{"id":16986,"date":"2024-09-30T00:08:02","date_gmt":"2024-09-29T22:08:02","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16986"},"modified":"2024-09-30T00:08:02","modified_gmt":"2024-09-29T22:08:02","slug":"european-journal-of-immunology","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/european-journal-of-immunology\/","title":{"rendered":"European Journal of Immunology"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/interferon%e2%80%90regulatory-factor-4-is-required-not-only-for-induction-but-also-for-maintenance-of-the-th17-phenotype-valuejanis-patten-prema-erramsetti-addi-josua-romero-olmedo-ol\/\">Interferon\u2010Regulatory Factor 4 Is Required Not Only for Induction but Also for Maintenance of the Th17 Phenotype. [[{&#8220;value&#8221;:&#8221;Janis Patten, \nPrema Erramsetti, \nAddi Josua Romero Olmedo, \nOlaf Pinkenburg, \nMagdalena Huber, \nMichael Lohoff&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T10:02:20+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We previously showed that primary differentiation of na\u00efve T cells is dependent on IRF4. Now we show that maintenance of already differentiated conventional and pathogenic Th17 cells is also dependent on IRF4.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/adar1-controls-macrophage-scavenging-and-lipid%e2%80%90buffering-programs-in-metabolic-tissues-valueachilleas-fardellas-emelie-barreby-madara-brice-sebastian-nock-jules-russick-an\/\">ADAR1 Controls Macrophage Scavenging and Lipid\u2010Buffering Programs in Metabolic Tissues. [[{&#8220;value&#8221;:&#8221;Achilleas Fardellas, \nEmelie Barreby, \nMadara Brice, \nSebastian Nock, \nJules Russick, \nAna Vankova, \nCharlotte Edberg, \nIda Robertsen, \nJens K. Hertel, \nPer St\u00e5l, \nGunnar Mellgren, \nCecilia Karlsson, \nJ\u00f8ran S. Hjelmesaeth, \nHannes Hagstr\u00f6m, \nErik N\u00e4slund, \nVolker M. Lauschke, \nJohan Fern\u00f8, \nPing Chen, \nCecilia Morgantini, \nMyriam Aouadi, \nNiklas K. Bj\u00f6rkstr\u00f6m&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T10:02:20+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ADAR1 expression increase during monocyte-to-macrophage differentiation via an alternative transcription start site. Isoform-specific ADAR1 activity governs key macrophage functions, including efferocytosis, endocytosis, lipid metabolism, and proliferation. Moreover, ADAR1 in macrophages responds to different metabolic states and buffers lipotoxicity under high metabolic load. Vectors obtained from https:\/\/BioRender.com. ABSTRACT Adenosine deaminase acting on RNA 1 (ADAR1) regulates &#8230; <a title=\"ADAR1 Controls Macrophage Scavenging and Lipid\u2010Buffering Programs in Metabolic Tissues. [[{&#8220;value&#8221;:&#8221;Achilleas Fardellas, \nEmelie Barreby, \nMadara Brice, \nSebastian Nock, \nJules Russick, \nAna Vankova, \nCharlotte Edberg, \nIda Robertsen, \nJens K. Hertel, \nPer St\u00e5l, \nGunnar Mellgren, \nCecilia Karlsson, \nJ\u00f8ran S. Hjelmesaeth, \nHannes Hagstr\u00f6m, \nErik N\u00e4slund, \nVolker M. Lauschke, \nJohan Fern\u00f8, \nPing Chen, \nCecilia Morgantini, \nMyriam Aouadi, \nNiklas K. Bj\u00f6rkstr\u00f6m&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/adar1-controls-macrophage-scavenging-and-lipid%e2%80%90buffering-programs-in-metabolic-tissues-valueachilleas-fardellas-emelie-barreby-madara-brice-sebastian-nock-jules-russick-an\/\" aria-label=\"Read more about ADAR1 Controls Macrophage Scavenging and Lipid\u2010Buffering Programs in Metabolic Tissues. [[{&#8220;value&#8221;:&#8221;Achilleas Fardellas, \nEmelie Barreby, \nMadara Brice, \nSebastian Nock, \nJules Russick, \nAna Vankova, \nCharlotte Edberg, \nIda Robertsen, \nJens K. Hertel, \nPer St\u00e5l, \nGunnar Mellgren, \nCecilia Karlsson, \nJ\u00f8ran S. Hjelmesaeth, \nHannes Hagstr\u00f6m, \nErik N\u00e4slund, \nVolker M. Lauschke, \nJohan Fern\u00f8, \nPing Chen, \nCecilia Morgantini, \nMyriam Aouadi, \nNiklas K. Bj\u00f6rkstr\u00f6m&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/human-blood-iga-memory-b-cells-differ-from-igg-b-cells-by-expressing-gut%e2%80%90homing-and-regulatory-markers-valuelouise-le-gal-leo-boussamet-alexandra-garcia-jeremy-morille-emi\/\">Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut\u2010Homing and Regulatory Markers. [[{&#8220;value&#8221;:&#8221;Louise Le Gal, \nL\u00e9o Boussamet, \nAlexandra Garcia, \nJ\u00e9r\u00e9my Morille, \nEmilie Dugast, \nArnaud B. Nicot, \nDavid\u2010Axel Laplaud, \nLaureline Berthelot&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T10:02:20+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Compared with IgG+ and IgM+ memory B cells, IgA+ memory B cells displayed distinct phenotypical markers: PD-L1, GPR183, CCR9, CCR10, \u03b14\u03b27, CD11b. A particular transcriptomic signature, with RUNX2, ARHGEF10L, XYLT1, TRPS1, and CHL1 upregulation, characterized the IgA+ memory B cell population, whereas miR4432HG was a marker of IgG+ memory B cells. ABSTRACT IgA is the &#8230; <a title=\"Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut\u2010Homing and Regulatory Markers. [[{&#8220;value&#8221;:&#8221;Louise Le Gal, \nL\u00e9o Boussamet, \nAlexandra Garcia, \nJ\u00e9r\u00e9my Morille, \nEmilie Dugast, \nArnaud B. Nicot, \nDavid\u2010Axel Laplaud, \nLaureline Berthelot&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/human-blood-iga-memory-b-cells-differ-from-igg-b-cells-by-expressing-gut%e2%80%90homing-and-regulatory-markers-valuelouise-le-gal-leo-boussamet-alexandra-garcia-jeremy-morille-emi\/\" aria-label=\"Read more about Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut\u2010Homing and Regulatory Markers. [[{&#8220;value&#8221;:&#8221;Louise Le Gal, \nL\u00e9o Boussamet, \nAlexandra Garcia, \nJ\u00e9r\u00e9my Morille, \nEmilie Dugast, \nArnaud B. Nicot, \nDavid\u2010Axel Laplaud, \nLaureline Berthelot&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/21\/accumulation-of-siglec10cx3cr1-macrophages-in-the-tumor-microenvironment-of-glioblastomas-valuenico-andreas-lucas-gath-paul-mike-jordan-saskia-steiner-oliver-werz-nazife-dinc\/\">Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas. [[{&#8220;value&#8221;:&#8221;Nico Andreas, \nLucas Gath, \nPaul Mike Jordan, \nSaskia Steiner, \nOliver Werz, \nNazife Dinc, \nPeter Baumgarten, \nChristian Senft, \nThe OncoSurgeJena Team, \nFalko Schwarz, \nNazeer Aboud, \nRamazan Dalkilic, \nSergio A. Calero Martinez, \nKatharina Klumbies, \nAaron Lawson McLean&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-21T10:38:05+02:00\" class=\"wp-block-latest-posts__post-date\">21 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">By comparing various brain tumors, we identified a CX3CR1+ Siglec10+ double-positive macrophage subpopulation specifically enriched in highly malignant Glioblastomas (GBMs), wherein they accumulated in metabolically active tumor areas. Thus, they potentially serve as a diagnostic indicator population for GBMs and as targets of future GBM-specific treatment strategies. ABSTRACT Glioblastoma (GBM) is one of the most &#8230; <a title=\"Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas. [[{&#8220;value&#8221;:&#8221;Nico Andreas, \nLucas Gath, \nPaul Mike Jordan, \nSaskia Steiner, \nOliver Werz, \nNazife Dinc, \nPeter Baumgarten, \nChristian Senft, \nThe OncoSurgeJena Team, \nFalko Schwarz, \nNazeer Aboud, \nRamazan Dalkilic, \nSergio A. Calero Martinez, \nKatharina Klumbies, \nAaron Lawson McLean&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/21\/accumulation-of-siglec10cx3cr1-macrophages-in-the-tumor-microenvironment-of-glioblastomas-valuenico-andreas-lucas-gath-paul-mike-jordan-saskia-steiner-oliver-werz-nazife-dinc\/\" aria-label=\"Read more about Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas. [[{&#8220;value&#8221;:&#8221;Nico Andreas, \nLucas Gath, \nPaul Mike Jordan, \nSaskia Steiner, \nOliver Werz, \nNazife Dinc, \nPeter Baumgarten, \nChristian Senft, \nThe OncoSurgeJena Team, \nFalko Schwarz, \nNazeer Aboud, \nRamazan Dalkilic, \nSergio A. Calero Martinez, \nKatharina Klumbies, \nAaron Lawson McLean&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/18\/expression-of-concern-activation-of-epstein%e2%80%90barr-virus-c3d-receptor-gp140-cr2-cd21-on-human-cell-surface-triggers-pp60src-and-akt%e2%80%90gsk3-activities-upstream-and-downstream-to-pi-3\/\">EXPRESSION OF CONCERN: Activation of Epstein\u2010Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt\u2010GSK3 Activities Upstream and Downstream to PI 3\u2010Kinase, Respectively.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-18T09:43:10+02:00\" class=\"wp-block-latest-posts__post-date\">18 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ABSTRACT EXPRESSION OF CONCERN: M. Barel, M. Balbo, M. Le Romancer and R. Frade, \u201cActivation of Epstein-Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt-GSK3 Activities Upstream and Downstream to PI 3-Kinase, Respectively,\u201d European Journal of Immunology 33, no. 9 (2003): 2557\u20132566, https:\/\/doi.org\/10.1002\/eji.200324059. This Expression of Concern is for the &#8230; <a title=\"EXPRESSION OF CONCERN: Activation of Epstein\u2010Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt\u2010GSK3 Activities Upstream and Downstream to PI 3\u2010Kinase, Respectively.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/18\/expression-of-concern-activation-of-epstein%e2%80%90barr-virus-c3d-receptor-gp140-cr2-cd21-on-human-cell-surface-triggers-pp60src-and-akt%e2%80%90gsk3-activities-upstream-and-downstream-to-pi-3\/\" aria-label=\"Read more about EXPRESSION OF CONCERN: Activation of Epstein\u2010Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt\u2010GSK3 Activities Upstream and Downstream to PI 3\u2010Kinase, Respectively.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/increased-constitutive-interferon%e2%80%90%ce%b2-levels-and-altered-cd4-t-cell-homeostasis-induced-by-expression-of-a-viral-glycoprotein-valuehanspeter-pircher-oliver-s-thomas-anne-s\/\">Increased Constitutive Interferon\u2010\u03b2 Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{&#8220;value&#8221;:&#8221;Hanspeter Pircher, \nOliver S. Thomas, \nAnne S. Haefke, \nAnnette Oxenius, \nThomas Boehm&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-14T10:21:55+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Constitutive interferon (IFN) production is regulated by microbiota and essential for optimal immune responses. Here, we demonstrate that expression of the glycoprotein of LCM virus upregulates constitutive IFN-\u03b2 levels and IFN-stimulated genes (ISGs) in transgenic mice. Moreover, it increased self-antigen-driven memory-phenotype CD4 T cells and effector regulatory CD4 T cells. ABSTRACT Besides the strong Type &#8230; <a title=\"Increased Constitutive Interferon\u2010\u03b2 Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{&#8220;value&#8221;:&#8221;Hanspeter Pircher, \nOliver S. Thomas, \nAnne S. Haefke, \nAnnette Oxenius, \nThomas Boehm&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/increased-constitutive-interferon%e2%80%90%ce%b2-levels-and-altered-cd4-t-cell-homeostasis-induced-by-expression-of-a-viral-glycoprotein-valuehanspeter-pircher-oliver-s-thomas-anne-s\/\" aria-label=\"Read more about Increased Constitutive Interferon\u2010\u03b2 Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{&#8220;value&#8221;:&#8221;Hanspeter Pircher, \nOliver S. Thomas, \nAnne S. Haefke, \nAnnette Oxenius, \nThomas Boehm&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/08\/uncovering-immune-niches-in-health-and-disease-using-spatial-transcriptomics-valuejohan-thorsson-yang-zhao-eduardo-j-villablanca-camilla-engblom\/\">Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics. [[{&#8220;value&#8221;:&#8221;Johan Thorsson, \nYang Zhao, \nEduardo J. Villablanca, \nCamilla Engblom&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-08T10:04:33+02:00\" class=\"wp-block-latest-posts__post-date\">8 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Through the lens of spatial transcriptomics and associated tools, novel immune niche constituents can now be resolved. Drawing on gut and tumor contexts, we propose a framework to define immune niches and integrate clonal dynamics, aiming to advance niche-directed therapies toward precise, context-specific immune modulation. ABSTRACT Spatial transcriptomics allows for the investigation of complex cellular &#8230; <a title=\"Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics. [[{&#8220;value&#8221;:&#8221;Johan Thorsson, \nYang Zhao, \nEduardo J. Villablanca, \nCamilla Engblom&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/08\/uncovering-immune-niches-in-health-and-disease-using-spatial-transcriptomics-valuejohan-thorsson-yang-zhao-eduardo-j-villablanca-camilla-engblom\/\" aria-label=\"Read more about Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics. [[{&#8220;value&#8221;:&#8221;Johan Thorsson, \nYang Zhao, \nEduardo J. Villablanca, \nCamilla Engblom&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/05\/b%e2%80%90cell-differentiation-of-human-hematopoietic-progenitors-is-efficiently-supported-by-wharton-jelly%e2%80%90derived-mesenchymal-stem-cells-valuelouison-collet-hakim-ouled%e2%80%90\/\">B\u2010Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly\u2010Derived Mesenchymal Stem Cells. [[{&#8220;value&#8221;:&#8221;Louison Collet, \nHakim Ouled\u2010Haddou, \nHussein Ghamlouch, \nWalaa Darwiche, \nCathy Gomila, \nBrigitte Gubler, \nLo\u00efc Garcon, \nDelphine Lebon, \nJean\u2010Pierre Marolleau&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-05T10:01:05+02:00\" class=\"wp-block-latest-posts__post-date\">5 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Wharton&#8217;s jelly-derived mesenchymal stromal cells isolated from umbilical cord were used to recreate a human stromal environment for B-cell development in vitro. In co-culture, CD34+ hematopoietic progenitors from bone marrow or cord blood differentiated into mature IgM-expressing B cells by day 11, while the Nalm-16 B-ALL cell line showed rapid IgM expression as early as &#8230; <a title=\"B\u2010Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly\u2010Derived Mesenchymal Stem Cells. [[{&#8220;value&#8221;:&#8221;Louison Collet, \nHakim Ouled\u2010Haddou, \nHussein Ghamlouch, \nWalaa Darwiche, \nCathy Gomila, \nBrigitte Gubler, \nLo\u00efc Garcon, \nDelphine Lebon, \nJean\u2010Pierre Marolleau&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/05\/b%e2%80%90cell-differentiation-of-human-hematopoietic-progenitors-is-efficiently-supported-by-wharton-jelly%e2%80%90derived-mesenchymal-stem-cells-valuelouison-collet-hakim-ouled%e2%80%90\/\" aria-label=\"Read more about B\u2010Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly\u2010Derived Mesenchymal Stem Cells. [[{&#8220;value&#8221;:&#8221;Louison Collet, \nHakim Ouled\u2010Haddou, \nHussein Ghamlouch, \nWalaa Darwiche, \nCathy Gomila, \nBrigitte Gubler, \nLo\u00efc Garcon, \nDelphine Lebon, \nJean\u2010Pierre Marolleau&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/nicotine-suppresses-human-memory-th-cell-subsets-with-preferential-effects-on-central-memory-th-cells-in-an-%ce%b17-nicotinic-acetylcholine-receptor%e2%80%90dependent-manner-valuefatemeh-gh\/\">Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an \u03b17 Nicotinic Acetylcholine Receptor\u2010Dependent Manner. [[{&#8220;value&#8221;:&#8221;Fatemeh Gholizadeh, \nMehri Hajiaghayi, \nNiloufar Rahbari, \nJennifer S. Choi, \nSamantha Heidt, \nAlexia Como, \nMaryam Kazerouni, \nMelika Kargar, \nAude Pinard\u2010LaRoche, \nSteve C. C. Shih, \nPeter J. Darlington&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-03T10:16:09+02:00\" class=\"wp-block-latest-posts__post-date\">3 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Human memory Th cells were separated into Tcm (CD45RO+ CD62L+) and Tem (CD45RO+ CD62L\u2212). Nicotine preferentially suppressed Th1-, Th2-, Th17-, and Tfh-associated programs in Tcm via an \u03b17nAChR-dependent mechanism, with minimal effect in Tem. ABSTRACT Memory T helper (Th) cells sustain protective recall responses but can also drive chronic inflammation, necessitating precise regulation of their &#8230; <a title=\"Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an \u03b17 Nicotinic Acetylcholine Receptor\u2010Dependent Manner. [[{&#8220;value&#8221;:&#8221;Fatemeh Gholizadeh, \nMehri Hajiaghayi, \nNiloufar Rahbari, \nJennifer S. Choi, \nSamantha Heidt, \nAlexia Como, \nMaryam Kazerouni, \nMelika Kargar, \nAude Pinard\u2010LaRoche, \nSteve C. C. Shih, \nPeter J. Darlington&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/nicotine-suppresses-human-memory-th-cell-subsets-with-preferential-effects-on-central-memory-th-cells-in-an-%ce%b17-nicotinic-acetylcholine-receptor%e2%80%90dependent-manner-valuefatemeh-gh\/\" aria-label=\"Read more about Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an \u03b17 Nicotinic Acetylcholine Receptor\u2010Dependent Manner. [[{&#8220;value&#8221;:&#8221;Fatemeh Gholizadeh, \nMehri Hajiaghayi, \nNiloufar Rahbari, \nJennifer S. Choi, \nSamantha Heidt, \nAlexia Como, \nMaryam Kazerouni, \nMelika Kargar, \nAude Pinard\u2010LaRoche, \nSteve C. C. Shih, \nPeter J. Darlington&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/structure%e2%80%90guided-engineering-of-tigit-to-modulate-its-interaction-with-nectin%e2%80%904-a-tumour%e2%80%90specific-antigen-for-the-development-of-therapeutic-strategy-valuenamrata-g\/\">Structure\u2010Guided Engineering of TIGIT to Modulate Its Interaction With Nectin\u20104, a Tumour\u2010Specific Antigen for the Development of Therapeutic Strategy. [[{&#8220;value&#8221;:&#8221;Namrata Ganguli, \nSayantan Shaw, \nSohini Sarkar, \nSaumyadeep Goswami, \nGayatri Mukherjee, \nDibyendu Samanta&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-03T10:16:09+02:00\" class=\"wp-block-latest-posts__post-date\">3 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Nectin-4 is a tumour-specific antigen that interacts selectively with the immune receptor TIGIT, resulting in inhibition of NK-cell cytotoxicity. We have explored the molecular and structural basis of this interaction and leveraged the information for structure-guided engineering of a TIGIT mutant exhibiting higher interaction affinity with nectin-4 and weaker binding to nectin-2 and PVR. The &#8230; <a title=\"Structure\u2010Guided Engineering of TIGIT to Modulate Its Interaction With Nectin\u20104, a Tumour\u2010Specific Antigen for the Development of Therapeutic Strategy. [[{&#8220;value&#8221;:&#8221;Namrata Ganguli, \nSayantan Shaw, \nSohini Sarkar, \nSaumyadeep Goswami, \nGayatri Mukherjee, \nDibyendu Samanta&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/structure%e2%80%90guided-engineering-of-tigit-to-modulate-its-interaction-with-nectin%e2%80%904-a-tumour%e2%80%90specific-antigen-for-the-development-of-therapeutic-strategy-valuenamrata-g\/\" aria-label=\"Read more about Structure\u2010Guided Engineering of TIGIT to Modulate Its Interaction With Nectin\u20104, a Tumour\u2010Specific Antigen for the Development of Therapeutic Strategy. [[{&#8220;value&#8221;:&#8221;Namrata Ganguli, \nSayantan Shaw, \nSohini Sarkar, \nSaumyadeep Goswami, \nGayatri Mukherjee, \nDibyendu Samanta&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/multi%e2%80%90parameter-spectral-flow-cytometry-panel-for-immune-phenotyping-of-murine-b-and-t-cell-responses-valuekassandra-hoetzel-hendrik-feuerstein-julia-ludwig-hedda-wardemann\/\">Multi\u2010Parameter Spectral Flow Cytometry Panel for Immune Phenotyping of Murine B and T Cell Responses. [[{&#8220;value&#8221;:&#8221;Kassandra Hoetzel, \nHendrik Feuerstein, \nJulia Ludwig, \nHedda Wardemann&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-03T10:16:09+02:00\" class=\"wp-block-latest-posts__post-date\">3 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">To enable the analysis of B cell and T cell immune responses in mouse lymph nodes, spleen, and bone marrow, including different B cell and T cell subsets and their activation status, as well as the antigen-reactivity and isotype of B cells, a novel 31-parameter spectral flow cytometry panel was developed.