{"id":16925,"date":"2024-09-29T10:16:37","date_gmt":"2024-09-29T08:16:37","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16925"},"modified":"2024-09-29T10:17:54","modified_gmt":"2024-09-29T08:17:54","slug":"seminars-in-immunology","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/seminars-in-immunology\/","title":{"rendered":"Seminars in Immunology"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/multinucleated-giant-cells-in-human-pancreatic-cancer-are-a-distinct-macrophage-population-undergoing-a-dna-damage-response-and-associated-with-an-aggressive-tumor-microenvironment\/\">Multinucleated giant cells in human pancreatic cancer are a distinct macrophage population undergoing a DNA damage response and associated with an aggressive tumor microenvironment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T19:23:12+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cancer Immunol Res. 2026 Jun 30. doi: 10.1158\/2326-6066.CIR-25-1602. Online ahead of print. ABSTRACT Macrophages constitute a dominant and functionally diverse immune population within the microenvironment of pancreatic ductal adenocarcinoma (PDAC), yet how macrophage heterogeneity contributes to the tumor remains poorly defined. In an institutional cohort of 145 PDAC specimens, we identified a population of multinucleated &#8230; <a title=\"Multinucleated giant cells in human pancreatic cancer are a distinct macrophage population undergoing a DNA damage response and associated with an aggressive tumor microenvironment\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/multinucleated-giant-cells-in-human-pancreatic-cancer-are-a-distinct-macrophage-population-undergoing-a-dna-damage-response-and-associated-with-an-aggressive-tumor-microenvironment\/\" aria-label=\"Read more about Multinucleated giant cells in human pancreatic cancer are a distinct macrophage population undergoing a DNA damage response and associated with an aggressive tumor microenvironment\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e014808?rss=1\">Metabolic inhibition of glutamate-cysteine ligase increases dendritic cell-mediated antitumor immunity in melanoma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T13:24:31+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nMetabolic competition and nutrient restriction in the tumor microenvironment (TME) shape the immune infiltrate in tumors and subsequently tumor immunity. In this study we used the transgenic melanoma mouse model tg(Grm1)EPv, which spontaneo&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/distinct-lymphocyte-immune-signatures-to-nivolumab-and-recombinant-il-7-ex-vivo-in-patients-with-sepsistimothy-arthur-chandos-snow-on-30-de-june-de-2026-at-1000\/\">Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis\u200bTimothy Arthur Chandos Snow   on 30 de June de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T13:14:25+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 Jun 8;118(6):qiag057. doi: 10.1093\/jleuko\/qiag057. ABSTRACT Therapeutic modulation of sepsis-induced immune dysfunction by targeting lymphocyte dysfunction with recombinant IL-7 (rIL-7) and anti-PD-1 (e.g. nivolumab) has shown promise in preclinical and early clinical studies. Prior to conducting large randomized controlled trials, an in-depth understanding of the changes induced by rIL-7 or nivolumab (and &#8230; <a title=\"Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis\u200bTimothy Arthur Chandos Snow   on 30 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/distinct-lymphocyte-immune-signatures-to-nivolumab-and-recombinant-il-7-ex-vivo-in-patients-with-sepsistimothy-arthur-chandos-snow-on-30-de-june-de-2026-at-1000\/\" aria-label=\"Read more about Distinct lymphocyte immune signatures to nivolumab and recombinant IL-7 ex vivo in patients with sepsis\u200bTimothy Arthur Chandos Snow   on 30 de June de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01333-y\">Glycolytic capacity instructs tumour vasculature and response to immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Giang Pham<\/div><time datetime=\"2026-06-30T12:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038\/s41577-026-01333-yA preprint by Serganova, Colombo et al. shows that tumour glycolytic capacity drives vascular abnormalities that influence the response to immunot&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01332-z\">Vaginal NK cells limit epithelial barrier disruption during infection<\/a><div class=\"wp-block-latest-posts__post-author\">by Rameen Jamil<\/div><time datetime=\"2026-06-30T12:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038\/s41577-026-01332-zA preprint by Vick et al. reports a crucial role for vaginal NK cells in maintaining epithelial integrity during infection.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/yefis-3rd-symposium-29th-june-1st-july-2026-prague-czech-republic\/\">yEFIS 3rd Symposium, 29th June\u20131st July, 2026, Prague, Czech Republic.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T10:10:33+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue S1, June 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01328-9\">New insights into progenitor exhausted T cell populations<\/a><div class=\"wp-block-latest-posts__post-author\">by Rafi Ahmed<\/div><time datetime=\"2026-06-30T10:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038\/s41577-026-01328-9In this Viewpoint, eight experts from the field of T cell exhaustion discuss current understanding of the self-renewing population of PD1+TCF1+TOX&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01318-x\">T cell engagers in autoimmune diseases<\/a><div class=\"wp-block-latest-posts__post-author\">by Ricardo Grieshaber-Bouyer<\/div><time datetime=\"2026-06-30T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038\/s41577-026-01318-xT cell engagers reprogramme T cells to eliminate pathogenic cell populations and are now emerging as a promising biologic strategy for autoimmune &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/antigen-presenting-cancer-associated-fibroblasts-in-murine-pancreatic-tumors-differentially-regulate-t-cell-phenotype-and-function\/\">Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T07:07:53+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag165. doi: 10.1093\/jimmun\/vkag165. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) in which cancer-associated fibroblasts (CAFs) play pivotal roles in shaping therapeutic responses. Among these, MHC-II-expressing antigen-presenting CAFs (apCAFs) modulate CD4 T-cell activity, yet their contribution to the antitumor immune response remains unclear. Using tumor clones &#8230; <a title=\"Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/antigen-presenting-cancer-associated-fibroblasts-in-murine-pancreatic-tumors-differentially-regulate-t-cell-phenotype-and-function\/\" aria-label=\"Read more about Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1868642\">Highly sensitized kidney transplant candidates: integrating acceptable mismatch, desensitization, imlifidase, and emerging immune-cell targeting strategies<\/a><div class=\"wp-block-latest-posts__post-author\">by Stefan Reuter<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Highly sensitized kidney transplant candidates are difficult to transplant because anti-human leukocyte antigen (HLA) sensitization restricts access to immunologically compatible organs, as transplantation across donor-specific antibodies (DSA) increas&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1855941\">Deciphering host\u2013virus interaction networks in ALV infection: an integrative multi-omics perspective<\/a><div class=\"wp-block-latest-posts__post-author\">by Junliang Xia<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Avian leukosis virus (ALV) remains a major threat to the poultry industry due to its ability to establish persistent infection, induce immunosuppression, and promote tumorigenesis. Despite progress in eradication programs, effective control is hindered&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1863502\">A rare case report: The impact of Mycobacterium colombiense localized infections in a person living with HIV\/AIDS<\/a><div class=\"wp-block-latest-posts__post-author\">by Lurun Wang<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Individuals living with HIV\/AIDS may be more susceptible to various opportunistic infections due to an immunocompromised status, which can result in diverse clinical manifestations. Among potential pathogens, Mycobacterium colombiense\u2014a slow-growing ba&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1878207\">Lipidomics of HIV\/HCV-related liver decompensation: association between plasma lipid depletion and immune dysregulation<\/a><div class=\"wp-block-latest-posts__post-author\">by