{"id":16986,"date":"2024-09-30T00:08:02","date_gmt":"2024-09-29T22:08:02","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=16986"},"modified":"2024-09-30T00:08:02","modified_gmt":"2024-09-29T22:08:02","slug":"european-journal-of-immunology","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/european-journal-of-immunology\/","title":{"rendered":"European Journal of Immunology"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/pro%e2%80%90-and-anti%e2%80%90inflammatory-macrophages-adjust-ucp2-protein-levels-based-on-their-intrinsic-metabolism-and-available-metabolites-valuejila-nasirzade-felix-sternberg-andre\/\">Pro\u2010 and Anti\u2010Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites. [[{&#8220;value&#8221;:&#8221;Jila Nasirzade, \nFelix Sternberg, \nAndrea Vogel, \nRoko Sango, \nTaraneh Beikbaghban, \nThomas Kolbe, \nThomas Rattei, \nThomas Weichhart, \nElena E. Pohl&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-10T10:38:05+02:00\" class=\"wp-block-latest-posts__post-date\">10 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">LPS-stimulated macrophages exhibit high glycolytic flux, with pyruvate preferentially converted to lactate even under normoglycemic conditions, limiting pyruvate availability for the tricarboxylic acid (TCA) cycle and reducing oxygen consumption rate (OCR). Glucose deprivation increases OCR; however, an innate hypoxic state is associated with low UCP2 levels in this phenotype. In contrast, under normal glucose conditions, &#8230; <a title=\"Pro\u2010 and Anti\u2010Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites. [[{&#8220;value&#8221;:&#8221;Jila Nasirzade, \nFelix Sternberg, \nAndrea Vogel, \nRoko Sango, \nTaraneh Beikbaghban, \nThomas Kolbe, \nThomas Rattei, \nThomas Weichhart, \nElena E. Pohl&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/pro%e2%80%90-and-anti%e2%80%90inflammatory-macrophages-adjust-ucp2-protein-levels-based-on-their-intrinsic-metabolism-and-available-metabolites-valuejila-nasirzade-felix-sternberg-andre\/\" aria-label=\"Read more about Pro\u2010 and Anti\u2010Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites. [[{&#8220;value&#8221;:&#8221;Jila Nasirzade, \nFelix Sternberg, \nAndrea Vogel, \nRoko Sango, \nTaraneh Beikbaghban, \nThomas Kolbe, \nThomas Rattei, \nThomas Weichhart, \nElena E. Pohl&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/identifying-negative-biomarkers-of-cd4-cytotoxic-t-lymphocytes-via-granzyme-b-exclusion-analysis-valuebingsu-wang-ayibaota-bahabayi-danyi-huang-ziqi-xiong-zhonghui-zhang-yiming-ga\/\">Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis. [[{&#8220;value&#8221;:&#8221;Bingsu Wang, \nAyibaota Bahabayi, \nDanyi Huang, \nZiqi Xiong, \nZhonghui Zhang, \nYiming Gao, \nWenling Han, \nChen Liu, \nPingzhang Wang&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-10T10:38:05+02:00\" class=\"wp-block-latest-posts__post-date\">10 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Given the relatively high level of coexistence, a nonlinear model is more suitable for mutual exclusion than a linear model. Based on mutual exclusion, negative markers were identified for CD4+ cytotoxic T cells, particularly CD126. However, according to FACS analysis, CD28 is the most effective cell surface negative marker. ABSTRACT CD4 cytotoxic T lymphocytes (CTLs) &#8230; <a title=\"Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis. [[{&#8220;value&#8221;:&#8221;Bingsu Wang, \nAyibaota Bahabayi, \nDanyi Huang, \nZiqi Xiong, \nZhonghui Zhang, \nYiming Gao, \nWenling Han, \nChen Liu, \nPingzhang Wang&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/10\/identifying-negative-biomarkers-of-cd4-cytotoxic-t-lymphocytes-via-granzyme-b-exclusion-analysis-valuebingsu-wang-ayibaota-bahabayi-danyi-huang-ziqi-xiong-zhonghui-zhang-yiming-ga\/\" aria-label=\"Read more about Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis. [[{&#8220;value&#8221;:&#8221;Bingsu Wang, \nAyibaota Bahabayi, \nDanyi Huang, \nZiqi Xiong, \nZhonghui Zhang, \nYiming Gao, \nWenling Han, \nChen Liu, \nPingzhang Wang&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/03\/a-unique-intraexonic-splicing-mechanism-in-the-immunoglobulin-domain-of-nkp30-produces-a-surface%e2%80%90expressed-receptor-with-altered-ligand-specificity-valueelisabeth-g-bjornsen-elle\/\">A Unique Intraexonic Splicing Mechanism in the Immunoglobulin Domain of NKp30 Produces a Surface\u2010Expressed Receptor With Altered Ligand Specificity. [[{&#8220;value&#8221;:&#8221;Elisabeth G. Bj\u00f8rnsen, \nEllen Sofie Pete, \nHanna Chan, \nMarit Inngjerdingen, \nTatyana Sandalova, \nAnne Spurkland, \nMichael R. Daws, \nAdnane Achour, \nAndreas Lossius, \nErik Dissen&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-03T09:48:42+02:00\" class=\"wp-block-latest-posts__post-date\">3 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The immunoglobulin (Ig) domain exon of human NKp30 contains internal splice sites. A unique intraexonic splicing mechanism produces a short Ig domain that lacks 25 residues but maintains the Ig-fold structure and is expressed on the cell surface. Unlike full-length NKp30, the short version (NKp30-S) does not bind the cancer cell ligand B7H6. ABSTRACT The &#8230; <a title=\"A Unique Intraexonic Splicing Mechanism in the Immunoglobulin Domain of NKp30 Produces a Surface\u2010Expressed Receptor With Altered Ligand Specificity. [[{&#8220;value&#8221;:&#8221;Elisabeth G. Bj\u00f8rnsen, \nEllen Sofie Pete, \nHanna Chan, \nMarit Inngjerdingen, \nTatyana Sandalova, \nAnne Spurkland, \nMichael R. Daws, \nAdnane Achour, \nAndreas Lossius, \nErik Dissen&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/03\/a-unique-intraexonic-splicing-mechanism-in-the-immunoglobulin-domain-of-nkp30-produces-a-surface%e2%80%90expressed-receptor-with-altered-ligand-specificity-valueelisabeth-g-bjornsen-elle\/\" aria-label=\"Read more about A Unique Intraexonic Splicing Mechanism in the Immunoglobulin Domain of NKp30 Produces a Surface\u2010Expressed Receptor With Altered Ligand Specificity. [[{&#8220;value&#8221;:&#8221;Elisabeth G. Bj\u00f8rnsen, \nEllen Sofie Pete, \nHanna Chan, \nMarit Inngjerdingen, \nTatyana Sandalova, \nAnne Spurkland, \nMichael R. Daws, \nAdnane Achour, \nAndreas Lossius, \nErik Dissen&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/cover-story-eur-j-immunol-626\/\">Cover Story: Eur. J. Immunol. 6&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-02T10:19:59+02:00\" class=\"wp-block-latest-posts__post-date\">2 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 6&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/cover-story-eur-j-immunol-626\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 6&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/issue-information-eur-j-immunol-626\/\">Issue Information: Eur. J. Immunol. 6&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-02T10:19:59+02:00\" class=\"wp-block-latest-posts__post-date\">2 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 6, June 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/managing-autofluorescence-in-spectral-flow-cytometry-for-macrophage-identification-in-the-liver-valuesabine-daemen-tuneille-i-adelaar-panos-barlampas-xiaodi-zhang-casper-g-schalkw\/\">Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver. [[{&#8220;value&#8221;:&#8221;Sabine Daemen, \nTuneille I. Adelaar, \nPanos Barlampas, \nXiaodi Zhang, \nCasper G. Schalkwijk, \nKristiaan Wouters&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-02T10:19:59+02:00\" class=\"wp-block-latest-posts__post-date\">2 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Autofluorescence in liver tissue is heterogeneous and dynamically altered during metabolic liver disease, complicating spectral flow cytometry analysis. We provide a structured framework for identifying and handling condition-dependent autofluorescence, demonstrating that inadequate autofluorescence correction biases macrophage quantification and subset resolution in complex liver samples. ABSTRACT Autofluorescence (AF) in biological tissues arises from the natural emission &#8230; <a title=\"Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver. [[{&#8220;value&#8221;:&#8221;Sabine Daemen, \nTuneille I. Adelaar, \nPanos Barlampas, \nXiaodi Zhang, \nCasper G. Schalkwijk, \nKristiaan Wouters&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/managing-autofluorescence-in-spectral-flow-cytometry-for-macrophage-identification-in-the-liver-valuesabine-daemen-tuneille-i-adelaar-panos-barlampas-xiaodi-zhang-casper-g-schalkw\/\" aria-label=\"Read more about Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver. [[{&#8220;value&#8221;:&#8221;Sabine Daemen, \nTuneille I. Adelaar, \nPanos Barlampas, \nXiaodi Zhang, \nCasper G. Schalkwijk, \nKristiaan Wouters&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/characterization-of-harderian-gland%e2%80%90derived-plasma-cells-in-chicken-valued-von-la-roche-i-naumann-e-szocs-v-halasy-m-kohn-b-kaspers-n-nagy-s-hartle\/\">Characterization of Harderian Gland\u2010Derived Plasma Cells in Chicken. [[{&#8220;value&#8221;:&#8221;D. von La Roche, \nI. Naumann, \nE. Sz\u0151cs, \nV. Halasy, \nM. Kohn, \nB. Kaspers, \nN. Nagy, \nS. H\u00e4rtle&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-06-02T10:19:59+02:00\" class=\"wp-block-latest-posts__post-date\">2 de June de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">An isolation protocol for plasma cells (PC) from the chicken Harderian gland (HG) was established, and analyses of PCs revealed a FSChigh\/CD45med\/sIgpos\/CD57pos\/CXCR4high\/TACIlow phenotype. Presence of CXCL12 and BAFF around HG PCs suggests a contribution of CXCL12\u2013CXCR4 and BAFF\u2013TACI to PC localization and survival. ABSTRACT Due to fundamental differences in B cell development between birds and &#8230; <a title=\"Characterization of Harderian Gland\u2010Derived Plasma Cells in Chicken. [[{&#8220;value&#8221;:&#8221;D. von La