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/31\/dynamic-thymic-stromal-lymphopoietin-and-its-receptor-complex-expression-on-skin-langerhans-cells-in-response-to-mc903%e2%80%90induced-skin-inflammation-valuemartin-i-gonzalez%e2%80%90rodr\/\">Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903\u2010induced Skin Inflammation. [[{&#8220;value&#8221;:&#8221;Mart\u00edn I. Gonz\u00e1lez\u2010Rodr\u00edguez, \nTanja Salomaa, \nCarolina Cabalin, \nTuomas Komulainen, \nLotta Hiihtola, \nLaura Kummola, \nTero A. H. J\u00e4rvinen, \nIlkka S. Junttila&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-31T10:36:42+02:00\" class=\"wp-block-latest-posts__post-date\">31 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon Calcipotriol &#8230; <a title=\"Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903\u2010induced Skin Inflammation. [[{&#8220;value&#8221;:&#8221;Mart\u00edn I. Gonz\u00e1lez\u2010Rodr\u00edguez, \nTanja Salomaa, \nCarolina Cabalin, \nTuomas Komulainen, \nLotta Hiihtola, \nLaura Kummola, \nTero A. H. J\u00e4rvinen, \nIlkka S. Junttila&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/31\/dynamic-thymic-stromal-lymphopoietin-and-its-receptor-complex-expression-on-skin-langerhans-cells-in-response-to-mc903%e2%80%90induced-skin-inflammation-valuemartin-i-gonzalez%e2%80%90rodr\/\" aria-label=\"Read more about Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903\u2010induced Skin Inflammation. [[{&#8220;value&#8221;:&#8221;Mart\u00edn I. Gonz\u00e1lez\u2010Rodr\u00edguez, \nTanja Salomaa, \nCarolina Cabalin, \nTuomas Komulainen, \nLotta Hiihtola, \nLaura Kummola, \nTero A. H. J\u00e4rvinen, \nIlkka S. Junttila&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/selective-depletion-of-autoreactive-plasma-cells-as-a-novel-strategy-to-treat-acetylcholine-receptor-antibody%e2%80%90positive-myasthenia-gravis-valuelaleh-khodadadi-deborah-puppe-dilar\/\">Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody\u2010Positive Myasthenia Gravis. [[{&#8220;value&#8221;:&#8221;Laleh Khodadadi, \nDeborah Puppe, \nDilara S. Cirillo, \nCarolina Martinez\u2010Cingolani, \nJens Klotsche, \nAndreas Pelz, \nSiegfried Kohler, \nQingyu Cheng, \nKonstantinos Lazaridis, \nMichael Fichtner, \nJan Pille, \nAndrey Kruglov, \nMarina Bondareva, \nTobias Alexander, \nAndreas Radbruch, \nAndreas Meisel, \nFalk Hiepe&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Current plasma cell\u2013targeting therapies lack antigen specificity. Using an antibody-mediated cytotoxicity engager (ACE) targeting the \u03b1-subunit of the extracellular domain of the human acetylcholine receptor (hAChR \u03b1ECD), we selectively depleted pathogenic antibody-secreting cells in a myasthenia gravis model, reducing autoantibody titers and disease severity while preserving nonspecific antibody-secreting cells and humoral immunity. ABSTRACT Myasthenia gravis &#8230; <a title=\"Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody\u2010Positive Myasthenia Gravis. [[{&#8220;value&#8221;:&#8221;Laleh Khodadadi, \nDeborah Puppe, \nDilara S. Cirillo, \nCarolina Martinez\u2010Cingolani, \nJens Klotsche, \nAndreas Pelz, \nSiegfried Kohler, \nQingyu Cheng, \nKonstantinos Lazaridis, \nMichael Fichtner, \nJan Pille, \nAndrey Kruglov, \nMarina Bondareva, \nTobias Alexander, \nAndreas Radbruch, \nAndreas Meisel, \nFalk Hiepe&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/selective-depletion-of-autoreactive-plasma-cells-as-a-novel-strategy-to-treat-acetylcholine-receptor-antibody%e2%80%90positive-myasthenia-gravis-valuelaleh-khodadadi-deborah-puppe-dilar\/\" aria-label=\"Read more about Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody\u2010Positive Myasthenia Gravis. [[{&#8220;value&#8221;:&#8221;Laleh Khodadadi, \nDeborah Puppe, \nDilara S. Cirillo, \nCarolina Martinez\u2010Cingolani, \nJens Klotsche, \nAndreas Pelz, \nSiegfried Kohler, \nQingyu Cheng, \nKonstantinos Lazaridis, \nMichael Fichtner, \nJan Pille, \nAndrey Kruglov, \nMarina Bondareva, \nTobias Alexander, \nAndreas Radbruch, \nAndreas Meisel, \nFalk Hiepe&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/depletion-of-neonatal-neutrophilic-cells-worsens-the-outcome-of-e-coli-sepsis-in-newborn-mice-valuejulian-schwarz-janine-hebel-stefanie-dietz%e2%80%90ziegler-jessica-ruhle-trim-laj\/\">Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. [[{&#8220;value&#8221;:&#8221;Julian Schwarz, \nJanine Hebel, \nStefanie Dietz\u2010Ziegler, \nJessica R\u00fchle, \nTrim Lajqi, \nThorsten Orlikowsky, \nChristian F. Poets, \nChristian Gille, \nNatascha K\u00f6stlin\u2010Gille&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In a neonatal mouse model of E. coli sepsis, depleting neonatal neutrophilic cells (NNC) increased mortality and systemic inflammation. The bacterial load increased slightly, and the immune cell populations remained unchanged. These findings suggest that NNC may play a role in controlling inflammation and protecting neonates from lethal sepsis. ABSTRACT Neonates are particularly susceptible to &#8230; <a title=\"Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. [[{&#8220;value&#8221;:&#8221;Julian Schwarz, \nJanine Hebel, \nStefanie Dietz\u2010Ziegler, \nJessica R\u00fchle, \nTrim Lajqi, \nThorsten Orlikowsky, \nChristian F. Poets, \nChristian Gille, \nNatascha K\u00f6stlin\u2010Gille&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/depletion-of-neonatal-neutrophilic-cells-worsens-the-outcome-of-e-coli-sepsis-in-newborn-mice-valuejulian-schwarz-janine-hebel-stefanie-dietz%e2%80%90ziegler-jessica-ruhle-trim-laj\/\" aria-label=\"Read more about Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. [[{&#8220;value&#8221;:&#8221;Julian Schwarz, \nJanine Hebel, \nStefanie Dietz\u2010Ziegler, \nJessica R\u00fchle, \nTrim Lajqi, \nThorsten Orlikowsky, \nChristian F. Poets, \nChristian Gille, \nNatascha K\u00f6stlin\u2010Gille&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/deletion-of-lymphatic-pd%e2%80%90l1-protects-mice-from-severe-autoimmune-encephalitis-valueziyuan-wang-eleni-meuffels-christian-ashworth-emma-reynaud-shruthi-hemanna-burkhard-bech\/\">Deletion of Lymphatic PD\u2010L1 Protects Mice From Severe Autoimmune Encephalitis. [[{&#8220;value&#8221;:&#8221;Ziyuan Wang, \nEl\u00e8ni Meuffels, \nChristian Ashworth, \nEmma Reynaud, \nShruthi Hemanna, \nBurkhard Becher, \nMichael Detmar, \nSarah Mundt, \nLothar C. Dieterich&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lymphatic endothelial cells at the cribriform plate and in brain-draining cervical lymph nodes express PD-L1 during autoimmune encephalitis. Unexpectedly, deletion of lymphatic PD-L1 expression ameliorates disease symptoms and is associated with increased brain infiltration of regulatory CD8+ Foxp3+ T cells.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/a-new-immunofluorescence-assay-allows-the-sensitive-detection-of-anti%e2%80%90cytosolic-5%e2%80%b2%e2%80%90nucleotidase-1a-autoantibodies-valuefleur-n-brinkman-isa-g-a-verlangen-fili\/\">A New Immunofluorescence Assay Allows the Sensitive Detection of Anti\u2010Cytosolic 5\u2032\u2010Nucleotidase 1A Autoantibodies. [[{&#8220;value&#8221;:&#8221;Fleur N. Brinkman, \nIsa G. A. Verlangen, \nFiline Swets, \nGer J. M. Pruijn&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Anti-cN1A autoantibodies are helpful for diagnosing inclusion body myositis (IBM). We have developed an immunofluorescence assay based on the perinuclear accumulation of GFP-cN1A. The analysis of patient sera indicated that this assay shows a higher sensitivity for anti-cN1A in IBM compared to alternative assays, without loss of specificity.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/systemic-type-i-interferon-blockade-mitigates-insulin-resistance-in-a-preclinical-model-of-psoriasis-valuebishnu-prasad-sinha-purbita-bandopadhyay-md-asmaul-hoque-chinky-shiu-chen-li\/\">Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis. [[{&#8220;value&#8221;:&#8221;Bishnu Prasad Sinha, \nPurbita Bandopadhyay, \nMd. Asmaul Hoque, \nChinky Shiu Chen Liu, \nSuravi Mukherjee, \nRanit D&#8217;Rozario, \nShreya Roy, \nRituparna Jana, \nShrestha Pattanayak, \nJafar Sarif, \nDipyaman Ganguly&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">A preclinical model of TLR7-agonist-induced psoriasis develops insulin resistance by 3 weeks. Development of this psoriasis-associated insulin resistance can be prevented by systemic blockade of type I interferon signaling. ABSTRACT Psoriasis is a cutaneous autoimmune disease with worldwide prevalence. In situ activation of skin-infiltrating plasmacytoid dendritic cells (pDCs) leading to local induction of type I &#8230; <a title=\"Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis. [[{&#8220;value&#8221;:&#8221;Bishnu Prasad Sinha, \nPurbita Bandopadhyay, \nMd. Asmaul Hoque, \nChinky Shiu Chen Liu, \nSuravi Mukherjee, \nRanit D&#8217;Rozario, \nShreya Roy, \nRituparna Jana, \nShrestha Pattanayak, \nJafar Sarif, \nDipyaman Ganguly&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/systemic-type-i-interferon-blockade-mitigates-insulin-resistance-in-a-preclinical-model-of-psoriasis-valuebishnu-prasad-sinha-purbita-bandopadhyay-md-asmaul-hoque-chinky-shiu-chen-li\/\" aria-label=\"Read more about Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis. [[{&#8220;value&#8221;:&#8221;Bishnu Prasad Sinha, \nPurbita Bandopadhyay, \nMd. Asmaul Hoque, \nChinky Shiu Chen Liu, \nSuravi Mukherjee, \nRanit D&#8217;Rozario, \nShreya Roy, \nRituparna Jana, \nShrestha Pattanayak, \nJafar Sarif, \nDipyaman Ganguly&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/irgm1-restrains-cd8-t-cell-cytokine-production-and-apoptosis-via-cell%e2%80%90extrinsic-regulation-of-type-i-interferon-signaling-valuecaitlyn-t-molloy-yazan-alwarawrah-jonathan-a-co\/\">Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell\u2010Extrinsic Regulation of Type I Interferon Signaling. [[{&#8220;value&#8221;:&#8221;Caitlyn T. Molloy, \nYazan Alwarawrah, \nJonathan A. Cohen, \nBrian E. Fee, \nJason K. Whitmire, \nGregory A. Taylor, \nNancie J. MacIver&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Irgm1 regulates inflammatory disease by modulating leukocyte responses including those of T cells. In CD4+ T cells, Irgm1 functions in a cell-intrinsic manner. However, in CD8+ T cells, Irgm1 restrains cytokine production and cell death in a cell-extrinsic manner by controlling type I interferon production from hematopoietic and other sources. ABSTRACT Immunity-related GTPases (IRGs) are &#8230; <a title=\"Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell\u2010Extrinsic Regulation of Type I Interferon Signaling. [[{&#8220;value&#8221;:&#8221;Caitlyn T. Molloy, \nYazan Alwarawrah, \nJonathan A. Cohen, \nBrian E. Fee, \nJason K. Whitmire, \nGregory A. Taylor, \nNancie J. MacIver&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/irgm1-restrains-cd8-t-cell-cytokine-production-and-apoptosis-via-cell%e2%80%90extrinsic-regulation-of-type-i-interferon-signaling-valuecaitlyn-t-molloy-yazan-alwarawrah-jonathan-a-co\/\" aria-label=\"Read more about Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell\u2010Extrinsic Regulation of Type I Interferon Signaling. [[{&#8220;value&#8221;:&#8221;Caitlyn T. Molloy, \nYazan Alwarawrah, \nJonathan A. Cohen, \nBrian E. Fee, \nJason K. Whitmire, \nGregory A. Taylor, \nNancie J. MacIver&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/post%e2%80%90acute-sequelae-patients-with-severe-covid%e2%80%9019-history-show-a-prolonged-inflammatory-vascular-injury-pattern-valuelouisa-ruhl-isabell-pink-evgeny-chichelnitskiy-no\/\">Post\u2010Acute Sequelae Patients with Severe COVID\u201019 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [[{&#8220;value&#8221;:&#8221;Louisa Ruhl, \nIsabell Pink, \nEvgeny Chichelnitskiy, \nNora Drick, \nAndrea Sauer, \nLennart Boblitz, \nKerstin Beushausen, \nJana Keil, \nAnna\u2010Lena Ullrich, \nJulius Schmidt, \nMarius M. Hoeper, \nTobias Welte, \nJenny F. K\u00fchne, \nChristine S. Falk&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Long-COVID or post-acute sequelae of COVID-19 syndrome (PASC) patients with previous severe COVID-19 ICU history prior vaccination display sustained significant changes in their immune profile at both the cellular and the inflammatory level, revealing signatures of persistent inflammation and endothelial injury. ABSTRACT SARS-CoV-2 infection can lead to persistent symptoms (i.e., long\/post-COVID), especially in unvaccinated individuals. &#8230; <a title=\"Post\u2010Acute Sequelae Patients with Severe COVID\u201019 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [[{&#8220;value&#8221;:&#8221;Louisa Ruhl, \nIsabell Pink, \nEvgeny Chichelnitskiy, \nNora Drick, \nAndrea Sauer, \nLennart Boblitz, \nKerstin Beushausen, \nJana Keil, \nAnna\u2010Lena Ullrich, \nJulius Schmidt, \nMarius M. Hoeper, \nTobias Welte, \nJenny F. K\u00fchne, \nChristine S. Falk&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/post%e2%80%90acute-sequelae-patients-with-severe-covid%e2%80%9019-history-show-a-prolonged-inflammatory-vascular-injury-pattern-valuelouisa-ruhl-isabell-pink-evgeny-chichelnitskiy-no\/\" aria-label=\"Read more about Post\u2010Acute Sequelae Patients with Severe COVID\u201019 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [[{&#8220;value&#8221;:&#8221;Louisa Ruhl, \nIsabell Pink, \nEvgeny Chichelnitskiy, \nNora Drick, \nAndrea Sauer, \nLennart Boblitz, \nKerstin Beushausen, \nJana Keil, \nAnna\u2010Lena Ullrich, \nJulius Schmidt, \nMarius M. Hoeper, \nTobias Welte, \nJenny F. K\u00fchne, \nChristine S. Falk&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/prophylactic-inhaled-pattern-recognition-receptor-agonists-reprogram-lung-epithelial-response-and-prevent-type-2-allergic-inflammation-valuembaya-ntita-celine-shuet-lin-kong-dalia-hassa\/\">Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [[{&#8220;value&#8221;:&#8221;Mbaya Ntita, \nCeline Shuet Lin Kong, \nDalia Hassan, \nRicha Nayak, \nJezreel Pantale\u00f3n Garc\u00eda, \nYongxing Wang, \nJichao Chen, \nScott E. Evans&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Inhaled pretreatment of mouse lungs with immunomodulatory Pam2ODN results in lung epithelial cell epigenetic reprogramming that is associated with attenuation of house dust mite extract (HDM)-induced cDC2s and moDCs expansion in the lung, causing tolerance against HDM sensitization and restricting Th2-cell-induced airway eosinophilic allergic inflammation. ABSTRACT Prophylactic inhalation of the synergistic agents ODN M362 and &#8230; <a title=\"Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [[{&#8220;value&#8221;:&#8221;Mbaya Ntita, \nCeline Shuet Lin Kong, \nDalia Hassan, \nRicha Nayak, \nJezreel Pantale\u00f3n Garc\u00eda, \nYongxing Wang, \nJichao Chen, \nScott E. Evans&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/prophylactic-inhaled-pattern-recognition-receptor-agonists-reprogram-lung-epithelial-response-and-prevent-type-2-allergic-inflammation-valuembaya-ntita-celine-shuet-lin-kong-dalia-hassa\/\" aria-label=\"Read more about Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [[{&#8220;value&#8221;:&#8221;Mbaya Ntita, \nCeline Shuet Lin Kong, \nDalia Hassan, \nRicha Nayak, \nJezreel Pantale\u00f3n Garc\u00eda, \nYongxing Wang, \nJichao Chen, \nScott E. Evans&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/cover-story-eur-j-immunol-426\/\">Cover Story: Eur. J. Immunol. 4&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 4&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/cover-story-eur-j-immunol-426\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 4&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/issue-information-eur-j-immunol-426\/\">Issue Information: Eur. J. Immunol. 4&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 4, April 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/no-correlation-between-interferon-signaling-and-cytosolic-mitochondrial-dna-rna-leakage-in-cultured-skin-fibroblasts-of-patients-with-mitochondrial-diseases-valuemanon-marchais-alessandra\/\">No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA\/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. [[{&#8220;value&#8221;:&#8221;Manon Marchais, \nAlessandra Pennisi, \nAlexandre Pierga, \nAlice Lepelley, \nNicolas Cagnard, \nChristine Bole, \nPatrick Nitschke, \nMohamed Hamici, \nFr\u00e9d\u00e9ric Rieux\u2010Laucat, \nManuel Schiff, \nArnold Munnich, \nAgn\u00e8s R\u00f6tig&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Investigation of IFN signaling in cultured skin fibroblasts from patients with genetically confirmed mitochondrial diseases of diverse origins revealed that altered IFN signaling is an inconsistent feature of these disorders. Cytosolic accumulation of mtDNA and mtRNA was variably detected and showed little correlation with ISG scores. ABSTRACT Mitochondria have long been known to be involved &#8230; <a title=\"No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA\/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. [[{&#8220;value&#8221;:&#8221;Manon Marchais, \nAlessandra Pennisi, \nAlexandre Pierga, \nAlice Lepelley, \nNicolas Cagnard, \nChristine Bole, \nPatrick Nitschke, \nMohamed Hamici, \nFr\u00e9d\u00e9ric Rieux\u2010Laucat, \nManuel Schiff, \nArnold Munnich, \nAgn\u00e8s R\u00f6tig&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/no-correlation-between-interferon-signaling-and-cytosolic-mitochondrial-dna-rna-leakage-in-cultured-skin-fibroblasts-of-patients-with-mitochondrial-diseases-valuemanon-marchais-alessandra\/\" aria-label=\"Read more about No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA\/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. [[{&#8220;value&#8221;:&#8221;Manon Marchais, \nAlessandra Pennisi, \nAlexandre Pierga, \nAlice Lepelley, \nNicolas Cagnard, \nChristine Bole, \nPatrick Nitschke, \nMohamed Hamici, \nFr\u00e9d\u00e9ric Rieux\u2010Laucat, \nManuel Schiff, \nArnold Munnich, \nAgn\u00e8s R\u00f6tig&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/17\/going-virtual-as-a-memory%e2%80%90phenotype-t-lymphocyte-valuebin-yang-benjamin-g-dewals\/\">Going Virtual as a Memory\u2010Phenotype T Lymphocyte. [[{&#8220;value&#8221;:&#8221;Bin Yang, \nBenjamin G. Dewals&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-17T09:20:52+01:00\" class=\"wp-block-latest-posts__post-date\">17 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This review highlights how memory-phenotype CD8+ T lymphocytes (TMP) develop in immunologically naive hosts in the absence of non-self-antigens (Ag). We discuss the current understanding and controversies on the origin, maintenance and functions of the main populations recognized as TMP, in comparison to naive (TN) and Ag-specific true memory T cells (TTM). ABSTRACT Conventional or &#8230; <a title=\"Going Virtual as a Memory\u2010Phenotype T Lymphocyte. [[{&#8220;value&#8221;:&#8221;Bin Yang, \nBenjamin G. Dewals&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/17\/going-virtual-as-a-memory%e2%80%90phenotype-t-lymphocyte-valuebin-yang-benjamin-g-dewals\/\" aria-label=\"Read more about Going Virtual as a Memory\u2010Phenotype T Lymphocyte. [[{&#8220;value&#8221;:&#8221;Bin Yang, \nBenjamin G. Dewals&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/oleic-acid-promotes-treg-cell-differentiation-via-autophagy-induction-and-ameliorates-dss%e2%80%90induced-colitis-valueminghui-xia-yang-liu-xiujuan-zhao-qiuyang-du-zijie-chen-jing\/\">Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS\u2010Induced Colitis. [[{&#8220;value&#8221;:&#8221;Minghui Xia, \nYang Liu, \nXiujuan Zhao, \nQiuyang Du, \nZijie Chen, \nJing Wang, \nKamran Ghoreschi, \nArian Laurence, \nXinxin Xiong, \nJunyan Zhang, \nMing Zeng, \nXiang\u2010Ping Yang&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-14T08:49:54+01:00\" class=\"wp-block-latest-posts__post-date\">14 