Raquel Behar-Lagares<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionGlobally, 15-30% of patients with chronic hepatitis C develop compensated advanced chronic liver disease (cACLD). cACLD may further advance to decompensated ACLD (dACLD), which is associated with higher liver-related mortality, even after s&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1849927\">Systemic skewing of peripheral blood leukocyte composition in neurofibromatosis type 1<\/a><div class=\"wp-block-latest-posts__post-author\">by Yoshimasa Nobeyama<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundThe present study aimed to characterize neurofibromatosis type 1 (NF1)-associated alterations in peripheral white blood cell differentials, focusing on overall patterns and sex-related differences.MethodsWe analyzed 225 Japanese patients with&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1845415\">Paratuberculosis: a mucosal immunology perspective<\/a><div class=\"wp-block-latest-posts__post-author\">by Itzel Aguilar-Lopez<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Johne\u2019s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteric infection of ruminants characterized by persistence in intestinal macrophages following invasion through Peyer\u2019s patches. Early studies established a pre&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1860332\">Natural therapeutics and traditional formulas targeting macrophage polarization in the fibrotic niche of idiopathic pulmonary fibrosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Lei Han<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease driven by a self-perpetuating \u201cfibrotic niche,\u201d where monocyte-derived alveolar macrophages (Mo-AMs) regulate disease progression. Conventional single-target antifibrotics s&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1863714\">Admission complete blood count-derived inflammatory indices for risk stratification in hemorrhagic fever with renal syndrome: comparative performance of NLR, PLR, SII, LMR, and the neutrophil-to-red blood cell ratio<\/a><div class=\"wp-block-latest-posts__post-author\">by Zhuoran Xiao<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundHemorrhagic fever with renal syndrome (HFRS) requires early risk stratification, yet the comparative value and reproducibility of complete blood count (CBC)-derived inflammatory indices remain unclear. We compared admission neutrophil-to-lymp&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1864405\">Systematic pan-cancer analysis reveals context-dependent prognostic and immunological roles of WDR1 with divergent effects in renal and gastric cancers<\/a><div class=\"wp-block-latest-posts__post-author\">by Qiu-shuang Li<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundWD-repeat domain 1 (WDR1), a key regulator of actin cytoskeleton dynamics, has been implicated in tumor progression. However, its pan-cancer characteristics and immunological relevance remain unclear. In this study, we performed an integrativ&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1760434\">Iron overload disrupts bone homeostasis via TfR1-dependent ferroptosis and cGAS\/STING-driven pyroptosis in pyogenic spondylitis<\/a><div class=\"wp-block-latest-posts__post-author\">by Wenchao Xu<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionPyogenic spondylitis (PS) accompanies with diverse destruction, especially the subsequent bone destruction, which leads to spine instability and severe neurological disability. However, the mechanism underlying bone loss induced by infectio&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1884478\">Macrophage polarization in gynecologic malignancies: key signaling pathways and clinical perspectives<\/a><div class=\"wp-block-latest-posts__post-author\">by Qian He<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Gynecological malignancies represent a significant global health burden for women worldwide. Tumor-associated macrophages (TAMs), as a critical component of the immune system, play a pivotal role within the tumor microenvironment (TME). Modulating sign&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1830162\">Downregulation of CD200 in the placenta of preeclampsia: a potential regulator of macrophage-mediated immune imbalance at the maternal-fetal interface<\/a><div class=\"wp-block-latest-posts__post-author\">by Shuzhen Huang<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveTo investigate the role and potential mechanism of CD200 in the pathogenesis of preeclampsia (PE) and to clarify its potential value as a biomarker candidate and possible therapeutic target for PE.MethodsThis retrospective study enrolled 57 pa&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1843611\">State-of-the-art of the high dose influenza vaccine in Spain<\/a><div class=\"wp-block-latest-posts__post-author\">by Iv\u00e1n Sanz-Mu\u00f1oz<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">High-dose (HD) influenza vaccines have demonstrated robust effectiveness in preventing severe influenza-related outcomes, including pneumonia, cardiorespiratory complications, and mortality, with evidence from randomized clinical trials, meta-analyses,&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1766393\">Alterations in the gut microbiota are associated with changes in intestinal antibody production in KK-Ay mice developing type 2 diabetes<\/a><div class=\"wp-block-latest-posts__post-author\">by Miho Chikazawa<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionType 2 diabetes mellitus (T2DM) develops due to multiple factors, including dietary and lifestyle habits and genetic predisposition. In addition, alterations in the immune system have been suggested to be involved in the onset and progressi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1872267\">IL-1 polymorphisms modulates functional recovery following rehabilitation in multiple sclerosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Cristina Agliardi<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundInterleukin-1 (IL-1) cytokines as well as IL-1 genes are key regulators of neuroinflammation in Multiple Sclerosis (MS), with emerging roles in synaptic plasticity and tissue repair. While genetic determinants of MS susceptibility have been e&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1777092\">Glycolysis-mediated H3K18la modifications drive aggressive bladder cancer through metabolic and epigenetic reprogramming<\/a><div class=\"wp-block-latest-posts__post-author\">by Zhan Wang<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundMetabolic reprogramming and epigenetic alterations contribute to the aggressiveness of human bladder cancer (BC). Lactate-dependent histone modification represents a novel class of histone marks that links the glycolytic metabolite to the epi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1882728\">Honokiol potentiates low-dose sulfamonomethoxine sodium against antimicrobial-resistant AHPND-causing Vibrio parahaemolyticus through bacterial membrane disruption and host recovery<\/a><div class=\"wp-block-latest-posts__post-author\">by Yihuan Chen<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Acute hepatopancreatic necrosis disease (AHPND), caused by Vibrio parahaemolyticus, poses a severe threat to global shrimp aquaculture. Reduced susceptibility of aquaculture-associated bacterial pathogens to conventional antibiotics,\u00a0together with conc&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1884482\">Tumor-intrinsic immune-genetic dynamics identify RNASE1 as an immune-evasion-associated biomarker and predictor of checkpoint blockade response in gastric adenocarcinoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Haoyun Xia<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Although immune checkpoint blockade (ICB) has changed treatment strategies for gastric adenocarcinoma (STAD), many patients show primary resistance. Tumor-intrinsic transcriptional heterogeneity may contribute to immune escape, but the malignant-cell p&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1913475\">Editorial: Community series in primary immunodeficiencies worldwide, volume III<\/a><div class=\"wp-block-latest-posts__post-author\">by Hirokazu Kanegane<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1861052\">Prophylactic and post-exposure efficacy of a Pichinde virus vector-based tuberculosis vaccine<\/a><div class=\"wp-block-latest-posts__post-author\">by Michaela Cain<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mycobacterium tuberculosis (Mtb) remains the leading cause of death from a single infectious agent, despite the availability of the Bacillus Calmette-Gu\u00e9rin (BCG) vaccine and antibiotic therapies. New tuberculosis (TB) vaccines