Roche, \nI. Naumann, \nE. Sz\u0151cs, \nV. Halasy, \nM. Kohn, \nB. Kaspers, \nN. Nagy, \nS. H\u00e4rtle&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/06\/02\/characterization-of-harderian-gland%e2%80%90derived-plasma-cells-in-chicken-valued-von-la-roche-i-naumann-e-szocs-v-halasy-m-kohn-b-kaspers-n-nagy-s-hartle\/\" aria-label=\"Read more about Characterization of Harderian Gland\u2010Derived Plasma Cells in Chicken. [[{&#8220;value&#8221;:&#8221;D. von La Roche, \nI. Naumann, \nE. Sz\u0151cs, \nV. Halasy, \nM. Kohn, \nB. Kaspers, \nN. Nagy, \nS. H\u00e4rtle&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/stable-%ce%b22%e2%80%90microglobulin-hla-class-i-association-reshapes-the-antigenic-landscape-and-tcr-recognition-of-cancer%e2%80%90associated-epitopes-valueana-barajas-molina-yeh\/\">Stable \u03b22\u2010Microglobulin\u2013HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer\u2010Associated Epitopes. [[{&#8220;value&#8221;:&#8221;Ana Barajas Molina, \nYehor Horokhovskyi, \nNicole Acuti, \nYee Kien Chong, \nMeghna Phanichkrivalkosil, \nSophie Siddons, \nHassnae Afrache, \nMegan Maloney, \nWai Tuck Soh, \nTom Hofland, \nCallum Hall, \nHenning Urlaub, \nGeorge Kassiotis, \nJuliane Liepe, \nMichele Mishto&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-28T10:30:28+02:00\" class=\"wp-block-latest-posts__post-date\">28 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We investigated differences in peptide repertoire when \u03b22-microglobulin is fused to the HLA-I heavy chain. We observed: (1) that immunopeptidomes changed in this condition, (2) an overall increased median IC50 of the entire peptide repertoire, and (3) a reduced presentation of cancer-specific epitopes with a strong predicted binding affinity for HLA-I. ABSTRACT \u03b22-Microglobulin (\u03b22m) is &#8230; <a title=\"Stable \u03b22\u2010Microglobulin\u2013HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer\u2010Associated Epitopes. [[{&#8220;value&#8221;:&#8221;Ana Barajas Molina, \nYehor Horokhovskyi, \nNicole Acuti, \nYee Kien Chong, \nMeghna Phanichkrivalkosil, \nSophie Siddons, \nHassnae Afrache, \nMegan Maloney, \nWai Tuck Soh, \nTom Hofland, \nCallum Hall, \nHenning Urlaub, \nGeorge Kassiotis, \nJuliane Liepe, \nMichele Mishto&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/stable-%ce%b22%e2%80%90microglobulin-hla-class-i-association-reshapes-the-antigenic-landscape-and-tcr-recognition-of-cancer%e2%80%90associated-epitopes-valueana-barajas-molina-yeh\/\" aria-label=\"Read more about Stable \u03b22\u2010Microglobulin\u2013HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer\u2010Associated Epitopes. [[{&#8220;value&#8221;:&#8221;Ana Barajas Molina, \nYehor Horokhovskyi, \nNicole Acuti, \nYee Kien Chong, \nMeghna Phanichkrivalkosil, \nSophie Siddons, \nHassnae Afrache, \nMegan Maloney, \nWai Tuck Soh, \nTom Hofland, \nCallum Hall, \nHenning Urlaub, \nGeorge Kassiotis, \nJuliane Liepe, \nMichele Mishto&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/sting-activation-in-dendritic-cells-enhances-antigen-presentation-by-live-tumor-cells-valueadriana-loverre-bakhos-jneid-magali-genest-maries-van-den-broek-nicolas-manel\/\">STING Activation in Dendritic Cells Enhances Antigen Presentation by Live Tumor Cells. [[{&#8220;value&#8221;:&#8221;Adriana Loverre, \nBakhos Jneid, \nMagali Genest, \nMaries van den Broek, \nNicolas Manel&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-28T10:30:28+02:00\" class=\"wp-block-latest-posts__post-date\">28 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our study reveals that STING activation in dendritic cells using cGAMP-VLP enhances CD8+ T cell recognition of live tumor cells by inducing type I interferon-dependent upregulation of MHC-I on tumor cells in vitro. In vivo, cGAMP-VLP boosts antitumor immunity even in cGAS-deficient tumors, thereby improving the efficacy of immune checkpoint blockade. These findings uncover a &#8230; <a title=\"STING Activation in Dendritic Cells Enhances Antigen Presentation by Live Tumor Cells. [[{&#8220;value&#8221;:&#8221;Adriana Loverre, \nBakhos Jneid, \nMagali Genest, \nMaries van den Broek, \nNicolas Manel&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/28\/sting-activation-in-dendritic-cells-enhances-antigen-presentation-by-live-tumor-cells-valueadriana-loverre-bakhos-jneid-magali-genest-maries-van-den-broek-nicolas-manel\/\" aria-label=\"Read more about STING Activation in Dendritic Cells Enhances Antigen Presentation by Live Tumor Cells. [[{&#8220;value&#8221;:&#8221;Adriana Loverre, \nBakhos Jneid, \nMagali Genest, \nMaries van den Broek, \nNicolas Manel&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/high%e2%80%90dimensional-spatial-immune-profiling-highlights-microglia%e2%80%90like-cells-in-human-dorsal-root-ganglia-valuemarius-schwabenland-busranur-oeztuerk-thomas-blank-juergen\/\">High\u2010dimensional Spatial Immune Profiling Highlights Microglia\u2010Like Cells in Human Dorsal Root Ganglia. [[{&#8220;value&#8221;:&#8221;Marius Schwabenland, \nBusranur Oeztuerk, \nThomas Blank, \nJuergen Beck, \nBertram Bengsch, \nMarco Prinz&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-20T10:16:08+02:00\" class=\"wp-block-latest-posts__post-date\">20 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">High-dimensional imaging mass cytometry reveals diverse macrophage populations in human dorsal root ganglia (DRG). Microglia-like cells, characterized by markers such as P2RY12, SLC2A5, and TMEM119, localize near neuronal structures, whereas other myeloid subsets are found in interstitial regions. Spatial analysis reveals distinct localization patterns within the DRG. ABSTRACT The human dorsal root ganglia (DRG) are &#8230; <a title=\"High\u2010dimensional Spatial Immune Profiling Highlights Microglia\u2010Like Cells in Human Dorsal Root Ganglia. [[{&#8220;value&#8221;:&#8221;Marius Schwabenland, \nBusranur Oeztuerk, \nThomas Blank, \nJuergen Beck, \nBertram Bengsch, \nMarco Prinz&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/high%e2%80%90dimensional-spatial-immune-profiling-highlights-microglia%e2%80%90like-cells-in-human-dorsal-root-ganglia-valuemarius-schwabenland-busranur-oeztuerk-thomas-blank-juergen\/\" aria-label=\"Read more about High\u2010dimensional Spatial Immune Profiling Highlights Microglia\u2010Like Cells in Human Dorsal Root Ganglia. [[{&#8220;value&#8221;:&#8221;Marius Schwabenland, \nBusranur Oeztuerk, \nThomas Blank, \nJuergen Beck, \nBertram Bengsch, \nMarco Prinz&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/sialylation-in-colorectal-cancer-rewires-antitumor-immunity-at-the-peritoneal-metastatic-site-valueirene-van-der-haar-avila-kristiaan-lenos-victor-lorrain-eleonora-nardini-ernesto-r\/\">Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site. [[{&#8220;value&#8221;:&#8221;Irene van der Haar \u00c0vila, \nKristiaan Lenos, \nVictor Lorrain, \nEleonora Nardini, \nErnesto Rodr\u00edguez, \nJuan J. Garc\u00eda\u2010Vallejo, \nYvette van Kooyk, \nJoep Grootjans, \nSandra J. van Vliet&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-20T10:16:08+02:00\" class=\"wp-block-latest-posts__post-date\">20 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This study shows that loss of sialylation in CT26 cells reduces peritoneal tumor burden, correlating with a lower peritoneal cancer index score. These tumors exhibited increased immune infiltration with prominent alterations in the myeloid compartment and immune cell correlations unique to desialylated tumors, indicating profound reshaping of antitumor immunity. ABSTRACT Colorectal cancer (CRC) patients are &#8230; <a title=\"Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site. [[{&#8220;value&#8221;:&#8221;Irene van der Haar \u00c0vila, \nKristiaan Lenos, \nVictor Lorrain, \nEleonora Nardini, \nErnesto Rodr\u00edguez, \nJuan J. Garc\u00eda\u2010Vallejo, \nYvette van Kooyk, \nJoep Grootjans, \nSandra J. van Vliet&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/sialylation-in-colorectal-cancer-rewires-antitumor-immunity-at-the-peritoneal-metastatic-site-valueirene-van-der-haar-avila-kristiaan-lenos-victor-lorrain-eleonora-nardini-ernesto-r\/\" aria-label=\"Read more about Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site. [[{&#8220;value&#8221;:&#8221;Irene van der Haar \u00c0vila, \nKristiaan Lenos, \nVictor Lorrain, \nEleonora Nardini, \nErnesto Rodr\u00edguez, \nJuan J. Garc\u00eda\u2010Vallejo, \nYvette van Kooyk, \nJoep Grootjans, \nSandra J. van Vliet&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/the-rna%e2%80%90-and-dna%e2%80%90binding-protein-y%e2%80%90box-binding-protein-1-yb%e2%80%901-regulates-inkt-cell-development-valuesilvia-schulze-laura-knop-nouria-jantz%e2%80%90naeem\/\">The RNA\u2010 and DNA\u2010Binding Protein Y\u2010Box Binding Protein 1 (YB\u20101) Regulates iNKT Cell Development. [[{&#8220;value&#8221;:&#8221;Silvia Schulze, \nLaura Knop, \nNouria Jantz\u2010Naeem, \nVladyslava Dovhan, \nStephan Fricke, \nSascha Kahlfu\u00df, \nThomas Sch\u00fcler, \nUrsula Bommhardt&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-20T10:16:08+02:00\" class=\"wp-block-latest-posts__post-date\">20 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">YB-1 is essential for invariant NKT cell development, integrating TCR, co-stimulatory, and IL-15 signaling to control maturation, subset differentiation, and survival. Its loss at the double-positive thymocyte stage causes \u223c80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis. ABSTRACT Y-box binding protein 1 (YB-1) is a multifunctional RNA- and DNA-binding protein with &#8230; <a title=\"The RNA\u2010 and DNA\u2010Binding Protein Y\u2010Box Binding Protein 1 (YB\u20101) Regulates iNKT Cell Development. [[{&#8220;value&#8221;:&#8221;Silvia Schulze, \nLaura Knop, \nNouria Jantz\u2010Naeem, \nVladyslava Dovhan, \nStephan Fricke, \nSascha Kahlfu\u00df, \nThomas Sch\u00fcler, \nUrsula