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Oleic acid enhances Treg cell differentiation by inducing autophagy via AMPK activation and mTORC1 inhibition. In DSS-induced colitis, oleic acid treatment expands colonic Tregs, reduces inflammatory cytokines, and ameliorates intestinal pathology. ABSTRACT Oleic acid (OA), a monounsaturated fatty acid (FA) prevalent in olive oil and key component of Mediterranean diet, exhibits anti-inflammatory effects in ulcerative &#8230; <a title=\"Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS\u2010Induced Colitis. [[{&#8220;value&#8221;:&#8221;Minghui Xia, \nYang Liu, \nXiujuan Zhao, \nQiuyang Du, \nZijie Chen, \nJing Wang, \nKamran Ghoreschi, \nArian Laurence, \nXinxin Xiong, \nJunyan Zhang, \nMing Zeng, \nXiang\u2010Ping Yang&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/oleic-acid-promotes-treg-cell-differentiation-via-autophagy-induction-and-ameliorates-dss%e2%80%90induced-colitis-valueminghui-xia-yang-liu-xiujuan-zhao-qiuyang-du-zijie-chen-jing\/\" aria-label=\"Read more about Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS\u2010Induced Colitis. [[{&#8220;value&#8221;:&#8221;Minghui Xia, \nYang Liu, \nXiujuan Zhao, \nQiuyang Du, \nZijie Chen, \nJing Wang, \nKamran Ghoreschi, \nArian Laurence, \nXinxin Xiong, \nJunyan Zhang, \nMing Zeng, \nXiang\u2010Ping Yang&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/human-systems-immunology-in-the-omics-era-challenges-methods-and-emerging-directions-valuelennart-riemann-reinhold-forster\/\">Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions. [[{&#8220;value&#8221;:&#8221;Lennart Riemann, \nReinhold F\u00f6rster&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-14T08:49:54+01:00\" class=\"wp-block-latest-posts__post-date\">14 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Systems immunology provides a transformative framework for decoding human immune complexity. This review evaluates high-throughput technologies and provides a roadmap for navigating analytical challenges\u2014such as batch effects and interindividual heterogeneity\u2014to successfully translate multimodal data into meaningful biological insights. ABSTRACT The human immune system is a highly complex, dynamic, and heterogeneous network shaped by genetic, environmental, &#8230; <a title=\"Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions. [[{&#8220;value&#8221;:&#8221;Lennart Riemann, \nReinhold F\u00f6rster&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/human-systems-immunology-in-the-omics-era-challenges-methods-and-emerging-directions-valuelennart-riemann-reinhold-forster\/\" aria-label=\"Read more about Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions. [[{&#8220;value&#8221;:&#8221;Lennart Riemann, \nReinhold F\u00f6rster&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/single%e2%80%90cell-profiling-of-splenic-immune-ageing-and-chronic-stress-adaptations-in-mice-with-natural-microbiota-valuechinna-susan-philip-igor-filippov-uku-haljasorg-part-peterso\/\">Single\u2010Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota. [[{&#8220;value&#8221;:&#8221;Chinna Susan Philip, \nIgor Filippov, \nUku Haljasorg, \nP\u00e4rt Peterson&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mice with natural microbiota show expected ageing spleen trends: na\u00efve T cell loss with effector-memory expansion, mature B cell shifts, Gzmk + CD8+ T cell heterogeneity, diminished NK cytotoxicity and pro-inflammatory macrophages. Chronic stress modestly counteracted these age-related changes. Splenocyte transcriptomic atlas reveals reproducible compositional shifts and defines conserved cell-type-specific ageing signatures. ABSTRACT Immune ageing &#8230; <a title=\"Single\u2010Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota. [[{&#8220;value&#8221;:&#8221;Chinna Susan Philip, \nIgor Filippov, \nUku Haljasorg, \nP\u00e4rt Peterson&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/single%e2%80%90cell-profiling-of-splenic-immune-ageing-and-chronic-stress-adaptations-in-mice-with-natural-microbiota-valuechinna-susan-philip-igor-filippov-uku-haljasorg-part-peterso\/\" aria-label=\"Read more about Single\u2010Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota. [[{&#8220;value&#8221;:&#8221;Chinna Susan Philip, \nIgor Filippov, \nUku Haljasorg, \nP\u00e4rt Peterson&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/non%e2%80%90cognate-cd8-binding-to-mhc-i-promotes-positive-selection-of-an-mhc%e2%80%90e-restricted-cd8-t-cell-population-valuexiaokun-yang-melissa-a-colden-rachel-coombs-kathya-aran\/\">Non\u2010cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC\u2010E Restricted CD8 T Cell Population. [[{&#8220;value&#8221;:&#8221;Xiaokun Yang, \nMelissa A. Colden, \nRachel Coombs, \nKathya Arana, \nDan Tran, \nMichael Manoharan Valerio, \nEllen A. Robey, \nLaurent Coscoy&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mouse Qa1b-restricted T cells show promiscuous requirements for positive selection. Using in vivo tetramer enrichment, in vitro APC engineering, and in vitro thymocyte stimulation, we demonstrate that a Qa1b-restricted T cell population can be selected by both Qa1b and H2-T11, and depends on non-cognate CD8-MHC I binding. ABSTRACT MHC-E-restricted CD8 T cells are emerging as &#8230; <a title=\"Non\u2010cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC\u2010E Restricted CD8 T Cell Population. [[{&#8220;value&#8221;:&#8221;Xiaokun Yang, \nMelissa A. Colden, \nRachel Coombs, \nKathya Arana, \nDan Tran, \nMichael Manoharan Valerio, \nEllen A. Robey, \nLaurent Coscoy&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/non%e2%80%90cognate-cd8-binding-to-mhc-i-promotes-positive-selection-of-an-mhc%e2%80%90e-restricted-cd8-t-cell-population-valuexiaokun-yang-melissa-a-colden-rachel-coombs-kathya-aran\/\" aria-label=\"Read more about Non\u2010cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC\u2010E Restricted CD8 T Cell Population. [[{&#8220;value&#8221;:&#8221;Xiaokun Yang, \nMelissa A. Colden, \nRachel Coombs, \nKathya Arana, \nDan Tran, \nMichael Manoharan Valerio, \nEllen A. Robey, \nLaurent Coscoy&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/heterogeneous-activated-b-cell-compartments-arising-early-and-transiently-after-sars%e2%80%90cov%e2%80%902-vaccination-valuelaura-fernandez-blanco-lisan-h-kuijper-laura-y-l-kummer-n\/\">Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS\u2010CoV\u20102 Vaccination. [[{&#8220;value&#8221;:&#8221;Laura Fernandez Blanco, \nLisan H. Kuijper, \nLaura Y.L. Kummer, \nNiels J.M. Verstegen, \nAm\u00e9lie Bos, \nMathieu Claireaux, \nMari\u00ebl C. Duurland, \nTineke Jorritsma, \nMaurice Steenhuis, \nGius Kerster, \nJuan J. Garcia Vallejo, \nMarit J. van Gils, \nKoos P.J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nLaura Boekel, \nGertjan J. Wolbink, \nSander W. Tas, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nAnja ten Brinke, \nS. Marieke van Ham, \nof T2B! Immunity Against SARS\u2010CoV\u20102 Study Group&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Characterization of the early antigen-specific B cell response post-SARS-CoV-2 vaccination reveals novel activated B cell clusters, showing different phenotypes and contraction dynamics. Some short-lived activated B cells expressed both CD71 and the extrafollicular marker CD11c. These results advance our understanding of B-cell differentiation regulation and biomarker potential. ABSTRACT In humans, the stages and dynamics of &#8230; <a title=\"Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS\u2010CoV\u20102 Vaccination. [[{&#8220;value&#8221;:&#8221;Laura Fernandez Blanco, \nLisan H. Kuijper, \nLaura Y.L. Kummer, \nNiels J.M. Verstegen, \nAm\u00e9lie Bos, \nMathieu Claireaux, \nMari\u00ebl C. Duurland, \nTineke Jorritsma, \nMaurice Steenhuis, \nGius Kerster, \nJuan J. Garcia Vallejo, \nMarit J. van Gils, \nKoos P.J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nLaura Boekel, \nGertjan J. Wolbink, \nSander W. Tas, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nAnja ten Brinke, \nS. Marieke van Ham, \nof T2B! Immunity Against SARS\u2010CoV\u20102 Study Group&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/heterogeneous-activated-b-cell-compartments-arising-early-and-transiently-after-sars%e2%80%90cov%e2%80%902-vaccination-valuelaura-fernandez-blanco-lisan-h-kuijper-laura-y-l-kummer-n\/\" aria-label=\"Read more about Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS\u2010CoV\u20102 Vaccination. [[{&#8220;value&#8221;:&#8221;Laura Fernandez Blanco, \nLisan H. Kuijper, \nLaura Y.L. Kummer, \nNiels J.M. Verstegen, \nAm\u00e9lie Bos, \nMathieu Claireaux, \nMari\u00ebl C. Duurland, \nTineke Jorritsma, \nMaurice Steenhuis, \nGius Kerster, \nJuan J. Garcia Vallejo, \nMarit J. van Gils, \nKoos P.J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nLaura Boekel, \nGertjan J. Wolbink, \nSander W. Tas, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nAnja ten Brinke, \nS. Marieke van Ham, \nof T2B! Immunity Against SARS\u2010CoV\u20102 Study Group&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/transcriptome-proteome-analysis-of-human-naive-and-memory-b-cell-subsets-reveals-isotype-and-subclass%e2%80%90specific-phenotypes-valuejana-koers-arie-j-hoogendijk-simon-tol\/\">Transcriptome\u2013Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass\u2010Specific Phenotypes. [[{&#8220;value&#8221;:&#8221;Jana Koers, \nArie J. Hoogendijk, \nSimon Tol, \nFloris P.J. Van Alphen, \nNinotska I.L. Derksen, \nMaartje van den Biggelaar, \nTheo Rispens&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We performed combined proteome and transcriptome analysis of human isotype-defined B cell subsets. IgG4-switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. SDR16C5 was identified as uniquely upregulated in IgG4-switched B cells. ABSTRACT Antibodies produced by B cells aid in the recognition and clearance &#8230; <a title=\"Transcriptome\u2013Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass\u2010Specific Phenotypes. [[{&#8220;value&#8221;:&#8221;Jana Koers, \nArie J. Hoogendijk, \nSimon Tol, \nFloris P.J. Van Alphen, \nNinotska I.L. Derksen, \nMaartje van den Biggelaar, \nTheo Rispens&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/transcriptome-proteome-analysis-of-human-naive-and-memory-b-cell-subsets-reveals-isotype-and-subclass%e2%80%90specific-phenotypes-valuejana-koers-arie-j-hoogendijk-simon-tol\/\" aria-label=\"Read more about Transcriptome\u2013Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass\u2010Specific Phenotypes. [[{&#8220;value&#8221;:&#8221;Jana Koers, \nArie J. Hoogendijk, \nSimon Tol, \nFloris P.J. Van Alphen, \nNinotska I.L. Derksen, \nMaartje van den Biggelaar, \nTheo Rispens&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/viral-immunity-in-immunoglobulin-products-global-immunity-debt-and-autoimmunity-in-the-postpandemic-era-valuehannes-lindahl-katy-shaw%e2%80%90saliba-h-benjamin-larman-c-i-edvard-s\/\">Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era. [[{&#8220;value&#8221;:&#8221;Hannes Lindahl, \nKaty Shaw\u2010Saliba, \nH. Benjamin Larman, \nC. I. Edvard Smith, \nPeter Bergman&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immunoglobulin products derived from pooled global plasma reflect population-level antiviral immunity. Analysis of batches from 2017 to 2023 reveals pandemic-driven shifts in viral antibody profiles and a concurrent rise in autoantibodies, notably against TRIM21\/Ro52, highlighting links between SARS-CoV-2, immunity debt, and autoimmunity. ABSTRACT Immunoglobulin (Ig) replacement therapy is commonly used to prevent infections in individuals &#8230; <a title=\"Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era. [[{&#8220;value&#8221;:&#8221;Hannes Lindahl, \nKaty Shaw\u2010Saliba, \nH. Benjamin Larman, \nC. I. Edvard Smith, \nPeter Bergman&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/viral-immunity-in-immunoglobulin-products-global-immunity-debt-and-autoimmunity-in-the-postpandemic-era-valuehannes-lindahl-katy-shaw%e2%80%90saliba-h-benjamin-larman-c-i-edvard-s\/\" aria-label=\"Read more about Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era. [[{&#8220;value&#8221;:&#8221;Hannes Lindahl, \nKaty Shaw\u2010Saliba, \nH. Benjamin Larman, \nC. I. Edvard Smith, \nPeter Bergman&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/changes-in-adaptive-immunity-in-autoimmune-diseases-and-aging-shared-features-key-differences-and-implications-for-immune-vulnerability-valuebojan-jevtic-milica-lazarevic-dorde-miljk\/\">Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for Immune Vulnerability. [[{&#8220;value&#8221;:&#8221;Bojan Jevti\u0107, \nMilica Lazarevi\u0107, \n\u0110or\u0111e Miljkovi\u0107, \nJanko \u017d. Nikolich&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Changes in adaptive immunity in autoimmune diseases and aging exhibit both shared and distinct alterations in immune cell compartments. Immune vulnerability is influenced by these alterations, which affect infection susceptibility and vaccination response in these clinically different but immunologically related conditions. ABSTRACT Immunologically vulnerable populations (IVP) are particularly at risk of infection due to dysregulated &#8230; <a title=\"Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for Immune Vulnerability. [[{&#8220;value&#8221;:&#8221;Bojan Jevti\u0107, \nMilica Lazarevi\u0107, \n\u0110or\u0111e Miljkovi\u0107, \nJanko \u017d. Nikolich&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/changes-in-adaptive-immunity-in-autoimmune-diseases-and-aging-shared-features-key-differences-and-implications-for-immune-vulnerability-valuebojan-jevtic-milica-lazarevic-dorde-miljk\/\" aria-label=\"Read more about Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for Immune Vulnerability. [[{&#8220;value&#8221;:&#8221;Bojan Jevti\u0107, \nMilica Lazarevi\u0107, \n\u0110or\u0111e Miljkovi\u0107, \nJanko \u017d. Nikolich&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/02\/38%e2%80%90marker-full%e2%80%90spectrum-flow-cytometry-panel-for-the-comprehensive-profiling-of-%ce%b3%ce%b4-t-cells-in-human-blood-and-lymphoid-tissues-valuemohamed-hamed-daniela-moreno\/\">38\u2010Marker Full\u2010Spectrum Flow Cytometry Panel for the Comprehensive Profiling of \u03b3\u03b4 T Cells in Human Blood and Lymphoid Tissues. [[{&#8220;value&#8221;:&#8221;Mohamed Hamed, \nDaniela Moreno\u2010Vicencio, \nDaniel Arsovski, \nMustafa Farhat, \nRosie Sanders, \nEllen Mann, \nAnnabelle Bennett, \nPriyanka Chevour, \nMartin S. Davey&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-02T10:26:00+01:00\" class=\"wp-block-latest-posts__post-date\">2 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This is an update to the\u00a0Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et\u00a0al. A 38-marker full-spectrum flow cytometry panel enabling high-resolution profiling of human \u03b3\u03b4 T cells across blood and lymphoid tissues, including robust identification of rare, tissue-adapted subsets.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/il%e2%80%9033-elicits-ltc4-synthesis-in-allergic-inflammation-via-st2%e2%80%90mediated-activation-of-eosinophils-valuevitoria-f-rosario%e2%80%90garcia-ericka-guimaraes%e2%80%90ferreira\/\">IL\u201033 Elicits LTC4 Synthesis in Allergic Inflammation via ST2\u2010Mediated Activation of Eosinophils. [[{&#8220;value&#8221;:&#8221;Vit\u00f3ria F. Ros\u00e1rio\u2010Garcia, \nEricka Guimaraes\u2010Ferreira, \nYasmin Brito\u2010Leite, \nJamille F. Oliveira, \nJulia Santos\u2010da\u2010Silva, \nNat\u00e1lia R. T. Amorim, \nValdirene S. Muniz, \nLukas Bolini, \nMiriam B. F. Werneck, \nClaudio Canetti, \nBruno L. Diaz, \nChristianne Bandeira\u2010Melo&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-01T10:06:16+01:00\" class=\"wp-block-latest-posts__post-date\">1 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Allergic reaction-derived IL-33 activates ST2 to trigger selective eosinophil activation. IL-33 in a type 2 immune response environment induces biogenesis of lipid bodies in eosinophils, platforms for the generation of lipid mediators, and selectively triggers LTC4 production. ABSTRACT Like pieces of a puzzle, IL-33, eosinophils, and cysteinyl leukotrienes seem to come together and orchestrate allergic &#8230; <a title=\"IL\u201033 Elicits LTC4 Synthesis in Allergic Inflammation via ST2\u2010Mediated Activation of Eosinophils. [[{&#8220;value&#8221;:&#8221;Vit\u00f3ria F. Ros\u00e1rio\u2010Garcia, \nEricka Guimaraes\u2010Ferreira, \nYasmin Brito\u2010Leite, \nJamille F. Oliveira, \nJulia Santos\u2010da\u2010Silva, \nNat\u00e1lia R. T. Amorim, \nValdirene S. Muniz, \nLukas Bolini, \nMiriam B. F. Werneck, \nClaudio Canetti, \nBruno L. Diaz, \nChristianne Bandeira\u2010Melo&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/il%e2%80%9033-elicits-ltc4-synthesis-in-allergic-inflammation-via-st2%e2%80%90mediated-activation-of-eosinophils-valuevitoria-f-rosario%e2%80%90garcia-ericka-guimaraes%e2%80%90ferreira\/\" aria-label=\"Read more about IL\u201033 Elicits LTC4 Synthesis in Allergic Inflammation via ST2\u2010Mediated Activation of Eosinophils. [[{&#8220;value&#8221;:&#8221;Vit\u00f3ria F. Ros\u00e1rio\u2010Garcia, \nEricka Guimaraes\u2010Ferreira, \nYasmin Brito\u2010Leite, \nJamille F. Oliveira, \nJulia Santos\u2010da\u2010Silva, \nNat\u00e1lia R. T. Amorim, \nValdirene S. Muniz, \nLukas Bolini, \nMiriam B. F. Werneck, \nClaudio Canetti, \nBruno L. Diaz, \nChristianne Bandeira\u2010Melo&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/cover-story-eur-j-immunol-326\/\">Cover Story: Eur. J. Immunol. 3&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-01T10:06:16+01:00\" class=\"wp-block-latest-posts__post-date\">1 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 3&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/cover-story-eur-j-immunol-326\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 3&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/issue-information-eur-j-immunol-326\/\">Issue Information: Eur. J. Immunol. 3&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-01T10:06:16+01:00\" class=\"wp-block-latest-posts__post-date\">1 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 3, March 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/26\/curbing-autoimmunity-a-new-fab-fragment-targeting-cd40%e2%80%90cd40l-halts-b%e2%80%90cell-activation-and-differentiation-valuekathrine-pedersen-kenneth-green-emil-l-kristoffersen-th\/\">Curbing Autoimmunity: A New Fab Fragment Targeting CD40\u2010CD40L Halts B\u2010Cell Activation and Differentiation. [[{&#8220;value&#8221;:&#8221;Kathrine Pedersen, \nKenneth Green, \nEmil L. Kristoffersen, \nThea Schinkel, \nAnnette G. Hansen, \nYaseelan Palarasah, \nAnne B. Rovsing, \nEbbe S. Andersen, \nJuli\u00e1n Valero, \nLaia Civit, \nNick S. Laursen, \nAnne Troldborg, \nS\u00f8ren E. Degn, \nSteffen Thiel&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-26T09:59:27+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The CD40-CD40L pathway is often dysregulated in B-cell-driven autoimmune diseases, making the development of CD40L inhibitors a promising therapeutic approach in managing autoimmune responses. We developed an inhibitory anti-CD40L Fab fragment, Fab20, and demonstrated that Fab20 effectively suppresses B-cell proliferation, differentiation, and antibody production in vitro. Made with Biorender. ABSTRACT Dysregulation of the CD40-CD40L axis &#8230; <a title=\"Curbing Autoimmunity: A New Fab Fragment Targeting CD40\u2010CD40L Halts B\u2010Cell Activation and Differentiation. [[{&#8220;value&#8221;:&#8221;Kathrine Pedersen, \nKenneth Green, \nEmil L. Kristoffersen, \nThea Schinkel, \nAnnette G. Hansen, \nYaseelan Palarasah, \nAnne B. Rovsing, \nEbbe S. Andersen, \nJuli\u00e1n Valero, \nLaia Civit, \nNick S. Laursen, \nAnne Troldborg, \nS\u00f8ren E. Degn, \nSteffen Thiel&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/26\/curbing-autoimmunity-a-new-fab-fragment-targeting-cd40%e2%80%90cd40l-halts-b%e2%80%90cell-activation-and-differentiation-valuekathrine-pedersen-kenneth-green-emil-l-kristoffersen-th\/\" aria-label=\"Read more about Curbing Autoimmunity: A New Fab Fragment Targeting CD40\u2010CD40L Halts B\u2010Cell Activation and Differentiation. [[{&#8220;value&#8221;:&#8221;Kathrine Pedersen, \nKenneth Green, \nEmil L. Kristoffersen, \nThea Schinkel, \nAnnette G. Hansen, \nYaseelan Palarasah, \nAnne B. Rovsing, \nEbbe S. Andersen, \nJuli\u00e1n Valero, \nLaia Civit, \nNick S. Laursen, \nAnne Troldborg, \nS\u00f8ren E. Degn, \nSteffen Thiel&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/25\/spatial-profiling-of-germinal-centers-in-mouse-secondary-lymphoid-organs-using-macsima-imaging-cyclic-staining-technology-valueisabel-san-martin-molina-hanneke-okkenhaug-simon-walker\/\">Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology. [[{&#8220;value&#8221;:&#8221;Isabel San Mart\u00edn Molina, \nHanneke Okkenhaug, \nSimon Walker, \nMichelle Linterman, \nEdith Marcial\u2010Ju\u00e1rez&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-25T09:35:29+01:00\" class=\"wp-block-latest-posts__post-date\">25 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, automated cyclic imaging, image preprocessing, and a new analysis method that detects morphological changes in irregularly shaped stromal cells.