are urgently needed to e&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1907859\">Editorial: Characterising the functional heterogeneity of synovial macrophages<\/a><div class=\"wp-block-latest-posts__post-author\">by Anna B. Montgomery<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1859167\">Breaking the resistance barrier: synergistic evolution of CAR-T cells and bispecific antibodies in the era of precision immuno-oncology<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaoqiang Wang<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The therapeutic landscape of oncology has undergone a profound paradigm shift, transitioning from conventional cytotoxic regimens to a sophisticated era of precision immunotherapy. Despite the remarkable clinical success of immune checkpoint inhibitors&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1859721\">Perspective: Hormones and immune development: bidirectional regulation between thyroid hormones and the immune system<\/a><div class=\"wp-block-latest-posts__post-author\">by Weiling Zhang<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The immune system operates within a dynamic physiological environment shaped by systemic regulatory signals, among which endocrine factors are increasingly recognized as important modulators of immune function. Although thyroid hormones are well known &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1821015\">Pagetoid reticulosis (Woringer\u2013Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review<\/a><div class=\"wp-block-latest-posts__post-author\">by Yansi Lyu<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Pagetoid reticulosis (PR), also known as Woringer\u2013Kolopp disease (WKD), is a rare subtype of cutaneous T-cell lymphoma. Due to its low incidence and non-specific clinical presentation, it is frequently prone to misdiagnosis. We report the case of a 53-&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1808904\">Skin barrier dysfunction and correlation with the onset and progression of psoriasis<\/a><div class=\"wp-block-latest-posts__post-author\">by Ying Wang<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The skin barrier serves as the body\u2019s primary line of defense against exogenous insults and is critical for maintaining systemic homeostasis. Emerging evidence indicates that skin barrier dysfunction is not merely a secondary manifestation of psoriasis&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1842528\">Wnt\/\u03b2-Catenin\u2013mTOR\u2013autophagy crosstalk in breast cancer: context-dependent control of tumor progression, immune suppression, and therapeutic resistance<\/a><div class=\"wp-block-latest-posts__post-author\">by Jian Zhang<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Autophagy plays paradoxical roles in breast cancer, functioning as both a stress-adaptive survival mechanism and a tumor-suppressive process depending on cellular and microenvironmental context. However, the molecular logic governing this functional du&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1726732\">Association between OLD and IBD: a systematic review and meta-analysis<\/a><div class=\"wp-block-latest-posts__post-author\">by Chaowei Ding<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveThis study aimed to systematically evaluate the bidirectional association between obstructive lung diseases (OLD) [including chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis] and inflammatory bowel disease (IBD) [includ&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1863009\">Nivolumab in previously treated metastatic renal cell carcinoma: real-world data from the Czech Republic and Slovakia<\/a><div class=\"wp-block-latest-posts__post-author\">by Ond\u0159ej Fiala<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundImmune checkpoint inhibitors (ICIs) have become a cornerstone of treatment for metastatic renal cell carcinoma (mRCC). Nivolumab monotherapy remains an established option in previously treated patients; however, real-world data (RWD) from Cen&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1912152\">Editorial: Advancing immune research in chronic liver diseases through new approach methodologies<\/a><div class=\"wp-block-latest-posts__post-author\">by Sara Massironi<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1828445\">Persistent priming of hypothalamic microglia is associated with sensitization of the hypothalamic-pituitary-adrenal axis to acute stress, hyperactivity and behavioral response disruption in male rats<\/a><div class=\"wp-block-latest-posts__post-author\">by Ana Le\u00f3n-Rodr\u00edguez<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundCentral and peripheral inflammation are under intense investigation because of their increasing relationship with neuropsychiatric disorders and neurodegeneration. Microglia, the main component of the innate immune system within the brain, co&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1815163\">Integration of transcriptomic data reveals lipid metabolic heterogeneity and identifies GSTO1 as a therapeutic target in acute myeloid leukemia<\/a><div class=\"wp-block-latest-posts__post-author\">by Fangmin Zhong<\/div><time datetime=\"2026-06-30T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundAcute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor prognosis and significant heterogeneity. Lipid metabolic reprogramming is a key hallmark of cancer, yet its systemic characterization and clinical relevance in AML&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/a-blind-spot-of-human-t-cell-immunology-epitope-specificity-in-secondary-lymphoid-organs\/\">A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:34+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 Jun 29;101:102809. doi: 10.1016\/j.coi.2026.102809. Online ahead of print. ABSTRACT The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, phenotypic and metabolic plasticity, effector function, as well as the evolution of complex repertoires of T cell clones. However, &#8230; <a title=\"A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/a-blind-spot-of-human-t-cell-immunology-epitope-specificity-in-secondary-lymphoid-organs\/\" aria-label=\"Read more about A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/mhc-class-ii-on-melanoma-cells-regulates-the-anti-tumor-t-cell-response\/\">MHC class II on melanoma cells regulates the anti-tumor T cell response<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:28+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag158. doi: 10.1093\/jimmun\/vkag158. ABSTRACT In human melanoma, tumor cell-specific MHC class II expression is associated with improved response to programmed death 1 and programmed death-ligand 1 blockade; yet the direct effect of melanoma cell-specific MHC class II expression on anti-melanoma T cell responses remains largely unknown. In the clinically relevant Yale &#8230; <a title=\"MHC class II on melanoma cells regulates the anti-tumor T cell response\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/mhc-class-ii-on-melanoma-cells-regulates-the-anti-tumor-t-cell-response\/\" aria-label=\"Read more about MHC class II on melanoma cells regulates the anti-tumor T cell response\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/enpp1-dependent-usp2-ubiquitination-governs-sqstm1-mediated-autophagy-dependent-ferroptosis-in-trophoblast-cells-and-exacerbates-placental-dysfunction-in-gestational-diabetes-mellitus\/\">ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:28+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag127. doi: 10.1093\/jimmun\/vkag127. ABSTRACT Downregulation of ectonucleotide pyrophosphatase\/phosphodiesterase 1 (ENPP1) has been implicated in autophagic cell death. However, how ENPP1 regulates the interplay between autophagy and ferroptosis to maintain trophoblast homeostasis in the context of gestational diabetes mellitus (GDM) remains unclear. To determine ENPP1&#8217;s role in autophagy-dependent ferroptosis and its contribution &#8230; <a title=\"ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/enpp1-dependent-usp2-ubiquitination-governs-sqstm1-mediated-autophagy-dependent-ferroptosis-in-trophoblast-cells-and-exacerbates-placental-dysfunction-in-gestational-diabetes-mellitus\/\" aria-label=\"Read more about ENPP1-dependent USP2 ubiquitination governs SQSTM1-mediated autophagy-dependent ferroptosis in trophoblast cells and exacerbates placental dysfunction in gestational diabetes mellitus\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/eosinophil-essentials-identification-and-assessment-of-activitysarah-almas-on-29-de-june-de-2026-at-1000\/\">Eosinophil Essentials: Identification and Assessment of Activity\u200bSarah Almas   on 29 de June