{"id":16925,"date":"2024-09-29T10:16:37","date_gmt":"2024-09-29T08:16:37","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16925"},"modified":"2024-09-29T10:17:54","modified_gmt":"2024-09-29T08:17:54","slug":"seminars-in-immunology","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/seminars-in-immunology\/","title":{"rendered":"Seminars in Immunology"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/the-role-of-different-apl-subpopulations-in-the-lupus-anticoagulant-phenomenon\/\">The role of different aPL subpopulations in the lupus anticoagulant phenomenon<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T07:30:56+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 May 4;100:102784. doi: 10.1016\/j.coi.2026.102784. Online ahead of print. ABSTRACT The lupus anticoagulant (LA) phenomenon represents a paradoxical prothrombotic state characterised by inhibition of phospholipid-dependent coagulation assays in vitro, despite a strong association with thrombosis and pregnancy morbidity in vivo. LA is a central laboratory criterion for the diagnosis and risk stratification &#8230; <a title=\"The role of different aPL subpopulations in the lupus anticoagulant phenomenon\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/the-role-of-different-apl-subpopulations-in-the-lupus-anticoagulant-phenomenon\/\" aria-label=\"Read more about The role of different aPL subpopulations in the lupus anticoagulant phenomenon\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/chemokine-receptor-expression-defines-a-trajectory-from-monocytes-to-mature-macrophages-in-the-lungheather-mathie-on-5-de-may-de-2026-at-1000\/\">Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung\u200bHeather Mathie   on 5 de May de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T07:30:51+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 May 6:qiag059. doi: 10.1093\/jleuko\/qiag059. Online ahead of print. ABSTRACT CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte\/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Using transcriptomic approaches to examine inflammatory chemokine receptor expression on lung &#8230; <a title=\"Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung\u200bHeather Mathie   on 5 de May de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/chemokine-receptor-expression-defines-a-trajectory-from-monocytes-to-mature-macrophages-in-the-lungheather-mathie-on-5-de-may-de-2026-at-1000\/\" aria-label=\"Read more about Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung\u200bHeather Mathie   on 5 de May de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1852625\">Editorial: Lipid influence on lung immune-structural cell crosstalk: implications for respiratory health<\/a><div class=\"wp-block-latest-posts__post-author\">by Benoit Allard<\/div><time datetime=\"2026-05-06T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1864583\">Editorial: Overcoming resistance to immune checkpoint inhibitors: mechanisms and strategies in cancer therapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Margherita Piccinelli<\/div><time datetime=\"2026-05-06T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1859297\">Editorial: Beyond therapeutic innovation in genitourinary cancers: the unmet need for biologically driven patient selection<\/a><div class=\"wp-block-latest-posts__post-author\">by Brigida Anna Maiorano<\/div><time datetime=\"2026-05-06T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/immune-landscape-of-covid-19-recovery-nucleocapsid-as-a-major-target-of-cd8-t-cell-antiviral-responses-in-convalescent-hla-a2-individuals-from-brazilagata-lopes-ribeiro-on-5-de-may-de-2\/\">Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil\u200b\u00c1gata Lopes-Ribeiro   on 5 de May de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T01:22:49+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 May 5:qiag050. doi: 10.1093\/jleuko\/qiag050. Online ahead of print. ABSTRACT Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific responses of acute and post-acute COVID-19 patients. Our results indicate that convalescent individuals displayed &#8230; <a title=\"Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil\u200b\u00c1gata Lopes-Ribeiro   on 5 de May de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/immune-landscape-of-covid-19-recovery-nucleocapsid-as-a-major-target-of-cd8-t-cell-antiviral-responses-in-convalescent-hla-a2-individuals-from-brazilagata-lopes-ribeiro-on-5-de-may-de-2\/\" aria-label=\"Read more about Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil\u200b\u00c1gata Lopes-Ribeiro   on 5 de May de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/uba2-high-osteosarcoma-suppresses-immune-infiltration-by-autophagy-mediated-mhc-i-degradation\/\">UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T01:22:49+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cancer Immunol Res. 2026 May 5. doi: 10.1158\/2326-6066.CIR-25-1321. Online ahead of print. ABSTRACT Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a &#8230; <a title=\"UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/uba2-high-osteosarcoma-suppresses-immune-infiltration-by-autophagy-mediated-mhc-i-degradation\/\" aria-label=\"Read more about UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e012427?rss=1\">Characterization of aberrant alternative splicing landscape in patients with metastatic renal cell carcinoma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T16:00:19+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nPurpose\nAberrant alternative splicing (AS) events have been implicated in cancer progression; however, their role in metastatic renal cell carcinoma (mRCC) remains underexplored. This study aims to identify AS events associated with clinical benefits &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01308-z\">CRISPR screen reveals regulators of age-associated CD8&lt;sup&gt;+&lt;\/sup&gt; T cell dysfunction in cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by Matthew Bianca<\/div><time datetime=\"2026-05-05T12:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 05 May 2026; doi:10.1038\/s41577-026-01308-zA preprint by Chen et al. identifies Dusp5 and Zfp219 as regulators of age-associated T cell dysfunction in the tumour microenvironment.