:07:17+02:00\" class=\"wp-block-latest-posts__post-date\">9 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag140. doi: 10.1093\/jimmun\/vkag140. ABSTRACT Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen species (ROS). Mechanistically, AKT activation &#8230; <a title=\"Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/inhba-is-transcriptionally-regulated-by-foxa1-through-the-pi3k-akt-signal-pathway-in-acute-lung-injury\/\" aria-label=\"Read more about Inhba is transcriptionally regulated by Foxa1 through the PI3K\/AKT signal pathway in acute lung injury\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection\/\">Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-09T07:07:17+02:00\" class=\"wp-block-latest-posts__post-date\">9 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag164. doi: 10.1093\/jimmun\/vkag164. ABSTRACT Memory CD8 T cells respond rapidly upon antigen re-encounter and are considered advantageous for protective immunity. However, they undergo a swift decline under chronic antigen stimulation. In this study, we found that memory CD8 T cells&#8217; heightened activation sensitivity promotes terminal differentiation and impairs the formation of &#8230; <a title=\"Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/09\/differential-stem-like-potential-of-naive-and-memory-cd8-t-cells-after-chronic-infection\/\" aria-label=\"Read more about Differential stem-like potential of na\u00efve and memory CD8 T cells after chronic infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/inflammatory-genital-strain-of-chlamydia-trachomatis-elicits-a-th17-immune-response\/\">Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-08T08:50:39+02:00\" class=\"wp-block-latest-posts__post-date\">8 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag177. doi: 10.1093\/jimmun\/vkag177. ABSTRACT In humans, infection with Chlamydia trachomatis can result in chronic infection with severe reproductive consequences. The immune response elicited by natural infection fails to protect against reinfection and can contribute to tissue inflammation and damage. CD4+ T cells are key mediators of protection against C. trachomatis. However, &#8230; <a title=\"Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/inflammatory-genital-strain-of-chlamydia-trachomatis-elicits-a-th17-immune-response\/\" aria-label=\"Read more about Inflammatory genital strain of Chlamydia trachomatis elicits a Th17 immune response\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/epigenetic-control-of-p53-activity-in-regulatory-t-cells-maintains-their-identity-to-prevent-inflammation\/\">Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-08T08:50:38+02:00\" class=\"wp-block-latest-posts__post-date\">8 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag145. doi: 10.1093\/jimmun\/vkag145. ABSTRACT Regulatory T cells (Tregs) are critical guardians of immune homeostasis that must operate in diverse and often inflammatory conditions. However, the mechanisms that Tregs use to maintain their stability and function, especially in response to the stresses of distinct microenvironments, remain incompletely understood. Previous work identified the &#8230; <a title=\"Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/08\/epigenetic-control-of-p53-activity-in-regulatory-t-cells-maintains-their-identity-to-prevent-inflammation\/\" aria-label=\"Read more about Epigenetic control of p53 activity in regulatory T cells maintains their identity to prevent inflammation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/07\/the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen\/\">The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-07T01:23:27+02:00\" class=\"wp-block-latest-posts__post-date\">7 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag115. doi: 10.1093\/jimmun\/vkag115. ABSTRACT Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the &#8230; <a title=\"The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/07\/the-scaffolding-protein-akap79-150-shapes-innate-immune-responses-to-allergen\/\" aria-label=\"Read more about The scaffolding protein AKAP79\/150 shapes innate immune responses to allergen\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/05\/optineurin-restrains-il-17-associated-neuroinflammation-in-trigeminal-ganglia-to-preserve-sensory-function-after-ocular-hsv-1-infection\/\">Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-05T06:47:56+02:00\" class=\"wp-block-latest-posts__post-date\">5 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag161. doi: 10.1093\/jimmun\/vkag161. ABSTRACT Neurotrophic keratitis (NK) arises when trigeminal sensory dysfunction reduces corneal sensation and compromises epithelial maintenance. Herpes simplex virus type 1 (HSV-1) establishes latency in the trigeminal ganglion (TG) and is a common trigger of acquired NK, yet the host programs that determine whether inflamed ganglia recover or &#8230; <a title=\"Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/05\/optineurin-restrains-il-17-associated-neuroinflammation-in-trigeminal-ganglia-to-preserve-sensory-function-after-ocular-hsv-1-infection\/\" aria-label=\"Read more about Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/04\/crystal-structure-and-immune-single-cell-atlas-provide-insights-into-the-functional-divergence-of-type-i-ifns-in-fish\/\">Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-04T01:21:05+02:00\" class=\"wp-block-latest-posts__post-date\">4 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag131. doi: 10.1093\/jimmun\/vkag131. ABSTRACT Type I interferons (IFNs) are central antiviral cytokines in vertebrates, yet the mechanisms underlying their functional diversification in early vertebrates remain unclear. Teleost fish, whose IFN repertoires expanded through whole-genome duplication, provide a powerful model to address this question. Here, we systematically characterize grass carp (Ctenopharyngodon idella) &#8230; <a title=\"Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/04\/crystal-structure-and-immune-single-cell-atlas-provide-insights-into-the-functional-divergence-of-type-i-ifns-in-fish\/\" aria-label=\"Read more about Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs\/\">Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag136. doi: 10.1093\/jimmun\/vkag136. ABSTRACT Foxp3+ regulatory T cells (Tregs) are capable suppressors of aberrant self-reactivity. However, how differences in affinity and specificity may support Treg function compared with autoimmune T cell function remains unresolved. In this study, we analyzed the T cell receptor (TCR) repertoires of the regulatory and effector T &#8230; <a title=\"Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/increased-nur77-is-disconnected-from-tcr-affinity-in-insulin-specific-tregs\/\" aria-label=\"Read more about Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/ftr85-negatively-regulates-type-i-ifn-antiviral-signaling-pathway-by-promoting-k48-linked-polyubiquitination-of-irf3\/\">FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag132. doi: 10.1093\/jimmun\/vkag132. ABSTRACT The finTRIM (FTR) subfamily, a group of fish-specific tripartite motif proteins, has arisen through gene duplication events specific to particular genera or species. However, the regulatory mechanisms of FTR in antiviral immune response remains largely unknown. In the present study, we identified a fish novel tripartite motif &#8230; <a title=\"FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/ftr85-negatively-regulates-type-i-ifn-antiviral-signaling-pathway-by-promoting-k48-linked-polyubiquitination-of-irf3\/\" aria-label=\"Read more about FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/an-mr1-specific-nanobody-capable-of-blocking-mr1t-cell-activation\/\">An MR1-specific nanobody capable of