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/25\/type-1-and-cd103-type-2-conventional-dendritic-cells-are-decreased-in-active-patients-with-ulcerative-colitis-but-not-with-crohns-disease-valueelisa-arribas%e2%80%90rodriguez-carolina\/\">Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn&#8217;s Disease. [[{&#8220;value&#8221;:&#8221;Elisa Arribas\u2010Rodr\u00edguez, \nCarolina G. de Castro, \nAida Fiz\u2010L\u00f3pez, \n\u00c1ngel De Prado, \n\u00c1lvaro Mart\u00edn\u2010Mu\u00f1oz, \nLuis Fern\u00e1ndez Salazar, \nJes\u00fas Barrio, \nSandra Izquierdo, \nJavier Garc\u00eda Alonso, \nBeatriz de Andr\u00e9s, \nJos\u00e9 Mar\u00eda Garc\u00eda\u2010Abril, \nAlejandro Romero, \nJavier S\u00e1nchez Gonz\u00e1lez, \nCecilio Santander, \nEduardo Arranz, \nMar\u00eda Chaparro, \nJos\u00e9 A. Garrote, \nJavier P. Gisbert, \nDavid Bernardo&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-25T09:35:29+01:00\" class=\"wp-block-latest-posts__post-date\">25 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Human lamina propia mononuclear cells (LPMC) were isolated from intestinal biopsies and resections, as well as peripheral blood mononuclear cells (PBMC) from blood. Using flow cytometry approaches, we characterized cDC subsets and assessed their functional capacity through T-cell coculture assays (after isolation of the different subsets of cDC using sorter cytometry). This approach enabled a &#8230; <a title=\"Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn&#8217;s Disease. [[{&#8220;value&#8221;:&#8221;Elisa Arribas\u2010Rodr\u00edguez, \nCarolina G. de Castro, \nAida Fiz\u2010L\u00f3pez, \n\u00c1ngel De Prado, \n\u00c1lvaro Mart\u00edn\u2010Mu\u00f1oz, \nLuis Fern\u00e1ndez Salazar, \nJes\u00fas Barrio, \nSandra Izquierdo, \nJavier Garc\u00eda Alonso, \nBeatriz de Andr\u00e9s, \nJos\u00e9 Mar\u00eda Garc\u00eda\u2010Abril, \nAlejandro Romero, \nJavier S\u00e1nchez Gonz\u00e1lez, \nCecilio Santander, \nEduardo Arranz, \nMar\u00eda Chaparro, \nJos\u00e9 A. Garrote, \nJavier P. Gisbert, \nDavid Bernardo&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/25\/type-1-and-cd103-type-2-conventional-dendritic-cells-are-decreased-in-active-patients-with-ulcerative-colitis-but-not-with-crohns-disease-valueelisa-arribas%e2%80%90rodriguez-carolina\/\" aria-label=\"Read more about Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn&#8217;s Disease. [[{&#8220;value&#8221;:&#8221;Elisa Arribas\u2010Rodr\u00edguez, \nCarolina G. de Castro, \nAida Fiz\u2010L\u00f3pez, \n\u00c1ngel De Prado, \n\u00c1lvaro Mart\u00edn\u2010Mu\u00f1oz, \nLuis Fern\u00e1ndez Salazar, \nJes\u00fas Barrio, \nSandra Izquierdo, \nJavier Garc\u00eda Alonso, \nBeatriz de Andr\u00e9s, \nJos\u00e9 Mar\u00eda Garc\u00eda\u2010Abril, \nAlejandro Romero, \nJavier S\u00e1nchez Gonz\u00e1lez, \nCecilio Santander, \nEduardo Arranz, \nMar\u00eda Chaparro, \nJos\u00e9 A. Garrote, \nJavier P. Gisbert, \nDavid Bernardo&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/24\/cd4-t%e2%80%90cell%e2%80%90intrinsic-il%e2%80%906-is-critical-for-th17-differentiation-and-dampened-responsiveness-to-cd8-t-cell%e2%80%90mediated-suppression-valuechakrapani-vemulawada\/\">CD4+ T\u2010Cell\u2010Intrinsic IL\u20106 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell\u2010Mediated Suppression. [[{&#8220;value&#8221;:&#8221;Chakrapani Vemulawada, \nKshitija Kale, \nMichael P. Crawford, \nNitin J. Karandikar&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-24T10:15:54+01:00\" class=\"wp-block-latest-posts__post-date\">24 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">1. Normal state: T-cell-endogenous IL-6 stabilizes IL6R and promotes STAT3 activation, functional Th17 differentiation with resistance to immune suppression. 2. Il6-KO: Loss of T-cell endogenous IL-6 destabilizes IL6R expression, leading to suboptimal Th17 and greater susceptibility to suppression, despite availability of exogenous IL-6. 3. IL-21 bypasses the requirement for endogenous IL-6 by restoring STAT3 signaling &#8230; <a title=\"CD4+ T\u2010Cell\u2010Intrinsic IL\u20106 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell\u2010Mediated Suppression. [[{&#8220;value&#8221;:&#8221;Chakrapani Vemulawada, \nKshitija Kale, \nMichael P. Crawford, \nNitin J. Karandikar&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/24\/cd4-t%e2%80%90cell%e2%80%90intrinsic-il%e2%80%906-is-critical-for-th17-differentiation-and-dampened-responsiveness-to-cd8-t-cell%e2%80%90mediated-suppression-valuechakrapani-vemulawada\/\" aria-label=\"Read more about CD4+ T\u2010Cell\u2010Intrinsic IL\u20106 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell\u2010Mediated Suppression. [[{&#8220;value&#8221;:&#8221;Chakrapani Vemulawada, \nKshitija Kale, \nMichael P. Crawford, \nNitin J. Karandikar&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/latent-lytic-and-linked-to-multiple-sclerosis-how-ebv-drives-autoimmunity-valuefabienne-laderach-elena-bremer-christian-munz\/\">Latent, Lytic, and Linked to Multiple Sclerosis\u2014How EBV Drives Autoimmunity. [[{&#8220;value&#8221;:&#8221;Fabienne L\u00e4derach, \nElena Bremer, \nChristian M\u00fcnz&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-23T09:57:17+01:00\" class=\"wp-block-latest-posts__post-date\">23 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B-cell repertoire and promotes the oligoclonal expansion and subsequent CNS infiltration of T-bet+CXCR3+ B cells, resulting in a cascade of immune dysregulation, CNS inflammation, and autoreactive T cell stimulation. Created in BioRender. &#8230; <a title=\"Latent, Lytic, and Linked to Multiple Sclerosis\u2014How EBV Drives Autoimmunity. [[{&#8220;value&#8221;:&#8221;Fabienne L\u00e4derach, \nElena Bremer, \nChristian M\u00fcnz&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/latent-lytic-and-linked-to-multiple-sclerosis-how-ebv-drives-autoimmunity-valuefabienne-laderach-elena-bremer-christian-munz\/\" aria-label=\"Read more about Latent, Lytic, and Linked to Multiple Sclerosis\u2014How EBV Drives Autoimmunity. [[{&#8220;value&#8221;:&#8221;Fabienne L\u00e4derach, \nElena Bremer, \nChristian M\u00fcnz&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/discovery-of-lomitapide-as-a-novel-mast-cell-regulatory-agent-through-chemical-library-screening-valueshiori-mamorita-atsushi-furukawa-yuka-nagata-ryo-suzuki\/\">Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [[{&#8220;value&#8221;:&#8221;Shiori Mamorita, \nAtsushi Furukawa, \nYuka Nagata, \nRyo Suzuki&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-23T09:57:17+01:00\" class=\"wp-block-latest-posts__post-date\">23 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Chemical library screening identified lomitapide as a novel mast cell (MC) regulatory agent. Lomitapide selectively inhibits IgE\/Ag- or phorbol 12-myristate 13-acetate (PMA)\/ionomycin-mediated MC degranulation by altering plasma membrane dynamics, including endocytosis and membrane fusion. ABSTRACT Allergic diseases are a global health concern, and new molecular insights and therapeutic agents are necessary to support future research &#8230; <a title=\"Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [[{&#8220;value&#8221;:&#8221;Shiori Mamorita, \nAtsushi Furukawa, \nYuka Nagata, \nRyo Suzuki&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/discovery-of-lomitapide-as-a-novel-mast-cell-regulatory-agent-through-chemical-library-screening-valueshiori-mamorita-atsushi-furukawa-yuka-nagata-ryo-suzuki\/\" aria-label=\"Read more about Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [[{&#8220;value&#8221;:&#8221;Shiori Mamorita, \nAtsushi Furukawa, \nYuka Nagata, \nRyo Suzuki&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/19\/il%e2%80%9021-selectively-augments-cytotoxic-potential-of-antigen%e2%80%90activated-mait-cells-valuelaura-e-wedlock-rajesh-lamichhane-meg-c-webley-selena-c-l-gilmer-andrea-j-ve\/\">IL\u201021 Selectively Augments Cytotoxic Potential of Antigen\u2010Activated MAIT Cells. [[{&#8220;value&#8221;:&#8221;Laura E. Wedlock, \nRajesh Lamichhane, \nMeg C. Webley, \nSelena C. L. Gilmer, \nAndrea J. Vernall, \nJames E. Ussher&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-19T10:22:31+01:00\" class=\"wp-block-latest-posts__post-date\">19 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Using an in vitro PBMC assay, we found that the addition of exogenous IL-21 enhances the cytotoxic potential of MAIT cells activated by 5-OP-RU. IL-21 induces STAT phosphorylation and provides co-stimulation to TCR-activated MAIT cells, selectively augmenting granzyme B and perforin expression without enhancing interferon-gamma or TNF production at 6\u00a0h. ABSTRACT Mucosal-associated invariant T (MAIT) &#8230; <a title=\"IL\u201021 Selectively Augments Cytotoxic Potential of Antigen\u2010Activated MAIT Cells. [[{&#8220;value&#8221;:&#8221;Laura E. Wedlock, \nRajesh Lamichhane, \nMeg C. Webley, \nSelena C. L. Gilmer, \nAndrea J. Vernall, \nJames E. Ussher&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/19\/il%e2%80%9021-selectively-augments-cytotoxic-potential-of-antigen%e2%80%90activated-mait-cells-valuelaura-e-wedlock-rajesh-lamichhane-meg-c-webley-selena-c-l-gilmer-andrea-j-ve\/\" aria-label=\"Read more about IL\u201021 Selectively Augments Cytotoxic Potential of Antigen\u2010Activated MAIT Cells. [[{&#8220;value&#8221;:&#8221;Laura E. Wedlock, \nRajesh Lamichhane, \nMeg C. Webley, \nSelena C. L. Gilmer, \nAndrea J. Vernall, \nJames E. Ussher&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/16\/charting-bird-tregs-valuelingling-wu-jingxia-wu-guoliang-cui\/\">Charting Bird Tregs. [[{&#8220;value&#8221;:&#8221;Lingling Wu, \nJingxia Wu, \nGuoliang Cui&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-16T10:14:01+01:00\" class=\"wp-block-latest-posts__post-date\">16 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">FoxP3, a lineage-defining transcription factor, defines mammalian Tregs together with antibodies against CD25, GITR, and CTLA-4. No valid chicken anti-FoxP3 or surface CTLA-4 antibodies are available to date. Given current experimental tools, the study proposes CD4+CD25+GITR+ as a practical panel for phenotypic characterization and sorting of viable chicken Tregs. ABSTRACT Regulatory T cells (Tregs) are &#8230; <a title=\"Charting Bird Tregs. [[{&#8220;value&#8221;:&#8221;Lingling Wu, \nJingxia Wu, \nGuoliang Cui&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/16\/charting-bird-tregs-valuelingling-wu-jingxia-wu-guoliang-cui\/\" aria-label=\"Read more about Charting Bird Tregs. [[{&#8220;value&#8221;:&#8221;Lingling Wu, \nJingxia Wu, \nGuoliang Cui&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/distinguishing-features-of-ilc2s-during-type-2-immune-responses-valuemanuel-o-jakob-patrycja-m-forster-christoph-s-n-klose\/\">Distinguishing Features of ILC2s During Type 2 Immune Responses. [[{&#8220;value&#8221;:&#8221;Manuel O. Jakob, \nPatrycja M. Forster, \nChristoph S. N. Klose&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-13T09:59:13+01:00\" class=\"wp-block-latest-posts__post-date\">13 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells regulated by diverse signals often emanating from surrounding nonhematopoietic cells at barrier surfaces. Their effector cytokines determine tissue homeostasis at steady state and during type 2 immunity in allergies or worm infections. Redundant and unique functions of ILC2s and T cells are assessed in this context. &#8230; <a title=\"Distinguishing Features of ILC2s During Type 2 Immune Responses. [[{&#8220;value&#8221;:&#8221;Manuel O. Jakob, \nPatrycja M. Forster, \nChristoph S. N. Klose&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/distinguishing-features-of-ilc2s-during-type-2-immune-responses-valuemanuel-o-jakob-patrycja-m-forster-christoph-s-n-klose\/\" aria-label=\"Read more about Distinguishing Features of ILC2s During Type 2 Immune Responses. [[{&#8220;value&#8221;:&#8221;Manuel O. Jakob, \nPatrycja M. Forster, \nChristoph S. N. Klose&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/multi%e2%80%90omics-analysis-reveals-sex%e2%80%90specific-signatures-for-bcg-vaccine-efficacy-valueqiuyao-zhan-liang-zhou-jianbo-fu-xun-jiang-xuan-liu-wenchao-li-simone-j-c-f-m\/\">Multi\u2010Omics Analysis Reveals Sex\u2010Specific Signatures for BCG Vaccine Efficacy. [[{&#8220;value&#8221;:&#8221;Qiuyao Zhan, \nLiang Zhou, \nJianbo Fu, \nXun Jiang, \nXuan Liu, \nWenchao Li, \nSimone J.C.F.M. Moorlag, \nValerie A.C.M. Koeken, \nL. Charlotte J. de Bree, \nVera P. Mourits, \nLeo A.B. Joosten, \nYang Li, \nMihai G. Netea, \nCheng\u2010Jian Xu&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-13T09:59:13+01:00\" class=\"wp-block-latest-posts__post-date\">13 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Sex-specific pre-vaccination immune landscapes associated with effective BCG vaccine responses. Male high responders exhibit a monocyte-enriched, pro-inflammatory innate immune profile, whereas female high responders display immune signatures associated with enhanced adaptive immune responses. ABSTRACT Vaccines are a cornerstone of global public health, but their efficacy can vary significantly among individuals. Bacille Calmette-Gu\u00e9rin (BCG) vaccine against &#8230; <a title=\"Multi\u2010Omics Analysis Reveals Sex\u2010Specific Signatures for BCG Vaccine Efficacy. [[{&#8220;value&#8221;:&#8221;Qiuyao Zhan, \nLiang Zhou, \nJianbo Fu, \nXun Jiang, \nXuan Liu, \nWenchao Li, \nSimone J.C.F.M. Moorlag, \nValerie A.C.M. Koeken, \nL. Charlotte J. de Bree, \nVera P. Mourits, \nLeo A.B. Joosten, \nYang Li, \nMihai G. Netea, \nCheng\u2010Jian Xu&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/multi%e2%80%90omics-analysis-reveals-sex%e2%80%90specific-signatures-for-bcg-vaccine-efficacy-valueqiuyao-zhan-liang-zhou-jianbo-fu-xun-jiang-xuan-liu-wenchao-li-simone-j-c-f-m\/\" aria-label=\"Read more about Multi\u2010Omics Analysis Reveals Sex\u2010Specific Signatures for BCG Vaccine Efficacy. [[{&#8220;value&#8221;:&#8221;Qiuyao Zhan, \nLiang Zhou, \nJianbo Fu, \nXun Jiang, \nXuan Liu, \nWenchao Li, \nSimone J.C.F.M. Moorlag, \nValerie A.C.M. Koeken, \nL. Charlotte J. de Bree, \nVera P. Mourits, \nLeo A.B. Joosten, \nYang Li, \nMihai G. Netea, \nCheng\u2010Jian Xu&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/10\/meningococcal-serogroup-y-meningitis-reveals-inborn-factor-b-deficiency-valuecamille-bougeard-eleonore-eskander-paula-vieira-martins-joan-bitan-julia-roquigny-christele-kyheng-t\/\">Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency. [[{&#8220;value&#8221;:&#8221;Camille Bougeard, \nEl\u00e9onore Eskander, \nPaula Vieira Martins, \nJoan Bitan, \nJulia Roquigny, \nChrist\u00e8le Kyheng, \nTamazoust Guiddir, \nV\u00e9ronique Fr\u00e9meaux\u2010Bacchi, \nC\u00e9cile Gonnin, \nCarine ElSissy&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-10T10:28:22+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and to the clinical use of Factor B &#8230; <a title=\"Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency. [[{&#8220;value&#8221;:&#8221;Camille Bougeard, \nEl\u00e9onore Eskander, \nPaula Vieira Martins, \nJoan Bitan, \nJulia Roquigny, \nChrist\u00e8le Kyheng, \nTamazoust Guiddir, \nV\u00e9ronique Fr\u00e9meaux\u2010Bacchi, \nC\u00e9cile Gonnin, \nCarine ElSissy&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/10\/meningococcal-serogroup-y-meningitis-reveals-inborn-factor-b-deficiency-valuecamille-bougeard-eleonore-eskander-paula-vieira-martins-joan-bitan-julia-roquigny-christele-kyheng-t\/\" aria-label=\"Read more about Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency. [[{&#8220;value&#8221;:&#8221;Camille Bougeard, \nEl\u00e9onore Eskander, \nPaula Vieira Martins, \nJoan Bitan, \nJulia Roquigny, \nChrist\u00e8le Kyheng, \nTamazoust Guiddir, \nV\u00e9ronique Fr\u00e9meaux\u2010Bacchi, \nC\u00e9cile Gonnin, \nCarine ElSissy&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/07\/cytomegalovirus%e2%80%90based-viral-vectors-elicit-robust-systemic-and-tissue%e2%80%90resident-immune-response-against-sars%e2%80%90cov%e2%80%902-antigens-valuemaja-cokaric-brdovcak-jelen\/\">Cytomegalovirus\u2010Based Viral Vectors Elicit Robust Systemic and Tissue\u2010Resident Immune Response Against SARS\u2010CoV\u20102 Antigens. [[{&#8220;value&#8221;:&#8221;Maja Cokari\u0107 Brdov\u010dak, \nJelena Materljan Franki, \nMarko \u0160usti\u0107, \nKarmela Mikli\u0107, \nMagdalena Medved, \nLydia Ga\u0107ina, \nTina Ru\u017ei\u0107, \nStipan Jonji\u0107, \nIlija Brizi\u0107, \nAstrid Krmpoti\u0107&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-07T09:45:38+01:00\" class=\"wp-block-latest-posts__post-date\">7 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We developed murine CMV-based viral vectors expressing SARS-CoV-2 spike antigen and compared immune response following intraperitoneal and intranasal delivery. Route of vaccine administration shaped antibody and CD8+ T cell response magnitude, kinetics, and tissue residency, highlighting the potential of CMV vectors for induction of protective lung immunity. Created in https:\/\/BioRender.com. ABSTRACT Current COVID-19 vaccines face &#8230; <a title=\"Cytomegalovirus\u2010Based Viral Vectors Elicit Robust Systemic and Tissue\u2010Resident Immune Response Against SARS\u2010CoV\u20102 Antigens. [[{&#8220;value&#8221;:&#8221;Maja Cokari\u0107 Brdov\u010dak, \nJelena Materljan Franki, \nMarko \u0160usti\u0107, \nKarmela Mikli\u0107, \nMagdalena Medved, \nLydia Ga\u0107ina, \nTina Ru\u017ei\u0107, \nStipan Jonji\u0107, \nIlija Brizi\u0107, \nAstrid Krmpoti\u0107&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/07\/cytomegalovirus%e2%80%90based-viral-vectors-elicit-robust-systemic-and-tissue%e2%80%90resident-immune-response-against-sars%e2%80%90cov%e2%80%902-antigens-valuemaja-cokaric-brdovcak-jelen\/\" aria-label=\"Read more about Cytomegalovirus\u2010Based Viral Vectors Elicit Robust Systemic and Tissue\u2010Resident Immune Response Against SARS\u2010CoV\u20102 Antigens. [[{&#8220;value&#8221;:&#8221;Maja Cokari\u0107 Brdov\u010dak, \nJelena Materljan Franki, \nMarko \u0160usti\u0107, \nKarmela Mikli\u0107, \nMagdalena Medved, \nLydia Ga\u0107ina, \nTina Ru\u017ei\u0107, \nStipan Jonji\u0107, \nIlija Brizi\u0107, \nAstrid Krmpoti\u0107&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/06\/isolation-of-pure-stable-human-treg-cells-based-on-expression-of-gpa33-valueflorencia-morgana-edith-slot-derk-amsen\/\">Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33. [[{&#8220;value&#8221;:&#8221;Florencia Morgana, \nEdith Slot, \nDerk