Bommhardt&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/the-rna%e2%80%90-and-dna%e2%80%90binding-protein-y%e2%80%90box-binding-protein-1-yb%e2%80%901-regulates-inkt-cell-development-valuesilvia-schulze-laura-knop-nouria-jantz%e2%80%90naeem\/\" aria-label=\"Read more about The RNA\u2010 and DNA\u2010Binding Protein Y\u2010Box Binding Protein 1 (YB\u20101) Regulates iNKT Cell Development. [[{&#8220;value&#8221;:&#8221;Silvia Schulze, \nLaura Knop, \nNouria Jantz\u2010Naeem, \nVladyslava Dovhan, \nStephan Fricke, \nSascha Kahlfu\u00df, \nThomas Sch\u00fcler, \nUrsula Bommhardt&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/a-novel-ptpn2-isoform-differentially-regulates-immune-response-valuexiaoguang-li-fedik-rahimov-rui-wang-lei-gao-renze-ma-tiankai-han-yingtao-bi-freidrich-cruz-jing-wang-sh\/\">A Novel PTPN2 Isoform Differentially Regulates Immune Response. [[{&#8220;value&#8221;:&#8221;Xiaoguang Li, \nFedik Rahimov, \nRui Wang, \nLei Gao, \nRenze Ma, \nTiankai Han, \nYingtao Bi, \nFreidrich Cruz, \nJing Wang, \nShaun Grosskurth, \nElizabeth Asque, \nJesus Paez\u2010Cortez, \nMarc C. Levesque, \nNancy E. Crosbie, \nTimothy Radstake, \nAmlan Biswas, \nKanstantsin Katlinski&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-20T10:16:08+02:00\" class=\"wp-block-latest-posts__post-date\">20 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The A allele of the intronic SNP rs80262450 in the PTPN2 gene favors the expression of the splicing isoform PTPN2.4. This cytoplasmic isoform enhances TNF-\u03b1 production in myeloid cells, thereby contributing to intestinal inflammation. These findings identify PTPN2.4 as a key pathogenic regulator and potential therapeutic target for inflammatory bowel disease. ABSTRACT Genome-wide association studies &#8230; <a title=\"A Novel PTPN2 Isoform Differentially Regulates Immune Response. [[{&#8220;value&#8221;:&#8221;Xiaoguang Li, \nFedik Rahimov, \nRui Wang, \nLei Gao, \nRenze Ma, \nTiankai Han, \nYingtao Bi, \nFreidrich Cruz, \nJing Wang, \nShaun Grosskurth, \nElizabeth Asque, \nJesus Paez\u2010Cortez, \nMarc C. Levesque, \nNancy E. Crosbie, \nTimothy Radstake, \nAmlan Biswas, \nKanstantsin Katlinski&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/a-novel-ptpn2-isoform-differentially-regulates-immune-response-valuexiaoguang-li-fedik-rahimov-rui-wang-lei-gao-renze-ma-tiankai-han-yingtao-bi-freidrich-cruz-jing-wang-sh\/\" aria-label=\"Read more about A Novel PTPN2 Isoform Differentially Regulates Immune Response. [[{&#8220;value&#8221;:&#8221;Xiaoguang Li, \nFedik Rahimov, \nRui Wang, \nLei Gao, \nRenze Ma, \nTiankai Han, \nYingtao Bi, \nFreidrich Cruz, \nJing Wang, \nShaun Grosskurth, \nElizabeth Asque, \nJesus Paez\u2010Cortez, \nMarc C. Levesque, \nNancy E. Crosbie, \nTimothy Radstake, \nAmlan Biswas, \nKanstantsin Katlinski&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/hypoxia-independently-induces-aid-expression-in-ch12-b-cells-valuevincent-heyer-sandy-haidar-ahmad-mira-haddad-ines-argentieri-coraline-gessier-bernardo-reina%e2%80%90san%e2%80%90\/\">Hypoxia Independently Induces AID Expression in CH12 B Cells. [[{&#8220;value&#8221;:&#8221;Vincent Heyer, \nSandy Haidar Ahmad, \nMira Haddad, \nIn\u00e8s Argentieri, \nCoraline Gessier, \nBernardo Reina\u2010San\u2010Martin&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-20T10:16:08+02:00\" class=\"wp-block-latest-posts__post-date\">20 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Hypoxia activates the HIF complex (HIF-1\u03b1, HIF-1\u03b2, HIF-2\u03b1) to induce AID expression in B cells independently of cytokine signaling. However, hypoxia alone is insufficient to trigger class switch recombination (CSR), which additionally requires cytokine-driven chromatin accessibility, highlighting a mechanistic uncoupling between AID induction and functional antibody diversification. ABSTRACT Hypoxia has been shown to shape the &#8230; <a title=\"Hypoxia Independently Induces AID Expression in CH12 B Cells. [[{&#8220;value&#8221;:&#8221;Vincent Heyer, \nSandy Haidar Ahmad, \nMira Haddad, \nIn\u00e8s Argentieri, \nCoraline Gessier, \nBernardo Reina\u2010San\u2010Martin&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/20\/hypoxia-independently-induces-aid-expression-in-ch12-b-cells-valuevincent-heyer-sandy-haidar-ahmad-mira-haddad-ines-argentieri-coraline-gessier-bernardo-reina%e2%80%90san%e2%80%90\/\" aria-label=\"Read more about Hypoxia Independently Induces AID Expression in CH12 B Cells. [[{&#8220;value&#8221;:&#8221;Vincent Heyer, \nSandy Haidar Ahmad, \nMira Haddad, \nIn\u00e8s Argentieri, \nCoraline Gessier, \nBernardo Reina\u2010San\u2010Martin&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/14\/sustained-effector-functions-and-memory-accumulation-of-%ce%b1%ce%b2-t-cells-in-children-with-congenital-heart-disease-valueyusuf-eshimutu-abu-christoph-kammeyer-tao-yang-rodrigo-guti\/\">Sustained Effector Functions and Memory Accumulation of \u03b1\u03b2 T Cells in Children With Congenital Heart Disease. [[{&#8220;value&#8221;:&#8221;Yusuf Eshimutu Abu, \nChristoph Kammeyer, \nTao Yang, \nRodrigo Gutierrez Jauregui, \nAlexa Cramer, \nClaudia Junge, \nSvea Kleiner, \nAnika Janssen, \nAdan Chari Jirmo, \nAlexander Horke, \nReinhold F\u00f6rster, \nPhilipp Beerbaum, \nMartin Boehne, \nSarina Ravens&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-14T10:03:25+02:00\" class=\"wp-block-latest-posts__post-date\">14 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This study showed dysregulated \u03b1\u03b2 T cell homeostasis with ongoing T cell activation and low-grade inflammation in 5-12-year-old CHD children who underwent early-life cardiac surgery with thymectomy, characterized by reduced na\u00efve T cells and increased memory\/effector and senescent-like T cells. There was also higher expression of inhibitory receptors on effector T cells and elevated suppressive &#8230; <a title=\"Sustained Effector Functions and Memory Accumulation of \u03b1\u03b2 T Cells in Children With Congenital Heart Disease. [[{&#8220;value&#8221;:&#8221;Yusuf Eshimutu Abu, \nChristoph Kammeyer, \nTao Yang, \nRodrigo Gutierrez Jauregui, \nAlexa Cramer, \nClaudia Junge, \nSvea Kleiner, \nAnika Janssen, \nAdan Chari Jirmo, \nAlexander Horke, \nReinhold F\u00f6rster, \nPhilipp Beerbaum, \nMartin Boehne, \nSarina Ravens&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/14\/sustained-effector-functions-and-memory-accumulation-of-%ce%b1%ce%b2-t-cells-in-children-with-congenital-heart-disease-valueyusuf-eshimutu-abu-christoph-kammeyer-tao-yang-rodrigo-guti\/\" aria-label=\"Read more about Sustained Effector Functions and Memory Accumulation of \u03b1\u03b2 T Cells in Children With Congenital Heart Disease. [[{&#8220;value&#8221;:&#8221;Yusuf Eshimutu Abu, \nChristoph Kammeyer, \nTao Yang, \nRodrigo Gutierrez Jauregui, \nAlexa Cramer, \nClaudia Junge, \nSvea Kleiner, \nAnika Janssen, \nAdan Chari Jirmo, \nAlexander Horke, \nReinhold F\u00f6rster, \nPhilipp Beerbaum, \nMartin Boehne, \nSarina Ravens&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/14\/integrating-genetics-and-environment-to-find-causal-mechanisms-for-multiple-sclerosis-valuealicia-munoz-leon-matthew-r-lincoln\/\">Integrating Genetics and Environment to Find Causal Mechanisms for Multiple Sclerosis. [[{&#8220;value&#8221;:&#8221;Alicia Munoz Leon, \nMatthew R. Lincoln&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-14T10:03:25+02:00\" class=\"wp-block-latest-posts__post-date\">14 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Genetic and epidemiological studies have together identified hundreds of risk factors for MS, but we know relatively little about the mechanisms through which these cause disease. In this review, we explore a new generation of studies that are integrating genetics and environment to uncover disease mechanisms. Progress toward novel therapeutics is likely to come from &#8230; <a title=\"Integrating Genetics and Environment to Find Causal Mechanisms for Multiple Sclerosis. [[{&#8220;value&#8221;:&#8221;Alicia Munoz Leon, \nMatthew R. Lincoln&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/14\/integrating-genetics-and-environment-to-find-causal-mechanisms-for-multiple-sclerosis-valuealicia-munoz-leon-matthew-r-lincoln\/\" aria-label=\"Read more about Integrating Genetics and Environment to Find Causal Mechanisms for Multiple Sclerosis. [[{&#8220;value&#8221;:&#8221;Alicia Munoz Leon, \nMatthew R. Lincoln&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/13\/nur77-is-associated-with-polyfunctional-properties-in-virus%e2%80%90specific-human-cd8-t-cells-valuefabiola-martel-daniel-rincon-caroline-passaes-leonardo-arevalo-marcela-torres\/\">Nur77 Is Associated With Polyfunctional Properties in Virus\u2010Specific Human CD8+ T Cells. [[{&#8220;value&#8221;:&#8221;Fabiola Martel, \nDaniel Rinc\u00f3n, \nCaroline Passaes, \nLeonardo Ar\u00e9valo, \nMarcela Torres, \nNatalia Ramirez, \nCarlos F. Narv\u00e1ez, \nJessica F. Toro, \nOtto Sussmann, \nManuel A. Franco, \nJos\u00e9 Mateus, \nJohn Sidney, \nAlessandro Sette, \nAsier S\u00e1ez\u2010Ciri\u00f3n, \nFederico Perdomo\u2010Celis&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-13T10:37:22+02:00\" class=\"wp-block-latest-posts__post-date\">13 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Nur77 is associated with a TCF-1+ memory-like, polyfunctional profile in virus-specific human CD8+ T cells across acute-resolved, vaccinated, and chronic viral infections, and its pharmacologic modulation in vitro enhances the functionality of dysfunctional HIV- and HBV-specific CD8+ T cells in chronic co-infections. ABSTRACT Human CD8+ T cells undergo significant metabolic and transcriptional shifts during activation &#8230; <a title=\"Nur77 Is Associated With Polyfunctional Properties in Virus\u2010Specific Human CD8+ T Cells. [[{&#8220;value&#8221;:&#8221;Fabiola Martel, \nDaniel Rinc\u00f3n, \nCaroline Passaes, \nLeonardo Ar\u00e9valo, \nMarcela Torres, \nNatalia Ramirez, \nCarlos F. Narv\u00e1ez, \nJessica F. Toro, \nOtto Sussmann, \nManuel