de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-30T01:00:20+02:00\" class=\"wp-block-latest-posts__post-date\">30 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 Jun 29:qiag091. doi: 10.1093\/jleuko\/qiag091. Online ahead of print. ABSTRACT Eosinophils are highly granulated white blood cells first identified as &#8220;granule blood cells&#8221; in the 19th century. In this review, we discuss techniques used to identify these unique cells and explore how they release a range of pro- and anti-inflammatory mediators. They &#8230; <a title=\"Eosinophil Essentials: Identification and Assessment of Activity\u200bSarah Almas   on 29 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/30\/eosinophil-essentials-identification-and-assessment-of-activitysarah-almas-on-29-de-june-de-2026-at-1000\/\" aria-label=\"Read more about Eosinophil Essentials: Identification and Assessment of Activity\u200bSarah Almas   on 29 de June de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/immune-cell-landscape-reveals-5-immune-related-subtypes-and-molecular-characteristics-with-prognostic-and-therapeutic-implications-in-pan-cancerhongjiu-wang-on-29-de-june-de-2026-at-1000\/\">Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer\u200bHongjiu Wang   on 29 de June de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-29T18:56:06+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 Jun 8;118(6):qiag062. doi: 10.1093\/jleuko\/qiag062. ABSTRACT The immunotherapy represents the most promising new cancer treatment approach but due to the high heterogeneity of the tumor microenvironment among patients, only a small portion of patients respond to a certain immunotherapy. Therefore, identifying the immune-related subtypes and immune molecular characteristics is of great guiding &#8230; <a title=\"Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer\u200bHongjiu Wang   on 29 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/immune-cell-landscape-reveals-5-immune-related-subtypes-and-molecular-characteristics-with-prognostic-and-therapeutic-implications-in-pan-cancerhongjiu-wang-on-29-de-june-de-2026-at-1000\/\" aria-label=\"Read more about Immune cell landscape reveals 5 immune-related subtypes and molecular characteristics with prognostic and therapeutic implications in pan-cancer\u200bHongjiu Wang   on 29 de June de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/high-dimensional-single-cell-mass-cytometry-analysis-of-il-4-treated-human-macrophages-reveals-heterogeneity-and-a-cd206high-anticolitic-subsetblanca-e-callejas-on-29-de-june-de-2026-at-10\/\">High-dimensional single-cell mass cytometry analysis of IL-4 treated human macrophages reveals heterogeneity and a CD206high anticolitic subset\u200bBlanca E Callejas   on 29 de June de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-29T18:56:06+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 Jun 8;118(6):qiag075. doi: 10.1093\/jleuko\/qiag075. ABSTRACT Autologous cell therapy is a patient-embraced approach to inflammatory disease. Murine models demonstrate that alternatively activated (or regulatory) macrophages can reduce the severity of disease, and human macrophages (M0) educated with interleukin-4 (M(IL4)) limit murine colitis. M0 and M(IL4) from healthy donors and individuals with Crohn&#8217;s &#8230; <a title=\"High-dimensional single-cell mass cytometry analysis of IL-4 treated human macrophages reveals heterogeneity and a CD206high anticolitic subset\u200bBlanca E Callejas   on 29 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/high-dimensional-single-cell-mass-cytometry-analysis-of-il-4-treated-human-macrophages-reveals-heterogeneity-and-a-cd206high-anticolitic-subsetblanca-e-callejas-on-29-de-june-de-2026-at-10\/\" aria-label=\"Read more about High-dimensional single-cell mass cytometry analysis of IL-4 treated human macrophages reveals heterogeneity and a CD206high anticolitic subset\u200bBlanca E Callejas   on 29 de June de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/fueling-immunotherapy-resistance-ssbp4-links-tumor-cholesterol-biosynthesis-to-immune-evasion\/\">Fueling Immunotherapy Resistance: SSBP4 Links Tumor Cholesterol Biosynthesis to Immune Evasion<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-29T18:56:06+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cancer Immunol Res. 2026 Jun 29:OF1-OF2. doi: 10.1158\/2326-6066.CIR-26-0635. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICI) have had a transformative impact on cancer treatment. However, many patients still fail to respond to ICIs, underscoring the need to identify novel drivers of resistance. In this issue, Ou and colleagues identify single-stranded DNA binding protein 4 &#8230; <a title=\"Fueling Immunotherapy Resistance: SSBP4 Links Tumor Cholesterol Biosynthesis to Immune Evasion\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/fueling-immunotherapy-resistance-ssbp4-links-tumor-cholesterol-biosynthesis-to-immune-evasion\/\" aria-label=\"Read more about Fueling Immunotherapy Resistance: SSBP4 Links Tumor Cholesterol Biosynthesis to Immune Evasion\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e015149?rss=1\">Guarding epithelial integrity: origins of adaptive immunity and cancer immunosurveillance over time and space<\/a><div class=\"wp-block-latest-posts__post-author\">by Wang, X.-S., Curtis, C., Lotze, M. T.<\/div><time datetime=\"2026-06-29T13:57:47+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nWhile conventionally viewed as a defense against external pathogens, we posit that the adaptive immune system likely evolved primarily to preserve internal epithelial order. We propose that adaptive immunity, with combinatorial diversity emerging ~0.5&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e015204?rss=1\">Pharmacokinetic variability with pembrolizumab dosage switching and its impact on immune-related adverse events in patients with non-small cell lung cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-29T13:57:47+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nPembrolizumab 400 mg every 6 weeks (Q6W) was approved based on population pharmacokinetic (pop-PK) modeling rather than pharmacokinetic measurements, leaving real-world concentrations insufficiently characterized. The impact of concentratio&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e015150?rss=1\">DEA hypothesis: disinhibition, enhancing recognition, and alerting the host are the three pillars of effective cancer immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Wang, X.-S., Lotze, M. T.<\/div><time datetime=\"2026-06-29T13:57:47+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nWhy are clonal neoantigens paradoxically rare in established tumors? Why does tumor-associated antigen (TAA) burden inversely correlate with T-cell infiltration? Why do damage-associated molecular pattern (DAMP)\/danger signal-inducing interventions (m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e014722?rss=1\">Chemotherapeutic induction of cytosolic single-stranded DNA accumulation sensitizes triple-negative breast cancer to immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Du, Y., Yang, L., Dai, H., Zhou, J., Zhou, Z., Yuan, R., Ye, R., Nguyen, A. T. Q., Bhatia, K., Lin, S.-Y.<\/div><time datetime=\"2026-06-29T13:57:47+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nDespite the widespread adoption of chemoimmunotherapy in triple-negative breast cancer (TNBC), the mechanisms by which cytotoxic chemotherapy engages antitumor immunity remain poorly defined. Identifying tumor-intrinsic immunogenic programs&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e003100corr1?rss=1\">Correction: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell<\/a><div class=\"wp-block-latest-posts__post-author\">by Journal for ImmunoTherapy of Cancer current issue<\/div><time datetime=\"2026-06-29T13:57:47+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/facial-dysmorphism-and-severe-vascular-phenotype-in-trnt1-deficiency-with-concomitant-antithrombin-iii-deficiency\/\">Facial Dysmorphism and Severe Vascular Phenotype in TRNT1 Deficiency with Concomitant Antithrombin III Deficiency<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-29T12:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Clin Immunol. 