Amsen&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-06T10:23:24+01:00\" class=\"wp-block-latest-posts__post-date\">6 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">GPA33 identifies stable human regulatory T cells suitable for therapeutic use. GPA33+ Treg subsets expand efficiently, maintain high FOXP3+Helios+ expression, and lack production of IL-2, IFN\u03b3, and IL-17A. GPA33, alone or combined with TIGIT, also enables robust post-expansion isolation of pure, stable Treg cells for adoptive cell therapy. ABSTRACT Adoptive cell therapy (ACT) with regulatory &#8230; <a title=\"Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33. [[{&#8220;value&#8221;:&#8221;Florencia Morgana, \nEdith Slot, \nDerk Amsen&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/06\/isolation-of-pure-stable-human-treg-cells-based-on-expression-of-gpa33-valueflorencia-morgana-edith-slot-derk-amsen\/\" aria-label=\"Read more about Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33. [[{&#8220;value&#8221;:&#8221;Florencia Morgana, \nEdith Slot, \nDerk Amsen&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/ubl3-participates-in-the-early-stages-of-cd83%e2%80%90dependent-cd4-t-cell-selection-valuehuw-morgan-haiyin-liu-jose-a-villadangos-justine-d-mintern\/\">UBL3 Participates in the Early Stages of CD83\u2010Dependent CD4+ T Cell Selection. [[{&#8220;value&#8221;:&#8221;Huw Morgan, \nHaiyin Liu, \nJose A. Villadangos, \nJustine D. Mintern&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-05T09:38:04+01:00\" class=\"wp-block-latest-posts__post-date\">5 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CD83 and UBL3 are regulators of MHCII surface expression; however, only CD83 has a known role in regulating CD4+ T cell selection. This paper describes a role for UBL3 in regulating MHC II expression on thymic epithelium in a CD83-deficient context, leading to alterations in CD4+ T cell positive selection. ABSTRACT CD83 is critical for &#8230; <a title=\"UBL3 Participates in the Early Stages of CD83\u2010Dependent CD4+ T Cell Selection. [[{&#8220;value&#8221;:&#8221;Huw Morgan, \nHaiyin Liu, \nJose A. Villadangos, \nJustine D. Mintern&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/ubl3-participates-in-the-early-stages-of-cd83%e2%80%90dependent-cd4-t-cell-selection-valuehuw-morgan-haiyin-liu-jose-a-villadangos-justine-d-mintern\/\" aria-label=\"Read more about UBL3 Participates in the Early Stages of CD83\u2010Dependent CD4+ T Cell Selection. [[{&#8220;value&#8221;:&#8221;Huw Morgan, \nHaiyin Liu, \nJose A. Villadangos, \nJustine D. Mintern&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/a-novel-murine-model-of-hemophagocytic-lymphohistiocytosis%e2%80%90like-inflammation-in-znfx1-deficiency-valuediana-tintor-samantha-milanesi-tommaso-marchetti-tiziana-lorenzini-seve\/\">A Novel Murine Model of Hemophagocytic Lymphohistiocytosis\u2010Like Inflammation in ZNFX1 Deficiency. [[{&#8220;value&#8221;:&#8221;Diana Tintor, \nSamantha Milanesi, \nTommaso Marchetti, \nTiziana Lorenzini, \nSeverin Walser, \nJunyi Chen, \nJulius K\u00f6ppen, \nAchim Weber, \nOla Sabet, \nJana Pachlopnik Schmid&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-05T09:38:04+01:00\" class=\"wp-block-latest-posts__post-date\">5 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">LCMV-infected Znfx1-deficient mice develop hemophagocytic lymphohistiocytosis (HLH)-like immune dysregulation, mirroring key aspects of the immunopathology observed in ZNFX1-deficient patients. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages. Recently, deleterious autosomal recessive mutations in ZNFX1 were reported to predispose pediatric patients to HLH-like disease upon viral trigger. &#8230; <a title=\"A Novel Murine Model of Hemophagocytic Lymphohistiocytosis\u2010Like Inflammation in ZNFX1 Deficiency. [[{&#8220;value&#8221;:&#8221;Diana Tintor, \nSamantha Milanesi, \nTommaso Marchetti, \nTiziana Lorenzini, \nSeverin Walser, \nJunyi Chen, \nJulius K\u00f6ppen, \nAchim Weber, \nOla Sabet, \nJana Pachlopnik Schmid&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/a-novel-murine-model-of-hemophagocytic-lymphohistiocytosis%e2%80%90like-inflammation-in-znfx1-deficiency-valuediana-tintor-samantha-milanesi-tommaso-marchetti-tiziana-lorenzini-seve\/\" aria-label=\"Read more about A Novel Murine Model of Hemophagocytic Lymphohistiocytosis\u2010Like Inflammation in ZNFX1 Deficiency. [[{&#8220;value&#8221;:&#8221;Diana Tintor, \nSamantha Milanesi, \nTommaso Marchetti, \nTiziana Lorenzini, \nSeverin Walser, \nJunyi Chen, \nJulius K\u00f6ppen, \nAchim Weber, \nOla Sabet, \nJana Pachlopnik Schmid&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/gene-regulatory-programs-of-nk-cells-show-that-ncam1-cd56-and-kirs-are-controlled-by-genetically-polymorphic-distal-regulatory-elements-valuemariam-a-salem-aditi-varkey-matthew-d-es\/\">Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements. [[{&#8220;value&#8221;:&#8221;Mariam A. Salem, \nAditi Varkey, \nMatthew D. Estrada, \nKruthika Sharma, \nCaprice D. Eisele, \nNitin Chakravarti, \nDean A. Lee, \nAharon G. Freud, \nBethany L. Mundy\u2010Bosse, \nPatrick L. Collins&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-05T09:38:04+01:00\" class=\"wp-block-latest-posts__post-date\">5 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">A deeper understanding of the natural killer cell gene expression regulation driving NK cell maturation and cytotoxicity could provide critical insights into optimizing NK therapies. Our findings reveal novel enhancers governing NK cell genes for NCAM1\/CD56 and cis-regulation for KIR receptors and clarify existing models of NK cell cis-accessibility regulation. ABSTRACT Owing to their immunoprotective &#8230; <a title=\"Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements. [[{&#8220;value&#8221;:&#8221;Mariam A. Salem, \nAditi Varkey, \nMatthew D. Estrada, \nKruthika Sharma, \nCaprice D. Eisele, \nNitin Chakravarti, \nDean A. Lee, \nAharon G. Freud, \nBethany L. Mundy\u2010Bosse, \nPatrick L. Collins&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/gene-regulatory-programs-of-nk-cells-show-that-ncam1-cd56-and-kirs-are-controlled-by-genetically-polymorphic-distal-regulatory-elements-valuemariam-a-salem-aditi-varkey-matthew-d-es\/\" aria-label=\"Read more about Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements. [[{&#8220;value&#8221;:&#8221;Mariam A. Salem, \nAditi Varkey, \nMatthew D. Estrada, \nKruthika Sharma, \nCaprice D. Eisele, \nNitin Chakravarti, \nDean A. Lee, \nAharon G. Freud, \nBethany L. Mundy\u2010Bosse, \nPatrick L. Collins&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/issue-information-eur-j-immunol-226\/\">Issue Information: Eur. J. Immunol. 2&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 2, February 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/microbial%e2%80%90immune-interplay-in-cns-autoimmune-diseases-lessons-from-animal-models-and-clinical-studies-valuematteo-ceccon-francesca-ronchi\/\">Microbial\u2010Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies. [[{&#8220;value&#8221;:&#8221;Matteo Ceccon, \nFrancesca Ronchi&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS-resident cells such as microglia and astrocytes, contributing to immune-mediated CNS pathology. Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), &#8230; <a title=\"Microbial\u2010Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies. [[{&#8220;value&#8221;:&#8221;Matteo Ceccon, \nFrancesca Ronchi&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/microbial%e2%80%90immune-interplay-in-cns-autoimmune-diseases-lessons-from-animal-models-and-clinical-studies-valuematteo-ceccon-francesca-ronchi\/\" aria-label=\"Read more about Microbial\u2010Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies. [[{&#8220;value&#8221;:&#8221;Matteo Ceccon, \nFrancesca Ronchi&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/proteomic-analysis-of-regulated-dendritic-cell-endosomes-reveals-dynamic-adaptation-to-antigen-uptake-and-cross%e2%80%90presentation-valuealice-senni-louise-grumbach-sara-ceccacci-mat\/\">Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross\u2010Presentation. [[{&#8220;value&#8221;:&#8221;Alice Senni, \nLouise Grumbach, \nSara Ceccacci, \nMathieu Frechin, \nNicolas Goudin, \nIda Chiara Guerrera, \nBarbara Bertocci, \nPeter van Endert&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross-presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated. ABSTRACT MHC class I (MHC-I) cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated &#8230; <a title=\"Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross\u2010Presentation. [[{&#8220;value&#8221;:&#8221;Alice Senni, \nLouise Grumbach, \nSara Ceccacci, \nMathieu Frechin, \nNicolas Goudin, \nIda Chiara Guerrera, \nBarbara Bertocci, \nPeter van Endert&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/proteomic-analysis-of-regulated-dendritic-cell-endosomes-reveals-dynamic-adaptation-to-antigen-uptake-and-cross%e2%80%90presentation-valuealice-senni-louise-grumbach-sara-ceccacci-mat\/\" aria-label=\"Read more about Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross\u2010Presentation. [[{&#8220;value&#8221;:&#8221;Alice Senni, \nLouise Grumbach, \nSara Ceccacci, \nMathieu Frechin, \nNicolas Goudin, \nIda Chiara Guerrera, \nBarbara Bertocci, \nPeter van Endert&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/a-cell%e2%80%90intrinsic-role-for-rank-in-regulatory-t-cells-of-the-human-thymus-valuezoe%e2%80%90isabella-junginger-ramona-adameck-alexandre-a-s-f-raposo-pedro-rosmaninho-ana-e\/\">A Cell\u2010Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus. [[{&#8220;value&#8221;:&#8221;Zoe\u2010Isabella Junginger, \nRamona Adameck, \nAlexandre A. S. F. Raposo, \nPedro Rosmaninho, \nAna E. Sousa, \nAfonso R. M. Almeida&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We identified RANK (TNFRSF11a) expression in human thymic FOXP3+ Tregs, revealing a previously unknown role for the RANK-RANKL axis in human tTreg development. We show that IL-2 and IL-15 can drive RANK expression in CD4+ tTregs, which in turn may modulate their maturation and proliferation within the thymic environment. Created in BioRender. Biorender, I. (2026) &#8230; <a title=\"A Cell\u2010Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus. [[{&#8220;value&#8221;:&#8221;Zoe\u2010Isabella Junginger, \nRamona Adameck, \nAlexandre A. S. F. Raposo, \nPedro Rosmaninho, \nAna E. Sousa, \nAfonso R. M. Almeida&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/a-cell%e2%80%90intrinsic-role-for-rank-in-regulatory-t-cells-of-the-human-thymus-valuezoe%e2%80%90isabella-junginger-ramona-adameck-alexandre-a-s-f-raposo-pedro-rosmaninho-ana-e\/\" aria-label=\"Read more about A Cell\u2010Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus. [[{&#8220;value&#8221;:&#8221;Zoe\u2010Isabella Junginger, \nRamona Adameck, \nAlexandre A. S. F. Raposo, \nPedro Rosmaninho, \nAna E. Sousa, \nAfonso R. M. Almeida&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/cover-story-eur-j-immunol-226\/\">Cover Story: Eur. J. Immunol. 2&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 2&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/cover-story-eur-j-immunol-226\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 2&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/stabilization-of-human-cd8-treg-in-inflammatory-environments-through-foxp3-expression-valueseverine-bezie-jenny-greig-sonia-salle-juliette-lasselin-lisa-dugast-laurent-tesson-c\/\">Stabilization of Human CD8+ Treg in Inflammatory Environments Through FOXP3 Expression. [[{&#8220;value&#8221;:&#8221;S\u00e9verine B\u00e9zie, \nJenny Greig, \nSonia Salle, \nJuliette Lasselin, \nLisa Dugast, \nLaurent Tesson, \nC\u00e9line S\u00e9razin, \nNad\u00e8ge Vimond, \nIgnacio Anegon, \nCarole Guillonneau&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Specific pro-inflammatory cytokines destabilize CD8+ Tregs, altering their phenotype and reducing FOXP3 expression. Enforced FOXP3 expression, or the upregulation of its molecular regulators, partially protects CD8+ Tregs from inflammatory disruption, restoring their phenotype and maintaining suppressive function under inflammatory conditions. ABSTRACT Cell therapy using regulatory T cells (Tregs) holds therapeutic promise in immune-mediated diseases, but &#8230; <a title=\"Stabilization of Human CD8+ Treg in Inflammatory Environments Through FOXP3 Expression. [[{&#8220;value&#8221;:&#8221;S\u00e9verine B\u00e9zie, \nJenny Greig, \nSonia Salle, \nJuliette Lasselin, \nLisa Dugast, \nLaurent Tesson, \nC\u00e9line S\u00e9razin, \nNad\u00e8ge Vimond, \nIgnacio Anegon, \nCarole Guillonneau&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/stabilization-of-human-cd8-treg-in-inflammatory-environments-through-foxp3-expression-valueseverine-bezie-jenny-greig-sonia-salle-juliette-lasselin-lisa-dugast-laurent-tesson-c\/\" aria-label=\"Read more about Stabilization of Human CD8+ Treg in Inflammatory Environments Through FOXP3 Expression. [[{&#8220;value&#8221;:&#8221;S\u00e9verine B\u00e9zie, \nJenny Greig, \nSonia Salle, \nJuliette Lasselin, \nLisa Dugast, \nLaurent Tesson, \nC\u00e9line S\u00e9razin, \nNad\u00e8ge Vimond, \nIgnacio Anegon, \nCarole Guillonneau&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/27\/developmental-impact-of-maternal-immune-activation-on-the-fetal-immune-system-and-lung-valuewalaa-jradi-kira-duhm-clarissa-prazeres-da-costa\/\">Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung. [[{&#8220;value&#8221;:&#8221;Walaa Jradi, \nKira Duhm, \nClarissa Prazeres da Costa&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-27T10:26:04+01:00\" class=\"wp-block-latest-posts__post-date\">27 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Maternal immune activation triggers elevated cytokines (IL-6 and IL-17A), disrupting fetal immune system development. This not only alters hematopoietic stem cell balance but also leads to ILC2 hyperactivation in the lung, which could potentially affect susceptibility to allergic diseases in the offspring. ABSTRACT Maternal immune activation (MIA) refers to an immune response triggered in a &#8230; <a title=\"Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung. [[{&#8220;value&#8221;:&#8221;Walaa Jradi, \nKira Duhm, \nClarissa Prazeres da Costa&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/27\/developmental-impact-of-maternal-immune-activation-on-the-fetal-immune-system-and-lung-valuewalaa-jradi-kira-duhm-clarissa-prazeres-da-costa\/\" aria-label=\"Read more about Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung. [[{&#8220;value&#8221;:&#8221;Walaa Jradi, \nKira Duhm, \nClarissa Prazeres da Costa&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/environmental-signals-that-drive-early-life-innate-lymphoid-cell-development-valueemily-n-kulp-colleen-m-lau\/\">Environmental Signals That Drive Early Life Innate Lymphoid Cell Development. [[{&#8220;value&#8221;:&#8221;Emily N. Kulp, \nColleen M. Lau&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-26T10:45:51+01:00\" class=\"wp-block-latest-posts__post-date\">26 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Recent evidence supports a model in which the pool of adult immune cells is actually composed of cells derived from fetal, neonatal, and adult waves of hematopoiesis. In this review, we discuss this evidence in the context of innate lymphoid cells (ILC), with a focus on the environmental signals required for their development during early &#8230; <a title=\"Environmental Signals That Drive Early Life Innate Lymphoid Cell Development. [[{&#8220;value&#8221;:&#8221;Emily N. Kulp, \nColleen M. Lau&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/environmental-signals-that-drive-early-life-innate-lymphoid-cell-development-valueemily-n-kulp-colleen-m-lau\/\" aria-label=\"Read more about Environmental Signals That Drive Early Life Innate Lymphoid Cell Development. [[{&#8220;value&#8221;:&#8221;Emily N. Kulp, \nColleen M. Lau&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/igd%e2%80%90expressing-mature-b-cells-exhibit-enhanced-sensitivity-to-glucocorticoid%e2%80%90induced-cell-death-valuekais-almohammad-marc-young-sabine-vettorazzi-franziska-greulich\/\">IgD\u2010Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid\u2010Induced Cell Death. [[{&#8220;value&#8221;:&#8221;Kais Almohammad, \nMarc Young, \nSabine Vettorazzi, \nFranziska Greulich, \nMahmoud Alkhatib, \nJan Tuckermann, \nHassan Jumaa, \nCorinna S. Setz&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-26T10:45:51+01:00\" class=\"wp-block-latest-posts__post-date\">26 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our study shows that mature B cells expressing IgD exhibit significantly higher sensitivity to glucocorticoid (GC)-induced cell death. This elevated sensitivity is specifically dependent on GC receptor (GR) expression and is accompanied by enhanced activation as well as terminal differentiation of B cells. Our findings elucidate how exogenous GCs affect B cell survival and suggest &#8230; <a title=\"IgD\u2010Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid\u2010Induced Cell Death. [[{&#8220;value&#8221;:&#8221;Kais Almohammad, \nMarc Young, \nSabine Vettorazzi, \nFranziska Greulich, \nMahmoud Alkhatib, \nJan Tuckermann, \nHassan Jumaa, \nCorinna S. Setz&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/igd%e2%80%90expressing-mature-b-cells-exhibit-enhanced-sensitivity-to-glucocorticoid%e2%80%90induced-cell-death-valuekais-almohammad-marc-young-sabine-vettorazzi-franziska-greulich\/\" aria-label=\"Read more about IgD\u2010Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid\u2010Induced Cell Death. [[{&#8220;value&#8221;:&#8221;Kais Almohammad, \nMarc Young, \nSabine Vettorazzi, \nFranziska Greulich, \nMahmoud Alkhatib, \nJan Tuckermann, \nHassan Jumaa, \nCorinna S. Setz&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/tissue-immunometabolism-in-autoimmunity-matteo-villa\/\">Tissue Immunometabolism in Autoimmunity. Matteo Villa<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-25T10:23:19+01:00\" class=\"wp-block-latest-posts__post-date\">25 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The tissue metabolic environment in autoimmunity influences immune and nonimmune cells via fuelling cellular metabolism or through metabolic signalling. Intracellular metabolic sensors combine several environmental cues to control transcription, metabolism, and cell function. The function of each cell contributes to the concerted dysfunctional behaviour of a tissue in autoimmunity. ABSTRACT Autoimmunity causes damage to organs &#8230; <a title=\"Tissue Immunometabolism in Autoimmunity. Matteo Villa\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/tissue-immunometabolism-in-autoimmunity-matteo-villa\/\" aria-label=\"Read more about Tissue Immunometabolism in Autoimmunity. Matteo Villa\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/restoring-immunological-tolerance-via-dendritic-cells-in-rheumatoid-arthritis-valuehannah-costello-andrea-woodcock-mary-canavan\/\">Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Hannah Costello, \nAndrea Woodcock, \nMary Canavan&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-25T10:23:19+01:00\" class=\"wp-block-latest-posts__post-date\">25 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This review examines the failure of peripheral immune tolerance as the initiating factor in rheumatoid arthritis (RA), focusing on the role of dendritic cells. It discusses strategies to convert these cells from immunogenic to tolerogenic states, while also exploring emerging research on the anatomical sites where this critical loss of tolerance occurs. ABSTRACT Rheumatoid arthritis &#8230; <a title=\"Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Hannah Costello, \nAndrea Woodcock, \nMary Canavan&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/restoring-immunological-tolerance-via-dendritic-cells-in-rheumatoid-arthritis-valuehannah-costello-andrea-woodcock-mary-canavan\/\" aria-label=\"Read more about Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Hannah Costello, \nAndrea Woodcock, \nMary Canavan&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/23\/downregulation-of-cd19-expression-associates-with-mantle-cell-lymphoma-relapse-following-car%e2%80%90t-cell-therapy-valuebenedetta-peruzzi-alessio-mazzoni-ilaria-cutini-francesca-mata\/\">Downregulation of CD19 Expression Associates With Mantle Cell Lymphoma Relapse Following CAR\u2010T Cell Therapy. [[{&#8220;value&#8221;:&#8221;Benedetta Peruzzi, \nAlessio Mazzoni, \nIlaria Cutini, \nFrancesca Matani, \nRoberto Caporale, \nSara Bencini, \nSara Pratesi, \nLaura Maggi, \nManuela Capone, \nAnna Vanni, \nGiulia Lamacchia, \nLucia Bartoli, \nFrancesco Liotta, \nLorenzo Cosmi, \nBenedetta Puccini, \nLuca Nassi, \nBenedetta Sordi, \nChiara Camerini, \nAlessandro Maria Vannucchi, \nChiara Nozzoli, \nFrancesco Annunziato&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-23T10:18:36+01:00\" class=\"wp-block-latest-posts__post-date\">23 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. However, downregulation of CD19 expression on malignant B cells led to sudden therapy failure.