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/spatial-multiomics-reveal-insights-into-adc-efficacy-valueosman-goni-niklas-klumper-maria-del-mar-muniz-moreno-markus-eckstein-christoph-kuppe\/\">Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Spatial multiomics profiling can reveal how tumor heterogeneity and microenvironment influence ADC efficacy. Combining spatial transcriptomics, proteomics, and AI-based analysis improves the identification of tissue factors influencing therapy response. This integrative approach potentially enables prediction of response, resistance, and optimized patient selection, which we review here. ABSTRACT Antibody\u2013drug conjugates (ADCs) have transformed the therapeutic landscape &#8230; <a title=\"Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/spatial-multiomics-reveal-insights-into-adc-efficacy-valueosman-goni-niklas-klumper-maria-del-mar-muniz-moreno-markus-eckstein-christoph-kuppe\/\" aria-label=\"Read more about Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/syk-signalling-in-nlrp3-inflammasome%e2%80%90mediated-response-of-murine-microglia-activated-by-immune-complexes-formed-of-viral-proteins-and-specific-igg-valuekristina-masalaite-milda-no\/\">SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IC-mediated inflammatory response\u2014the NLRP3 inflammasome activation, cytokine secretion, and antigen presentation depend on SYK signalling pathways in primary murine microglia. ABSTRACT Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation, but the precise mechanism remains unknown. The NLRP3 inflammasome is a vital component of &#8230; <a title=\"SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/syk-signalling-in-nlrp3-inflammasome%e2%80%90mediated-response-of-murine-microglia-activated-by-immune-complexes-formed-of-viral-proteins-and-specific-igg-valuekristina-masalaite-milda-no\/\" aria-label=\"Read more about SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/borrelia-burgdorferi-sensu-lato-employs-several-escape-mechanisms-to-bypass-the-human-defense-system-valuezara-karami-hadewych-j-m-ter-hofstede-leo-a-b-joosten\/\">Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva-mediated suppression of innate defenses, TLR2\/NOD2-driven cytokine dysregulation, and interference with JAK\/STAT and CIITA-dependent antigen presentation. Impaired autophagy skews responses toward pathogenic Th17 activity, while disrupted lymph node architecture, persistent IgM, and defective CD4+ T cell function collectively impair &#8230; <a title=\"Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/borrelia-burgdorferi-sensu-lato-employs-several-escape-mechanisms-to-bypass-the-human-defense-system-valuezara-karami-hadewych-j-m-ter-hofstede-leo-a-b-joosten\/\" aria-label=\"Read more about Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/cover-story-eur-j-immunol-526\/\">Cover Story: Eur. J. Immunol. 5&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:04:59+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 5&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/cover-story-eur-j-immunol-526\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 5&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/adapted-live-sars%e2%80%90cov%e2%80%902-vaccine-elicits-rapid-mucosal-immunity-protects-from-disease-and-reduces-shedding-of-xbb-1-5-valuejana-kochmann-tobias-britzke-nico-joel-halwe\/\">Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:04:59+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">An attenuated live vaccine (OTS-300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination. Therefore, vaccination with the OTS LAV platform may help to disrupt transmission chains. ABSTRACT The emergence of &#8230; <a title=\"Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/adapted-live-sars%e2%80%90cov%e2%80%902-vaccine-elicits-rapid-mucosal-immunity-protects-from-disease-and-reduces-shedding-of-xbb-1-5-valuejana-kochmann-tobias-britzke-nico-joel-halwe\/\" aria-label=\"Read more about Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01303-4\">Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by Shokrollah Elahi<\/div><time datetime=\"2026-05-05T10:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 05 May 2026; doi:10.1038\/s41577-026-01303-4This Review from Shokrollah Elahi considers how erythroid cells \u2014 including erythroid progenitors and precursors and mature red blood cells \u2014 can m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1805513\">Immunity beyond borders: non-lethal Plasmodium confers cross-protection against lethal Babesia via macrophage activation<\/a><div class=\"wp-block-latest-posts__post-author\">by Iqra Zafar<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionIn co-endemic regions, hosts are concurrently infected by related apicomplexan hemoparasites, Plasmodium and the zoonotic pathogen Babesia. This study investigates how Plasmodium berghei XAT-Babesia rodhaini co-infection modulates host immu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1811583\">Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis<\/a><div class=\"wp-block-latest-posts__post-author\">by Qingyi Mao<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundNumerous studies indicated inflammatory bowel disease (IBD) patients suffered from sleep disturbances. Although melatonin (MT) exerts positive effects on maintaining circadian rhythms and anti-inflammation, its impact on the gut microbiome an&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1845580\">Obinutuzumab-induced acute thrombocytopenia and leukopenia in ANCA-associated glomerulonephritis: case report and literature review<\/a><div class=\"wp-block-latest-posts__post-author\">by Yiming Jin<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Obinutuzumab is a humanized type II anti-CD20 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity. It is widely used in B-cell malignancies and is increasingly being explored in autoimmune diseases such as lupus nephritis. The ma&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1834595\">Antigen-specific tolerance and control of autoimmunity effected by liver sinusoidal endothelial cells is unimpaired in liver fibrosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Cornelia Gottwick<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Background and aimsLiver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune tolerance to ingested antigens. The scavenger and tolerance function of&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1808890\">Surface-enhanced Raman spectroscopy-based liquid biopsy for diagnosis and classification of lupus nephritis using urine biomarkers<\/a><div class=\"wp-block-latest-posts__post-author\">by Xue Xia<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Background Lupus nephritis (LN) is a leading cause of mortality in patients with systemic lupus erythematosus (SLE), and the accurate classification of renal pathological subtypes is crucial for reducing mortality rates and improving long-term prognosi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1816335\">Immune cells and high-density lipoprotein cholesterol derivative markers mediate the impact of hypertriglyceridemia on hyperuricemia in diabetes mellitus<\/a><div class=\"wp-block-latest-posts__post-author\">by Wei Wang<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundAs markers of inflammation and oxidative stress, immune cells and high-density lipoprotein cholesterol (HDL-c) derivative markers, such as the monocyte to HDL-c ratio (MHR) and lymphocyte to HDL-c ratio (LHR), have been widely utilized in cli&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1787877\">Preclinical evaluation of a multi-epitope mRNA vaccine platform for broad and durable SARS-CoV-2 protection<\/a><div class=\"wp-block-latest-posts__post-author\">by Laura Marcos-Villar<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionThe emergence of immune-evasive SARS-CoV-2 variants has exposed limitations in the breadth and durability of protection conferred by