A. Franco, \nJos\u00e9 Mateus, \nJohn Sidney, \nAlessandro Sette, \nAsier S\u00e1ez\u2010Ciri\u00f3n, \nFederico Perdomo\u2010Celis&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/13\/nur77-is-associated-with-polyfunctional-properties-in-virus%e2%80%90specific-human-cd8-t-cells-valuefabiola-martel-daniel-rincon-caroline-passaes-leonardo-arevalo-marcela-torres\/\" aria-label=\"Read more about Nur77 Is Associated With Polyfunctional Properties in Virus\u2010Specific Human CD8+ T Cells. [[{&#8220;value&#8221;:&#8221;Fabiola Martel, \nDaniel Rinc\u00f3n, \nCaroline Passaes, \nLeonardo Ar\u00e9valo, \nMarcela Torres, \nNatalia Ramirez, \nCarlos F. Narv\u00e1ez, \nJessica F. Toro, \nOtto Sussmann, \nManuel A. Franco, \nJos\u00e9 Mateus, \nJohn Sidney, \nAlessandro Sette, \nAsier S\u00e1ez\u2010Ciri\u00f3n, \nFederico Perdomo\u2010Celis&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/mapping-of-neutrophils-in-cancers-insights-from-spatial-omics-technologies-valuexiaohe-li-xi-he-shan-cao-changming-shih-xiaoxiang-chen-lai-guan-ng\/\">Mapping of Neutrophils in Cancers: Insights From Spatial Omics Technologies. [[{&#8220;value&#8221;:&#8221;Xiaohe Li, \nXi He, \nShan Cao, \nChangming Shih, \nXiaoxiang Chen, \nLai Guan Ng&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-08T10:21:52+02:00\" class=\"wp-block-latest-posts__post-date\">8 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The evolving landscape of transcriptomic technologies tailored for neutrophil research. ABSTRACT Tumor neutrophils exhibit marked phenotypic plasticity and can play dual roles in tumor biology, encompassing both tumor-promoting and tumor-suppressive activities. Single-cell RNA sequencing (scRNA-seq) enables transcriptomic profiling of tumor neutrophils at single-cell resolution, whereas spatial transcriptomics (ST) addresses key limitations of scRNA-seq by preserving &#8230; <a title=\"Mapping of Neutrophils in Cancers: Insights From Spatial Omics Technologies. [[{&#8220;value&#8221;:&#8221;Xiaohe Li, \nXi He, \nShan Cao, \nChangming Shih, \nXiaoxiang Chen, \nLai Guan Ng&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/mapping-of-neutrophils-in-cancers-insights-from-spatial-omics-technologies-valuexiaohe-li-xi-he-shan-cao-changming-shih-xiaoxiang-chen-lai-guan-ng\/\" aria-label=\"Read more about Mapping of Neutrophils in Cancers: Insights From Spatial Omics Technologies. [[{&#8220;value&#8221;:&#8221;Xiaohe Li, \nXi He, \nShan Cao, \nChangming Shih, \nXiaoxiang Chen, \nLai Guan Ng&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/unfavourable-h%e2%80%90cdr3-loops-in-preb-cells-lead-to-highly-expanded-plasma-cell-clones-valuealaitz-aranburu-erik-engstrom-erik-demitz%e2%80%90helin-julia-m-scheffler-alessandro\/\">Unfavourable H\u2010CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones. [[{&#8220;value&#8221;:&#8221;Alaitz Aranburu, \nErik Engstr\u00f6m, \nErik Demitz\u2010Helin, \nJulia M. Scheffler, \nAlessandro Camponeschi, \nTimothy Sundell, \nZhong Ni, \nInga\u2010Lill M\u00e5rtensson&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-08T10:21:52+02:00\" class=\"wp-block-latest-posts__post-date\">8 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In the absence of a pre-BCR, a subset of mature B cells that expresses IgH chains with very short, hydrophobic and positively charged H-CDR3 loops is generated. This results in massive clonal expansion\u00a0and the development of autoreactive plasma cells exhibiting these characteristics. ABSTRACT The immune system is essential for protection against invading pathogens. However, if &#8230; <a title=\"Unfavourable H\u2010CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones. [[{&#8220;value&#8221;:&#8221;Alaitz Aranburu, \nErik Engstr\u00f6m, \nErik Demitz\u2010Helin, \nJulia M. Scheffler, \nAlessandro Camponeschi, \nTimothy Sundell, \nZhong Ni, \nInga\u2010Lill M\u00e5rtensson&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/unfavourable-h%e2%80%90cdr3-loops-in-preb-cells-lead-to-highly-expanded-plasma-cell-clones-valuealaitz-aranburu-erik-engstrom-erik-demitz%e2%80%90helin-julia-m-scheffler-alessandro\/\" aria-label=\"Read more about Unfavourable H\u2010CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones. [[{&#8220;value&#8221;:&#8221;Alaitz Aranburu, \nErik Engstr\u00f6m, \nErik Demitz\u2010Helin, \nJulia M. Scheffler, \nAlessandro Camponeschi, \nTimothy Sundell, \nZhong Ni, \nInga\u2010Lill M\u00e5rtensson&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/cd8-t-cell-sensing-of-type-i-interferon-impacts-anergy-valueanne-s-haefke-hanna-grober-ioana-sandu-vanessa-skipness-nikos-pantouloufos-fabienne-grabnitz-marie%e2%80%90elen-tuch\/\">CD8 T Cell Sensing of Type I Interferon Impacts Anergy. [[{&#8220;value&#8221;:&#8221;Anne S. Haefke, \nHanna Gr\u00f6ber, \nIoana Sandu, \nVanessa Skipness, \nNikos Pantouloufos, \nFabienne Gr\u00e4bnitz, \nMarie\u2010Elen Tuchel, \nNathan Zangger, \nDominique Stark, \nMarvin K\u0159\u00ed\u017e, \nCarmine Cristinzio, \nHanspeter Pircher, \nRoman Sp\u00f6rri, \nIsaak Quast, \nAnnette Oxenius&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-08T10:21:52+02:00\" class=\"wp-block-latest-posts__post-date\">8 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Basal IFN-I acts as a rheostat to fine-tune CD8 T cell anergy. The presence of IFN-I induces a less deep anergic state characterised by greater expansion, residual effector function and plasticity. This favours the accumulation of autoreactive T cells that retain the potential to break tolerance rather than undergoing deletion. Created in BioRender (2026). https:\/\/BioRender.com\/y0syq8s &#8230; <a title=\"CD8 T Cell Sensing of Type I Interferon Impacts Anergy. [[{&#8220;value&#8221;:&#8221;Anne S. Haefke, \nHanna Gr\u00f6ber, \nIoana Sandu, \nVanessa Skipness, \nNikos Pantouloufos, \nFabienne Gr\u00e4bnitz, \nMarie\u2010Elen Tuchel, \nNathan Zangger, \nDominique Stark, \nMarvin K\u0159\u00ed\u017e, \nCarmine Cristinzio, \nHanspeter Pircher, \nRoman Sp\u00f6rri, \nIsaak Quast, \nAnnette Oxenius&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/cd8-t-cell-sensing-of-type-i-interferon-impacts-anergy-valueanne-s-haefke-hanna-grober-ioana-sandu-vanessa-skipness-nikos-pantouloufos-fabienne-grabnitz-marie%e2%80%90elen-tuch\/\" aria-label=\"Read more about CD8 T Cell Sensing of Type I Interferon Impacts Anergy. [[{&#8220;value&#8221;:&#8221;Anne S. Haefke, \nHanna Gr\u00f6ber, \nIoana Sandu, \nVanessa Skipness, \nNikos Pantouloufos, \nFabienne Gr\u00e4bnitz, \nMarie\u2010Elen Tuchel, \nNathan Zangger, \nDominique Stark, \nMarvin K\u0159\u00ed\u017e, \nCarmine Cristinzio, \nHanspeter Pircher, \nRoman Sp\u00f6rri, \nIsaak Quast, \nAnnette Oxenius&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/08\/correction-to-deletion-of-lymphatic-pd%e2%80%90l1-protects-mice-from-severe-autoimmune-encephalitis\/\">Correction to \u201cDeletion of Lymphatic PD\u2010L1 Protects Mice From Severe Autoimmune Encephalitis\u201d.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-08T10:21:52+02:00\" class=\"wp-block-latest-posts__post-date\">8 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 5, May 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/borrelia-burgdorferi-sensu-lato-employs-several-escape-mechanisms-to-bypass-the-human-defense-system-valuezara-karami-hadewych-j-m-ter-hofstede-leo-a-b-joosten\/\">Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva-mediated suppression of innate defenses, TLR2\/NOD2-driven cytokine dysregulation, and interference with JAK\/STAT and CIITA-dependent antigen presentation. Impaired autophagy skews responses toward pathogenic Th17 activity, while disrupted lymph node architecture, persistent IgM, and defective CD4+ T cell function collectively impair &#8230; <a title=\"Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/borrelia-burgdorferi-sensu-lato-employs-several-escape-mechanisms-to-bypass-the-human-defense-system-valuezara-karami-hadewych-j-m-ter-hofstede-leo-a-b-joosten\/\" aria-label=\"Read more about Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/spatial-multiomics-reveal-insights-into-adc-efficacy-valueosman-goni-niklas-klumper-maria-del-mar-muniz-moreno-markus-eckstein-christoph-kuppe\/\">Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Spatial multiomics profiling can reveal how tumor heterogeneity and microenvironment influence ADC efficacy. Combining spatial transcriptomics, proteomics, and AI-based analysis improves the identification of tissue factors influencing therapy response. This integrative approach potentially enables prediction of response, resistance, and optimized patient selection, which we review here. ABSTRACT Antibody\u2013drug conjugates (ADCs) have transformed the therapeutic landscape &#8230; <a title=\"Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/spatial-multiomics-reveal-insights-into-adc-efficacy-valueosman-goni-niklas-klumper-maria-del-mar-muniz-moreno-markus-eckstein-christoph-kuppe\/\" aria-label=\"Read more about Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/syk-signalling-in-nlrp3-inflammasome%e2%80%90mediated-response-of-murine-microglia-activated-by-immune-complexes-formed-of-viral-proteins-and-specific-igg-valuekristina-masalaite-milda-no\/\">SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IC-mediated inflammatory response\u2014the NLRP3 inflammasome activation, cytokine secretion, and antigen presentation depend on SYK signalling pathways in primary murine microglia. ABSTRACT Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation, but the precise mechanism remains unknown. The NLRP3 inflammasome is a vital component of &#8230; <a title=\"SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/syk-signalling-in-nlrp3-inflammasome%e2%80%90mediated-response-of-murine-microglia-activated-by-immune-complexes-formed-of-viral-proteins-and-specific-igg-valuekristina-masalaite-milda-no\/\" aria-label=\"Read more about SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/cover-story-eur-j-immunol-526\/\">Cover Story: Eur. J. Immunol. 