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/fam83h-regulates-postnatal-t-cell-development-through-thymic-stroma-organization-valuebetul-melike-ogan-veronika-forstlova-laura-jane-dowling-michaela-simova-kristina-vicikova-ven\/\">FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{&#8220;value&#8221;:&#8221;Betul Melike Ogan, \nVeronika Forstlova, \nLaura Jane Dowling, \nMichaela Simova, \nKristina Vicikova, \nVendula Novosadova, \nFrantisek Spoutil, \nSylvie Cervenkova, \nMichaela Proch\u00e1zkov\u00e1, \nJolana Tureckova, \nOlha Fedosieieva, \nJuraj Labaj, \nPetr Nickl, \nKamila Krizova, \nJan Prochazka, \nJana Balounova, \nRadislav Sedlacek&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-17T09:55:03+01:00\" class=\"wp-block-latest-posts__post-date\">17 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Loss of the casein kinase 1 scaffolding protein FAM83H compromises bone marrow lymphopoiesis, reduces Foxn1 expression in cortical thymic epithelial cells (TEC), disrupts thymic architecture and TEC identity, and ultimately impairs double-negative thymocyte proliferation and T-cell production. ABSTRACT Family of Sequence Similarity 83H (FAM83H\/SACK1H) is primarily expressed in epithelial cells, where it interacts with casein &#8230; <a title=\"FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{&#8220;value&#8221;:&#8221;Betul Melike Ogan, \nVeronika Forstlova, \nLaura Jane Dowling, \nMichaela Simova, \nKristina Vicikova, \nVendula Novosadova, \nFrantisek Spoutil, \nSylvie Cervenkova, \nMichaela Proch\u00e1zkov\u00e1, \nJolana Tureckova, \nOlha Fedosieieva, \nJuraj Labaj, \nPetr Nickl, \nKamila Krizova, \nJan Prochazka, \nJana Balounova, \nRadislav Sedlacek&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/fam83h-regulates-postnatal-t-cell-development-through-thymic-stroma-organization-valuebetul-melike-ogan-veronika-forstlova-laura-jane-dowling-michaela-simova-kristina-vicikova-ven\/\" aria-label=\"Read more about FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{&#8220;value&#8221;:&#8221;Betul Melike Ogan, \nVeronika Forstlova, \nLaura Jane Dowling, \nMichaela Simova, \nKristina Vicikova, \nVendula Novosadova, \nFrantisek Spoutil, \nSylvie Cervenkova, \nMichaela Proch\u00e1zkov\u00e1, \nJolana Tureckova, \nOlha Fedosieieva, \nJuraj Labaj, \nPetr Nickl, \nKamila Krizova, \nJan Prochazka, \nJana Balounova, \nRadislav Sedlacek&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/shared-hla%e2%80%90e-and-mamu%e2%80%90e-peptide-repertoires-with-subtle-peptide-binding-differences-revealed-by-combined-ndsf%e2%80%90-and-fluorescence-polarisation%e2%80%90based-methods-value\/\">Shared HLA\u2010E and Mamu\u2010E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF\u2010 and Fluorescence Polarisation\u2010Based Methods. [[{&#8220;value&#8221;:&#8221;Max N. Quastel, \nSashini A. Ranawana, \nBas W. A. Peeters, \nAndy van Hateren, \nAndrew J. McMichael, \nGeraldine M. Gillespie&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-17T09:55:03+01:00\" class=\"wp-block-latest-posts__post-date\">17 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The MHC-E peptide binding methods described here\u2014nano-differential scanning fluorimetry and fluorescence polarisation\u2014demonstrate shared peptide binding repertoires with subtle binding hierarchy differences for the tested HLA-E and Mamu-E allotypes. When combined, these methods illustrate how minor MHC-E-peptide thermal stability changes equate to significant binding strength differences. ABSTRACT The primary function of MHC-E\u2014human leukocyte antigen (HLA)-E in &#8230; <a title=\"Shared HLA\u2010E and Mamu\u2010E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF\u2010 and Fluorescence Polarisation\u2010Based Methods. [[{&#8220;value&#8221;:&#8221;Max N. Quastel, \nSashini A. Ranawana, \nBas W. A. Peeters, \nAndy van Hateren, \nAndrew J. McMichael, \nGeraldine M. Gillespie&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/shared-hla%e2%80%90e-and-mamu%e2%80%90e-peptide-repertoires-with-subtle-peptide-binding-differences-revealed-by-combined-ndsf%e2%80%90-and-fluorescence-polarisation%e2%80%90based-methods-value\/\" aria-label=\"Read more about Shared HLA\u2010E and Mamu\u2010E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF\u2010 and Fluorescence Polarisation\u2010Based Methods. [[{&#8220;value&#8221;:&#8221;Max N. Quastel, \nSashini A. Ranawana, \nBas W. A. Peeters, \nAndy van Hateren, \nAndrew J. McMichael, \nGeraldine M. Gillespie&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/13\/correction-to-immunological-impact-of-oncolytic-adenoviruses-on-cancer-therapy-clinical-insights-2\/\">Correction to \u201cImmunological Impact of Oncolytic Adenoviruses on Cancer Therapy: Clinical Insights\u201d.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-13T10:40:32+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 1, January 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/13\/the-increased-secretion-of-lactate-observed-in-obesity-and-aging-leads-to-the-generation-of-pathogenic-b-cells-valuemaria-romero-amanda-virtue-kate-miller-andrew-gelsomini-dhananjay\/\">The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{&#8220;value&#8221;:&#8221;Maria Romero, \nAmanda Virtue, \nKate Miller, \nAndrew Gelsomini, \nDhananjay Suresh, \nSophie LaPointe, \nSuresh Pallikkuth, \nDaniela Frasca&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-13T10:40:32+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The increased lactate secretion by B cells from people with obesity and aging is a stimulus for pathogenic autoimmune anti-dsDNA antibodies. The effects of lactate are mediated by phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and inhibited by a neutralizing antibody that blocks the lactate transporter SLC5A12, responsible for lactate uptake and activation &#8230; <a title=\"The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{&#8220;value&#8221;:&#8221;Maria Romero, \nAmanda Virtue, \nKate Miller, \nAndrew Gelsomini, \nDhananjay Suresh, \nSophie LaPointe, \nSuresh Pallikkuth, \nDaniela Frasca&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/13\/the-increased-secretion-of-lactate-observed-in-obesity-and-aging-leads-to-the-generation-of-pathogenic-b-cells-valuemaria-romero-amanda-virtue-kate-miller-andrew-gelsomini-dhananjay\/\" aria-label=\"Read more about The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{&#8220;value&#8221;:&#8221;Maria Romero, \nAmanda Virtue, \nKate Miller, \nAndrew Gelsomini, \nDhananjay Suresh, \nSophie LaPointe, \nSuresh Pallikkuth, \nDaniela Frasca&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/11\/a-transcriptional-map-of-human-tonsil-architecture-beyond-the-sum-of-single-cell-parts-valuehelena-l-crowell-laura-llao%e2%80%90cid-gerard-frigola-samuel-gunz-irene-ruano-patr\/\">A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{&#8220;value&#8221;:&#8221;Helena L. Crowell, \nLaura Lla\u00f3\u2010Cid, \nGerard Frigola, \nSamuel Gunz, \nIrene Ruano, \nPatricia Lorden, \nMax Ruiz, \nMarta Kulis, \nJos\u00e9 Ignacio Martin\u2010Subero, \nHolger Heyn, \nElias Campo, \nAnna Pascual\u2010Reguant&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-11T09:59:32+01:00\" class=\"wp-block-latest-posts__post-date\">11 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Picture-book compartmentalization makes tonsillar tissue an ideal model to study spatial immunology. Using single-molecule imaging (SMI) of whole-tissue sections, we showcase many an alternative view on tissue composition and architecture that these data and concomitant analyses provide\u2014at the level of single cells, cellular neighborhoods, and anatomical units such as germinal centers and epithelial\u00a0substructures. ABSTRACT The &#8230; <a title=\"A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{&#8220;value&#8221;:&#8221;Helena L. Crowell, \nLaura Lla\u00f3\u2010Cid, \nGerard Frigola, \nSamuel Gunz, \nIrene Ruano, \nPatricia Lorden, \nMax Ruiz, \nMarta Kulis, \nJos\u00e9 Ignacio Martin\u2010Subero, \nHolger Heyn, \nElias Campo, \nAnna Pascual\u2010Reguant&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/11\/a-transcriptional-map-of-human-tonsil-architecture-beyond-the-sum-of-single-cell-parts-valuehelena-l-crowell-laura-llao%e2%80%90cid-gerard-frigola-samuel-gunz-irene-ruano-patr\/\" aria-label=\"Read more about A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{&#8220;value&#8221;:&#8221;Helena L. Crowell, \nLaura Lla\u00f3\u2010Cid, \nGerard Frigola, \nSamuel Gunz, \nIrene Ruano, \nPatricia Lorden, \nMax Ruiz, \nMarta Kulis, \nJos\u00e9 Ignacio Martin\u2010Subero, \nHolger Heyn, \nElias Campo, \nAnna Pascual\u2010Reguant&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/09\/correction-to-immunological-impact-of-oncolytic-adenoviruses-on-cancer-therapy-clinical-insights\/\">Correction to \u201cImmunological Impact of Oncolytic Adenoviruses on Cancer Therapy: Clinical Insights\u201d.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-09T10:25:14+01:00\" class=\"wp-block-latest-posts__post-date\">9 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 1, January 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/08\/sars%e2%80%90cov%e2%80%902-mrna-vaccination-leads-to-transient-humoral-and-b-cell-bystander-responses-in-adults-valuelisan-h-kuijper-laura-y-l-kummer-laura-fernandez-blanco-karlijn\/\">SARS\u2010CoV\u20102 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{&#8220;value&#8221;:&#8221;Lisan H. Kuijper, \nLaura Y. L. Kummer, \nLaura Fernandez Blanco, \nKarlijn van der Straten, \nMathieu A. F. Claireaux, \nAm\u00e9lie V. Bos, \nMiranda C. Dieker\u2010Meijer, \nTineke Jorritsma, \nMari\u00ebl C. Duurland, \nMaurice Steenhuis, \nJuan J. Garcia Vallejo, \nKoos P. J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nSander W. Tas, \nLaura Boekel, \nGert\u2010Jan Wolbink, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nMarit J. van Gils, \nAnja ten Brinke, \nS. Marieke van Ham, \nT2B! immunity against SARS\u2010CoV\u20102 study group&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-08T10:07:24+01:00\" class=\"wp-block-latest-posts__post-date\">8 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">SARS-CoV-2 mRNA vaccination triggers bystander activation of B cells, transiently increasing antibody levels after the first vaccination against influenza, RSV, and tetanus. Reactivation of B cell responses also occurred, where (CD11c+) MBC and DN3 are expanded after SARS-CoV-2 mRNA vaccination, independent of antigen exposure. ABSTRACT After antigen encounter, long-lived antibody-secreting cells (ASC) secrete high-affinity circulating &#8230; <a title=\"SARS\u2010CoV\u20102 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{&#8220;value&#8221;:&#8221;Lisan H. Kuijper, \nLaura Y. L. Kummer, \nLaura Fernandez Blanco, \nKarlijn van der Straten, \nMathieu A. F. Claireaux, \nAm\u00e9lie V. Bos, \nMiranda C. Dieker\u2010Meijer, \nTineke Jorritsma, \nMari\u00ebl C. Duurland, \nMaurice Steenhuis, \nJuan J. Garcia Vallejo, \nKoos P. J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nSander W. Tas, \nLaura Boekel, \nGert\u2010Jan Wolbink, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nMarit J. van Gils, \nAnja ten Brinke, \nS. Marieke van Ham, \nT2B! immunity against SARS\u2010CoV\u20102 study group&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/08\/sars%e2%80%90cov%e2%80%902-mrna-vaccination-leads-to-transient-humoral-and-b-cell-bystander-responses-in-adults-valuelisan-h-kuijper-laura-y-l-kummer-laura-fernandez-blanco-karlijn\/\" aria-label=\"Read more about SARS\u2010CoV\u20102 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{&#8220;value&#8221;:&#8221;Lisan H. Kuijper, \nLaura Y. L. Kummer, \nLaura Fernandez Blanco, \nKarlijn van der Straten, \nMathieu A. F. Claireaux, \nAm\u00e9lie V. Bos, \nMiranda C. Dieker\u2010Meijer, \nTineke Jorritsma, \nMari\u00ebl C. Duurland, \nMaurice Steenhuis, \nJuan J. Garcia Vallejo, \nKoos P. J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nSander W. Tas, \nLaura Boekel, \nGert\u2010Jan Wolbink, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nMarit J. van Gils, \nAnja ten Brinke, \nS. Marieke van Ham, \nT2B! immunity against SARS\u2010CoV\u20102 study group&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/issue-information-eur-j-immunol-126\/\">Issue Information: Eur. J. Immunol. 1&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-06T09:37:17+01:00\" class=\"wp-block-latest-posts__post-date\">6 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 1, January 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/synovial-tissue-macrophage-heterogeneity-in-rheumatoid-arthritis-valuemegan-m-hanlon-ursula-fearon-ellen-m-gravallese\/\">Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Megan M. Hanlon, \nUrsula Fearon, \nEllen M. Gravallese&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-06T09:37:16+01:00\" class=\"wp-block-latest-posts__post-date\">6 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Synovial tissue macrophages are essential coordinators of joint homeostasis and inflammatory responses in rheumatoid arthritis. Here, we highlight recent advances that have enabled a deeper characterization of synovial tissue macrophages and their distinct phenotypes and functions in health and disease. ABSTRACT Synovial tissue macrophages are critical orchestrators in the pathogenesis of rheumatoid arthritis, comprising a &#8230; <a title=\"Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Megan M. Hanlon, \nUrsula Fearon, \nEllen M. Gravallese&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/synovial-tissue-macrophage-heterogeneity-in-rheumatoid-arthritis-valuemegan-m-hanlon-ursula-fearon-ellen-m-gravallese\/\" aria-label=\"Read more about Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Megan M. Hanlon, \nUrsula Fearon, \nEllen M. Gravallese&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/cover-story-eur-j-immunol-126\/\">Cover Story: Eur. J. Immunol. 1&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-06T09:37:16+01:00\" class=\"wp-block-latest-posts__post-date\">6 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 1&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/cover-story-eur-j-immunol-126\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 1&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/29\/thrombospondin%e2%80%901-is-a-contact-sensor-triggering-adhesion-in-t-cells-and-platelets-while-differentially-regulating-2d-and-3d-motility-in-t-cells-karl%e2%80%90gosta-sundqvist\/\">Thrombospondin\u20101 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells. Karl\u2010G\u00f6sta Sundqvist<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-29T10:01:27+01:00\" class=\"wp-block-latest-posts__post-date\">29 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The C-terminal of TSP-1 senses cell contact, which triggers N-terminal cleavage by urokinase, adhesion, and cytoplasmic spreading in T cells and platelets. In contrast, full-length TSP-1 induces the development of polar cell shape and migration in T cells 2D and 3D; polar cell shape 2D, independent of its receptor LRP1, and polar cell shape 3D &#8230; <a title=\"Thrombospondin\u20101 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells. Karl\u2010G\u00f6sta Sundqvist\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/29\/thrombospondin%e2%80%901-is-a-contact-sensor-triggering-adhesion-in-t-cells-and-platelets-while-differentially-regulating-2d-and-3d-motility-in-t-cells-karl%e2%80%90gosta-sundqvist\/\" aria-label=\"Read more about Thrombospondin\u20101 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells. Karl\u2010G\u00f6sta Sundqvist\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/23\/spatially-resolved-profiling-of-compartmentalized-muscle-and-brain-inflammation-valuethorge-dobbertin-lucas-schirmer\/\">Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation. [[{&#8220;value&#8221;:&#8221;Thorge Dobbertin, \nLucas Schirmer&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-23T10:13:10+01:00\" class=\"wp-block-latest-posts__post-date\">23 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This review summarizes emerging spatially resolved multi-omics approaches revealing organized cell\u2013cell interactions in skeletal muscle and brain inflammation. These tools uncover radiating molecular programs and niche-specific immunopathology that shape cellular reactivity and vulnerability. ABSTRACT Spatial omics technologies enable high-resolution mapping of transcriptomic, proteomic, and metabolic profiles within intact tissues, revealing how immune, stromal, and parenchymal &#8230; <a title=\"Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation. [[{&#8220;value&#8221;:&#8221;Thorge Dobbertin, \nLucas Schirmer&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/23\/spatially-resolved-profiling-of-compartmentalized-muscle-and-brain-inflammation-valuethorge-dobbertin-lucas-schirmer\/\" aria-label=\"Read more about Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation. [[{&#8220;value&#8221;:&#8221;Thorge Dobbertin, \nLucas Schirmer&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/21\/ccl21a-rather-than-ccl21b-is-essential-for-thymocyte-migration-in-mouse-valueizumi-ohigashi-hitomi-kyuma-eri-otsu-shinichi-hayashi-tatsuya-takemoto-yousuke-takahama\/\">Ccl21a, Rather Than Ccl21b, is Essential for Thymocyte Migration in Mouse. [[{&#8220;value&#8221;:&#8221;Izumi Ohigashi, \nHitomi Kyuma, \nEri Otsu, \nShinichi Hayashi, \nTatsuya Takemoto, \nYousuke Takahama&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-21T10:31:42+01:00\" class=\"wp-block-latest-posts__post-date\">21 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CCR7-mediated chemokine signaling regulates the medullary migration of thymocytes to establish self-tolerance. By comparing the thymic phenotype of Ccl21b-KO mice with that of Ccl21a-KO mice, we show that Ccl21a plays a predominant role compared with Ccl21b among CCR7 ligands in the thymus. ABSTRACT Self-tolerance in T cells is a vital self-defense strategy for mammals to &#8230; <a title=\"Ccl21a, Rather Than Ccl21b, is Essential for Thymocyte Migration in Mouse. [[{&#8220;value&#8221;:&#8221;Izumi Ohigashi, \nHitomi Kyuma, \nEri Otsu, \nShinichi Hayashi, \nTatsuya Takemoto, \nYousuke Takahama&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/21\/ccl21a-rather-than-ccl21b-is-essential-for-thymocyte-migration-in-mouse-valueizumi-ohigashi-hitomi-kyuma-eri-otsu-shinichi-hayashi-tatsuya-takemoto-yousuke-takahama\/\" aria-label=\"Read more about Ccl21a, Rather Than Ccl21b, is Essential for Thymocyte Migration in Mouse. [[{&#8220;value&#8221;:&#8221;Izumi Ohigashi, \nHitomi Kyuma, \nEri Otsu, \nShinichi