current Spike-based vaccines, highlighting the need for next-generation approaches targeting conserved vira&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1784757\">Ankylosing spondylitis and the gut microbiome: future research hotspots and trends<\/a><div class=\"wp-block-latest-posts__post-author\">by Xingxiao Yin<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundAnkylosing spondylitis (AS) is an autoimmune disease. Its exact cause remains unclear. It is generally believed to result from a combination of genetic and environmental factors, as well as immune disorders. However, growing evidence suggests&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1798542\">NLRP3 inflammasomes at the ARDS-cancer interface: mechanisms and translational hypotheses<\/a><div class=\"wp-block-latest-posts__post-author\">by Salima Shebbo<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Acute respiratory distress syndrome (ARDS) and cancer share common pathogenetic mechanisms that involve immune dysregulation and inflammatory responses. Inflammasomes, part of the initial innate immune response to infection and injury, play a pivotal r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1792155\">Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation<\/a><div class=\"wp-block-latest-posts__post-author\">by Poorya Foroutan Pajoohian<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study was to assess how vaccine delivery routes (homologous versus heterologous) in mice &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1790014\">Correction: Premature renal epithelial cell senescence promoted by LXN\/Rps3\/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage polarization<\/a><div class=\"wp-block-latest-posts__post-author\">by Maolin Chu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1702830\">Performance of Tai Chi Chuan and NF-\u03baB-driven proinflammatory gene expression (IL-6, IL-1\u03b2, TNF-\u03b1) in adult chronic disease patients: a systematic review and meta-analysis of randomized controlled trials<\/a><div class=\"wp-block-latest-posts__post-author\">by Si-Qi Zhu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveThis systematic review and meta-analysis aims to evaluate the effects of Tai Chi Chuan on the expression of pro-inflammatory genes IL-6, IL-1\u03b2, and TNF-\u03b1\u2014downstream of the NF-\u03baB pathway\u2014in adults with chronic diseases. It further explores pote&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1733373\">Antibiotic use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database<\/a><div class=\"wp-block-latest-posts__post-author\">by Jia Yu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundThe use of antibiotics may influence the efficacy and toxicity of immune checkpoint inhibitors (ICIs) by altering the gut microbiota. However, current evidence on the link between antibiotic use and immune-related adverse events (irAEs) is li&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1778359\">Recurrent spinal IgG4-related hypertrophic pachymeningitis and its management: a case report<\/a><div class=\"wp-block-latest-posts__post-author\">by Gorbachev Jowah<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">AimIn this report, we share a case of recurrent spinal immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis (IgG4-RHP) in a patient who initially achieved near-complete recovery of muscle weakness after decompression surgery and steroid therap&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1726565\">T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype<\/a><div class=\"wp-block-latest-posts__post-author\">by Aaron B. Schultz<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutations of STAT3 are strikingly pre&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1781797\">Immunometabolic control of cytokine production by micronutrients in health, aging, and inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by Joyeta Ghosh<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Micronutrients serve as critical metabolic sensors and epigenetic regulators that orchestrate cytokine production through multiple overlapping signalling cascades, transcriptional networks, and cellular metabolic states. This comprehensive review synth&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1751523\">Cell death in uveitis: pyroptosis, ferroptosis, apoptosis, and beyond<\/a><div class=\"wp-block-latest-posts__post-author\">by Jianxin Liu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Uveitis is a group of diseases characterized by intraocular inflammation, closely associated with infectious, autoimmune, genetic, or environmental factors. Cell death, a critical biological process involved in development, the maintenance of homeostas&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1772425\">Compositional maturation of the microbiome and adaptive immunity in the postnatal period<\/a><div class=\"wp-block-latest-posts__post-author\">by Miranda Green<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionRecent research has highlighted the role of the gut microbiome in shaping the development and function of the mammalian immune system. Interactions between these complex networks of microbes and host cells serve not only to train major aspe&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1793865\">Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies<\/a><div class=\"wp-block-latest-posts__post-author\">by Xingyu Su<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Non-infectious uveitis encompasses a diverse array of autoimmune ocular disorders marked by the breakdown of immune tolerance and recurrent inflammatory episodes. Regulatory T cells (Tregs) are integral to the maintenance of ocular homeostasis in all s&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1818127\">The antimicrobial potential of the secretome from Wharton\u2019s jelly mesenchymal stem cells in the context of regenerative medicine: an in vitro study<\/a><div class=\"wp-block-latest-posts__post-author\">by Filomena Napolitano<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionThe secretome derived from Mesenchymal Stem Cells (MSCs) have received significant attention as a promising tool in regenerative medicine. This \u201ccell-free\u201d strategy offers a promising alternative to stem cell therapies, potentially avoiding&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1823338\">Biomarkers for predicting immunotherapy response and resistance in glioblastoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Samuel Kim<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive patients has been identified, b&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1796042\">Qijia Rougan Formula alleviates liver fibrosis by inhibiting NLRP3-mediated pyroptosis and regulating macrophage polarization<\/a><div class=\"wp-block-latest-posts__post-author\">by Xin Ding<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundStage F3 liver fibrosis represents a critical phase for intercepting the progression toward irreversible cirrhosis. Despite its clinical significance, effective interventions remain