5&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:04:59+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 5&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/cover-story-eur-j-immunol-526\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 5&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/adapted-live-sars%e2%80%90cov%e2%80%902-vaccine-elicits-rapid-mucosal-immunity-protects-from-disease-and-reduces-shedding-of-xbb-1-5-valuejana-kochmann-tobias-britzke-nico-joel-halwe\/\">Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:04:59+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">An attenuated live vaccine (OTS-300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination. Therefore, vaccination with the OTS LAV platform may help to disrupt transmission chains. ABSTRACT The emergence of &#8230; <a title=\"Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/adapted-live-sars%e2%80%90cov%e2%80%902-vaccine-elicits-rapid-mucosal-immunity-protects-from-disease-and-reduces-shedding-of-xbb-1-5-valuejana-kochmann-tobias-britzke-nico-joel-halwe\/\" aria-label=\"Read more about Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/interferon%e2%80%90regulatory-factor-4-is-required-not-only-for-induction-but-also-for-maintenance-of-the-th17-phenotype-valuejanis-patten-prema-erramsetti-addi-josua-romero-olmedo-ol\/\">Interferon\u2010Regulatory Factor 4 Is Required Not Only for Induction but Also for Maintenance of the Th17 Phenotype. [[{&#8220;value&#8221;:&#8221;Janis Patten, \nPrema Erramsetti, \nAddi Josua Romero Olmedo, \nOlaf Pinkenburg, \nMagdalena Huber, \nMichael Lohoff&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T10:02:20+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We previously showed that primary differentiation of na\u00efve T cells is dependent on IRF4. Now we show that maintenance of already differentiated conventional and pathogenic Th17 cells is also dependent on IRF4.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/adar1-controls-macrophage-scavenging-and-lipid%e2%80%90buffering-programs-in-metabolic-tissues-valueachilleas-fardellas-emelie-barreby-madara-brice-sebastian-nock-jules-russick-an\/\">ADAR1 Controls Macrophage Scavenging and Lipid\u2010Buffering Programs in Metabolic Tissues. [[{&#8220;value&#8221;:&#8221;Achilleas Fardellas, \nEmelie Barreby, \nMadara Brice, \nSebastian Nock, \nJules Russick, \nAna Vankova, \nCharlotte Edberg, \nIda Robertsen, \nJens K. Hertel, \nPer St\u00e5l, \nGunnar Mellgren, \nCecilia Karlsson, \nJ\u00f8ran S. Hjelmesaeth, \nHannes Hagstr\u00f6m, \nErik N\u00e4slund, \nVolker M. Lauschke, \nJohan Fern\u00f8, \nPing Chen, \nCecilia Morgantini, \nMyriam Aouadi, \nNiklas K. Bj\u00f6rkstr\u00f6m&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T10:02:20+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ADAR1 expression increase during monocyte-to-macrophage differentiation via an alternative transcription start site. Isoform-specific ADAR1 activity governs key macrophage functions, including efferocytosis, endocytosis, lipid metabolism, and proliferation. Moreover, ADAR1 in macrophages responds to different metabolic states and buffers lipotoxicity under high metabolic load. Vectors obtained from https:\/\/BioRender.com. ABSTRACT Adenosine deaminase acting on RNA 1 (ADAR1) regulates &#8230; <a title=\"ADAR1 Controls Macrophage Scavenging and Lipid\u2010Buffering Programs in Metabolic Tissues. [[{&#8220;value&#8221;:&#8221;Achilleas Fardellas, \nEmelie Barreby, \nMadara Brice, \nSebastian Nock, \nJules Russick, \nAna Vankova, \nCharlotte Edberg, \nIda Robertsen, \nJens K. Hertel, \nPer St\u00e5l, \nGunnar Mellgren, \nCecilia Karlsson, \nJ\u00f8ran S. Hjelmesaeth, \nHannes Hagstr\u00f6m, \nErik N\u00e4slund, \nVolker M. Lauschke, \nJohan Fern\u00f8, \nPing Chen, \nCecilia Morgantini, \nMyriam Aouadi, \nNiklas K. Bj\u00f6rkstr\u00f6m&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/adar1-controls-macrophage-scavenging-and-lipid%e2%80%90buffering-programs-in-metabolic-tissues-valueachilleas-fardellas-emelie-barreby-madara-brice-sebastian-nock-jules-russick-an\/\" aria-label=\"Read more about ADAR1 Controls Macrophage Scavenging and Lipid\u2010Buffering Programs in Metabolic Tissues. [[{&#8220;value&#8221;:&#8221;Achilleas Fardellas, \nEmelie Barreby, \nMadara Brice, \nSebastian Nock, \nJules Russick, \nAna Vankova, \nCharlotte Edberg, \nIda Robertsen, \nJens K. Hertel, \nPer St\u00e5l, \nGunnar Mellgren, \nCecilia Karlsson, \nJ\u00f8ran S. Hjelmesaeth, \nHannes Hagstr\u00f6m, \nErik N\u00e4slund, \nVolker M. Lauschke, \nJohan Fern\u00f8, \nPing Chen, \nCecilia Morgantini, \nMyriam Aouadi, \nNiklas K. Bj\u00f6rkstr\u00f6m&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/human-blood-iga-memory-b-cells-differ-from-igg-b-cells-by-expressing-gut%e2%80%90homing-and-regulatory-markers-valuelouise-le-gal-leo-boussamet-alexandra-garcia-jeremy-morille-emi\/\">Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut\u2010Homing and Regulatory Markers. [[{&#8220;value&#8221;:&#8221;Louise Le Gal, \nL\u00e9o Boussamet, \nAlexandra Garcia, \nJ\u00e9r\u00e9my Morille, \nEmilie Dugast, \nArnaud B. Nicot, \nDavid\u2010Axel Laplaud, \nLaureline Berthelot&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-27T10:02:20+02:00\" class=\"wp-block-latest-posts__post-date\">27 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Compared with IgG+ and IgM+ memory B cells, IgA+ memory B cells displayed distinct phenotypical markers: PD-L1, GPR183, CCR9, CCR10, \u03b14\u03b27, CD11b. A particular transcriptomic signature, with RUNX2, ARHGEF10L, XYLT1, TRPS1, and CHL1 upregulation, characterized the IgA+ memory B cell population, whereas miR4432HG was a marker of IgG+ memory B cells. ABSTRACT IgA is the &#8230; <a title=\"Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut\u2010Homing and Regulatory Markers. [[{&#8220;value&#8221;:&#8221;Louise Le Gal, \nL\u00e9o Boussamet, \nAlexandra Garcia, \nJ\u00e9r\u00e9my Morille, \nEmilie Dugast, \nArnaud B. Nicot, \nDavid\u2010Axel Laplaud, \nLaureline Berthelot&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/27\/human-blood-iga-memory-b-cells-differ-from-igg-b-cells-by-expressing-gut%e2%80%90homing-and-regulatory-markers-valuelouise-le-gal-leo-boussamet-alexandra-garcia-jeremy-morille-emi\/\" aria-label=\"Read more about Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut\u2010Homing and Regulatory Markers. [[{&#8220;value&#8221;:&#8221;Louise Le Gal, \nL\u00e9o Boussamet, \nAlexandra Garcia, \nJ\u00e9r\u00e9my Morille, \nEmilie Dugast, \nArnaud B. Nicot, \nDavid\u2010Axel Laplaud, \nLaureline Berthelot&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/21\/accumulation-of-siglec10cx3cr1-macrophages-in-the-tumor-microenvironment-of-glioblastomas-valuenico-andreas-lucas-gath-paul-mike-jordan-saskia-steiner-oliver-werz-nazife-dinc\/\">Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas. [[{&#8220;value&#8221;:&#8221;Nico Andreas, \nLucas Gath, \nPaul Mike Jordan, \nSaskia Steiner, \nOliver Werz, \nNazife Dinc, \nPeter Baumgarten, \nChristian Senft, \nThe OncoSurgeJena Team, \nFalko Schwarz, \nNazeer Aboud, \nRamazan Dalkilic, \nSergio A. Calero Martinez, \nKatharina Klumbies, \nAaron Lawson McLean&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-21T10:38:05+02:00\" class=\"wp-block-latest-posts__post-date\">21 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">By comparing various brain tumors, we identified a CX3CR1+ Siglec10+ double-positive macrophage subpopulation specifically enriched in highly malignant Glioblastomas (GBMs), wherein they accumulated in metabolically active tumor areas. Thus, they potentially serve as a diagnostic indicator population for GBMs and as targets of future GBM-specific treatment strategies. ABSTRACT Glioblastoma (GBM) is one of the most &#8230; <a title=\"Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas. [[{&#8220;value&#8221;:&#8221;Nico Andreas, \nLucas Gath, \nPaul Mike Jordan, \nSaskia Steiner, \nOliver Werz, \nNazife Dinc, \nPeter Baumgarten, \nChristian Senft, \nThe OncoSurgeJena Team, \nFalko Schwarz, \nNazeer Aboud, \nRamazan Dalkilic, \nSergio A. Calero Martinez, \nKatharina Klumbies, \nAaron Lawson McLean&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/21\/accumulation-of-siglec10cx3cr1-macrophages-in-the-tumor-microenvironment-of-glioblastomas-valuenico-andreas-lucas-gath-paul-mike-jordan-saskia-steiner-oliver-werz-nazife-dinc\/\" aria-label=\"Read more about Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas. [[{&#8220;value&#8221;:&#8221;Nico Andreas, \nLucas Gath, \nPaul Mike Jordan, \nSaskia Steiner, \nOliver Werz, \nNazife Dinc, \nPeter Baumgarten, \nChristian Senft, \nThe OncoSurgeJena Team, \nFalko Schwarz, \nNazeer Aboud, \nRamazan Dalkilic, \nSergio A. Calero Martinez, \nKatharina Klumbies, \nAaron Lawson McLean&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/18\/expression-of-concern-activation-of-epstein%e2%80%90barr-virus-c3d-receptor-gp140-cr2-cd21-on-human-cell-surface-triggers-pp60src-and-akt%e2%80%90gsk3-activities-upstream-and-downstream-to-pi-3\/\">EXPRESSION OF CONCERN: Activation of Epstein\u2010Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt\u2010GSK3 Activities Upstream and Downstream to PI 3\u2010Kinase, Respectively.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-18T09:43:10+02:00\" class=\"wp-block-latest-posts__post-date\">18 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ABSTRACT EXPRESSION OF CONCERN: M. Barel, M. Balbo, M. Le Romancer and R. Frade, \u201cActivation of Epstein-Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt-GSK3 Activities Upstream and Downstream to PI 3-Kinase, Respectively,\u201d European Journal of Immunology 33, no. 9 (2003): 2557\u20132566, https:\/\/doi.org\/10.1002\/eji.200324059. This Expression of Concern is for the &#8230; <a title=\"EXPRESSION OF CONCERN: Activation of Epstein\u2010Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt\u2010GSK3 Activities Upstream and Downstream to PI 3\u2010Kinase, Respectively.