Hayashi, \nTatsuya Takemoto, \nYousuke Takahama&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/21\/cd-molecules-nomenclature-2025-antibody-validation-and-expression-profiling-of-immune-system-g-protein%e2%80%90coupled-receptors-valuejavier-fernandez%e2%80%90calles-daniela-kuzilkova\/\">CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein\u2010Coupled Receptors. [[{&#8220;value&#8221;:&#8221;Javier Fern\u00e1ndez\u2010Calles, \nDaniela Ku\u017e\u00edlkov\u00e1, \nFanny Hedin, \nVioleta Bakardjieva\u2010Mihaylova, \nKarolina \u0160kv\u00e1rov\u00e1 Kramarzov\u00e1, \nMenno C. van Zelm, \nAntonio Cosma, \nTomas Kalina, \nPablo Engel, \nthe Human Cell Differentiation Molecules (HCDM) organization&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-21T10:31:42+01:00\" class=\"wp-block-latest-posts__post-date\">21 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">HLDA Workshops were established 40 years ago to develop a standardized CD molecule nomenclature for leukocyte cell-surface molecules by comparing monoclonal antibodies (mAbs) produced by different laboratories and companies. The HLDA11 Workshop focused on validating G-protein-coupled receptors (GPCRs) targeting mAbs and assessing cell-type-specific expression patterns in leukocytes. ABSTRACT Monoclonal antibodies (mAbs) targeting cell-surface molecules are &#8230; <a title=\"CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein\u2010Coupled Receptors. [[{&#8220;value&#8221;:&#8221;Javier Fern\u00e1ndez\u2010Calles, \nDaniela Ku\u017e\u00edlkov\u00e1, \nFanny Hedin, \nVioleta Bakardjieva\u2010Mihaylova, \nKarolina \u0160kv\u00e1rov\u00e1 Kramarzov\u00e1, \nMenno C. van Zelm, \nAntonio Cosma, \nTomas Kalina, \nPablo Engel, \nthe Human Cell Differentiation Molecules (HCDM) organization&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/21\/cd-molecules-nomenclature-2025-antibody-validation-and-expression-profiling-of-immune-system-g-protein%e2%80%90coupled-receptors-valuejavier-fernandez%e2%80%90calles-daniela-kuzilkova\/\" aria-label=\"Read more about CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein\u2010Coupled Receptors. [[{&#8220;value&#8221;:&#8221;Javier Fern\u00e1ndez\u2010Calles, \nDaniela Ku\u017e\u00edlkov\u00e1, \nFanny Hedin, \nVioleta Bakardjieva\u2010Mihaylova, \nKarolina \u0160kv\u00e1rov\u00e1 Kramarzov\u00e1, \nMenno C. van Zelm, \nAntonio Cosma, \nTomas Kalina, \nPablo Engel, \nthe Human Cell Differentiation Molecules (HCDM) organization&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/serous-cavity-mast-cells-depend-on-the-roquin-paralogs-valueklaus-heger-ali-masjedi-assa-yeroslaviz-theodor-zeng-seren-baygun-angela-vicente%e2%80%90luque-chia%e2%80%90i-lien\/\">Serous Cavity Mast Cells Depend on the ROQUIN Paralogs. [[{&#8220;value&#8221;:&#8221;Klaus Heger, \nAli Masjedi, \nAssa Yeroslaviz, \nTheodor Zeng, \nSeren Bayg\u00fcn, \nAngela Vicente\u2010Luque, \nChia\u2010I. Lien, \nLena Osswald, \nDieter Saur, \nDaniel Kovacs, \nMarc Schmidt\u2010Supprian&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The RNA-binding ROQUIN paralogs are critical immune regulators. We demonstrate that mast cell-specific deficiency for ROQUIN-1 and ROQUIN-2 in mice leads to loss of mast cells in serous cavities. ROQUIN-1 and 2 ablation does not affect mast cell degranulation or proinflammatory cytokine secretion, although they regulate many mRNAs directly or indirectly. ABSTRACT Mast cells are &#8230; <a title=\"Serous Cavity Mast Cells Depend on the ROQUIN Paralogs. [[{&#8220;value&#8221;:&#8221;Klaus Heger, \nAli Masjedi, \nAssa Yeroslaviz, \nTheodor Zeng, \nSeren Bayg\u00fcn, \nAngela Vicente\u2010Luque, \nChia\u2010I. Lien, \nLena Osswald, \nDieter Saur, \nDaniel Kovacs, \nMarc Schmidt\u2010Supprian&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/serous-cavity-mast-cells-depend-on-the-roquin-paralogs-valueklaus-heger-ali-masjedi-assa-yeroslaviz-theodor-zeng-seren-baygun-angela-vicente%e2%80%90luque-chia%e2%80%90i-lien\/\" aria-label=\"Read more about Serous Cavity Mast Cells Depend on the ROQUIN Paralogs. [[{&#8220;value&#8221;:&#8221;Klaus Heger, \nAli Masjedi, \nAssa Yeroslaviz, \nTheodor Zeng, \nSeren Bayg\u00fcn, \nAngela Vicente\u2010Luque, \nChia\u2010I. Lien, \nLena Osswald, \nDieter Saur, \nDaniel Kovacs, \nMarc Schmidt\u2010Supprian&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/characterization-of-the-sars%e2%80%90cov%e2%80%902%e2%80%90specific-t-cell-responses-in-rheumatoid-arthritis-subjects-vaccinated-for-covid%e2%80%9019-protection-valuejaeyoon-song-ricardo\/\">Characterization of the SARS\u2010CoV\u20102\u2010Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID\u201019 Protection. [[{&#8220;value&#8221;:&#8221;Jaeyoon Song, \nRicardo da Silva Antunes, \nMehrnaz Agili Seyede, \nMonica Guma, \nAlessandro Sette, \nAlessandra Franco&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">SARS-CoV-2 vaccination in rheumatoid arthritis leads to the development of CD4+ and CD8+ spike-specific T cell memory, regardless of immunosuppressive therapies, and the number of vaccine injections. CD4\u2212CD8\u2212 double-negative (DN) T cells responded to SARS-CoV-2 peptide epitopes and differentiated into CD8+ cytotoxic T cells after stimulation, suggesting a role in exacerbating the inflammation in RA &#8230; <a title=\"Characterization of the SARS\u2010CoV\u20102\u2010Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID\u201019 Protection. [[{&#8220;value&#8221;:&#8221;Jaeyoon Song, \nRicardo da Silva Antunes, \nMehrnaz Agili Seyede, \nMonica Guma, \nAlessandro Sette, \nAlessandra Franco&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/characterization-of-the-sars%e2%80%90cov%e2%80%902%e2%80%90specific-t-cell-responses-in-rheumatoid-arthritis-subjects-vaccinated-for-covid%e2%80%9019-protection-valuejaeyoon-song-ricardo\/\" aria-label=\"Read more about Characterization of the SARS\u2010CoV\u20102\u2010Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID\u201019 Protection. [[{&#8220;value&#8221;:&#8221;Jaeyoon Song, \nRicardo da Silva Antunes, \nMehrnaz Agili Seyede, \nMonica Guma, \nAlessandro Sette, \nAlessandra Franco&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/mastering-immunity-antibody-feedback-as-a-driver-of-germinal-center-fate-and-vaccine-responses-valueshuang-liu-yang-zhang-kai%e2%80%90michael-toellner\/\">Mastering Immunity: Antibody Feedback as a Driver of Germinal Center Fate and Vaccine Responses. [[{&#8220;value&#8221;:&#8221;Shuang Liu, \nYang Zhang, \nKai\u2010Michael Toellner&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Antibody feedback dynamically shapes the selective landscape for GC B-cells, acting as a driving force of Darwinian-like affinity maturation of B-cell receptors (A). It also balances epitope usage, leading to equal competition among B cell clones specific for different epitopes and allowing the emergence of clones specific for new epitopes (B). ABSTRACT Antibody feedback in &#8230; <a title=\"Mastering Immunity: Antibody Feedback as a Driver of Germinal Center Fate and Vaccine Responses. [[{&#8220;value&#8221;:&#8221;Shuang Liu, \nYang Zhang, \nKai\u2010Michael Toellner&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/mastering-immunity-antibody-feedback-as-a-driver-of-germinal-center-fate-and-vaccine-responses-valueshuang-liu-yang-zhang-kai%e2%80%90michael-toellner\/\" aria-label=\"Read more about Mastering Immunity: Antibody Feedback as a Driver of Germinal Center Fate and Vaccine Responses. [[{&#8220;value&#8221;:&#8221;Shuang Liu, \nYang Zhang, \nKai\u2010Michael Toellner&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/fc%c2%b5r-and-igm%e2%80%90mediated-complement-activation-cooperate-to-enhance-humoral-immunity-valuezichao-wen-lulu-dong-jun-liu-qing-min-ying-wang-ziying-hu-xiaoqian-feng-cha\/\">Fc\u00b5R and IgM\u2010Mediated Complement Activation Cooperate to Enhance Humoral Immunity. [[{&#8220;value&#8221;:&#8221;Zichao Wen, \nLulu Dong, \nJun Liu, \nQing Min, \nYing Wang, \nZiying Hu, \nXiaoqian Feng, \nChaoqun Cui, \nYaxuan Li, \nYingying Luan, \nRunyun zhang, \nXin Meng, \nYue Tang, \nHai Zhang, \nMeiping Yu, \nChunhui Lu, \nXuzhe Wu, \nJingjing Zhao, \nJue Wang, \nAnqi Wang, \nBirgitta Heyman, \nJi\u2010Yang Wang&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Early B cell activation requires both Fc\u00b5R and IgM-mediated complement signaling, which together drive initial clonal expansion, class-switch recombination, germinal center (GC) entry, and plasma cell differentiation. During the GC reaction, IgM BCR-mediated complement activation, but not Fc\u00b5R, supports GC B cell survival, proliferation, and affinity maturation. ABSTRACT Secretory IgM plays a pivotal role in &#8230; <a title=\"Fc\u00b5R and IgM\u2010Mediated Complement Activation Cooperate to Enhance Humoral Immunity. [[{&#8220;value&#8221;:&#8221;Zichao Wen, \nLulu Dong, \nJun Liu, \nQing Min, \nYing Wang, \nZiying Hu, \nXiaoqian Feng, \nChaoqun Cui, \nYaxuan Li, \nYingying Luan, \nRunyun zhang, \nXin Meng, \nYue Tang, \nHai Zhang, \nMeiping Yu, \nChunhui Lu, \nXuzhe Wu, \nJingjing Zhao, \nJue Wang, \nAnqi Wang, \nBirgitta Heyman, \nJi\u2010Yang Wang&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/fc%c2%b5r-and-igm%e2%80%90mediated-complement-activation-cooperate-to-enhance-humoral-immunity-valuezichao-wen-lulu-dong-jun-liu-qing-min-ying-wang-ziying-hu-xiaoqian-feng-cha\/\" aria-label=\"Read more about Fc\u00b5R and IgM\u2010Mediated Complement Activation Cooperate to Enhance Humoral Immunity. [[{&#8220;value&#8221;:&#8221;Zichao Wen, \nLulu Dong, \nJun Liu, \nQing Min, \nYing Wang, \nZiying Hu, \nXiaoqian Feng, \nChaoqun Cui, \nYaxuan Li, \nYingying Luan, \nRunyun zhang, \nXin Meng, \nYue Tang, \nHai Zhang, \nMeiping Yu, \nChunhui Lu, \nXuzhe Wu, \nJingjing Zhao, \nJue Wang, \nAnqi Wang, \nBirgitta Heyman, \nJi\u2010Yang Wang&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/insights-into-complex-murine-models-of-allergy-and-anaphylaxis-the-central-role-of-ige-and-mast-cells-in-advancing-human-therapies-valueyuka-nagata-ryo-suzuki\/\">Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies. [[{&#8220;value&#8221;:&#8221;Yuka Nagata, \nRyo Suzuki&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Murine allergy model outcomes differ by sensitization route, allergen type, and mouse strain, influencing mechanisms such as IgE and mast cell involvement and the therapeutic relevance of each model. Understanding how experimental parameters shape outcomes is essential for selecting appropriate models and effectively translating findings to clinical applications. ABSTRACT Immunoglobulin E (IgE)\u2013mediated immediate hypersensitivity reactions &#8230; <a title=\"Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies. [[{&#8220;value&#8221;:&#8221;Yuka Nagata, \nRyo Suzuki&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/insights-into-complex-murine-models-of-allergy-and-anaphylaxis-the-central-role-of-ige-and-mast-cells-in-advancing-human-therapies-valueyuka-nagata-ryo-suzuki\/\" aria-label=\"Read more about Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies. [[{&#8220;value&#8221;:&#8221;Yuka Nagata, \nRyo Suzuki&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/staphylococcal-enterotoxin-a-shapes-monocyte-transcription-and-macrophage-polarization-implications-for-immune-responses-in-infection-and-inflammation-valueclaudia-arasa-khaleda-rahman-q\/\">Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation. [[{&#8220;value&#8221;:&#8221;Claudia Arasa, \nKhaleda Rahman Qazi, \nDavid Brodin, \nManuel Mata Forsberg, \nEva Sverremark\u2010Ekstr\u00f6m&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Staphylococcal enterotoxin A (SEA) alters monocyte differentiation and function, while preserving T cell stimulatory capacity. SEA-primed macrophages downregulate antigen-presenting markers yet drive heightened T-cell proliferation and IFN-\u03b3 secretion. These findings reveal mechanisms of SEA-mediated immune modulation and superantigen-driven inflammation. ABSTRACT Staphylococcal enterotoxins (SE) crosslink the MHC-II on antigen-presenting cells (APC) with the T-cell receptor, inducing &#8230; <a title=\"Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation. [[{&#8220;value&#8221;:&#8221;Claudia Arasa, \nKhaleda Rahman Qazi, \nDavid Brodin, \nManuel Mata Forsberg, \nEva Sverremark\u2010Ekstr\u00f6m&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/staphylococcal-enterotoxin-a-shapes-monocyte-transcription-and-macrophage-polarization-implications-for-immune-responses-in-infection-and-inflammation-valueclaudia-arasa-khaleda-rahman-q\/\" aria-label=\"Read more about Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation. [[{&#8220;value&#8221;:&#8221;Claudia Arasa, \nKhaleda Rahman Qazi, \nDavid Brodin, \nManuel Mata Forsberg, \nEva Sverremark\u2010Ekstr\u00f6m&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/hyperinflammation-by-human-macrophages-induced-by-sars%e2%80%90cov%e2%80%902-anti%e2%80%90spike-igg-is-dependent-on-glucose-and-fatty-acid-metabolism-valuechiara-e-geyer-luis-almeida-l\/\">Hyperinflammation by Human Macrophages Induced by SARS\u2010CoV\u20102 Anti\u2010Spike IgG Is Dependent on Glucose and Fatty Acid Metabolism. [[{&#8220;value&#8221;:&#8221;Chiara E. Geyer, \nLu\u00eds Almeida, \nLynn Mes, \nFrank Otto, \nW. Ashwin Mak, \nGraham A. Heieis, \nJennifer Veth, \nSteven W. de Taeye, \nTom G. Caniels, \nTom P. L. Bijl, \nMarit J. van Gils, \nMenno de Winther, \nAmsterdam UMC COVID\u201019 Biobank, \nJan Van den Bossche, \nHung\u2010Jen Chen, \nRiekelt H. Houtkooper, \nBart Everts, \nJeroen den Dunnen&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Severe COVID-19 is associated with hyperinflammation driven by anti-spike IgG immune complexes (ICs) contributing to macrophage hyperactivation, thrombosis, and tissue damage. This study shows that anti-spike IgG ICs induce rapid metabolic reprogramming, specifically glycolysis, fatty acid synthesis, and the pentose phosphate pathway, which is essential for the inflammatory response. Targeting these metabolic pathways may offer &#8230; <a title=\"Hyperinflammation by Human Macrophages Induced by SARS\u2010CoV\u20102 Anti\u2010Spike IgG Is Dependent on Glucose and Fatty Acid Metabolism. [[{&#8220;value&#8221;:&#8221;Chiara E. Geyer, \nLu\u00eds Almeida, \nLynn Mes, \nFrank Otto, \nW. Ashwin Mak, \nGraham A. Heieis, \nJennifer Veth, \nSteven W. de Taeye, \nTom G. Caniels, \nTom P. L. Bijl, \nMarit J. van Gils, \nMenno de Winther, \nAmsterdam UMC COVID\u201019 Biobank, \nJan Van den Bossche, \nHung\u2010Jen Chen, \nRiekelt H. Houtkooper, \nBart Everts, \nJeroen den Dunnen&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/hyperinflammation-by-human-macrophages-induced-by-sars%e2%80%90cov%e2%80%902-anti%e2%80%90spike-igg-is-dependent-on-glucose-and-fatty-acid-metabolism-valuechiara-e-geyer-luis-almeida-l\/\" aria-label=\"Read more about Hyperinflammation by Human Macrophages Induced by SARS\u2010CoV\u20102 Anti\u2010Spike IgG Is Dependent on Glucose and Fatty Acid Metabolism. [[{&#8220;value&#8221;:&#8221;Chiara E. Geyer, \nLu\u00eds Almeida, \nLynn Mes, \nFrank Otto, \nW. Ashwin Mak, \nGraham A. Heieis, \nJennifer Veth, \nSteven W. de Taeye, \nTom G. Caniels, \nTom P. L. Bijl, \nMarit J. van Gils, \nMenno de Winther, \nAmsterdam UMC COVID\u201019 Biobank, \nJan Van den Bossche, \nHung\u2010Jen Chen, \nRiekelt H. Houtkooper, \nBart Everts, \nJeroen den Dunnen&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/decoding-the-cryptic-proteome-between-antigens-and-novel-functional-proteins-valueemma-g-bawden-sebastian-amigorena-yago-a-arribas\/\">Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins. [[{&#8220;value&#8221;:&#8221;Emma G. Bawden, \nSebastian Amigorena, \nYago A. Arribas&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Unannotated splicing and translation of non-canonical open reading frames generate a diverse repertoire of cryptic proteins. Most are rapidly degraded, rendering them possible MHC-I substrates. Yet, a subpopulation can adopt stable structures and impart advantageous functions. This dichotomy both expands the antigen landscape and provides a framework for protein evolution. ABSTRACT The widespread translation of &#8230; <a title=\"Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins. [[{&#8220;value&#8221;:&#8221;Emma G. Bawden, \nSebastian Amigorena, \nYago A. Arribas&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/decoding-the-cryptic-proteome-between-antigens-and-novel-functional-proteins-valueemma-g-bawden-sebastian-amigorena-yago-a-arribas\/\" aria-label=\"Read more about Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins. [[{&#8220;value&#8221;:&#8221;Emma G. Bawden, \nSebastian Amigorena, \nYago A. Arribas&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/optimising-recovery-of-hepatic-regulatory-t-cells-a-practical-guide-using-artc2-blockade-valuecaitlin-abbott-violette-mouro-chiara-perucchini-chiara-vespari-matteo-iannacone\/\">Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade. [[{&#8220;value&#8221;:&#8221;Caitlin Abbott, \nViolette Mouro, \nChiara Perucchini, \nChiara Vespari, \nMatteo Iannacone&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This is an update to the Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition), Chapter 3: 12C, by Cossarizza et al. Administration of anti-ARTC2 nanobody(S+16a) prevents cell death during tissue processing. We demonstrate that the phenotype of CD44midTreg is significantly impacted, whereas the eTreg phenotype remains stable following &#8230; <a title=\"Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade. [[{&#8220;value&#8221;:&#8221;Caitlin Abbott, \nViolette Mouro, \nChiara Perucchini, \nChiara Vespari, \nMatteo Iannacone&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/optimising-recovery-of-hepatic-regulatory-t-cells-a-practical-guide-using-artc2-blockade-valuecaitlin-abbott-violette-mouro-chiara-perucchini-chiara-vespari-matteo-iannacone\/\" aria-label=\"Read more about Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade. [[{&#8220;value&#8221;:&#8221;Caitlin Abbott, \nViolette Mouro, \nChiara Perucchini, \nChiara Vespari, \nMatteo Iannacone&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/augmented-mhc-class-i-on-professional-antigen%e2%80%90presenting-cells-and-enhanced-cytokine-production-by-cd8-t-cells-in-type-2-diabetes-mellitus-valueshan-liu-tharushika-jayasinghe-d\/\">Augmented MHC Class I on Professional Antigen\u2010Presenting Cells and Enhanced Cytokine Production by CD8+ T Cells in Type 2 Diabetes Mellitus. [[{&#8220;value&#8221;:&#8221;Shan Liu, \nTharushika Jayasinghe, \nDaria Kami\u0144ska, \nXiaoqiang Xu, \nXu Ren, \nYang Jiao, \nYing Kong, \nXiaozhen Li, \nKe Li, \nAntony N. Antoniou, \nWang Li, \nKatarzyna B\u0142a\u017cewska, \nEdyta Gendaszewska\u2010Darmach, \nJing Xu, \nMalgorzata A. Garstka&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-20T09:59:55+01:00\" class=\"wp-block-latest-posts__post-date\">20 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Here, we show increased MHC class I levels on B cells, classical and intermediate monocytes, and a shift in CD8+ T cells toward a Tc1-skewed, proinflammatory phenotype in the peripheral blood mononuclear cells of people with type 2 diabetes mellitus. ABSTRACT Effective antigen presentation by major histocompatibility complex (MHC) molecules to T cells is crucial &#8230; <a title=\"Augmented MHC Class I on Professional Antigen\u2010Presenting Cells and Enhanced Cytokine Production by CD8+ T Cells in Type 2 Diabetes Mellitus. [[{&#8220;value&#8221;:&#8221;Shan Liu, \nTharushika Jayasinghe, \nDaria Kami\u0144ska, \nXiaoqiang Xu, \nXu Ren, \nYang Jiao, \nYing Kong, \nXiaozhen Li, \nKe Li, \nAntony N. Antoniou, \nWang Li, \nKatarzyna B\u0142a\u017cewska, \nEdyta Gendaszewska\u2010Darmach, \nJing Xu, \nMalgorzata