scarce. Clinical observations indicate that the traditional &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1823240\">STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Tiffany S. Nelson<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) is a DNA virus linked to multiple malignancies associated with compromised immunity, such as Kaposi\u2019s sarcoma (KS) and primary effusion lymphoma (PEL). These malignancies are strongly linked to HIV coinfec&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1810985\">Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Gunapati Bhargavi<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">L-arginine (ARG) availability is a critical determinant of macrophage antimicrobial capacity, as it fuels nitric oxide production and other immune effector pathways essential for restricting Mycobacterium tuberculosis (Mtb), the causative agent of tube&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1764099\">Research progress in the inhibitory mechanisms of traditional Chinese medicine therapies against influenza A<\/a><div class=\"wp-block-latest-posts__post-author\">by Mingjiang Liu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Influenza A, an acute or subacute respiratory infectious disease caused by the influenza A virus (IAV), affects humans and animals, and poses a serious threat to public health. Currently, IAV prevention and treatment rely primarily on antiviral drugs a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1777564\">Design of the MERCURION-IPF trial \u2013 intravenous immunoglobulin for the treatment of acute exacerbations of idiopathic pulmonary fibrosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Vasilina Sotiropoulou<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionDespite their profound clinical impact and high mortality, acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) still lack any effective or standardized treatment strategies. This manuscript describes the rationale and design of a &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1829051\">CD8 regulatory T cells are a novel type regulatory T cells in the induction of transplantation immune tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Jin-can Huang<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveRegulatory T cells (Tregs) play an essential role in transplantation immune tolerance. Although CD4+ Tregs have been extensively studied, the contribution of CD8+ regulatory T-cell subsets to transplant tolerance remains less well defined. Thi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1789537\">MesenSistem-EB: systemic haploidentical mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa associated with clinical benefits and correlated with MCP1 and sCD40L dynamics<\/a><div class=\"wp-block-latest-posts__post-author\">by Roc\u00edo Maseda<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and survival. Effective inflammatory c&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014314?rss=1\">Safety and immunogenicity of a tri-antigen vaccine targeting IGFBP-2, HER2, and IGF-IR in participants with non-metastatic breast cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nDuctal carcinoma in situ (DCIS) is a preinvasive form of breast cancer. Current treatment consists of surgery, radiation, and often systemic therapy exposing patients to unnecessary health risks. Vaccines targeting DCIS may be a way to inte&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e013906?rss=1\">Phase II trial of combination radiation, hormone, and immunotherapy in grade group 5 prostate cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nGrade group 5 (GG5) prostate cancer (PCa) carries a less favorable prognosis after standard-of-care (SOC) therapy, necessitating novel therapeutic approaches. High-dose rate brachytherapy (HDRBT) and androgen deprivation therapy (ADT) may m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e009702?rss=1\">Cancer-associated fibroblast targeting therapies as a tool to enhance responses to radiotherapy and immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Garate-Soraluze, E., Martinez-Zubiaurre, I., Rodriguez-Ruiz, M. E.<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nCancer-associated fibroblasts (CAFs) are one of the main components of the tumor microenvironment (TME) of solid tumors. They have several functions, which all contribute to tumor growth and immune evasion. CAF presence is associated with poor clinica&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014592?rss=1\">CAR-engineering of innate and innate-like immune cells: a new horizon in adoptive cell therapy for solid tumors<\/a><div class=\"wp-block-latest-posts__post-author\">by Nardo, G., Putti, F., Indini, A., Del Vecchio, M., De Braud, F., Di Nicola, M., De Santis, F.<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nChimeric antigen receptor (CAR) therapies have revolutionized cancer immunotherapy, particularly in hematologic malignancies, but their efficacy in solid tumors remains limited. Key barriers include tumor antigen heterogeneity, on-target\/of&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e015063?rss=1\">Discontinuation of combo immunotherapy and outcome of patients with melanoma brain metastases<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nNivolumab plus ipilimumab (COMBO) is the standard treatment for asymptomatic melanoma brain metastases (MBM), but current guidelines do not provide specific recommendations for treatment discontinuation in responding patients. This study ai&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014555?rss=1\">Patient-derived organotypic tumor spheroids as a functional platform for predicting immunotherapeutic responses and guiding precision treatment for hepatocellular carcinoma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nHepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide. While immune checkpoint blockade has revolutionized the treatment of many cancers, responses in HCC remain limited. Robust functional platforms capable of&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014346?rss=1\">Phase 2 study of palbociclib plus retifanlimab in patients with advanced dedifferentiated liposarcoma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nThe cyclin-dependent kinase 4 and 6 (CDK4\/6) inhibitor palbociclib delays disease progression in dedifferentiated liposarcoma (DDLPS) by inducing tumor cell quiescence or senescence, though most tumors ultimately progress. Preclinical data &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/a-sampling-of-highlights-from-the-literature-article-recommendations-from-our-deputy-and-senior-editors-12\/\">A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T12:41:35+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cancer Immunol Res. 2026 May 4;14(5):715. doi: 10.1158\/2326-6066.CIR-14-5-WWR. NO ABSTRACT PMID:42076931 | DOI:10.1158\/2326-6066.CIR-14-5-WWR<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king\/\">Cytokine networks driving eosinophil functional heterogeneity. James I King<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T06:37:14+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mucosal Immunol. 