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/18\/expression-of-concern-activation-of-epstein%e2%80%90barr-virus-c3d-receptor-gp140-cr2-cd21-on-human-cell-surface-triggers-pp60src-and-akt%e2%80%90gsk3-activities-upstream-and-downstream-to-pi-3\/\" aria-label=\"Read more about EXPRESSION OF CONCERN: Activation of Epstein\u2010Barr Virus\/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt\u2010GSK3 Activities Upstream and Downstream to PI 3\u2010Kinase, Respectively.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/increased-constitutive-interferon%e2%80%90%ce%b2-levels-and-altered-cd4-t-cell-homeostasis-induced-by-expression-of-a-viral-glycoprotein-valuehanspeter-pircher-oliver-s-thomas-anne-s\/\">Increased Constitutive Interferon\u2010\u03b2 Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{&#8220;value&#8221;:&#8221;Hanspeter Pircher, \nOliver S. Thomas, \nAnne S. Haefke, \nAnnette Oxenius, \nThomas Boehm&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-14T10:21:55+02:00\" class=\"wp-block-latest-posts__post-date\">14 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Constitutive interferon (IFN) production is regulated by microbiota and essential for optimal immune responses. Here, we demonstrate that expression of the glycoprotein of LCM virus upregulates constitutive IFN-\u03b2 levels and IFN-stimulated genes (ISGs) in transgenic mice. Moreover, it increased self-antigen-driven memory-phenotype CD4 T cells and effector regulatory CD4 T cells. ABSTRACT Besides the strong Type &#8230; <a title=\"Increased Constitutive Interferon\u2010\u03b2 Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{&#8220;value&#8221;:&#8221;Hanspeter Pircher, \nOliver S. Thomas, \nAnne S. Haefke, \nAnnette Oxenius, \nThomas Boehm&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/14\/increased-constitutive-interferon%e2%80%90%ce%b2-levels-and-altered-cd4-t-cell-homeostasis-induced-by-expression-of-a-viral-glycoprotein-valuehanspeter-pircher-oliver-s-thomas-anne-s\/\" aria-label=\"Read more about Increased Constitutive Interferon\u2010\u03b2 Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein. [[{&#8220;value&#8221;:&#8221;Hanspeter Pircher, \nOliver S. Thomas, \nAnne S. Haefke, \nAnnette Oxenius, \nThomas Boehm&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/08\/uncovering-immune-niches-in-health-and-disease-using-spatial-transcriptomics-valuejohan-thorsson-yang-zhao-eduardo-j-villablanca-camilla-engblom\/\">Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics. [[{&#8220;value&#8221;:&#8221;Johan Thorsson, \nYang Zhao, \nEduardo J. Villablanca, \nCamilla Engblom&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-08T10:04:33+02:00\" class=\"wp-block-latest-posts__post-date\">8 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Through the lens of spatial transcriptomics and associated tools, novel immune niche constituents can now be resolved. Drawing on gut and tumor contexts, we propose a framework to define immune niches and integrate clonal dynamics, aiming to advance niche-directed therapies toward precise, context-specific immune modulation. ABSTRACT Spatial transcriptomics allows for the investigation of complex cellular &#8230; <a title=\"Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics. [[{&#8220;value&#8221;:&#8221;Johan Thorsson, \nYang Zhao, \nEduardo J. Villablanca, \nCamilla Engblom&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/08\/uncovering-immune-niches-in-health-and-disease-using-spatial-transcriptomics-valuejohan-thorsson-yang-zhao-eduardo-j-villablanca-camilla-engblom\/\" aria-label=\"Read more about Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics. [[{&#8220;value&#8221;:&#8221;Johan Thorsson, \nYang Zhao, \nEduardo J. Villablanca, \nCamilla Engblom&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/05\/b%e2%80%90cell-differentiation-of-human-hematopoietic-progenitors-is-efficiently-supported-by-wharton-jelly%e2%80%90derived-mesenchymal-stem-cells-valuelouison-collet-hakim-ouled%e2%80%90\/\">B\u2010Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly\u2010Derived Mesenchymal Stem Cells. [[{&#8220;value&#8221;:&#8221;Louison Collet, \nHakim Ouled\u2010Haddou, \nHussein Ghamlouch, \nWalaa Darwiche, \nCathy Gomila, \nBrigitte Gubler, \nLo\u00efc Garcon, \nDelphine Lebon, \nJean\u2010Pierre Marolleau&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-05T10:01:05+02:00\" class=\"wp-block-latest-posts__post-date\">5 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Wharton&#8217;s jelly-derived mesenchymal stromal cells isolated from umbilical cord were used to recreate a human stromal environment for B-cell development in vitro. In co-culture, CD34+ hematopoietic progenitors from bone marrow or cord blood differentiated into mature IgM-expressing B cells by day 11, while the Nalm-16 B-ALL cell line showed rapid IgM expression as early as &#8230; <a title=\"B\u2010Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly\u2010Derived Mesenchymal Stem Cells. [[{&#8220;value&#8221;:&#8221;Louison Collet, \nHakim Ouled\u2010Haddou, \nHussein Ghamlouch, \nWalaa Darwiche, \nCathy Gomila, \nBrigitte Gubler, \nLo\u00efc Garcon, \nDelphine Lebon, \nJean\u2010Pierre Marolleau&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/05\/b%e2%80%90cell-differentiation-of-human-hematopoietic-progenitors-is-efficiently-supported-by-wharton-jelly%e2%80%90derived-mesenchymal-stem-cells-valuelouison-collet-hakim-ouled%e2%80%90\/\" aria-label=\"Read more about B\u2010Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly\u2010Derived Mesenchymal Stem Cells. [[{&#8220;value&#8221;:&#8221;Louison Collet, \nHakim Ouled\u2010Haddou, \nHussein Ghamlouch, \nWalaa Darwiche, \nCathy Gomila, \nBrigitte Gubler, \nLo\u00efc Garcon, \nDelphine Lebon, \nJean\u2010Pierre Marolleau&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/nicotine-suppresses-human-memory-th-cell-subsets-with-preferential-effects-on-central-memory-th-cells-in-an-%ce%b17-nicotinic-acetylcholine-receptor%e2%80%90dependent-manner-valuefatemeh-gh\/\">Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an \u03b17 Nicotinic Acetylcholine Receptor\u2010Dependent Manner. [[{&#8220;value&#8221;:&#8221;Fatemeh Gholizadeh, \nMehri Hajiaghayi, \nNiloufar Rahbari, \nJennifer S. Choi, \nSamantha Heidt, \nAlexia Como, \nMaryam Kazerouni, \nMelika Kargar, \nAude Pinard\u2010LaRoche, \nSteve C. C. Shih, \nPeter J. Darlington&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-03T10:16:09+02:00\" class=\"wp-block-latest-posts__post-date\">3 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Human memory Th cells were separated into Tcm (CD45RO+ CD62L+) and Tem (CD45RO+ CD62L\u2212). Nicotine preferentially suppressed Th1-, Th2-, Th17-, and Tfh-associated programs in Tcm via an \u03b17nAChR-dependent mechanism, with minimal effect in Tem. ABSTRACT Memory T helper (Th) cells sustain protective recall responses but can also drive chronic inflammation, necessitating precise regulation of their &#8230; <a title=\"Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an \u03b17 Nicotinic Acetylcholine Receptor\u2010Dependent Manner. [[{&#8220;value&#8221;:&#8221;Fatemeh Gholizadeh, \nMehri Hajiaghayi, \nNiloufar Rahbari, \nJennifer S. Choi, \nSamantha Heidt, \nAlexia Como, \nMaryam Kazerouni, \nMelika Kargar, \nAude Pinard\u2010LaRoche, \nSteve C. C. Shih, \nPeter J. Darlington&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/nicotine-suppresses-human-memory-th-cell-subsets-with-preferential-effects-on-central-memory-th-cells-in-an-%ce%b17-nicotinic-acetylcholine-receptor%e2%80%90dependent-manner-valuefatemeh-gh\/\" aria-label=\"Read more about Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an \u03b17 Nicotinic Acetylcholine Receptor\u2010Dependent Manner. [[{&#8220;value&#8221;:&#8221;Fatemeh Gholizadeh, \nMehri Hajiaghayi, \nNiloufar Rahbari, \nJennifer S. Choi, \nSamantha Heidt, \nAlexia Como, \nMaryam Kazerouni, \nMelika Kargar, \nAude Pinard\u2010LaRoche, \nSteve C. C. Shih, \nPeter J. Darlington&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/structure%e2%80%90guided-engineering-of-tigit-to-modulate-its-interaction-with-nectin%e2%80%904-a-tumour%e2%80%90specific-antigen-for-the-development-of-therapeutic-strategy-valuenamrata-g\/\">Structure\u2010Guided Engineering of TIGIT to Modulate Its Interaction With Nectin\u20104, a Tumour\u2010Specific Antigen for the Development of Therapeutic Strategy. [[{&#8220;value&#8221;:&#8221;Namrata Ganguli, \nSayantan Shaw, \nSohini Sarkar, \nSaumyadeep Goswami, \nGayatri Mukherjee, \nDibyendu Samanta&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-03T10:16:09+02:00\" class=\"wp-block-latest-posts__post-date\">3 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Nectin-4 is a tumour-specific antigen that interacts selectively with the immune receptor TIGIT, resulting in inhibition of NK-cell cytotoxicity. We have explored the molecular and structural basis of this interaction and leveraged the information for structure-guided engineering of a TIGIT mutant exhibiting higher interaction affinity with nectin-4 and weaker binding to nectin-2 and PVR. The &#8230; <a title=\"Structure\u2010Guided Engineering of TIGIT to Modulate Its Interaction With Nectin\u20104, a Tumour\u2010Specific Antigen for the Development of Therapeutic Strategy. [[{&#8220;value&#8221;:&#8221;Namrata Ganguli, \nSayantan Shaw, \nSohini Sarkar, \nSaumyadeep Goswami, \nGayatri Mukherjee, \nDibyendu Samanta&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/structure%e2%80%90guided-engineering-of-tigit-to-modulate-its-interaction-with-nectin%e2%80%904-a-tumour%e2%80%90specific-antigen-for-the-development-of-therapeutic-strategy-valuenamrata-g\/\" aria-label=\"Read more about Structure\u2010Guided Engineering of TIGIT to Modulate Its Interaction With Nectin\u20104, a Tumour\u2010Specific Antigen for the Development of Therapeutic Strategy. [[{&#8220;value&#8221;:&#8221;Namrata Ganguli, \nSayantan Shaw, \nSohini Sarkar, \nSaumyadeep Goswami, \nGayatri Mukherjee, \nDibyendu Samanta&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/04\/03\/multi%e2%80%90parameter-spectral-flow-cytometry-panel-for-immune-phenotyping-of-murine-b-and-t-cell-responses-valuekassandra-hoetzel-hendrik-feuerstein-julia-ludwig-hedda-wardemann\/\">Multi\u2010Parameter Spectral Flow Cytometry Panel for Immune Phenotyping of Murine B and T Cell Responses. [[{&#8220;value&#8221;:&#8221;Kassandra Hoetzel, \nHendrik Feuerstein, \nJulia Ludwig, \nHedda Wardemann&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-04-03T10:16:09+02:00\" class=\"wp-block-latest-posts__post-date\">3 de April de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">To enable the analysis of B cell and T cell immune responses in mouse lymph nodes, spleen, and bone marrow, including different B cell and T cell subsets and their activation status, as well as the antigen-reactivity and isotype of B cells, a novel 31-parameter spectral flow cytometry panel was developed.