2026 Jun 27. doi: 10.1007\/s10875-026-02047-5. Online ahead of print. ABSTRACT TRNT1 deficiency (SIFD syndrome) is a rare inborn error of immunity characterized by sideroblastic anemia, immunodeficiency, periodic fevers, and developmental delay. We report two Romanian patients with genetically confirmed TRNT1 deficiency presenting with characteristic hematologic and immunologic abnormalities and a distinctive facial &#8230; <a title=\"Facial Dysmorphism and Severe Vascular Phenotype in TRNT1 Deficiency with Concomitant Antithrombin III Deficiency\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/29\/facial-dysmorphism-and-severe-vascular-phenotype-in-trnt1-deficiency-with-concomitant-antithrombin-iii-deficiency\/\" aria-label=\"Read more about Facial Dysmorphism and Severe Vascular Phenotype in TRNT1 Deficiency with Concomitant Antithrombin III Deficiency\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e013127?rss=1\">Lenalidomide boosts CD1d-V{delta}2 bispecific antibody-engaged V{gamma}9V{delta}2-T cell effector functions via CD28, Notch signaling and IL-2 release<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-29T08:05:08+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nV9V2-T cells form a conserved T-cell subset known for its potent intrinsic antitumor activity and versatility in recognizing diverse cancer types independently of the major histocompatibility complex. Previously, we reported the preclinical&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e015742?rss=1\">Translational landscape of cytokine-induced killer cell therapy: an analysis based on the Informa database<\/a><div class=\"wp-block-latest-posts__post-author\">by Zhang, Y., Sun, H., Yuan, Y., Liu, D., Qiao, J.<\/div><time datetime=\"2026-06-29T08:05:08+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nThis study maps the global clinical trial landscape of cytokine-induced killer (CIK) cell therapy across malignancies and selected immune-related disorders, based on 199 interventional trials retrieved from the Informa database up to February 2026. An&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/6\/e015177?rss=1\">Lithocholic acid-activated VDR in macrophages promotes HCC recurrence post-ablation via SOCS3-mediated suppression of CXCL16<\/a><div class=\"wp-block-latest-posts__post-author\">by Li, R., Luo, W., Li, Z., Zheng, S., Luo, M., Wei, Q., Zhu, X., Zhang, W., Luo, B.<\/div><time datetime=\"2026-06-29T08:05:08+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nIncomplete thermal ablation (iTA) for hepatocellular carcinoma (HCC) fosters an immunosuppressive microenvironment driving local recurrence, yet the metabolic cues linking tissue injury to immune evasion remain undefined. Bile acids, partic&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1847882\">Immunological and clinical characteristics of severe thrombocytopenia in neonates with Kasabach\u2013Merritt phenomenon<\/a><div class=\"wp-block-latest-posts__post-author\">by Cancan Li<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveThis study aimed to characterize the immune profile of neonates with Kasabach-Merritt phenomenon (KMP) and to identify clinical features linked to severe thrombocytopenia in these patients.MethodsThis multicenter retrospective study included n&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1820962\">N4-acetylcytidine modification bridges metabolic reprogramming and immune evasion in cancer: mechanisms and therapeutic implications<\/a><div class=\"wp-block-latest-posts__post-author\">by Ming-Zhu Jin<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">N4-acetylcytidine (ac4C) is an evolutionarily conserved RNA modification catalyzed by N-acetyltransferase 10 (NAT10), representing the sole known acetylation modification in eukaryotic mRNA. Recent studies have revealed that ac4C modification plays mul&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1905985\">Correction: CD32b defines distinct dendritic cell lineages generated from the culture of bone marrow with GM-CSF<\/a><div class=\"wp-block-latest-posts__post-author\">by Wanho Choi<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1736778\">Evaluating glycolysis-associated biomarkers for radiotherapy sensitivity in head and neck squamous cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by Bilan Xie<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundHead and neck squamous cell carcinoma (HNSC) present a significant treatment challenge due to variability in radiotherapy response, where glycolysis may play a pivotal role in modulating sensitivity. This study aimed to develop a glycolysis-a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1860941\">Case Report: A novel homozygous splice-site variant in the C3 gene causing complete complement C3 deficiency in two unrelated Moroccan patients<\/a><div class=\"wp-block-latest-posts__post-author\">by Chaymae Oujane<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Complement component 3 (C3) plays a central role in innate immunity as a convergence point of the classical, alternative, and lectin pathways. Complete C3 deficiency is an extremely rare inborn error of immunity, typically associated with recurrent sev&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1863647\">NAFLD-associated immune remodeling in colorectal cancer liver metastasis: mechanisms and implications for immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Hui Wang<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Non-alcoholic fatty liver disease (NAFLD) affects over 30% of the global adult population and has been increasingly recognized as an adverse prognostic factor for colorectal cancer (CRC) liver metastasis (CRLM). However, the underlying immune mechanism&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1856864\">Protective effect and mechanisms of Buyang Huanwu decoction against hypobaric hypoxia-induced brain injury in mice: involvement of inflammatory responses and HIF-1\/PI3K-Akt-related pathways<\/a><div class=\"wp-block-latest-posts__post-author\">by Zhixing Wang<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Background\/objectivesThis study aimed to investigate the preventive and protective effect of Buyang Huanwu Decoction (BHD) against hypobaric hypoxia-induced brain injury in mice and to explore its underlying mechanisms. Particular emphasis was placed o&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1819630\">Association of gut microbiota and inflammation with carotid atherosclerosis in HIV infection with poor immune reconstitution<\/a><div class=\"wp-block-latest-posts__post-author\">by Lisi Deng<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundPeople living with HIV (PLWH) have an excess risk of cardiovascular disease (CVD), but little is known regarding intrinsic links between gut microbiota profiles, inflammatory factors, and the risk of carotid atherosclerosis in HIV infection w&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1877094\">Multiple sclerosis as an asynchronous neuroinflammatory system<\/a><div class=\"wp-block-latest-posts__post-author\">by Emanuele D\u2019Amico<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Multiple sclerosis (MS) has traditionally been conceptualized through an event-based framework in which relapses, lesion accumulation, and disability progression evolve along a linear temporal axis. However, converging pathological, imaging, biomarker,&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1912492\">Editorial: Mechanisms regulating immune evasion by B-cell lymphoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Nethaji Muniraj<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1851554\">Case Report: Epidermodysplasia verruciformis misdiagnosed as pityriasis alba in a child: a diagnostic pitfall in facial hypopigmented lesions<\/a><div class=\"wp-block-latest-posts__post-author\">by Siyi Pan<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveEpidermodysplasia verruciformis (EV) is a rare genodermatosis with susceptibility to specific HPVs and risk of malignant transformation. Atypical EV presenting as isolated facial hypopigmented macules closely mimicking pityriasis alba can lead&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1789212\">Radiotherapy-synergized in situ hydrogel vaccine with engineered Lactococcus lactis FOLactis potentiates anti-tumor immunity in pancreatic cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by Jingjing Chen<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundImmunotherapy has emerged as a promising strategy for pancreatic cancer. Radiotherapy not only mediates direct tumor cell killing but also provides a source of tumor antigens for dendritic cells (DCs) uptake and presentation via the induction&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1875226\">BIRC3-CASP8 axis orchestrates the PANoptosis spectrum: taming the inflammatory storm to prevent post-ischemic heart failure<\/a><div class=\"wp-block-latest-posts__post-author\">by Quancheng Han<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundThe progression of heart failure (HF) following myocardial ischemia\/reperfusion (I\/R) injury is driven by regulated cell death. Unlike the restrained nature of apoptosis, pyroptosis and necroptosis are lytic processes that trigger