2026 May 1:100347. doi: 10.1016\/j.mucimm.2026.100347. Online ahead of print. ABSTRACT Eosinophils have traditionally been viewed as terminally differentiated type 2 effector cells involved in anti-helminth immunity and allergic inflammation. Recent advances in single-cell transcriptomics have refined this view, revealing substantial developmental and functional heterogeneity across tissues and inflammatory settings. Eosinophil development in the &#8230; <a title=\"Cytokine networks driving eosinophil functional heterogeneity. James I King\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king\/\" aria-label=\"Read more about Cytokine networks driving eosinophil functional heterogeneity. James I King\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1780328\">Targeting the miR-32533\/CREB5 axis: a promising immunomodulatory and therapeutic strategy for Alzheimer\u2019s disease<\/a><div class=\"wp-block-latest-posts__post-author\">by Lizhen Li<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1776159\">Bile acid metabolomics reveals distinct immunometabolic niches and enables accurate diagnosis of AQP4-IgG\u2013seronegative NMOSD<\/a><div class=\"wp-block-latest-posts__post-author\">by Zixin Chen<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Background and ObjectiveDifferentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is clinically difficult, especially when patients are seronegative for anti\u2013aquaporin-4 immunoglobulin G (AQP4-IgG). Bile acids (BAs) fu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1803771\">Malignant reninoma with pulmonary metastasis and ATRX mutation treated with olaparib: a case report of specialized treatment<\/a><div class=\"wp-block-latest-posts__post-author\">by Guo run Zi<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We report a rare case of 32-year-old female with malignant reninoma complicated by pulmonary metastasis and ATRX mutation (p.G1964*, VAF 23.73%), initially misdiagnosed as renal pelvic carcinoma and treated with radical left nephrectomy and ureterectom&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1820374\">Epigenetics: the master switch of nasopharyngeal carcinoma invasion and metastasis<\/a><div class=\"wp-block-latest-posts__post-author\">by Hongpeng Chen<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy that is highly prevalent in endemic regions. Epigenetic dysregulation, including aberrant DNA\/RNA\/protein methylation, histone modifications, and non-coding RNA networks, contributes to NP&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1766685\">Genetic variants associated with Sj\u00f6gren\u2019s disease subtypes stratified by clinical feature<\/a><div class=\"wp-block-latest-posts__post-author\">by Nitesh Enduru<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionSj\u00f6gren\u2019s disease (SjD) is a chronic autoimmune disorder characterized by dry mouth (xerostomia) and dry eyes (xerophthalmia) due to inflammation in exocrine glands, particularly the salivary and lacrimal glands. The condition presents a wi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1769749\">Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B<\/a><div class=\"wp-block-latest-posts__post-author\">by Fangfang Li<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundChronic hepatitis B (CHB) caused by the hepatitis B virus (HBV) remains a major global health burden. The immune-active (IA) phase, characterized by positive Hepatitis B surface antigens (HBsAg), elevated alanine transaminase (ALT) levels, an&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1819473\">Case Report: triple therapy with pembrolizumab, ipilimumab, and lenvatinib in mitotane- and radiation-refractory, cortisol-secreting stage IV adrenocortical carcinoma: a genomically guided approach<\/a><div class=\"wp-block-latest-posts__post-author\">by Afif Nakhleh<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options following the failure of standard adjuvant therapies. We present a 54-year-old female with stage IV cortisol-secreting ACC that progressed despite radical adrenalectom&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1820173\">The lipid\u2013inflammation axis in rosacea: mechanistic insights and therapeutic implications<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaoyu Zhang<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Rosacea is a chronic inflammatory skin disorder primarily characterized by persistent facial erythema, episodic flushing, papules and pustules, as well as phymatous changes. Despite extensive research, the pathogenesis of rosacea has not yet been fully&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1840165\">Investigate the heterogeneity of colorectal cancer patients at the single-cell level prior to and subsequent to immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Heng Zhao<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundImmune checkpoint blockade (ICB) has improved outcomes for a subset of colorectal cancer (CRC) patients, yet the cellular determinants that drive heterogeneous treatment responses remain insufficiently understood. The extent to which ICB resh&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1828994\">Human neutrophils recognize group B streptococci via formylated peptide receptors and toll-like receptor 8<\/a><div class=\"wp-block-latest-posts__post-author\">by Luigi Fiore<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionNeutrophils, the most abundant leukocyte population, play a central role in host defense against group B Streptococcus (GBS), an encapsulated bacterium that frequently causes severe infections in humans, including sepsis and meningitis. How&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1812964\">Baicalin suppresses colorectal cancer proliferation and induces M1 polarization of tumor-associated macrophages by promoting proteasomal degradation of HK2<\/a><div class=\"wp-block-latest-posts__post-author\">by Dong-hui Bai<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Colorectal cancer (CRC) ranks as the third most diagnosed cancer and the second leading cause of cancer-related mortality globally. Hexokinase II, a key rate-limiting enzyme in tumor glycolysis, is an important therapeutic target. In this study, we rep&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1796820\">Metabolomics discover distinct metabolite profiles in children with different airway allergic diseases<\/a><div class=\"wp-block-latest-posts__post-author\">by Yida Zhang<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Allergic rhinitis (AR), asthma, and their combined allergic rhinitis and asthma syndrome (CARAS) frequently coexist. However, the underlying pathophysiological and metabolic mechanisms, as well as reliable diagnostic differentiation, remain challenging&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1830866\">Long-term anakinra therapy in Schnitzler syndrome: real-world evidence on remission of neutrophilic dermatitis and systemic inflammation, safety, biomarker insights and dose optimization<\/a><div class=\"wp-block-latest-posts__post-author\">by