blocking MR1T cell activation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag094. doi: 10.1093\/jimmun\/vkag094. ABSTRACT MR1 is a non-polymorphic, ubiquitously expressed, MHC class I-like antigen-presenting molecule that presents small-molecule metabolites to T cells. Studies have shown that MR1 plays a role in microbial infection, inflammation, and tumor immunity. The antigens it presents include metabolites of microbial and self-origin as well as small-molecule &#8230; <a title=\"An MR1-specific nanobody capable of blocking MR1T cell activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/an-mr1-specific-nanobody-capable-of-blocking-mr1t-cell-activation\/\" aria-label=\"Read more about An MR1-specific nanobody capable of blocking MR1T cell activation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/tgf-%ce%b2-controls-developmental-fate-and-functional-identity-of-thymic-%ce%b3%ce%b4-t-cells\/\">TGF-\u03b2 controls developmental fate and functional identity of thymic \u03b3\u03b4 T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag134. doi: 10.1093\/jimmun\/vkag134. ABSTRACT Gamma delta (\u03b3\u03b4) T cells undergo a distinct developmental pathway within the thymus, where transforming growth factor \u03b2 (TGF-\u03b2) exerts pivotal regulatory influence. However, the precise mechanistic contributions of TGF-\u03b2 to \u03b3\u03b4 T cells differentiation and functional maturation remain incompletely understood. Here, we show that TGF-\u03b2 regulates &#8230; <a title=\"TGF-\u03b2 controls developmental fate and functional identity of thymic \u03b3\u03b4 T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/tgf-%ce%b2-controls-developmental-fate-and-functional-identity-of-thymic-%ce%b3%ce%b4-t-cells\/\" aria-label=\"Read more about TGF-\u03b2 controls developmental fate and functional identity of thymic \u03b3\u03b4 T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/complement-c3-deficiency-increases-the-effector-and-cytotoxic-functions-of-nk-cells-and-suppresses-tumor-growth\/\">Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-03T01:03:00+02:00\" class=\"wp-block-latest-posts__post-date\">3 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag157. doi: 10.1093\/jimmun\/vkag157. ABSTRACT The complement system and natural killer (NK) cells play crucial roles in tumor growth and metastasis. The role of the complement system in affecting the phenotype and anti-tumor function of NK cells remains poorly understood. Using the B16F10 mouse melanoma model, we demonstrated that NK cells from &#8230; <a title=\"Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/03\/complement-c3-deficiency-increases-the-effector-and-cytotoxic-functions-of-nk-cells-and-suppresses-tumor-growth\/\" aria-label=\"Read more about Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/01\/getting-on-your-last-nerve-ifns-and-resistance-to-infection\/\">Getting on your last nerve: IFNs and resistance to infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-01T01:27:57+02:00\" class=\"wp-block-latest-posts__post-date\">1 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag169. doi: 10.1093\/jimmun\/vkag169. ABSTRACT Interferons (IFNs) affect almost all nucleated cells and induce transcriptional events that are associated with control of intracellular infections as well as regulatory pathways that influence inflammatory processes. How different hematopoietic and non-hematopoietic cell types interpret these signals is a reflection of cellular context and function. For &#8230; <a title=\"Getting on your last nerve: IFNs and resistance to infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/01\/getting-on-your-last-nerve-ifns-and-resistance-to-infection\/\" aria-label=\"Read more about Getting on your last nerve: IFNs and resistance to infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/antigen-presenting-cancer-associated-fibroblasts-in-murine-pancreatic-tumors-differentially-regulate-t-cell-phenotype-and-function\/\">Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T07:07:53+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag165. doi: 10.1093\/jimmun\/vkag165. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) in which cancer-associated fibroblasts (CAFs) play pivotal roles in shaping therapeutic responses. Among these, MHC-II-expressing antigen-presenting CAFs (apCAFs) modulate CD4 T-cell activity, yet their contribution to the antitumor immune response remains unclear. Using tumor clones &#8230; <a title=\"Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/antigen-presenting-cancer-associated-fibroblasts-in-murine-pancreatic-tumors-differentially-regulate-t-cell-phenotype-and-function\/\" aria-label=\"Read more about Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/mhc-class-ii-on-melanoma-cells-regulates-the-anti-tumor-t-cell-response\/\">MHC class II on melanoma cells regulates the anti-tumor T cell response<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:28+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag158. doi: 10.1093\/jimmun\/vkag158. ABSTRACT In human melanoma, tumor cell-specific MHC class II expression is associated with improved response to programmed death 1 and programmed death-ligand 1 blockade; yet the direct effect of melanoma cell-specific MHC class II expression on anti-melanoma T cell responses remains largely unknown. In the clinically relevant Yale &#8230; <a title=\"MHC class II on melanoma cells regulates the anti-tumor T cell response\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/mhc-class-ii-on-melanoma-cells-regulates-the-anti-tumor-t-cell-response\/\" aria-label=\"Read more about MHC class II on melanoma cells regulates the anti-tumor T cell response\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/enpp1-dependent-usp2-ubiquitination-governs-sqstm1-mediated-autophagy-dependent-ferroptosis-in-trophoblast-cells-and-exacerbates-placental-dysfunction-in-gestational-diabetes-mellitus\/\">ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:28+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag127. doi: 10.1093\/jimmun\/vkag127. ABSTRACT Downregulation of ectonucleotide pyrophosphatase\/phosphodiesterase 1 (ENPP1) has been implicated in autophagic cell death. However, how ENPP1 regulates the interplay between autophagy and ferroptosis to maintain trophoblast homeostasis in the context of gestational diabetes mellitus (GDM) remains unclear. To determine ENPP1&#8217;s role in autophagy-dependent ferroptosis and its contribution &#8230; <a title=\"ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/enpp1-dependent-usp2-ubiquitination-governs-sqstm1-mediated-autophagy-dependent-ferroptosis-in-trophoblast-cells-and-exacerbates-placental-dysfunction-in-gestational-diabetes-mellitus\/\" aria-label=\"Read more about ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/er-stress-amplifies-inflammation-via-a-dual-mechanism-involving-i%ce%bab%ce%b6-xbp1s-synergism-and-regnase-1-degradation\/\">ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T01:03:23+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag151. doi: 10.1093\/jimmun\/vkag151. ABSTRACT Inflammatory diseases arise from complex interactions between immune signaling and cellular stress. Although endoplasmic reticulum (ER) stress is a key modulator of immunity, the mechanisms by which it promotes inflammatory pathology remain incompletely understood. Notably, ER stress-induced NF-\u03baB activation alone is insufficient to account for robust IL-6 &#8230; <a title=\"ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/er-stress-amplifies-inflammation-via-a-dual-mechanism-involving-i%ce%bab%ce%b6-xbp1s-synergism-and-regnase-1-degradation\/\" aria-label=\"Read more about ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/the-v158f-polymorphism-in-human-fc%ce%b3riiia-cd16a-defines-opposing-receptor-responses-when-interacting-with-soluble-immune-complexes\/\">The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag160. doi: 10.1093\/jimmun\/vkag160. ABSTRACT The V158F polymorphism found in the human Fc receptor CD16a (also known as Fc\u03b3RIIIa) is thought to influence autoimmune disorders and responses to IgG-based therapies. V158F is known to influence the IgG affinity, and thereby triggering of the CD16a receptor expressed on various immune cells. In contrast &#8230; <a title=\"The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/the-v158f-polymorphism-in-human-fc%ce%b3riiia-cd16a-defines-opposing-receptor-responses-when-interacting-with-soluble-immune-complexes\/\" aria-label=\"Read more about The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/foxp1-controls-fezf2-dependent-gene-expression-mimetic-mtec-diversity-and-thymic-central-tolerance\/\">Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag168. doi: 10.1093\/jimmun\/vkag168. ABSTRACT Forkhead Box P1 (Foxp1) is a transcription factor critical for the proper development of multiple tissues. While Foxp1 has a well-described role in regulating adaptive immunity through modulation of T and B cells, a function in medullary thymic epithelial cells (mTECs) has not been reported. Here we &#8230; <a title=\"Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/foxp1-controls-fezf2-dependent-gene-expression-mimetic-mtec-diversity-and-thymic-central-tolerance\/\" aria-label=\"Read more about Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/mapk-activated-protein-kinase-2-orchestrates-memory-t-cell-inflation-in-cytomegalovirus-infection\/\">MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag170. doi: 10.1093\/jimmun\/vkag170. ABSTRACT Memory T-cell inflation is a distinctive immunological phenomenon observed during persistent viral infections such as cytomegalovirus (CMV). Unlike conventional memory T-cell responses, which contract after infection resolution, a subset of CMV-specific T cells undergoes a progressive and sustained expansion, termed &#8220;inflation&#8221;, which is thought to be critical &#8230; <a title=\"MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/mapk-activated-protein-kinase-2-orchestrates-memory-t-cell-inflation-in-cytomegalovirus-infection\/\" aria-label=\"Read more about MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/genetic-deletion-of-the-inflammatory-bowel-disease-associated-risk-gene-rgs14-aggravates-experimental-colitis\/\">Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag135. doi: 10.1093\/jimmun\/vkag135. ABSTRACT Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20 RGS, the Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease, and Rgs14 expression is higher in macrophages than in epithelial cells. &#8230; <a title=\"Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/genetic-deletion-of-the-inflammatory-bowel-disease-associated-risk-gene-rgs14-aggravates-experimental-colitis\/\" aria-label=\"Read more about Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/csf1r-dependent-macrophages-control-b-cell-development-and-function-in-the-chicken-immune-system\/\">CSF1R-dependent macrophages control B cell development and function in the chicken immune system<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag143. doi: 10.1093\/jimmun\/vkag143. ABSTRACT Acquired immunity in mammals depends upon capture and presentation of antigens by specialized macrophage populations in splenic marginal zone and lymph node sinuses and follicular dendritic cells within germinal centers. Cells referred to as follicular dendritic cells in chickens express CSF1R, the receptor for CSF1 and IL34. &#8230; <a title=\"CSF1R-dependent macrophages control B cell development and function in the chicken immune system\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/csf1r-dependent-macrophages-control-b-cell-development-and-function-in-the-chicken-immune-system\/\" aria-label=\"Read more about CSF1R-dependent macrophages control B cell development and function in the chicken immune system\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/slc1a5-augmentation-bypasses-nk-cell-transduction-barriers-to-deliver-complex-car-payloads\/\">SLC1A5 augmentation bypasses NK cell transduction barriers to deliver complex CAR payloads<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag133. doi: 10.1093\/jimmun\/vkag133. ABSTRACT Reproducible and efficient genetic engineering of human NK cells remains a primary challenge to next-generation chimeric antigen receptor (CAR) therapies, specifically for larger constructs with multiple plasmids and transgenes. Lentiviral vectors (LVs) pseudotyped with baboon envelope (BaEV) outperform vesicular stomatitis virus G protein in transducing hematopoietic stem &#8230; <a title=\"SLC1A5 augmentation bypasses NK cell transduction barriers to deliver complex CAR payloads\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/slc1a5-augmentation-bypasses-nk-cell-transduction-barriers-to-deliver-complex-car-payloads\/\" aria-label=\"Read more about SLC1A5 augmentation bypasses NK cell transduction barriers to deliver complex CAR payloads\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/incorporation-of-multiple-diversity-genes-in-the-tcr%ce%b4-chain-is-highly-regulated-and-evolutionarily-conserved\/\">Incorporation of multiple diversity genes in the TCR\u03b4 chain is highly regulated and evolutionarily conserved<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag137. doi: 10.1093\/jimmun\/vkag137. ABSTRACT In the canonical model of VDJ recombination, a single diversity (D) gene is incorporated into the complementarity-determining region 3 (CDR3) to produce a T cell receptor \u03b4 (TCR\u03b4; TRD) or TCR\u03b2 (TRB) chain. But by constructing a dataset of more than 2.7 million TRD CDR3 sequences from &#8230; <a title=\"Incorporation of multiple diversity genes in the TCR\u03b4 chain is highly regulated and evolutionarily conserved\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/incorporation-of-multiple-diversity-genes-in-the-tcr%ce%b4-chain-is-highly-regulated-and-evolutionarily-conserved\/\" aria-label=\"Read more about Incorporation of multiple diversity genes in the TCR\u03b4 chain is highly regulated and evolutionarily conserved\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/distinct-immune-trajectories-after-severe-trauma-identify-a-th17-biased-immunophenotype-in-chronic-critical-illness\/\">Distinct immune trajectories after severe trauma identify a Th17-biased immunophenotype in chronic critical illness<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-25T13:03:39+02:00\" class=\"wp-block-latest-posts__post-date\">25 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag125. doi: 10.1093\/jimmun\/vkag125. ABSTRACT Severe trauma triggers a dynamic disturbance of immune function that can progress from early hyperinflammation to prolonged dysregulation, increasing patient vulnerability to infection and chronic critical illness (CCI). To identify immune features linked to different postinjury clinical trajectories, we prospectively evaluated severely injured trauma patients and categorized &#8230; <a title=\"Distinct immune trajectories after severe trauma identify a Th17-biased immunophenotype in chronic critical illness\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/distinct-immune-trajectories-after-severe-trauma-identify-a-th17-biased-immunophenotype-in-chronic-critical-illness\/\" aria-label=\"Read more about Distinct immune trajectories after severe trauma identify a Th17-biased immunophenotype in chronic critical illness\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/single-cell-profiling-of-immune-activation-dysregulation-and-reconstitution-in-rhesus-macaques-after-measles-virus-infection\/\">Single-cell