inflammator&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1840240\">Taxonomy, carcinogenic mechanisms, and advanced molecular diagnosis of Fusobacterium nucleatum in colorectal cancer: from bench to clinical practice<\/a><div class=\"wp-block-latest-posts__post-author\">by Bin Li<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Fusobacterium nucleatum (Fn) is recognized as a novel oncogenic organism closely correlated with colorectal cancer (CRC). Fn can induce gut dysbiosis and promote tumorigenesis through various mechanisms, including activation of oncogenic signaling, mod&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1767881\">Baihe Gujin decoction ameliorates sepsis-induced acute lung injury through Nrf2\/GPX4-mediated antioxidant defense and PPAR\u03b1-driven metabolic reprogramming: a multi-omics investigation<\/a><div class=\"wp-block-latest-posts__post-author\">by Kaiyuan Zhang<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundSepsis-induced acute lung injury (ALI) represents the earliest and most severe complication of sepsis, with extraordinarily high mortality rates. Baihe Gujin decoction (BHGJD), a classical traditional Chinese medicine formula, has demonstrate&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1841316\">Anti-IgLON5 disease presenting with myokymia and favourable response to FcRN-antagonist combined with oral glucocorticoids: case report<\/a><div class=\"wp-block-latest-posts__post-author\">by Tianling Shang<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Anti-IgLON5 disease is a rare autoimmune neurological disorder characterized by anti- neuronal surface autoantibodies targeting the Immunoglobulin-Like Cell Adhesion Molecule 5 (IgLON5) protein. We report a 53-year-old male patient diagnosed with anti-&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1827753\">Immunotherapeutic potential of PD-1 blockade in chronic Leishmania mexicana infection through the enhancement of progenitor-like CXCR5+ and intermediate CXCR5+TIM-3+ exhausted T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Mariana Diupotex<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Diffuse cutaneous leishmaniasis (DCL), caused by Leishmania mexicana, is a chronic, treatment-refractory form of leishmaniasis characterized by multiple nodular lesions and high parasite load. During chronic infection, T cells acquire an exhausted immu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1857374\">Immunoinformatics-driven design of a multi-epitope vaccine against Clostridium perfringens in yaks<\/a><div class=\"wp-block-latest-posts__post-author\">by Dan Wu<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionClostridium perfringens is the primary causative agent of enterotoxemia in yaks, resulting in substantial economic losses on the Qinghai-Tibet Plateau. Conventional vaccines exhibit limited protective breadth and suboptimal efficacy, highli&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1801117\">Promising non-invasive biomarkers for kidney allograft monitoring: a mini review<\/a><div class=\"wp-block-latest-posts__post-author\">by Luke Barr<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Significant advancements have been made in kidney transplantation, with a wealth of immunosuppressive and antimicrobial therapies that have significantly improved graft survival. Despite these accomplishments, the ability to promptly identify kidney al&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1776060\">Mechanism of liposome arsenic trioxide regulating tumor microenvironment and sensitizing tumor immune response after radiofrequency ablation<\/a><div class=\"wp-block-latest-posts__post-author\">by Chao Liang<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveWe hypothesized that preoperative administration of liposome arsenic trioxide (LATO) would downregulate hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) in residual tumors following incomplete radiofrequency ablation (iRFA), thereby modulating the tumor m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1847018\">Case Report: Functional characterization of lymphocyte populations in a pediatric patient with WHIM syndrome<\/a><div class=\"wp-block-latest-posts__post-author\">by Marialaura Mastrovito<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">WHIM syndrome is a rare primary immunodeficiency disorder caused by gain-of-function mutations of the chemokine receptor CXCR4, leading to abnormal and exacerbated leukocyte trafficking. It is associated with severe neutropenia and lymphopenia, and rec&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1753797\">Refractory mastoiditis as the initial manifestation of granulomatosis with polyangiitis:a case report and literature review<\/a><div class=\"wp-block-latest-posts__post-author\">by Xinying Cui<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundGranulomatosis with Polyangiitis (GPA) is an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis that predominantly affects the upper or lower respiratory tracts and the kidney. While otologic involvement is relatively common in &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1866019\">From the Petri dish to the patient\u2019s bedside: interpreting Trichosporon asahii positive urine cultures in hospitalized patients<\/a><div class=\"wp-block-latest-posts__post-author\">by Let\u00edcia Rebello Machado<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Urinary tract infections (UTIs) are common and traditionally linked to bacteria; however, yeasts\u2014 particularly Trichosporon asahii \u2014 have emerged as opportunistic pathogens in immunocompromised and hospitalized patients. The presence of fungi may repre&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1823850\">CD4+ T cell signature in long COVID: insights from an unvaccinated cohort<\/a><div class=\"wp-block-latest-posts__post-author\">by Thiago Cerqueira-Silva<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveThe pathogenesis of Long COVID (LC) remains poorly understood, with the analysis of immune responses often obscured by variables such as vaccination and reinfection. This study aimed to determine the primary immunological footprint of LC by ex&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1829226\">Neutrophil-derived ROS as a rapid functional biomarker: diagnostic and prognostic performance of the Leukocyte ImmunoTest in infection and sepsis<\/a><div class=\"wp-block-latest-posts__post-author\">by Nazl\u0131han Boyac\u0131 D\u00fcndar<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundEarly diagnosis of sepsis remains a major clinical challenge due to the dynamic interplay between infection and host immune response. Conventional biomarkers often fail to capture the dynamic nature of immune activation. Neutrophil-derived re&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1868145\">Hemorrhage-coagulation immune phenotype is associated with CD163\/HO-1-enriched heme-processing macrophage remodeling and predicts recurrence in colorectal cancer: a real-world retrospective cohort study<\/a><div class=\"wp-block-latest-posts__post-author\">by Yiqi Yan<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundCoagulation activation and tumor hemorrhage are common in colorectal cancer, but their combined immunological meaning remains incompletely defined. We developed a prespecified hemorrhage-coagulation immune phenotype (HCIP) integrating local h&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1778330\">Comparative efficacy of postoperative adjuvant transcatheter arterial chemoembolization versus lenvatinib plus tislelizumab in patients with BCLC stage 0 -B hepatocellular carcinoma after radical resection<\/a><div class=\"wp-block-latest-posts__post-author\">by Xu Feng<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">AimThis study aimed to compare the efficacy of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) and adjuvant lenvatinib plus tislelizumab (PA-LT) in patients with Barcelona Clinic Liver Cancer (BCLC) stage 0\u2013B hepatocellular ca&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1832952\">Impact of anti-TNF and anti-IL-12\/IL-23 antibody therapy on periodontal inflammation and gingival crevicular fluid IL-6 in patients with inflammatory bowel diseases<\/a><div class=\"wp-block-latest-posts__post-author\">by Nicole Neurath<\/div><time datetime=\"2026-06-29T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">29 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionPeriodontitis prevalence is elevated in patients with inflammatory bowel diseases (IBD). Biological therapies targeting cytokines such as tumor necrosis factor (TNF) and interleukin-12\/23 (IL-12\/23) are central to IBD management, yet their &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/postbiotic-lactobacillus-sakei-cvl-001-promotes-mucosal-tolerance-via-nod2-dependent-programming-of-tolerogenic-cd11c-antigen-presenting-cells-dong-yeon-kim\/\">Postbiotic Lactobacillus sakei CVL-001 promotes mucosal tolerance via NOD2-dependent programming of tolerogenic CD11c+ antigen-presenting cells. Dong-Yeon Kim<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T07:11:14+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mucosal Immunol. 