Mariusz Sikora<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionSchnitzler syndrome (SchS) is a rare, late-onset, acquired autoinflammatory disorder characterized by recurrent urticarial lesions, monoclonal gammopathy and systemic inflammation. Although interleukin-1 (IL-1) blockade with anakinra is con&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1808815\">Exhausted CD4+T cells are associated with CCL4-driven immunosuppressive macrophage accumulation in enzootic bovine leukosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Hayato Nakamura<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In enzootic bovine leukosis (EBL), a B-cell lymphoma caused by bovine leukemia virus (BLV) infection, immune remodeling within tumor-affected lymph nodes is currently poorly understood. Here, we analyzed chemokine production and macrophage phenotypes i&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1673871\">Prevalence of female sexual dysfunction among women with systemic lupus erythematosus: a systematic review and meta-analysis<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaowei Dai<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundThe prevalence of female sexual dysfunction (FSD) among women with systemic lupus erythematosus (SLE) is inconsistent, and whether SLE is a risk factor for FSD among women remains controversial. Therefore, this study aimed to conduct a system&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1847070\">Editorial: Interactions among immune cells in leishmaniasis: exploring markers, enzymes and cytokines<\/a><div class=\"wp-block-latest-posts__post-author\">by Herbert Leonel de Matos Guedes<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1799675\">The mechanism of gut microbiota in septic cardiomyopathy based on the bulk transcriptome and Mendelian randomization analysis<\/a><div class=\"wp-block-latest-posts__post-author\">by Yuxia Tao<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundSeptic cardiomyopathy (SCM) is one of the most common and serious complications of sepsis. Earlier research has identified reciprocal regulation between SCM and gut microbiota (GM), but the mechanistic basis of GM in SCM development remains o&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1820004\">Characteristics of peripheral blood neutrophil subsets in patients with primary Sjogren\u2019s syndrome based on single-cell RNA sequencing<\/a><div class=\"wp-block-latest-posts__post-author\">by Zhaomeng Gao<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundNeutrophils, which are polymorphonuclear leukocytes of the phagocytic system, serve as critical mediators of inflammation-induced injury and are implicated in various diseases. However, the role of neutrophils in primary Sj\u00f6gren\u2019s syndrome (p&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1744480\">Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study<\/a><div class=\"wp-block-latest-posts__post-author\">by Chao Li<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundSleep disruption(SD) has been shown to amplify inflammatory signaling and promote pain hypersensitivity, but how inflammation interacts with brain functional alterations to drive pain sensitization remains unclear. This study therefore aims t&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1787799\">De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection<\/a><div class=\"wp-block-latest-posts__post-author\">by Sergio Sanhueza<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundGlucose metabolism disorders (GMDs) are established risk factors for severe COVID-19, but increasing evidence indicates that they may also develop de novo after SARS-CoV-2 infection. Neutrophil extracellular trap formation (NETosis) plays a c&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1798455\">Case Report: Treatment of refractory lung disease in systemic juvenile idiopathic arthritis with cyclophosphamide and rituximab combination therapy<\/a><div class=\"wp-block-latest-posts__post-author\">by William J. Freeman<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionSystemic juvenile idiopathic arthritis-associated lung disease (sJIA-LD) is a rare, potentially fatal complication of sJIA, often accompanied by pulmonary hypertension (PHTN) and macrophage activation syndrome (MAS). The underlying pathophy&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1806088\">Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic<\/a><div class=\"wp-block-latest-posts__post-author\">by Siyao Ma<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance in lung cancer. Flavonoid compone&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1809668\">Revisiting B-cell targeted therapies in rheumatoid arthritis: from paradoxical biology to deep immune reset<\/a><div class=\"wp-block-latest-posts__post-author\">by Min Huang<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Targeted B-cell depletion via the anti-CD20 monoclonal antibody rituximab fundamentally altered the therapeutic algorithm for rheumatoid arthritis (RA). Despite its clinical entrenchment, approximately 40% of patients exhibit primary or secondary non-r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1642583\">Cytokine release syndrome after allogeneic hematopoietic stem cell transplantation using posttransplant cyclophosphamide: current understanding and management<\/a><div class=\"wp-block-latest-posts__post-author\">by Jiasheng Wang<\/div><time datetime=\"2026-05-04T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Post-transplant cyclophosphamide (PTCy) is increasingly used for graft-versus-host disease (GVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (alloHCT), across both haploidentical and HLA-matched donor settings. However, PTCy-base&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/chronic-chagas-disease-and-type-2-diabetes-comorbidity-the-scenario-in-which-two-differently-driven-inflammatory-mechanisms-meet-brenda-dinatale\/\">Chronic Chagas disease and type 2 diabetes comorbidity. The scenario in which two differently driven inflammatory mechanisms meet. Brenda Dinatale<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T00:32:54+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Semin Immunol. 2026 May 2;82:102028. doi: 10.1016\/j.smim.2026.102028. Online ahead of print. ABSTRACT Chagas disease (ChD) and Type 2 diabetes (T2D) originate from distinct etiological processes -infectious and metabolic, respectively- yet both share a chronic inflammatory and metabolic imbalance that profoundly impacts immune-endocrine homeostasis. Persistent Trypanosoma cruzi infection in ChD induces sustained immune activation, altered adrenal &#8230; <a title=\"Chronic Chagas disease and type 2 diabetes comorbidity. The scenario in which two differently driven inflammatory mechanisms meet. Brenda Dinatale\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/chronic-chagas-disease-and-type-2-diabetes-comorbidity-the-scenario-in-which-two-differently-driven-inflammatory-mechanisms-meet-brenda-dinatale\/\" aria-label=\"Read more about Chronic Chagas disease and type 2 diabetes comorbidity. The scenario in which two differently driven inflammatory mechanisms meet. Brenda Dinatale\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/03\/cooling-inflammation-through-metabolism-with-4-octyl-itaconate-hanna-f-vos-willenbockel\/\">Cooling inflammation through metabolism with 4-octyl itaconate. Hanna F Vo\u00df-Willenbockel<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-03T12:22:11+02:00\" class=\"wp-block-latest-posts__post-date\">3 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Trends Immunol. 