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/31\/dynamic-thymic-stromal-lymphopoietin-and-its-receptor-complex-expression-on-skin-langerhans-cells-in-response-to-mc903%e2%80%90induced-skin-inflammation-valuemartin-i-gonzalez%e2%80%90rodr\/\">Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903\u2010induced Skin Inflammation. [[{&#8220;value&#8221;:&#8221;Mart\u00edn I. Gonz\u00e1lez\u2010Rodr\u00edguez, \nTanja Salomaa, \nCarolina Cabalin, \nTuomas Komulainen, \nLotta Hiihtola, \nLaura Kummola, \nTero A. H. J\u00e4rvinen, \nIlkka S. Junttila&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-31T10:36:42+02:00\" class=\"wp-block-latest-posts__post-date\">31 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon Calcipotriol &#8230; <a title=\"Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903\u2010induced Skin Inflammation. [[{&#8220;value&#8221;:&#8221;Mart\u00edn I. Gonz\u00e1lez\u2010Rodr\u00edguez, \nTanja Salomaa, \nCarolina Cabalin, \nTuomas Komulainen, \nLotta Hiihtola, \nLaura Kummola, \nTero A. H. J\u00e4rvinen, \nIlkka S. Junttila&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/31\/dynamic-thymic-stromal-lymphopoietin-and-its-receptor-complex-expression-on-skin-langerhans-cells-in-response-to-mc903%e2%80%90induced-skin-inflammation-valuemartin-i-gonzalez%e2%80%90rodr\/\" aria-label=\"Read more about Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903\u2010induced Skin Inflammation. [[{&#8220;value&#8221;:&#8221;Mart\u00edn I. Gonz\u00e1lez\u2010Rodr\u00edguez, \nTanja Salomaa, \nCarolina Cabalin, \nTuomas Komulainen, \nLotta Hiihtola, \nLaura Kummola, \nTero A. H. J\u00e4rvinen, \nIlkka S. Junttila&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/selective-depletion-of-autoreactive-plasma-cells-as-a-novel-strategy-to-treat-acetylcholine-receptor-antibody%e2%80%90positive-myasthenia-gravis-valuelaleh-khodadadi-deborah-puppe-dilar\/\">Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody\u2010Positive Myasthenia Gravis. [[{&#8220;value&#8221;:&#8221;Laleh Khodadadi, \nDeborah Puppe, \nDilara S. Cirillo, \nCarolina Martinez\u2010Cingolani, \nJens Klotsche, \nAndreas Pelz, \nSiegfried Kohler, \nQingyu Cheng, \nKonstantinos Lazaridis, \nMichael Fichtner, \nJan Pille, \nAndrey Kruglov, \nMarina Bondareva, \nTobias Alexander, \nAndreas Radbruch, \nAndreas Meisel, \nFalk Hiepe&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Current plasma cell\u2013targeting therapies lack antigen specificity. Using an antibody-mediated cytotoxicity engager (ACE) targeting the \u03b1-subunit of the extracellular domain of the human acetylcholine receptor (hAChR \u03b1ECD), we selectively depleted pathogenic antibody-secreting cells in a myasthenia gravis model, reducing autoantibody titers and disease severity while preserving nonspecific antibody-secreting cells and humoral immunity. ABSTRACT Myasthenia gravis &#8230; <a title=\"Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody\u2010Positive Myasthenia Gravis. [[{&#8220;value&#8221;:&#8221;Laleh Khodadadi, \nDeborah Puppe, \nDilara S. Cirillo, \nCarolina Martinez\u2010Cingolani, \nJens Klotsche, \nAndreas Pelz, \nSiegfried Kohler, \nQingyu Cheng, \nKonstantinos Lazaridis, \nMichael Fichtner, \nJan Pille, \nAndrey Kruglov, \nMarina Bondareva, \nTobias Alexander, \nAndreas Radbruch, \nAndreas Meisel, \nFalk Hiepe&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/selective-depletion-of-autoreactive-plasma-cells-as-a-novel-strategy-to-treat-acetylcholine-receptor-antibody%e2%80%90positive-myasthenia-gravis-valuelaleh-khodadadi-deborah-puppe-dilar\/\" aria-label=\"Read more about Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody\u2010Positive Myasthenia Gravis. [[{&#8220;value&#8221;:&#8221;Laleh Khodadadi, \nDeborah Puppe, \nDilara S. Cirillo, \nCarolina Martinez\u2010Cingolani, \nJens Klotsche, \nAndreas Pelz, \nSiegfried Kohler, \nQingyu Cheng, \nKonstantinos Lazaridis, \nMichael Fichtner, \nJan Pille, \nAndrey Kruglov, \nMarina Bondareva, \nTobias Alexander, \nAndreas Radbruch, \nAndreas Meisel, \nFalk Hiepe&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/depletion-of-neonatal-neutrophilic-cells-worsens-the-outcome-of-e-coli-sepsis-in-newborn-mice-valuejulian-schwarz-janine-hebel-stefanie-dietz%e2%80%90ziegler-jessica-ruhle-trim-laj\/\">Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. [[{&#8220;value&#8221;:&#8221;Julian Schwarz, \nJanine Hebel, \nStefanie Dietz\u2010Ziegler, \nJessica R\u00fchle, \nTrim Lajqi, \nThorsten Orlikowsky, \nChristian F. Poets, \nChristian Gille, \nNatascha K\u00f6stlin\u2010Gille&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">In a neonatal mouse model of E. coli sepsis, depleting neonatal neutrophilic cells (NNC) increased mortality and systemic inflammation. The bacterial load increased slightly, and the immune cell populations remained unchanged. These findings suggest that NNC may play a role in controlling inflammation and protecting neonates from lethal sepsis. ABSTRACT Neonates are particularly susceptible to &#8230; <a title=\"Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. [[{&#8220;value&#8221;:&#8221;Julian Schwarz, \nJanine Hebel, \nStefanie Dietz\u2010Ziegler, \nJessica R\u00fchle, \nTrim Lajqi, \nThorsten Orlikowsky, \nChristian F. Poets, \nChristian Gille, \nNatascha K\u00f6stlin\u2010Gille&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/depletion-of-neonatal-neutrophilic-cells-worsens-the-outcome-of-e-coli-sepsis-in-newborn-mice-valuejulian-schwarz-janine-hebel-stefanie-dietz%e2%80%90ziegler-jessica-ruhle-trim-laj\/\" aria-label=\"Read more about Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice. [[{&#8220;value&#8221;:&#8221;Julian Schwarz, \nJanine Hebel, \nStefanie Dietz\u2010Ziegler, \nJessica R\u00fchle, \nTrim Lajqi, \nThorsten Orlikowsky, \nChristian F. Poets, \nChristian Gille, \nNatascha K\u00f6stlin\u2010Gille&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/deletion-of-lymphatic-pd%e2%80%90l1-protects-mice-from-severe-autoimmune-encephalitis-valueziyuan-wang-eleni-meuffels-christian-ashworth-emma-reynaud-shruthi-hemanna-burkhard-bech\/\">Deletion of Lymphatic PD\u2010L1 Protects Mice From Severe Autoimmune Encephalitis. [[{&#8220;value&#8221;:&#8221;Ziyuan Wang, \nEl\u00e8ni Meuffels, \nChristian Ashworth, \nEmma Reynaud, \nShruthi Hemanna, \nBurkhard Becher, \nMichael Detmar, \nSarah Mundt, \nLothar C. Dieterich&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lymphatic endothelial cells at the cribriform plate and in brain-draining cervical lymph nodes express PD-L1 during autoimmune encephalitis. Unexpectedly, deletion of lymphatic PD-L1 expression ameliorates disease symptoms and is associated with increased brain infiltration of regulatory CD8+ Foxp3+ T cells.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/a-new-immunofluorescence-assay-allows-the-sensitive-detection-of-anti%e2%80%90cytosolic-5%e2%80%b2%e2%80%90nucleotidase-1a-autoantibodies-valuefleur-n-brinkman-isa-g-a-verlangen-fili\/\">A New Immunofluorescence Assay Allows the Sensitive Detection of Anti\u2010Cytosolic 5\u2032\u2010Nucleotidase 1A Autoantibodies. [[{&#8220;value&#8221;:&#8221;Fleur N. Brinkman, \nIsa G. A. Verlangen, \nFiline Swets, \nGer J. M. Pruijn&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Anti-cN1A autoantibodies are helpful for diagnosing inclusion body myositis (IBM). We have developed an immunofluorescence assay based on the perinuclear accumulation of GFP-cN1A. The analysis of patient sera indicated that this assay shows a higher sensitivity for anti-cN1A in IBM compared to alternative assays, without loss of specificity.