A. Garstka&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/20\/augmented-mhc-class-i-on-professional-antigen%e2%80%90presenting-cells-and-enhanced-cytokine-production-by-cd8-t-cells-in-type-2-diabetes-mellitus-valueshan-liu-tharushika-jayasinghe-d\/\" aria-label=\"Read more about Augmented MHC Class I on Professional Antigen\u2010Presenting Cells and Enhanced Cytokine Production by CD8+ T Cells in Type 2 Diabetes Mellitus. [[{&#8220;value&#8221;:&#8221;Shan Liu, \nTharushika Jayasinghe, \nDaria Kami\u0144ska, \nXiaoqiang Xu, \nXu Ren, \nYang Jiao, \nYing Kong, \nXiaozhen Li, \nKe Li, \nAntony N. Antoniou, \nWang Li, \nKatarzyna B\u0142a\u017cewska, \nEdyta Gendaszewska\u2010Darmach, \nJing Xu, \nMalgorzata A. Garstka&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/functional-antigen%e2%80%90specific-cd8-tscm-responses-are-associated-with-repeated-clearance-of-hepatitis-c-virus-infection-valueyanran-zhao-elizabeth-keoshkerian-hui-li-rachel-sacks\/\">Functional Antigen\u2010Specific CD8 TSCM Responses Are Associated with Repeated Clearance of Hepatitis C Virus Infection. [[{&#8220;value&#8221;:&#8221;Yanran Zhao, \nElizabeth Keoshkerian, \nHui Li, \nRachel Sacks\u2010David, \nIrene Boo, \nPaul Dietze, \nMargaret Hellard, \nHeidi Drummer, \nFabio Luciani, \nRowena A. Bull, \nAndrew R. Lloyd&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-19T09:36:13+01:00\" class=\"wp-block-latest-posts__post-date\">19 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">HCV re-infection is common after spontaneous clearance of the initial infection. In the rare group of super-clearers who clear repeatedly, HCV-specific CD8+ T memory stem cells (TSCM) retain stemness, proliferation, and multipotency, sustaining immune protection. In contrast, clearer chronics lose these properties. TSCM self-renewal underpins durable immunity and should inform vaccine design. ABSTRACT Natural clearance &#8230; <a title=\"Functional Antigen\u2010Specific CD8 TSCM Responses Are Associated with Repeated Clearance of Hepatitis C Virus Infection. [[{&#8220;value&#8221;:&#8221;Yanran Zhao, \nElizabeth Keoshkerian, \nHui Li, \nRachel Sacks\u2010David, \nIrene Boo, \nPaul Dietze, \nMargaret Hellard, \nHeidi Drummer, \nFabio Luciani, \nRowena A. Bull, \nAndrew R. Lloyd&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/functional-antigen%e2%80%90specific-cd8-tscm-responses-are-associated-with-repeated-clearance-of-hepatitis-c-virus-infection-valueyanran-zhao-elizabeth-keoshkerian-hui-li-rachel-sacks\/\" aria-label=\"Read more about Functional Antigen\u2010Specific CD8 TSCM Responses Are Associated with Repeated Clearance of Hepatitis C Virus Infection. [[{&#8220;value&#8221;:&#8221;Yanran Zhao, \nElizabeth Keoshkerian, \nHui Li, \nRachel Sacks\u2010David, \nIrene Boo, \nPaul Dietze, \nMargaret Hellard, \nHeidi Drummer, \nFabio Luciani, \nRowena A. Bull, \nAndrew R. Lloyd&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/ultrasensitive-test-systems-are-required-to-quantify-interferon-alpha-protein-in-serum-samples-valueliis-haljasmagi-sandra-meisalu-vincent-bondet-part-peterson-darragh-duffy-kai-k\/\">Ultrasensitive Test Systems Are Required to Quantify Interferon Alpha Protein in Serum Samples. [[{&#8220;value&#8221;:&#8221;Liis Haljasm\u00e4gi, \nSandra Meisalu, \nVincent Bondet, \nP\u00e4rt Peterson, \nDarragh Duffy, \nKai Kisand&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-19T09:36:13+01:00\" class=\"wp-block-latest-posts__post-date\">19 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Selecting a sensitive test system is crucial to measure IFN\u03b1 in serum samples. Simoa digital ELISA stands out for its high sensitivity and strong correlation with transcript-based IFN-induced gene (ISG) scores. In SLE, the ISG score is explained by circulating IFN\u03b1 levels with negligible contribution from IFN\u03b2 or IFN\u03b3. Created in BioRender.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/mass-cytometry%e2%80%90based-approach-for-the-investigation-of-stimulator-of-interferon-genes-pathway-valueanne-reversat-paul-t-kennedy-anni-georghiou-joseph-r-slupsky-lekh-n-dah\/\">Mass Cytometry\u2010Based Approach for the Investigation of Stimulator of Interferon Genes Pathway. [[{&#8220;value&#8221;:&#8221;Anne Reversat, \nPaul T. Kennedy, \nAnni Georghiou, \nJoseph R. Slupsky, \nLekh N. Dahal&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-19T09:36:13+01:00\" class=\"wp-block-latest-posts__post-date\">19 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Using mass cytometry, we map the heterogeneous activation of the STING pathway at single-cell resolution in cell lines and primary human immune cells and validate them with conventional techniques. ABSTRACT The stimulator of interferon genes (STING) pathway plays a pivotal role in innate immunity, acting as a key sensor of cytosolic DNA to initiate type-I &#8230; <a title=\"Mass Cytometry\u2010Based Approach for the Investigation of Stimulator of Interferon Genes Pathway. [[{&#8220;value&#8221;:&#8221;Anne Reversat, \nPaul T. Kennedy, \nAnni Georghiou, \nJoseph R. Slupsky, \nLekh N. Dahal&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/mass-cytometry%e2%80%90based-approach-for-the-investigation-of-stimulator-of-interferon-genes-pathway-valueanne-reversat-paul-t-kennedy-anni-georghiou-joseph-r-slupsky-lekh-n-dah\/\" aria-label=\"Read more about Mass Cytometry\u2010Based Approach for the Investigation of Stimulator of Interferon Genes Pathway. [[{&#8220;value&#8221;:&#8221;Anne Reversat, \nPaul T. Kennedy, \nAnni Georghiou, \nJoseph R. Slupsky, \nLekh N. Dahal&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/selection-and-characterisation-of-minor-histocompatibility-antigen%e2%80%90specific-regulatory-t-cells-in-fully-hla%e2%80%90matched-setting-for-gvhd-therapy-valuepacini-carolina-paulino-r\/\">Selection and Characterisation of Minor Histocompatibility Antigen\u2010Specific Regulatory T Cells in Fully HLA\u2010Matched Setting for GVHD Therapy. [[{&#8220;value&#8221;:&#8221;Pacini Carolina Paulino, \nRita I. Azevedo, \nLu\u00eds Ramalhete, \nHugo A. J. Lain\u00e9, \nMaria V. D. Soares, \nJo\u00e3o F. Lacerda&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-19T09:36:13+01:00\" class=\"wp-block-latest-posts__post-date\">19 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We optimised a protocol for mHA-specific Treg (mTreg) selection in an HLA-matched context while defining its phenotype, transcriptional state and function. mTreg were highly activated and exerted specific, HLA class II-, contact-dependent suppression. This protocol can be explored as a highly personalised antigen-specific Treg-based therapy in future clinical trials for cGVHD. ABSTRACT Graft-versus-host disease is &#8230; <a title=\"Selection and Characterisation of Minor Histocompatibility Antigen\u2010Specific Regulatory T Cells in Fully HLA\u2010Matched Setting for GVHD Therapy. [[{&#8220;value&#8221;:&#8221;Pacini Carolina Paulino, \nRita I. Azevedo, \nLu\u00eds Ramalhete, \nHugo A. J. Lain\u00e9, \nMaria V. D. Soares, \nJo\u00e3o F. Lacerda&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/selection-and-characterisation-of-minor-histocompatibility-antigen%e2%80%90specific-regulatory-t-cells-in-fully-hla%e2%80%90matched-setting-for-gvhd-therapy-valuepacini-carolina-paulino-r\/\" aria-label=\"Read more about Selection and Characterisation of Minor Histocompatibility Antigen\u2010Specific Regulatory T Cells in Fully HLA\u2010Matched Setting for GVHD Therapy. [[{&#8220;value&#8221;:&#8221;Pacini Carolina Paulino, \nRita I. Azevedo, \nLu\u00eds Ramalhete, \nHugo A. J. Lain\u00e9, \nMaria V. D. Soares, \nJo\u00e3o F. Lacerda&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/transcriptional-regulation-of-macrophage-specification-and-function-valuedomien-vanneste-thomas-marichal\/\">Transcriptional Regulation of Macrophage Specification and Function. [[{&#8220;value&#8221;:&#8221;Domien Vanneste, \nThomas Marichal&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-19T09:36:13+01:00\" class=\"wp-block-latest-posts__post-date\">19 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This review highlights the hierarchical transcriptional networks that govern macrophage specification and function. We describe how lineage-determining, identity-imprinting, and tissue-specific transcription factors coordinate macrophage differentiation and specialization across organs, emphasizing the transcriptional regulation underlying macrophage diversity in health and disease. ABSTRACT Tissue-resident and recruited macrophages are integral to organ development, homeostasis, immunity, and disease pathogenesis. &#8230; <a title=\"Transcriptional Regulation of Macrophage Specification and Function. [[{&#8220;value&#8221;:&#8221;Domien Vanneste, \nThomas Marichal&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/transcriptional-regulation-of-macrophage-specification-and-function-valuedomien-vanneste-thomas-marichal\/\" aria-label=\"Read more about Transcriptional Regulation of Macrophage Specification and Function. [[{&#8220;value&#8221;:&#8221;Domien Vanneste, \nThomas Marichal&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/the-antigen-presenting-capabilities-of-group-3-innate-lymphoid-cells-insights-into-immunogenic-or-tolerogenic-outcomes-for-t-cells-valuealessia-calabro-sayuri-yamazaki-guido-ferlazzo\/\">The Antigen Presenting Capabilities of Group 3 Innate Lymphoid Cells: Insights Into Immunogenic or Tolerogenic Outcomes for T Cells. [[{&#8220;value&#8221;:&#8221;Alessia Calabr\u00f2, \nSayuri Yamazaki, \nGuido Ferlazzo, \nStefania Campana&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-19T09:36:13+01:00\" class=\"wp-block-latest-posts__post-date\">19 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The Janus face of group 3 innate lymphoid cells (ILC3s). ILC3s are highly plastic and can adapt their immunoregulatory roles according to the local context, balancing tolerance and activation. Influenced by tissue-specific environmental cues, they can express MHC class II molecules either alone or jointly with costimulatory molecules, therefore presenting acquired antigens for controlling or &#8230; <a title=\"The Antigen Presenting Capabilities of Group 3 Innate Lymphoid Cells: Insights Into Immunogenic or Tolerogenic Outcomes for T Cells. [[{&#8220;value&#8221;:&#8221;Alessia Calabr\u00f2, \nSayuri Yamazaki, \nGuido Ferlazzo, \nStefania Campana&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/19\/the-antigen-presenting-capabilities-of-group-3-innate-lymphoid-cells-insights-into-immunogenic-or-tolerogenic-outcomes-for-t-cells-valuealessia-calabro-sayuri-yamazaki-guido-ferlazzo\/\" aria-label=\"Read more about The Antigen Presenting Capabilities of Group 3 Innate Lymphoid Cells: Insights Into Immunogenic or Tolerogenic Outcomes for T Cells. [[{&#8220;value&#8221;:&#8221;Alessia Calabr\u00f2, \nSayuri Yamazaki, \nGuido Ferlazzo, \nStefania Campana&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/10\/issue-information-eur-j-immunol-1225\/\">Issue Information: Eur. J. Immunol. 12&#8217;25.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-10T10:27:45+01:00\" class=\"wp-block-latest-posts__post-date\">10 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 55, Issue 12, December 2025.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/10\/cover-story-eur-j-immunol-1225\/\">Cover Story: Eur. J. Immunol. 12&#8217;25.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-10T10:27:45+01:00\" class=\"wp-block-latest-posts__post-date\">10 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 12&#8217;25.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/10\/cover-story-eur-j-immunol-1225\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 12&#8217;25.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/10\/il%e2%80%9010%e2%80%90-and-il%e2%80%9013%e2%80%90biased-t-cell-responses-to-sars%e2%80%90cov%e2%80%902-vaccination-in-diabetes-valueemma-m-jones-caren-sourij-martin-stradner-peter-sc\/\">IL\u201010\u2010 and IL\u201013\u2010Biased T Cell Responses to SARS\u2010CoV\u20102 Vaccination in Diabetes. [[{&#8220;value&#8221;:&#8221;Emma M. Jones, \nCaren Sourij, \nMartin Stradner, \nPeter Schlenke, \nNazanin Sereban, \nOthmar Moser, \nRachael Quinlan, \nCharlotte\u2010Eve Short, \nBenjamin H. L. Harris, \nMichael Fertleman, \nGraham P. Taylor, \nNick Oliver, \nHarald Sourij, \nMargarita Dominguez\u2010Villar&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-12-10T10:27:45+01:00\" class=\"wp-block-latest-posts__post-date\">10 de December de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">How the immune system of people with diabetes responds to vaccination against respiratory viruses is not well understood. Using activation-induced markers to identify, quantify, and functionally characterize Spike-specific CD4+ and CD8+ T cells after SARS-CoV-2 vaccination, we show defects in T cell memory maintenance and an IL-10 and IL-13-dominated T cell response in people with &#8230; <a title=\"IL\u201010\u2010 and IL\u201013\u2010Biased T Cell Responses to SARS\u2010CoV\u20102 Vaccination in Diabetes. [[{&#8220;value&#8221;:&#8221;Emma M. Jones, \nCaren Sourij, \nMartin Stradner, \nPeter Schlenke, \nNazanin Sereban, \nOthmar Moser, \nRachael Quinlan, \nCharlotte\u2010Eve Short, \nBenjamin H. L. Harris, \nMichael Fertleman, \nGraham P. Taylor, \nNick Oliver, \nHarald Sourij, \nMargarita Dominguez\u2010Villar&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/10\/il%e2%80%9010%e2%80%90-and-il%e2%80%9013%e2%80%90biased-t-cell-responses-to-sars%e2%80%90cov%e2%80%902-vaccination-in-diabetes-valueemma-m-jones-caren-sourij-martin-stradner-peter-sc\/\" aria-label=\"Read more about IL\u201010\u2010 and IL\u201013\u2010Biased T Cell Responses to SARS\u2010CoV\u20102 Vaccination in Diabetes. [[{&#8220;value&#8221;:&#8221;Emma M. Jones, \nCaren Sourij, \nMartin Stradner, \nPeter Schlenke, \nNazanin Sereban, \nOthmar Moser, \nRachael Quinlan, \nCharlotte\u2010Eve Short, \nBenjamin H. L. Harris, \nMichael Fertleman, \nGraham P. Taylor, \nNick Oliver, \nHarald Sourij, \nMargarita Dominguez\u2010Villar&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/15\/spatial-immunometabolism-integrating-technologies-to-decode-cellular-metabolism-in-tissues-felix-j-hartmann\/\">Spatial Immunometabolism: Integrating Technologies to Decode Cellular Metabolism in Tissues. Felix J. Hartmann<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-15T10:47:36+01:00\" class=\"wp-block-latest-posts__post-date\">15 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This review highlights recent advances that enable spatially resolved analysis of immunometabolism within tissue microenvironments. Integrating mass spectrometry imaging, vibrational microscopy, and spatial omics reveals how metabolic organization shapes immune function in cancer and other pathologies. ABSTRACT The metabolic programs of immune cells influence their activation, differentiation, and effector functions. While much of immunometabolism has &#8230; <a title=\"Spatial Immunometabolism: Integrating Technologies to Decode Cellular Metabolism in Tissues. Felix J. Hartmann\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/15\/spatial-immunometabolism-integrating-technologies-to-decode-cellular-metabolism-in-tissues-felix-j-hartmann\/\" aria-label=\"Read more about Spatial Immunometabolism: Integrating Technologies to Decode Cellular Metabolism in Tissues. Felix J. Hartmann\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/15\/divergent-effects-of-cytomegalovirus-and-rheumatoid-arthritis-on-senescent-cd4-t-cells-valuelea-williams-ali-o-saber-silina-awad-xi-su-asgar-ansari-ruozhang-xu-hannah-jung-a\/\">Divergent Effects of Cytomegalovirus and Rheumatoid Arthritis on Senescent CD4+ T Cells. [[{&#8220;value&#8221;:&#8221;Lea Williams, \nAli O. Saber, \nSilina Awad, \nXi Su, \nAsgar Ansari, \nRuozhang Xu, \nHannah Jung, \nAnupama Shahane, \nJoshua F. Baker, \nLaura F. Su&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-15T10:47:35+01:00\" class=\"wp-block-latest-posts__post-date\">15 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">How chronic immune stimulations differentially shape CD4\u207a T cell senescence remains unclear. Using high-dimensional mass cytometry and functional profiling, we show that cytomegalovirus (CMV) drives expansion of cytotoxic CD27\u2212CD28\u2212 CD4\u207a T cells, whereas rheumatoid arthritis (RA) exerts nonredundant effects by modulating their effector capacity. ABSTRACT Chronic antigen exposure drives CD4\u207a T cell senescence, yet how &#8230; <a title=\"Divergent Effects of Cytomegalovirus and Rheumatoid Arthritis on Senescent CD4+ T Cells. [[{&#8220;value&#8221;:&#8221;Lea Williams, \nAli O. Saber, \nSilina Awad, \nXi Su, \nAsgar Ansari, \nRuozhang Xu, \nHannah Jung, \nAnupama Shahane, \nJoshua F. Baker, \nLaura F. Su&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/15\/divergent-effects-of-cytomegalovirus-and-rheumatoid-arthritis-on-senescent-cd4-t-cells-valuelea-williams-ali-o-saber-silina-awad-xi-su-asgar-ansari-ruozhang-xu-hannah-jung-a\/\" aria-label=\"Read more about Divergent Effects of Cytomegalovirus and Rheumatoid Arthritis on Senescent CD4+ T Cells. [[{&#8220;value&#8221;:&#8221;Lea Williams, \nAli O. Saber, \nSilina Awad, \nXi Su, \nAsgar Ansari, \nRuozhang Xu, \nHannah Jung, \nAnupama Shahane, \nJoshua F. Baker, \nLaura F. Su&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/10\/enhanced-mhc-class%e2%80%90ii-expression-in-fibroblastic-reticular-cells-associates-with-maturation-valuejanna-e-g-roet-catarina-gago-da-graca-michael-de-kok-daphne-panocha-tanja\/\">Enhanced MHC Class\u2010II Expression in Fibroblastic Reticular Cells Associates with Maturation. [[{&#8220;value&#8221;:&#8221;Janna E. G. Roet, \nCatarina Gago da Gra\u00e7a, \nMichael de Kok, \nDaphne Panocha, \nTanja Konijn, \nHenk P. Roest, \nLuc J. W. van der Laan, \nLisa G. M. van Baarsen, \nCharlotte M. de Winde, \nReina E. Mebius&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2025-11-10T17:49:35+01:00\" class=\"wp-block-latest-posts__post-date\">10 de November de 2025<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Fibroblastic reticular cells (FRCs) in lymph nodes contribute to peripheral tolerance via MHC-class-II-mediated antigen presentation. Using scRNAseq and protein analysis, we identify BST1+CD200+ FRCs, including the mature T cell-zone FRCs, as key MHC-class-II expressing subsets in mice and humans, highlighting their potential role in immune regulation. ABSTRACT Autoimmunity can be initiated by autoreactive T cells &#8230; <a title=\"Enhanced MHC Class\u2010II Expression in Fibroblastic Reticular Cells Associates with Maturation. [[{&#8220;value&#8221;:&#8221;Janna E. G. Roet, \nCatarina Gago da Gra\u00e7a, \nMichael de Kok, \nDaphne Panocha, \nTanja Konijn, \nHenk P. Roest, \nLuc J. W. van der Laan, \nLisa G. M. van Baarsen, \nCharlotte M. de Winde, \nReina E. Mebius&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/10\/enhanced-mhc-class%e2%80%90ii-expression-in-fibroblastic-reticular-cells-associates-with-maturation-valuejanna-e-g-roet-catarina-gago-da-graca-michael-de-kok-daphne-panocha-tanja\/\" aria-label=\"Read more about Enhanced MHC Class\u2010II Expression in Fibroblastic Reticular Cells Associates with Maturation. [[{&#8220;value&#8221;:&#8221;Janna E. G. Roet, \nCatarina Gago da Gra\u00e7a, \nMichael de Kok, \nDaphne Panocha, \nTanja Konijn, \nHenk P. Roest, \nLuc J. W. van der Laan, \nLisa G. M. van Baarsen, \nCharlotte M. de Winde, \nReina E. Mebius&#8221;}]]\">Read more<\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16986","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16986","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16986"}],"version-history":[{"count":1,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16986\/revisions"}],"predecessor-version":[{"id":16987,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16986\/revisions\/16987"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16986"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}