profiling of immune activation, dysregulation, and reconstitution in rhesus macaques after measles virus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-25T13:03:39+02:00\" class=\"wp-block-latest-posts__post-date\">25 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag139. doi: 10.1093\/jimmun\/vkag139. ABSTRACT Protective immunity is induced by both, wild-type measles virus (WT MeV) and live-attenuated (LA) measles virus vaccine (LAMV), affording the opportunity to compare common and selective immunological underpinnings of immune protection. Here, peripheral blood mononuclear cells (PBMCs) were collected from rhesus macaques at several timepoints after infection &#8230; <a title=\"Single-cell profiling of immune activation, dysregulation, and reconstitution in rhesus macaques after measles virus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/single-cell-profiling-of-immune-activation-dysregulation-and-reconstitution-in-rhesus-macaques-after-measles-virus-infection\/\" aria-label=\"Read more about Single-cell profiling of immune activation, dysregulation, and reconstitution in rhesus macaques after measles virus infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/computational-and-experimental-mapping-of-antigenic-epitopes-on-iridovirus-major-capsid-protein-for-precision-vaccine-design\/\">Computational and experimental mapping of antigenic epitopes on iridovirus major capsid protein for precision vaccine design<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-25T13:03:39+02:00\" class=\"wp-block-latest-posts__post-date\">25 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag159. doi: 10.1093\/jimmun\/vkag159. ABSTRACT The major capsid protein (MCP), owing to its strong immunogenicity, has emerged as a critical target for largemouth bass ranavirus (LMBV) vaccine development. However, its key antigenic epitopes remain uncharacterized. This study integrated phage display technology with bioinformatics approaches to design a multiepitope vaccine against LMBV. By &#8230; <a title=\"Computational and experimental mapping of antigenic epitopes on iridovirus major capsid protein for precision vaccine design\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/25\/computational-and-experimental-mapping-of-antigenic-epitopes-on-iridovirus-major-capsid-protein-for-precision-vaccine-design\/\" aria-label=\"Read more about Computational and experimental mapping of antigenic epitopes on iridovirus major capsid protein for precision vaccine design\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/bacterial-transfer-messenger-rna-activates-antiviral-rna-sensing-to-induce-inflammatory-innate-immune-responses\/\">Bacterial transfer-messenger RNA activates antiviral RNA sensing to induce inflammatory innate immune responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-22T07:28:20+02:00\" class=\"wp-block-latest-posts__post-date\">22 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag149. doi: 10.1093\/jimmun\/vkag149. ABSTRACT Pathogen-derived RNAs function as pathogen-associated molecular patterns (PAMPs) that activate innate immune responses through pattern recognition receptors (PRRs). While viral RNA is well established as a trigger of antiviral immunity, the identity of bacterial RNA species that function as immunostimulatory ligands and the host PRRs that recognize &#8230; <a title=\"Bacterial transfer-messenger RNA activates antiviral RNA sensing to induce inflammatory innate immune responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/bacterial-transfer-messenger-rna-activates-antiviral-rna-sensing-to-induce-inflammatory-innate-immune-responses\/\" aria-label=\"Read more about Bacterial transfer-messenger RNA activates antiviral RNA sensing to induce inflammatory innate immune responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/disease-progression-is-associated-with-differential-neutrophil-maturation-in-mycobacterium-tuberculosis-infected-macaques\/\">Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-22T05:26:46+02:00\" class=\"wp-block-latest-posts__post-date\">22 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag114. doi: 10.1093\/jimmun\/vkag114. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is associated with clinical diversity and outcomes ranging from latent TB to active TB with distinct pathophysiologies. However, our understanding of the innate immune mechanisms related to the protection or progression of TB is limited. Among innate immune cells, the &#8230; <a title=\"Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/disease-progression-is-associated-with-differential-neutrophil-maturation-in-mycobacterium-tuberculosis-infected-macaques\/\" aria-label=\"Read more about Disease progression is associated with differential neutrophil maturation in Mycobacterium tuberculosis-infected macaques\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/bptf-is-essential-for-vaccine-induced-germinal-center-b-cell-responses\/\">BPTF is essential for vaccine-induced germinal center B cell responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-22T05:26:46+02:00\" class=\"wp-block-latest-posts__post-date\">22 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag126. doi: 10.1093\/jimmun\/vkag126. ABSTRACT Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to select high-affinity clones that differentiate into memory B cells and plasma cells (PCs). B cell progression through the GC is tightly regulated, and the molecular determinants that modulate &#8230; <a title=\"BPTF is essential for vaccine-induced germinal center B cell responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/bptf-is-essential-for-vaccine-induced-germinal-center-b-cell-responses\/\" aria-label=\"Read more about BPTF is essential for vaccine-induced germinal center B cell responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/mechanisms-and-functions-of-intercellular-mitochondria-transfer-to-and-from-macrophages\/\">Mechanisms and functions of intercellular mitochondria transfer to and from macrophages<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-22T05:26:46+02:00\" class=\"wp-block-latest-posts__post-date\">22 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag147. doi: 10.1093\/jimmun\/vkag147. ABSTRACT Cell-to-cell communication is essential for maintaining homeostasis and coordinating complex biological processes in multicellular organisms. Classically, cells communicate using secreted peptides and metabolites and through cell contact-dependent signaling. Emerging studies over the past 20 years indicate that many cell types, including innate immune cells such as macrophages, &#8230; <a title=\"Mechanisms and functions of intercellular mitochondria transfer to and from macrophages\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/22\/mechanisms-and-functions-of-intercellular-mitochondria-transfer-to-and-from-macrophages\/\" aria-label=\"Read more about Mechanisms and functions of intercellular mitochondria transfer to and from macrophages\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/19\/transmembrane-orientation-and-extracellular-juxtamembrane-residues-of-gp130-are-critical-for-signal-transduction\/\">Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transduction<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-19T00:52:16+02:00\" class=\"wp-block-latest-posts__post-date\">19 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag118. doi: 10.1093\/jimmun\/vkag118. ABSTRACT Glycoprotein 130 (GP130) is an archetypal class I cytokine receptor that serves as a shared signalling subunit for a group of cytokines known as interleukin 6 (IL-6)-type cytokines. GP130 does not have an intrinsic kinase activity and relies on Janus kinases (JAK) 1, 2, or Tyrosine kinase &#8230; <a