2026 May 1:S1471-4906(26)00097-9. doi: 10.1016\/j.it.2026.04.004. Online ahead of print. ABSTRACT Itaconate is an immunomodulatory metabolite that links metabolism and inflammation. Li et al. uncover a mechanism by which itaconate and 4-octyl itaconate suppress cytokine signaling through the alkylation of tyrosine kinase 2 and Janus kinase 1. This study reveals a direct metabolic control &#8230; <a title=\"Cooling inflammation through metabolism with 4-octyl itaconate. Hanna F Vo\u00df-Willenbockel\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/03\/cooling-inflammation-through-metabolism-with-4-octyl-itaconate-hanna-f-vos-willenbockel\/\" aria-label=\"Read more about Cooling inflammation through metabolism with 4-octyl itaconate. Hanna F Vo\u00df-Willenbockel\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/02\/outcome-measures-in-systemic-lupus-erythematosus\/\">Outcome measures in systemic lupus erythematosus<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-02T06:53:47+02:00\" class=\"wp-block-latest-posts__post-date\">2 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 Apr 30;100:102782. doi: 10.1016\/j.coi.2026.102782. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by fluctuating multisystem involvement, relapsing-remitting activity, and substantial risk of irreversible organ damage. Standardized disease activity indices have facilitated clinical trials and research, yet integration into clinical practice has not occurred for &#8230; <a title=\"Outcome measures in systemic lupus erythematosus\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/02\/outcome-measures-in-systemic-lupus-erythematosus\/\" aria-label=\"Read more about Outcome measures in systemic lupus erythematosus\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/02\/scaling-immunity-sickness-as-a-host-defense-strategy-a-clare-sparling\/\">Scaling immunity: sickness as a host defense strategy. A Clare Sparling<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-02T06:53:43+02:00\" class=\"wp-block-latest-posts__post-date\">2 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Trends Immunol. 2026 Apr 30:S1471-4906(26)00076-1. doi: 10.1016\/j.it.2026.03.015. Online ahead of print. ABSTRACT Sickness, or sickness behavior, is a state of altered physiology and behavior generated by the brain-immune axis during infection, which is generally assumed to contribute to host defense. Here, we examine this assumption by framing sickness as organismal-scale immunity and explore predicted parallels &#8230; <a title=\"Scaling immunity: sickness as a host defense strategy. A Clare Sparling\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/02\/scaling-immunity-sickness-as-a-host-defense-strategy-a-clare-sparling\/\" aria-label=\"Read more about Scaling immunity: sickness as a host defense strategy. A Clare Sparling\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01306-1\">Freedom of scientific inquiry: reclaiming space for controversy<\/a><div class=\"wp-block-latest-posts__post-author\">by Akiko Iwasaki<\/div><time datetime=\"2026-05-01T16:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 01 May 2026; doi:10.1038\/s41577-026-01306-1No matter how small the possibility, or how inconvenient the topic, scientists must maintain the humility to acknowledge that we could be wrong. Ou&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciimmunol.aei2832?af=R\">B cells gone broad: A deep dive into SARS-CoV-2 antibody breadth<\/a><div class=\"wp-block-latest-posts__post-author\">by Easton E. Ford and Melissa L. Smith<\/div><time datetime=\"2026-05-01T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Science Immunology, Volume 11, Issue 119, May 2026. <\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciimmunol.aei2411?af=R\">A parasite partner for regulatory affairs<\/a><div class=\"wp-block-latest-posts__post-author\">by Isabella O. Conway and Christopher A. Hunter<\/div><time datetime=\"2026-05-01T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Science Immunology, Volume 11, Issue 119, May 2026. <\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciimmunol.aed2111?af=R\">Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-01T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Science Immunology, Volume 11, Issue 119, May 2026. <\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciimmunol.aeg4759?af=R\">Foxp3: The epigenetic engineer of regulatory T cell identity<\/a><div class=\"wp-block-latest-posts__post-author\">by Mieke Metzemaekers and Ralph Stadhouders<\/div><time datetime=\"2026-05-01T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Science Immunology, Volume 11, Issue 119, May 2026. <\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciimmunol.adz0348?af=R\">Citraconate preserves T cell stemness and antitumor immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-01T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Science Immunology, Volume 11, Issue 119, May 2026. <\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/01\/optimal-donor-selection-for-transplant-to-reduce-gvhd-risk-and-augment-graft-versus-malignancy-efficacy\/\">Optimal donor selection for transplant to reduce GVHD risk and augment graft-versus-malignancy efficacy<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-01T07:24:02+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 Apr 29;100:102783. doi: 10.1016\/j.coi.2026.102783. Online ahead of print. ABSTRACT Allogeneic hematopoietic cell transplantation (alloHCT) is curative for many patients with high-risk, hematologic malignancies. AlloHCT depends on a graft versus malignancy (GVM) phenomenon, whereby donor-derived immune cells recognize and eradicate malignant host cells. Successful GVM correlates with the risk of alloreactivity against &#8230; <a title=\"Optimal donor selection for transplant to reduce GVHD risk and augment graft-versus-malignancy efficacy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/01\/optimal-donor-selection-for-transplant-to-reduce-gvhd-risk-and-augment-graft-versus-malignancy-efficacy\/\" aria-label=\"Read more about Optimal donor selection for transplant to reduce GVHD risk and augment graft-versus-malignancy efficacy\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1727925\">Cladribine treatment in pediatric-onset multiple sclerosis: real-world clinical outcomes and safety insights<\/a><div class=\"wp-block-latest-posts__post-author\">by Esther Ganelin-Cohen<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionPediatric-onset multiple sclerosis (POMS) poses unique therapeutic challenges due to high inflammatory activity, early cognitive and psychosocial