2026 Jun 27:100371. doi: 10.1016\/j.mucimm.2026.100371. Online ahead of print. ABSTRACT Postbiotics offer improved safety and stability over live probiotics for modulating intestinal immunity, yet the receptor-mediated mechanisms underlying mucosal tolerance remain unclear. Nucleotide-binding oligomerization domain 2 (NOD2), a cytosolic sensor of bacterial cell wall components and a major genetic risk factor for inflammatory &#8230; <a title=\"Postbiotic Lactobacillus sakei CVL-001 promotes mucosal tolerance via NOD2-dependent programming of tolerogenic CD11c+ antigen-presenting cells. Dong-Yeon Kim\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/postbiotic-lactobacillus-sakei-cvl-001-promotes-mucosal-tolerance-via-nod2-dependent-programming-of-tolerogenic-cd11c-antigen-presenting-cells-dong-yeon-kim\/\" aria-label=\"Read more about Postbiotic Lactobacillus sakei CVL-001 promotes mucosal tolerance via NOD2-dependent programming of tolerogenic CD11c+ antigen-presenting cells. Dong-Yeon Kim\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/myeloid-cells-as-sources-and-targets-of-il-1-family-cytokines-in-cancer-silvia-carnevale\/\">Myeloid cells as sources and targets of IL-1 family cytokines in cancer. Silvia Carnevale<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T07:11:13+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Semin Immunol. 2026 Jun 27;83:102048. doi: 10.1016\/j.smim.2026.102048. Online ahead of print. ABSTRACT Inflammation is a defining feature of the tumor microenvironment (TME) and a key driver of cancer progression. Among inflammatory mediators, the interleukin-1 (IL-1) family of cytokines serves as a central mediator linking tissue damage, metabolic stress and microbial cues to innate immune activation. &#8230; <a title=\"Myeloid cells as sources and targets of IL-1 family cytokines in cancer. Silvia Carnevale\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/myeloid-cells-as-sources-and-targets-of-il-1-family-cytokines-in-cancer-silvia-carnevale\/\" aria-label=\"Read more about Myeloid cells as sources and targets of IL-1 family cytokines in cancer. Silvia Carnevale\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/ocular-sarcoidosis-from-clinical-signs-to-targeted-interventions\/\">Ocular sarcoidosis: from clinical signs to targeted interventions<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T01:03:24+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 Jun 27;101:102810. doi: 10.1016\/j.coi.2026.102810. Online ahead of print. ABSTRACT Ocular sarcoidosis is a frequent manifestation of sarcoidosis and may occur most commonly affecting adults between 30 and 60 years old. Uveitis may be anterior, intermediate, posterior, or present as panuveitis, with marked heterogeneity in severity and clinical course. Diagnosis relies on &#8230; <a title=\"Ocular sarcoidosis: from clinical signs to targeted interventions\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/ocular-sarcoidosis-from-clinical-signs-to-targeted-interventions\/\" aria-label=\"Read more about Ocular sarcoidosis: from clinical signs to targeted interventions\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/germinal-center-responses-at-barrier-organ-sites\/\">Germinal center responses at barrier organ sites<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T01:03:24+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 Jun 27;101:102807. doi: 10.1016\/j.coi.2026.102807. Online ahead of print. ABSTRACT In this review, we detail the features of barrier germinal centers (GC) that form in tertiary lymphoid structures (TLSs) within non-immune organs that host a local microbiome, and posit a framework of immunity where TLS-GCs created at barrier sites are a key &#8230; <a title=\"Germinal center responses at barrier organ sites\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/germinal-center-responses-at-barrier-organ-sites\/\" aria-label=\"Read more about Germinal center responses at barrier organ sites\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/er-stress-amplifies-inflammation-via-a-dual-mechanism-involving-i%ce%bab%ce%b6-xbp1s-synergism-and-regnase-1-degradation\/\">ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T01:03:23+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag151. doi: 10.1093\/jimmun\/vkag151. ABSTRACT Inflammatory diseases arise from complex interactions between immune signaling and cellular stress. Although endoplasmic reticulum (ER) stress is a key modulator of immunity, the mechanisms by which it promotes inflammatory pathology remain incompletely understood. Notably, ER stress-induced NF-\u03baB activation alone is insufficient to account for robust IL-6 &#8230; <a title=\"ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/er-stress-amplifies-inflammation-via-a-dual-mechanism-involving-i%ce%bab%ce%b6-xbp1s-synergism-and-regnase-1-degradation\/\" aria-label=\"Read more about ER stress amplifies inflammation via a dual mechanism involving I\u03baB\u03b6-XBP1s synergism and Regnase-1 degradation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/ship-blocks-mdplps-induced-synergy-in-macrophages-independent-of-catalytic-activityyvonne-c-f-pang-on-27-de-june-de-2026-at-1000\/\">SHIP Blocks (MDP+LPS)-Induced Synergy in Macrophages Independent of Catalytic Activity\u200bYvonne C F Pang   on 27 de June de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T01:03:21+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 Jun 27:qiag090. doi: 10.1093\/jleuko\/qiag090. Online ahead of print. ABSTRACT Macrophages coordinate cytokine responses by integrating signals from pattern recognition receptors including NOD2 and TLR4. NOD2 detects muramyl dipeptide derived from bacterial peptidoglycan, and TLR4 recognizes lipopolysaccharide in the outer membrane of Gram-negative bacteria. NOD2 and TLR4 signals synergize to enhance cytokine &#8230; <a title=\"SHIP Blocks (MDP+LPS)-Induced Synergy in Macrophages Independent of Catalytic Activity\u200bYvonne C F Pang   on 27 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/ship-blocks-mdplps-induced-synergy-in-macrophages-independent-of-catalytic-activityyvonne-c-f-pang-on-27-de-june-de-2026-at-1000\/\" aria-label=\"Read more about SHIP Blocks (MDP+LPS)-Induced Synergy in Macrophages Independent of Catalytic Activity\u200bYvonne C F Pang   on 27 de June de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/cd43-recent-advances-and-emerging-functionsmariana-diupotex-on-27-de-june-de-2026-at-1000\/\">CD43: Recent Advances and Emerging Functions\u200bMariana Diupotex   on 27 de June de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-28T01:03:21+02:00\" class=\"wp-block-latest-posts__post-date\">28 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 Jun 27:qiag084. doi: 10.1093\/jleuko\/qiag084. Online ahead of print. ABSTRACT Originally characterized for its roles in T-cell activation and adhesion, CD43 is a prominent mucin-like sialoglycoprotein expressed on hematopoietic cells. CD43 is broadly expressed across leukocyte populations, with its levels, molecular configuration, and ligand interactions varying by cell type, activation state, and &#8230; <a title=\"CD43: Recent Advances and Emerging Functions\u200bMariana Diupotex   on 27 de June de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/28\/cd43-recent-advances-and-emerging-functionsmariana-diupotex-on-27-de-june-de-2026-at-1000\/\" aria-label=\"Read more about CD43: Recent Advances and Emerging Functions\u200bMariana Diupotex   on 27 de June de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/on-or-within-spatial-determinants-of-antigen-handling-in-the-nasal-turbinates\/\">On or within: spatial determinants of antigen handling in the nasal turbinates<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:50+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 Jun 26;101:102808. doi: 10.1016\/j.coi.2026.102808. Online ahead of print. ABSTRACT The SARS-CoV-2 pandemic has renewed interest in mucosal vaccines, yet these approaches have long struggled to generate durable protection against airway pathogens. A key limitation is the incomplete understanding of how upper airway antigens are handled to shape immune response quality and &#8230; <a title=\"On or within: spatial determinants of antigen handling in the nasal