title=\"Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transduction\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/19\/transmembrane-orientation-and-extracellular-juxtamembrane-residues-of-gp130-are-critical-for-signal-transduction\/\" aria-label=\"Read more about Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transduction\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/silencing-the-alarm-nucleoside-modifications-suppress-innate-immune-sensing-of-rna\/\">Silencing the alarm: nucleoside modifications suppress innate immune sensing of RNA<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-18T12:37:23+02:00\" class=\"wp-block-latest-posts__post-date\">18 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkaf345. doi: 10.1093\/jimmun\/vkaf345. NO ABSTRACT PMID:42311113 | DOI:10.1093\/jimmun\/vkaf345<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/increased-ulbp1-by-doxorubicin-sensitizes-neuroblastoma-to-%ce%b3%ce%b4t-cell-cytotoxicity\/\">Increased ULBP1 by doxorubicin sensitizes neuroblastoma to \u03b3\u03b4T-cell cytotoxicity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-18T10:35:44+02:00\" class=\"wp-block-latest-posts__post-date\">18 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag144. doi: 10.1093\/jimmun\/vkag144. ABSTRACT Neuroblastoma (NB) is the most common extracranial solid tumor in children and remains a major therapeutic challenge in high-risk patients because of frequent recurrence and metastasis. \u03b3\u03b4T cells are a unique lymphocyte subset with potent antitumor activity and are widely distributed in NB tumors. However, the immunosuppressive &#8230; <a title=\"Increased ULBP1 by doxorubicin sensitizes neuroblastoma to \u03b3\u03b4T-cell cytotoxicity\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/increased-ulbp1-by-doxorubicin-sensitizes-neuroblastoma-to-%ce%b3%ce%b4t-cell-cytotoxicity\/\" aria-label=\"Read more about Increased ULBP1 by doxorubicin sensitizes neuroblastoma to \u03b3\u03b4T-cell cytotoxicity\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/mitochondrial-potential-reflects-t-cell-fitness-and-function-during-cancer-immunotherapy\/\">Mitochondrial potential reflects T cell fitness and function during cancer immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-18T06:28:04+02:00\" class=\"wp-block-latest-posts__post-date\">18 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag120. doi: 10.1093\/jimmun\/vkag120. ABSTRACT Checkpoint inhibitors have transformed cancer treatment, yet predicting responses remains challenging. Mitochondrial quality decreases in tumor infiltrating lymphocytes and correlates with impaired antitumor immunity in animal models. Mitochondrial membrane potential (MMP) increases with T cell activation and may also indicate cellular dysfunction. Here, we assessed the MMP &#8230; <a title=\"Mitochondrial potential reflects T cell fitness and function during cancer immunotherapy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/mitochondrial-potential-reflects-t-cell-fitness-and-function-during-cancer-immunotherapy\/\" aria-label=\"Read more about Mitochondrial potential reflects T cell fitness and function during cancer immunotherapy\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/compensatory-relationships-determine-the-impact-of-tgf-%ce%b2-on-the-humoral-immune-response-to-hepatitis-b-surface-antigen\/\">Compensatory relationships determine the impact of TGF-\u03b2 on the humoral immune response to hepatitis B surface antigen<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-18T06:28:04+02:00\" class=\"wp-block-latest-posts__post-date\">18 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag129. doi: 10.1093\/jimmun\/vkag129. ABSTRACT Despite an effective vaccine against the hepatitis B virus (HBV), there are about 250 million people living with chronic HBV (CHB) worldwide and one million deaths annually. Most children and about 5% of adults exposed to HBV will fail to clear the virus, developing a lifelong infection. &#8230; <a title=\"Compensatory relationships determine the impact of TGF-\u03b2 on the humoral immune response to hepatitis B surface antigen\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/compensatory-relationships-determine-the-impact-of-tgf-%ce%b2-on-the-humoral-immune-response-to-hepatitis-b-surface-antigen\/\" aria-label=\"Read more about Compensatory relationships determine the impact of TGF-\u03b2 on the humoral immune response to hepatitis B surface antigen\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/correction-to-porcine-respiratory-coronavirus-as-a-model-for-acute-respiratory-disease-mechanisms-of-different-infection-outcome\/\">Correction to:\u00a0Porcine respiratory coronavirus as a model for acute respiratory disease: mechanisms of different infection outcome<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-18T06:28:04+02:00\" class=\"wp-block-latest-posts__post-date\">18 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag095. doi: 10.1093\/jimmun\/vkag095. NO ABSTRACT PMID:42309535 | DOI:10.1093\/jimmun\/vkag095<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/correction-to-sting-agonists-drive-recruitment-and-intrinsic-type-i-interferon-responses-in-monocytic-lineage-cells-for-optimal-anti-tumor-immunity\/\">Correction to: STING agonists drive recruitment and intrinsic type I interferon responses in monocytic lineage cells for optimal anti-tumor immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-18T06:28:04+02:00\" class=\"wp-block-latest-posts__post-date\">18 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag055. doi: 10.1093\/jimmun\/vkag055. NO ABSTRACT PMID:42309534 | DOI:10.1093\/jimmun\/vkag055<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/metabolic-adaptations-of-inflammatory-macrophages-govern-ferroptosis-susceptibility-via-the-gch1-bh4-inos-axis\/\">Metabolic adaptations of inflammatory macrophages govern ferroptosis susceptibility via the GCH1-BH4-iNOS axis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-18T06:28:04+02:00\" class=\"wp-block-latest-posts__post-date\">18 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag146. doi: 10.1093\/jimmun\/vkag146. ABSTRACT In inflammatory tissue niches, macrophages encounter intense oxidative stress due to their own production of reactive oxygen and nitrogen species as part of antimicrobial defense. Our findings reveal that inflammatory macrophages deploy distinct, context-dependent redox-protective mechanisms to survive this self-inflicted stress, thereby avoiding ferroptotic cell death. Specifically, &#8230; <a title=\"Metabolic adaptations of inflammatory macrophages govern ferroptosis susceptibility via the GCH1-BH4-iNOS axis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/18\/metabolic-adaptations-of-inflammatory-macrophages-govern-ferroptosis-susceptibility-via-the-gch1-bh4-inos-axis\/\" aria-label=\"Read more about Metabolic adaptations of inflammatory macrophages govern ferroptosis susceptibility via the GCH1-BH4-iNOS axis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/correction-to-abin2-function-is-required-to-suppress-dss-induced-colitis-by-a-tpl2-independent-mechanism\/\">Correction to: ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-16T19:41:51+02:00\" class=\"wp-block-latest-posts__post-date\">16 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag156. doi: 10.1093\/jimmun\/vkag156. NO ABSTRACT PMID:42300803 | DOI:10.1093\/jimmun\/vkag156<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/human-xirp1-is-a-new-podosome-protein-targeting-cytosolic-bacteria-as-part-of-the-ifn-%ce%b3-defense-program\/\">Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-\u03b3 defense program<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-16T07:23:14+02:00\" class=\"wp-block-latest-posts__post-date\">16 