impact, and difficulties with long-term treatment adherence. This retrospective cohort study e&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1822567\">Exploring the mechanism by which modified huangqi chifeng decoction protects podocytes via Arid5a-mediated transcriptional regulation of the AIM2 pyroptosis signaling axis<\/a><div class=\"wp-block-latest-posts__post-author\">by Mingming Zhao<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundChronic kidney disease (CKD) is a major global health burden with substantial morbidity and mortality. Proteinuria is strongly associated with adverse renal outcomes, and podocyte pyroptosis is increasingly recognized as a key driver of glome&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1805196\">Case Report: Sustained immune and pulmonary recovery three years after hematopoietic stem cell transplantation for ITCH E3 ubiquitin ligase deficiency<\/a><div class=\"wp-block-latest-posts__post-author\">by Brittany Ashe<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundItchy E3 ubiquitin ligase deficiency (ITCH deficiency) is a rare monogenic immune dysregulation syndrome characterized by early-onset multisystem autoimmunity and significant morbidity and mortality. Only one prior case report has described a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1777957\">Case Report: Long-term survival in advanced PD-L1-high squamous cell lung cancer following severe immune-related cardiotoxicity<\/a><div class=\"wp-block-latest-posts__post-author\">by Qi-Qing Zhang<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The introduction of immune checkpoint inhibitors (ICIs) has reshaped the therapeutic landscape of advanced non-small cell lung cancer. However, immune-related adverse events (irAEs), including rare cases of life-threatening cardiotoxicity, pose a signi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1739946\">Comparative effectiveness and safety of biologics and targeted small-molecule therapies plus stable background therapy in systemic lupus erythematosus: a systematic review and network meta-analysis<\/a><div class=\"wp-block-latest-posts__post-author\">by Wenjuan Li<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveTo compare the efficacy and safety of biologics and targeted small molecule drugs plus stable background therapy for the systemic lupus erythematosus (SLE).MethodsA systematic search was conducted across PubMed, EMBASE and Cochrane Library for&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1840386\">Persistent residual inflammatory risk at 1 month after contemporary PCI: rationale for routine hsCRP reassessment and dual-target therapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Xinwang Gong<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Despite major advances in lipid-lowering therapy and stent technology, a substantial proportion of patients undergoing contemporary percutaneous coronary intervention (PCI) experience recurrent major adverse cardiovascular events (MACE) driven by persi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1776849\">The long noncoding RNA lnc-FAM164A1-ACLY axis promotes pro-inflammatory responses in human primary macrophages: a systems approach<\/a><div class=\"wp-block-latest-posts__post-author\">by Jian-Guo Wang<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionMacrophages play a key role in inflammatory diseases. We aimed to identify long noncoding RNAs that regulate pro-inflammatory activation of human macrophages. MethodsWe performed human lncRNA microarray analysis in LPS-stimulated primary hu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1784630\">A dynamic vascular\u2013inflammatory\u2013fibrotic loop in systemic sclerosis: an integrative immuno-vascular framework<\/a><div class=\"wp-block-latest-posts__post-author\">by Razvan Constantin Ionitescu<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundSystemic sclerosis (SSc) is characterized by a complex and heterogeneous interplay between vascular dysfunction, immune activation, and progressive fibrosis. Despite advances in molecular characterization, therapeutic\u00a0responses remain inconsi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1797975\">Fc-mediated antibody functions are associated with disease severity in COVID-19<\/a><div class=\"wp-block-latest-posts__post-author\">by Sungim Choi<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionFc-mediated antibody effector functions play key roles in both antiviral immunity and immunopathology in COVID-19. While antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC) contribute to patho&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1787836\">Navigating renal safety in the biologic treatment of psoriasis: from immunologic mechanisms to clinical practice<\/a><div class=\"wp-block-latest-posts__post-author\">by Zijie Tang<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Psoriasis is a common chronic inflammatory skin disorder frequently accompanied by multisystem involvement, with increasing concern regarding its association with renal impairment. The advent and widespread use of biologic agents in the treatment of mo&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1806864\">MicroRNA-based integrated diagnosis and therapy for GBM: current status and advances<\/a><div class=\"wp-block-latest-posts__post-author\">by Ye Chen<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Glioblastoma (GBM) is the most common and aggressive type of central nervous system cancer, characterized by high rates of recurrence and mortality. As the highest-grade glioma, patient prognosis remains poor despite multimodal interventions including &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1807421\">Case Report: Different faces of LRBA deficiency in five Moroccan families<\/a><div class=\"wp-block-latest-posts__post-author\">by Mohamed Hbibi<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency belonging to the spectrum of common variable immunodeficiency disorders, frequently associated with immune dysregulation, autoimmunity, and lymphoproliferation. It&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1819885\">Treatment for intermediate and advanced-stage hepatocellular carcinoma: does systemic therapy synergize the therapeutic efficacy of TACE?<\/a><div class=\"wp-block-latest-posts__post-author\">by Zhuo Li<\/div><time datetime=\"2026-05-01T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">1 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundTransarterial chemoembolization (TACE) is a standard treatment for intermediate-stage hepatocellular carcinoma (HCC), but its efficacy varies due to patient heterogeneity. Combining TACE with systemic therapies, such as targeted agents or imm&#8230;<\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16925","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16925"}],"version-history":[{"count":2,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16925\/revisions"}],"predecessor-version":[{"id":16927,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16925\/revisions\/16927"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}