turbinates\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/on-or-within-spatial-determinants-of-antigen-handling-in-the-nasal-turbinates\/\" aria-label=\"Read more about On or within: spatial determinants of antigen handling in the nasal turbinates\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/the-v158f-polymorphism-in-human-fc%ce%b3riiia-cd16a-defines-opposing-receptor-responses-when-interacting-with-soluble-immune-complexes\/\">The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag160. doi: 10.1093\/jimmun\/vkag160. ABSTRACT The V158F polymorphism found in the human Fc receptor CD16a (also known as Fc\u03b3RIIIa) is thought to influence autoimmune disorders and responses to IgG-based therapies. V158F is known to influence the IgG affinity, and thereby triggering of the CD16a receptor expressed on various immune cells. In contrast &#8230; <a title=\"The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/the-v158f-polymorphism-in-human-fc%ce%b3riiia-cd16a-defines-opposing-receptor-responses-when-interacting-with-soluble-immune-complexes\/\" aria-label=\"Read more about The V158F polymorphism in human Fc\u03b3RIIIa\/CD16a defines opposing receptor responses when interacting with soluble immune complexes\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/foxp1-controls-fezf2-dependent-gene-expression-mimetic-mtec-diversity-and-thymic-central-tolerance\/\">Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag168. doi: 10.1093\/jimmun\/vkag168. ABSTRACT Forkhead Box P1 (Foxp1) is a transcription factor critical for the proper development of multiple tissues. While Foxp1 has a well-described role in regulating adaptive immunity through modulation of T and B cells, a function in medullary thymic epithelial cells (mTECs) has not been reported. Here we &#8230; <a title=\"Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/foxp1-controls-fezf2-dependent-gene-expression-mimetic-mtec-diversity-and-thymic-central-tolerance\/\" aria-label=\"Read more about Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/mapk-activated-protein-kinase-2-orchestrates-memory-t-cell-inflation-in-cytomegalovirus-infection\/\">MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:49+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag170. doi: 10.1093\/jimmun\/vkag170. ABSTRACT Memory T-cell inflation is a distinctive immunological phenomenon observed during persistent viral infections such as cytomegalovirus (CMV). Unlike conventional memory T-cell responses, which contract after infection resolution, a subset of CMV-specific T cells undergoes a progressive and sustained expansion, termed &#8220;inflation&#8221;, which is thought to be critical &#8230; <a title=\"MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/mapk-activated-protein-kinase-2-orchestrates-memory-t-cell-inflation-in-cytomegalovirus-infection\/\" aria-label=\"Read more about MAPK-activated protein kinase 2 orchestrates memory T-cell inflation in cytomegalovirus infection\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/peripheral-th17-immune-signature-associates-with-excellent-response-to-anti-pd1-anti-pd-l1-therapy-across-solid-tumors\/\">Peripheral Th17 immune signature associates with excellent response to anti-PD1\/anti-PD-L1 therapy across solid tumors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-27T07:45:48+02:00\" class=\"wp-block-latest-posts__post-date\">27 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cancer Immunol Res. 2026 Jun 26. doi: 10.1158\/2326-6066.CIR-25-1611. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have transformed cancer care, at times generating durable partial or even complete responses in advanced cancers. However, only a minority of patients experience these &#8220;excellent&#8221; responses. Thus, there is a need for novel biomarkers that can identify those &#8230; <a title=\"Peripheral Th17 immune signature associates with excellent response to anti-PD1\/anti-PD-L1 therapy across solid tumors\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/27\/peripheral-th17-immune-signature-associates-with-excellent-response-to-anti-pd1-anti-pd-l1-therapy-across-solid-tumors\/\" aria-label=\"Read more about Peripheral Th17 immune signature associates with excellent response to anti-PD1\/anti-PD-L1 therapy across solid tumors\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/csf1r-dependent-macrophages-control-b-cell-development-and-function-in-the-chicken-immune-system\/\">CSF1R-dependent macrophages control B cell development and function in the chicken immune system<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag143. doi: 10.1093\/jimmun\/vkag143. ABSTRACT Acquired immunity in mammals depends upon capture and presentation of antigens by specialized macrophage populations in splenic marginal zone and lymph node sinuses and follicular dendritic cells within germinal centers. Cells referred to as follicular dendritic cells in chickens express CSF1R, the receptor for CSF1 and IL34. &#8230; <a title=\"CSF1R-dependent macrophages control B cell development and function in the chicken immune system\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/csf1r-dependent-macrophages-control-b-cell-development-and-function-in-the-chicken-immune-system\/\" aria-label=\"Read more about CSF1R-dependent macrophages control B cell development and function in the chicken immune system\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/slc1a5-augmentation-bypasses-nk-cell-transduction-barriers-to-deliver-complex-car-payloads\/\">SLC1A5 augmentation bypasses NK cell transduction barriers to deliver complex CAR payloads<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag133. doi: 10.1093\/jimmun\/vkag133. ABSTRACT Reproducible and efficient genetic engineering of human NK cells remains a primary challenge to next-generation chimeric antigen receptor (CAR) therapies, specifically for larger constructs with multiple plasmids and transgenes. Lentiviral vectors (LVs) pseudotyped with baboon envelope (BaEV) outperform vesicular stomatitis virus G protein in transducing hematopoietic stem &#8230; <a title=\"SLC1A5 augmentation bypasses NK cell transduction barriers to deliver complex CAR payloads\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/slc1a5-augmentation-bypasses-nk-cell-transduction-barriers-to-deliver-complex-car-payloads\/\" aria-label=\"Read more about SLC1A5 augmentation bypasses NK cell transduction barriers to deliver complex CAR payloads\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/incorporation-of-multiple-diversity-genes-in-the-tcr%ce%b4-chain-is-highly-regulated-and-evolutionarily-conserved\/\">Incorporation of multiple diversity genes in the TCR\u03b4 chain is highly regulated and evolutionarily conserved<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag137. doi: 10.1093\/jimmun\/vkag137. ABSTRACT In the canonical model of VDJ recombination, a single diversity (D) gene is incorporated into the complementarity-determining region 3 (CDR3) to produce a T cell receptor \u03b4 (TCR\u03b4; TRD) or TCR\u03b2 (TRB) chain. But by constructing a dataset of more than 2.7 million TRD CDR3 sequences from &#8230; <a title=\"Incorporation of multiple diversity genes in the TCR\u03b4 chain is highly regulated and evolutionarily conserved\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/incorporation-of-multiple-diversity-genes-in-the-tcr%ce%b4-chain-is-highly-regulated-and-evolutionarily-conserved\/\" aria-label=\"Read more about Incorporation of multiple diversity genes in the TCR\u03b4 chain is highly regulated and evolutionarily conserved\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/genetic-deletion-of-the-inflammatory-bowel-disease-associated-risk-gene-rgs14-aggravates-experimental-colitis\/\">Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-26T13:26:16+02:00\" class=\"wp-block-latest-posts__post-date\">26 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jun 7;215(6):vkag135. doi: 10.1093\/jimmun\/vkag135. ABSTRACT Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20 RGS, the Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease, and Rgs14 expression is higher in macrophages than in epithelial cells. &#8230; <a title=\"Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/26\/genetic-deletion-of-the-inflammatory-bowel-disease-associated-risk-gene-rgs14-aggravates-experimental-colitis\/\" aria-label=\"Read more about Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis\">Read more<\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16925","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16925"}],"version-history":[{"count":2,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16925\/revisions"}],"predecessor-version":[{"id":16927,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16925\/revisions\/16927"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}