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag116. doi: 10.1093\/jimmun\/vkag116. ABSTRACT Interferon-gamma (IFN-\u03b3) is a powerful transactivating signal eliciting hundreds of IFN-stimulated genes (ISGs) in humans to help combat infection. Most ISGs remain uncharacterized, and here we searched for actin-binding candidates that could potentially target intracellular pathogens to block their spread or promote immune cell migration into infected &#8230; <a title=\"Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-\u03b3 defense program\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/16\/human-xirp1-is-a-new-podosome-protein-targeting-cytosolic-bacteria-as-part-of-the-ifn-%ce%b3-defense-program\/\" aria-label=\"Read more about Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-\u03b3 defense program\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/reply-toward-a-more-translational-ss-ild-model-sex-differences-endpoints-and-b-cell-targets\/\">Reply: &#8220;Toward a more translational SS-ILD model: Sex differences, endpoints, and B cell targets&#8221;<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T19:04:57+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkaf379. doi: 10.1093\/jimmun\/vkaf379. NO ABSTRACT PMID:42295821 | DOI:10.1093\/jimmun\/vkaf379<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/congenital-cytomegalovirus-infection-drives-oligoclonal-expansion-of-cytotoxic-%ce%b3%ce%b4-t-cells-from-early-fetal-progenitors\/\">Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic \u03b3\u03b4 T cells from early fetal progenitors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T19:04:57+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag099. doi: 10.1093\/jimmun\/vkag099. ABSTRACT Gamma delta (\u03b3\u03b4) T cells emerge early during human gestation and are uniquely equipped to protect the fetus and infant following infection, due to their innate-like recognition of conserved molecular ligands. Following congenital cytomegalovirus infection (cCMV), V\u03b41 T cells have been shown to expand, differentiate, and upregulate &#8230; <a title=\"Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic \u03b3\u03b4 T cells from early fetal progenitors\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/congenital-cytomegalovirus-infection-drives-oligoclonal-expansion-of-cytotoxic-%ce%b3%ce%b4-t-cells-from-early-fetal-progenitors\/\" aria-label=\"Read more about Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic \u03b3\u03b4 T cells from early fetal progenitors\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/comment-on-toward-clinically-actionable-explainable-ai-in-pulmonary-arterial-hypertension-endpoints-calibration-and-external-validation\/\">Comment on &#8220;Toward clinically actionable explainable AI in pulmonary arterial hypertension: Endpoints, calibration, and external validation&#8221;<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T19:04:57+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkaf377. doi: 10.1093\/jimmun\/vkaf377. NO ABSTRACT PMID:42295822 | DOI:10.1093\/jimmun\/vkaf377<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/p120-catenin-enhances-macrophage-efferocytosis-and-facilitates-resolution-of-lung-inflammatory-injury\/\">p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T18:03:56+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag109. doi: 10.1093\/jimmun\/vkag109. ABSTRACT Defective resolution of inflammation following sepsis contributes to persistent immune dysfunction and increased morbidity and mortality worldwide. Efficient clearance of apoptotic polymorphonuclear neutrophils (PMNs) by macrophages, a process known as efferocytosis, is essential for resolving inflammation, promoting tissue repair, and restoring immune homeostasis; however, the molecular mechanisms &#8230; <a title=\"p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/p120-catenin-enhances-macrophage-efferocytosis-and-facilitates-resolution-of-lung-inflammatory-injury\/\" aria-label=\"Read more about p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/parenteral-vaccination-protects-against-mucosal-salmonella-infection-by-inducing-liver-tissue-resident-memory-cd4-t-cells\/\">Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T18:03:56+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag138. doi: 10.1093\/jimmun\/vkag138. ABSTRACT Salmonella enterica is a gastrointestinal pathogen that causes a variety of intestinal and systemic clinical disease. Vaccine development for systemic salmonellosis requires a deeper understanding of protective mechanisms and the relative contribution of mucosal and systemic host responses to bacterial elimination. Here, we examined the relative importance &#8230; <a title=\"Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/parenteral-vaccination-protects-against-mucosal-salmonella-infection-by-inducing-liver-tissue-resident-memory-cd4-t-cells\/\" aria-label=\"Read more about Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/a-novel-monocyte-derived-antigen-presenting-cell-t-regulatory-cell-axis-contributes-to-skin-wound-healing-and-is-impaired-in-diabetic-mice\/\">A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-15T18:03:55+02:00\" class=\"wp-block-latest-posts__post-date\">15 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag128. doi: 10.1093\/jimmun\/vkag128. ABSTRACT Despite a vast literature on the role of macrophages in wound healing, the role of dermal monocyte (Mo)-derived antigen presenting cells (APC) has received scant attention. Using scRNAseq and flow cytometry, we identify a population of APC that is prominent in wounds of non-diabetic mice but is &#8230; <a title=\"A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/15\/a-novel-monocyte-derived-antigen-presenting-cell-t-regulatory-cell-axis-contributes-to-skin-wound-healing-and-is-impaired-in-diabetic-mice\/\" aria-label=\"Read more about A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/13\/preselection-cd4cd8-thymocytes-modulate-tcr-responsiveness-following-tcr%ce%b2-selection\/\">Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCR\u03b2 selection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-13T06:48:35+02:00\" class=\"wp-block-latest-posts__post-date\">13 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag105. doi: 10.1093\/jimmun\/vkag105. ABSTRACT Modulation of T cell receptor (TCR) sensitivity during positive selection is critical to avoid negative selection and direct thymocytes into their appropriate lineage. Thymocytes just prior to positive selection (preselection) are highly responsive to low affinity self-ligands and are also actively rearranging their TCR\u03b1 locus as they &#8230; <a title=\"Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCR\u03b2 selection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/13\/preselection-cd4cd8-thymocytes-modulate-tcr-responsiveness-following-tcr%ce%b2-selection\/\" aria-label=\"Read more about Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCR\u03b2 selection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/variable-fab-domain-n-glycosylation-patterns-in-the-b-cell-receptor-repertoires-of-healthy-individuals-and-patients-with-rheumatoid-arthritis\/\">Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-11T12:00:49+02:00\" class=\"wp-block-latest-posts__post-date\">11 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag113. doi: 10.1093\/jimmun\/vkag113. ABSTRACT N-linked glycosylation (N-glyc) sites (N-X-S\/T, X\u2260P) can be introduced by somatic hypermutation in immunoglobulin Fab regions. In patients with rheumatoid arthritis (RA), anti-citrullinated protein antibodies have a striking overrepresentation of Fab N-glycosylation. To further explore this, we sequenced B cell receptors (BCRs) from peripheral blood of 13 &#8230; <a title=\"Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/variable-fab-domain-n-glycosylation-patterns-in-the-b-cell-receptor-repertoires-of-healthy-individuals-and-patients-with-rheumatoid-arthritis\/\" aria-label=\"Read more about Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/bach1-orchestrates-macrophage-state-transitions-to-coordinate-regenerative-inflammation\/\">BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-11T12:00:49+02:00\" class=\"wp-block-latest-posts__post-date\">11 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag101. doi: 10.1093\/jimmun\/vkag101. ABSTRACT Efficient tissue regeneration requires the precise coordination of inflammatory and regenerative programs, principally mediated by monocyte-derived macrophages. However, the transcriptional wiring and epigenomic processes behind complex macrophage subtype specification and transition between the different states are not known. Here we have identified the transcriptional repressor BACH1 as &#8230; <a title=\"BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/11\/bach1-orchestrates-macrophage-state-transitions-to-coordinate-regenerative-inflammation\/\" aria-label=\"Read more about BACH1 orchestrates macrophage state transitions to coordinate regenerative inflammation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/crispri-screening-identifies-son-and-map4k1-as-regulators-of-type-iii-cytokine-expression-in-innate-lymphoid-cells\/\">CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-10T17:44:19+02:00\" class=\"wp-block-latest-posts__post-date\">10 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag110. doi: 10.1093\/jimmun\/vkag110. ABSTRACT The cytokines interleukin (IL)-22 and IL-17 are secreted by innate and adaptive immune cells to drive &#8220;type III&#8221; responses that protect against extracellular pathogens, promote mucosal barrier integrity, and foster microbiota homeostasis. However, dysregulation of IL-22 and\/or IL-17 contributes to autoimmunity, chronic inflammation, and malignancy. Thus, a &#8230; <a title=\"CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/crispri-screening-identifies-son-and-map4k1-as-regulators-of-type-iii-cytokine-expression-in-innate-lymphoid-cells\/\" aria-label=\"Read more about CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/cd7-drives-cd8-t-cell-exhaustion-during-chronic-viral-infection\/\">CD7 drives CD8 T cell exhaustion during chronic viral infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-09T01:49:31+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag091. doi: 10.1093\/jimmun\/vkag091. ABSTRACT Viral or tumor persistence is often associated with CD8 T cell &#8220;exhaustion,&#8221; a differentiation process characterized by co-inhibitory receptor upregulation and loss of effector function. Recent data show that &#8220;exhausted&#8221; T cells are a heterogenous population that includes a progenitor subset that transitions through an intermediate state &#8230; <a title=\"CD7 drives CD8 T cell exhaustion during chronic viral infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/cd7-drives-cd8-t-cell-exhaustion-during-chronic-viral-infection\/\" aria-label=\"Read more about CD7 drives CD8 T cell exhaustion during chronic viral infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation\/\">Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-09T01:49:31+02:00\" class=\"wp-block-latest-posts__post-date\">9 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag074. doi: 10.1093\/jimmun\/vkag074. ABSTRACT Messenger RNA (mRNA) vaccines effectively induce protective immunity, but antigen-specific CD8+ T cell responses exhibit limited persistence. In this study, we aimed to assess CD8+ T cell responses following a third dose of the Pfizer BNT162b2 COVID-19 vaccine and identify factors contributing to their longevity. Using HLA &#8230; <a title=\"Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/09\/sustained-antigen-specific-cd8-t-cell-immunity-post-mrna-booster-requires-notch-pathway-activation\/\" aria-label=\"Read more about Sustained antigen-specific CD8+ T cell immunity post-mRNA booster requires notch pathway activation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/sleep-interruption-aggravates-sepsis-by-rewiring-the-macrophage-immune-response\/\">Sleep interruption aggravates sepsis by rewiring the macrophage immune response<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T19:37:05+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag130. doi: 10.1093\/jimmun\/vkag130. ABSTRACT Sepsis is the leading cause of death in hospitals and is very common in intensive care units (ICUs). Sleep is frequently interrupted in the hospital setting, especially within the ICU. Patients who sleep poorly have worse outcomes, such as increased mortality and longer hospital stays; however, the &#8230; <a title=\"Sleep interruption aggravates sepsis by rewiring the macrophage immune response\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/sleep-interruption-aggravates-sepsis-by-rewiring-the-macrophage-immune-response\/\" aria-label=\"Read more about Sleep interruption aggravates sepsis by rewiring the macrophage immune response\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/fate-mapping-reveals-a-prenatal-to-neonatal-wave-of-ilc2s-with-a-history-of-cd3g-expression\/\">Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T07:15:44+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag124. doi: 10.1093\/jimmun\/vkag124. ABSTRACT Group 2 innate lymphoid cells (ILC2s) are thought to develop in the bone marrow and fetal liver. However, increasing evidence supports the presence of thymic ILC2s in mice and humans. In this study, we introduce a novel fate-mapping mouse model designed to track thymic ILC2s in peripheral &#8230; <a title=\"Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/fate-mapping-reveals-a-prenatal-to-neonatal-wave-of-ilc2s-with-a-history-of-cd3g-expression\/\" aria-label=\"Read more about Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/adjuvants-orchestrate-cross-organ-induction-of-mucosal-cd8-t-cell-immune-responses-in-respiratory-tracts\/\">Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T07:15:44+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag117. doi: 10.1093\/jimmun\/vkag117. ABSTRACT Mucosal immunity is paramount for combating respiratory infections, but conventional vaccination methods, such as intramuscular injection, often struggle to induce it. Although direct mucosal vaccination is effective, it carries an increased risk of respiratory adverse effects, making it particularly challenging for individuals with chronic respiratory diseases. Consequently, &#8230; <a title=\"Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/adjuvants-orchestrate-cross-organ-induction-of-mucosal-cd8-t-cell-immune-responses-in-respiratory-tracts\/\" aria-label=\"Read more about Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/ifitm1-differentially-regulates-antibacterial-immunity-and-immunopathology-but-is-dispensable-for-antiparasitic-responses\/\">IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-08T07:15:44+02:00\" class=\"wp-block-latest-posts__post-date\">8 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag122. doi: 10.1093\/jimmun\/vkag122. ABSTRACT Interferon-induced transmembrane (IFITM) proteins underpin antiviral responses, yet their role in bacterial infections remains underexplored, particularly for parasites. We probed the role of IFITM1 in Mycobacterium tuberculosis (Mtb), Listeria monocytogenes (Lm), and Leishmania major infection using IFITM1 knockout mice. Notably, IFITM1 was upregulated in murine and human &#8230; <a title=\"IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/08\/ifitm1-differentially-regulates-antibacterial-immunity-and-immunopathology-but-is-dispensable-for-antiparasitic-responses\/\" aria-label=\"Read more about IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/04\/pgrn-promotes-host-defense-against-b-thailandensis-induced-sepsis-by-augmenting-macrophage-antibacterial-capacity-via-jak1-stat3-pathway\/\">PGRN promotes host defense against B. thailandensis-induced sepsis by augmenting macrophage antibacterial capacity via JAK1-STAT3 pathway<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-04T13:25:18+02:00\" class=\"wp-block-latest-posts__post-date\">4 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag069. doi: 10.1093\/jimmun\/vkag069. ABSTRACT Burkholderia thailandensis (B. thailandensis) is an emerging pathogen. Although it has not yet caused large-scale outbreaks, severe infections can lead to sepsis. Currently, there are no effective treatment strategies available, highlighting the urgent need to develop novel therapies. Progranulin (PGRN) is a multifunctional protein with complex roles &#8230; <a title=\"PGRN promotes host defense against B. thailandensis-induced sepsis by augmenting macrophage antibacterial capacity via JAK1-STAT3 pathway\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/04\/pgrn-promotes-host-defense-against-b-thailandensis-induced-sepsis-by-augmenting-macrophage-antibacterial-capacity-via-jak1-stat3-pathway\/\" aria-label=\"Read more about PGRN promotes host defense against B. thailandensis-induced sepsis by augmenting macrophage antibacterial capacity via JAK1-STAT3 pathway\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/03\/correction-to-combinatorial-action-of-tgf%ce%b2-and-il-10-induces-monocyte-and-monocyte-derived-dendritic-cell-dysfunction-in-people-living-with-hiv-3717\/\">Correction to:\u00a0Combinatorial action of TGF\u03b2 and IL-10 induces monocyte and monocyte-derived dendritic cell dysfunction in people living with HIV 3717<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-03T06:45:23+02:00\" class=\"wp-block-latest-posts__post-date\">3 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag047. doi: 10.1093\/jimmun\/vkag047. NO ABSTRACT PMID:42229912 | DOI:10.1093\/jimmun\/vkag047<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/correction-to-hepatitis-c-virus-inhibits-dna-damage-repair-through-reactive-oxygen-and-nitrogen-species-and-by-interfering-with-the-atm-nbs1-mre11-rad50-dna-repair-pathway-in-monocytes-and-hepatocyte\/\">Correction to: Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1\/Mre11\/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-02T13:24:49+02:00\" class=\"wp-block-latest-posts__post-date\">2 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkaf166. doi: 10.1093\/jimmun\/vkaf166. NO ABSTRACT PMID:42226503 | DOI:10.1093\/jimmun\/vkaf166<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/pi3k%ce%b4-inhibition-alters-cd8-t-cell-differentiation-and-reprograms-the-tumor-microenvironment-following-adoptive-immunotherapy\/\">PI3K\u03b4 inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-30T07:14:14+02:00\" class=\"wp-block-latest-posts__post-date\">30 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag108. doi: 10.1093\/jimmun\/vkag108. ABSTRACT T cell exhaustion remains a significant barrier to effective adoptive cell therapy in solid tumors. Here, we demonstrate that in vitro treatment with the PI3K\u03b4 inhibitor CAL-101 generates T cells with enhanced stemness and metabolic fitness. These cells show increased mitochondrial dependence and spare respiratory capacity while &#8230; <a title=\"PI3K\u03b4 inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/pi3k%ce%b4-inhibition-alters-cd8-t-cell-differentiation-and-reprograms-the-tumor-microenvironment-following-adoptive-immunotherapy\/\" aria-label=\"Read more about PI3K\u03b4 inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/the-role-of-electroacupuncture-in-altering-lipoic-acid-metabolism-to-reduce-joint-inflammation-in-rheumatoid-arthritis-rats\/\">The role of electroacupuncture in altering lipoic acid metabolism to reduce joint inflammation in rheumatoid arthritis rats<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-30T07:14:14+02:00\" class=\"wp-block-latest-posts__post-date\">30 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag083. doi: 10.1093\/jimmun\/vkag083. ABSTRACT Rheumatoid arthritis (RA) is characterized by severe synovial inflammation and progressive joint destruction. This study evaluated the therapeutic effects of electroacupuncture (EA) in a rat model of RA and explored its potential association with lipoic acid (LA) metabolism. Collagen-induced arthritis (CIA) was established in rats, followed by &#8230; <a title=\"The role of electroacupuncture in altering lipoic acid metabolism to reduce joint inflammation in rheumatoid arthritis rats\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/30\/the-role-of-electroacupuncture-in-altering-lipoic-acid-metabolism-to-reduce-joint-inflammation-in-rheumatoid-arthritis-rats\/\" aria-label=\"Read more about The role of electroacupuncture in altering lipoic acid metabolism to reduce joint inflammation in rheumatoid arthritis rats\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/29\/contributions-of-t-helper-9-cells-in-endometriosis-associated-inflammation-and-lesion-growth\/\">Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-29T22:08:28+02:00\" class=\"wp-block-latest-posts__post-date\">29 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag123. doi: 10.1093\/jimmun\/vkag123. ABSTRACT Endometriosis is an inflammatory gynecologic disease characterized by ectopic growth of endometrial-like tissue, resulting in pelvic pain and infertility. T-helper 9 (Th9) cells play a known role in various chronic inflammatory diseases. Despite parallels between endometriosis and Th9-driven diseases, their role in endometriosis has not been extensively &#8230; <a title=\"Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/29\/contributions-of-t-helper-9-cells-in-endometriosis-associated-inflammation-and-lesion-growth\/\" aria-label=\"Read more about Contributions of T-helper 9 cells in endometriosis-associated inflammation and lesion growth\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/cns1-dependent-regulatory-t-cells-shape-recovery-from-acute-lung-injury\/\">CNS1-dependent regulatory T cells shape recovery from acute lung injury<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-28T01:23:53+02:00\" class=\"wp-block-latest-posts__post-date\">28 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 May 14;215(5):vkag119. doi: 10.1093\/jimmun\/vkag119. ABSTRACT Regulatory T cells (Tregs) play a crucial role in mediating recovery from acute lung injury (ALI). However, the complex roles of functionally heterogeneous Treg subsets in the lung during the resolution of acute inflammation remain unclear. To investigate the role of peripherally induced Tregs, we utilized mice &#8230; <a title=\"CNS1-dependent regulatory T cells shape recovery from acute lung injury\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/cns1-dependent-regulatory-t-cells-shape-recovery-from-acute-lung-injury\/\" aria-label=\"Read more about CNS1-dependent regulatory T cells shape recovery from acute lung injury\">Read more<\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":16690,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16689","page","type-page","status-publish","has-post-thumbnail"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16689"}],"version-history":[{"count":1,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689\/revisions"}],"predecessor-version":[{"id":16691,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16689\/revisions\/16691"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media\/16690"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}