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/systemic-type-i-interferon-blockade-mitigates-insulin-resistance-in-a-preclinical-model-of-psoriasis-valuebishnu-prasad-sinha-purbita-bandopadhyay-md-asmaul-hoque-chinky-shiu-chen-li\/\">Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis. [[{&#8220;value&#8221;:&#8221;Bishnu Prasad Sinha, \nPurbita Bandopadhyay, \nMd. Asmaul Hoque, \nChinky Shiu Chen Liu, \nSuravi Mukherjee, \nRanit D&#8217;Rozario, \nShreya Roy, \nRituparna Jana, \nShrestha Pattanayak, \nJafar Sarif, \nDipyaman Ganguly&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">A preclinical model of TLR7-agonist-induced psoriasis develops insulin resistance by 3 weeks. Development of this psoriasis-associated insulin resistance can be prevented by systemic blockade of type I interferon signaling. ABSTRACT Psoriasis is a cutaneous autoimmune disease with worldwide prevalence. In situ activation of skin-infiltrating plasmacytoid dendritic cells (pDCs) leading to local induction of type I &#8230; <a title=\"Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis. [[{&#8220;value&#8221;:&#8221;Bishnu Prasad Sinha, \nPurbita Bandopadhyay, \nMd. Asmaul Hoque, \nChinky Shiu Chen Liu, \nSuravi Mukherjee, \nRanit D&#8217;Rozario, \nShreya Roy, \nRituparna Jana, \nShrestha Pattanayak, \nJafar Sarif, \nDipyaman Ganguly&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/systemic-type-i-interferon-blockade-mitigates-insulin-resistance-in-a-preclinical-model-of-psoriasis-valuebishnu-prasad-sinha-purbita-bandopadhyay-md-asmaul-hoque-chinky-shiu-chen-li\/\" aria-label=\"Read more about Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis. [[{&#8220;value&#8221;:&#8221;Bishnu Prasad Sinha, \nPurbita Bandopadhyay, \nMd. Asmaul Hoque, \nChinky Shiu Chen Liu, \nSuravi Mukherjee, \nRanit D&#8217;Rozario, \nShreya Roy, \nRituparna Jana, \nShrestha Pattanayak, \nJafar Sarif, \nDipyaman Ganguly&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/irgm1-restrains-cd8-t-cell-cytokine-production-and-apoptosis-via-cell%e2%80%90extrinsic-regulation-of-type-i-interferon-signaling-valuecaitlyn-t-molloy-yazan-alwarawrah-jonathan-a-co\/\">Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell\u2010Extrinsic Regulation of Type I Interferon Signaling. [[{&#8220;value&#8221;:&#8221;Caitlyn T. Molloy, \nYazan Alwarawrah, \nJonathan A. Cohen, \nBrian E. Fee, \nJason K. Whitmire, \nGregory A. Taylor, \nNancie J. MacIver&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Irgm1 regulates inflammatory disease by modulating leukocyte responses including those of T cells. In CD4+ T cells, Irgm1 functions in a cell-intrinsic manner. However, in CD8+ T cells, Irgm1 restrains cytokine production and cell death in a cell-extrinsic manner by controlling type I interferon production from hematopoietic and other sources. ABSTRACT Immunity-related GTPases (IRGs) are &#8230; <a title=\"Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell\u2010Extrinsic Regulation of Type I Interferon Signaling. [[{&#8220;value&#8221;:&#8221;Caitlyn T. Molloy, \nYazan Alwarawrah, \nJonathan A. Cohen, \nBrian E. Fee, \nJason K. Whitmire, \nGregory A. Taylor, \nNancie J. MacIver&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/irgm1-restrains-cd8-t-cell-cytokine-production-and-apoptosis-via-cell%e2%80%90extrinsic-regulation-of-type-i-interferon-signaling-valuecaitlyn-t-molloy-yazan-alwarawrah-jonathan-a-co\/\" aria-label=\"Read more about Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell\u2010Extrinsic Regulation of Type I Interferon Signaling. [[{&#8220;value&#8221;:&#8221;Caitlyn T. Molloy, \nYazan Alwarawrah, \nJonathan A. Cohen, \nBrian E. Fee, \nJason K. Whitmire, \nGregory A. Taylor, \nNancie J. MacIver&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/post%e2%80%90acute-sequelae-patients-with-severe-covid%e2%80%9019-history-show-a-prolonged-inflammatory-vascular-injury-pattern-valuelouisa-ruhl-isabell-pink-evgeny-chichelnitskiy-no\/\">Post\u2010Acute Sequelae Patients with Severe COVID\u201019 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [[{&#8220;value&#8221;:&#8221;Louisa Ruhl, \nIsabell Pink, \nEvgeny Chichelnitskiy, \nNora Drick, \nAndrea Sauer, \nLennart Boblitz, \nKerstin Beushausen, \nJana Keil, \nAnna\u2010Lena Ullrich, \nJulius Schmidt, \nMarius M. Hoeper, \nTobias Welte, \nJenny F. K\u00fchne, \nChristine S. Falk&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-30T10:14:17+02:00\" class=\"wp-block-latest-posts__post-date\">30 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Long-COVID or post-acute sequelae of COVID-19 syndrome (PASC) patients with previous severe COVID-19 ICU history prior vaccination display sustained significant changes in their immune profile at both the cellular and the inflammatory level, revealing signatures of persistent inflammation and endothelial injury. ABSTRACT SARS-CoV-2 infection can lead to persistent symptoms (i.e., long\/post-COVID), especially in unvaccinated individuals. &#8230; <a title=\"Post\u2010Acute Sequelae Patients with Severe COVID\u201019 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [[{&#8220;value&#8221;:&#8221;Louisa Ruhl, \nIsabell Pink, \nEvgeny Chichelnitskiy, \nNora Drick, \nAndrea Sauer, \nLennart Boblitz, \nKerstin Beushausen, \nJana Keil, \nAnna\u2010Lena Ullrich, \nJulius Schmidt, \nMarius M. Hoeper, \nTobias Welte, \nJenny F. K\u00fchne, \nChristine S. Falk&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/30\/post%e2%80%90acute-sequelae-patients-with-severe-covid%e2%80%9019-history-show-a-prolonged-inflammatory-vascular-injury-pattern-valuelouisa-ruhl-isabell-pink-evgeny-chichelnitskiy-no\/\" aria-label=\"Read more about Post\u2010Acute Sequelae Patients with Severe COVID\u201019 History Show a Prolonged Inflammatory, Vascular Injury Pattern. [[{&#8220;value&#8221;:&#8221;Louisa Ruhl, \nIsabell Pink, \nEvgeny Chichelnitskiy, \nNora Drick, \nAndrea Sauer, \nLennart Boblitz, \nKerstin Beushausen, \nJana Keil, \nAnna\u2010Lena Ullrich, \nJulius Schmidt, \nMarius M. Hoeper, \nTobias Welte, \nJenny F. K\u00fchne, \nChristine S. Falk&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/prophylactic-inhaled-pattern-recognition-receptor-agonists-reprogram-lung-epithelial-response-and-prevent-type-2-allergic-inflammation-valuembaya-ntita-celine-shuet-lin-kong-dalia-hassa\/\">Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [[{&#8220;value&#8221;:&#8221;Mbaya Ntita, \nCeline Shuet Lin Kong, \nDalia Hassan, \nRicha Nayak, \nJezreel Pantale\u00f3n Garc\u00eda, \nYongxing Wang, \nJichao Chen, \nScott E. Evans&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Inhaled pretreatment of mouse lungs with immunomodulatory Pam2ODN results in lung epithelial cell epigenetic reprogramming that is associated with attenuation of house dust mite extract (HDM)-induced cDC2s and moDCs expansion in the lung, causing tolerance against HDM sensitization and restricting Th2-cell-induced airway eosinophilic allergic inflammation. ABSTRACT Prophylactic inhalation of the synergistic agents ODN M362 and &#8230; <a title=\"Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [[{&#8220;value&#8221;:&#8221;Mbaya Ntita, \nCeline Shuet Lin Kong, \nDalia Hassan, \nRicha Nayak, \nJezreel Pantale\u00f3n Garc\u00eda, \nYongxing Wang, \nJichao Chen, \nScott E. Evans&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/prophylactic-inhaled-pattern-recognition-receptor-agonists-reprogram-lung-epithelial-response-and-prevent-type-2-allergic-inflammation-valuembaya-ntita-celine-shuet-lin-kong-dalia-hassa\/\" aria-label=\"Read more about Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation. [[{&#8220;value&#8221;:&#8221;Mbaya Ntita, \nCeline Shuet Lin Kong, \nDalia Hassan, \nRicha Nayak, \nJezreel Pantale\u00f3n Garc\u00eda, \nYongxing Wang, \nJichao Chen, \nScott E. Evans&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/cover-story-eur-j-immunol-426\/\">Cover Story: Eur. J. Immunol. 4&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 4&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/cover-story-eur-j-immunol-426\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 4&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/issue-information-eur-j-immunol-426\/\">Issue Information: Eur. J. Immunol. 4&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 4, April 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/no-correlation-between-interferon-signaling-and-cytosolic-mitochondrial-dna-rna-leakage-in-cultured-skin-fibroblasts-of-patients-with-mitochondrial-diseases-valuemanon-marchais-alessandra\/\">No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA\/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. [[{&#8220;value&#8221;:&#8221;Manon Marchais, \nAlessandra Pennisi, \nAlexandre Pierga, \nAlice Lepelley, \nNicolas Cagnard, \nChristine Bole, \nPatrick Nitschke, \nMohamed Hamici, \nFr\u00e9d\u00e9ric Rieux\u2010Laucat, \nManuel Schiff, \nArnold Munnich, \nAgn\u00e8s R\u00f6tig&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-28T09:02:28+01:00\" class=\"wp-block-latest-posts__post-date\">28 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Investigation of IFN signaling in cultured skin fibroblasts from patients with genetically confirmed mitochondrial diseases of diverse origins revealed that altered IFN signaling is an inconsistent feature of these disorders. Cytosolic accumulation of mtDNA and mtRNA was variably detected and showed little correlation with ISG scores. ABSTRACT Mitochondria have long been known to be involved &#8230; <a title=\"No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA\/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. [[{&#8220;value&#8221;:&#8221;Manon Marchais, \nAlessandra Pennisi, \nAlexandre Pierga, \nAlice Lepelley, \nNicolas Cagnard, \nChristine Bole, \nPatrick Nitschke, \nMohamed Hamici, \nFr\u00e9d\u00e9ric Rieux\u2010Laucat, \nManuel Schiff, \nArnold Munnich, \nAgn\u00e8s R\u00f6tig&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/28\/no-correlation-between-interferon-signaling-and-cytosolic-mitochondrial-dna-rna-leakage-in-cultured-skin-fibroblasts-of-patients-with-mitochondrial-diseases-valuemanon-marchais-alessandra\/\" aria-label=\"Read more about No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA\/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. [[{&#8220;value&#8221;:&#8221;Manon Marchais, \nAlessandra Pennisi, \nAlexandre Pierga, \nAlice Lepelley, \nNicolas Cagnard, \nChristine Bole, \nPatrick Nitschke, \nMohamed Hamici, \nFr\u00e9d\u00e9ric Rieux\u2010Laucat, \nManuel Schiff, \nArnold Munnich, \nAgn\u00e8s R\u00f6tig&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/17\/going-virtual-as-a-memory%e2%80%90phenotype-t-lymphocyte-valuebin-yang-benjamin-g-dewals\/\">Going Virtual as a Memory\u2010Phenotype T Lymphocyte. [[{&#8220;value&#8221;:&#8221;Bin Yang, \nBenjamin G. Dewals&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-17T09:20:52+01:00\" class=\"wp-block-latest-posts__post-date\">17 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This review highlights how memory-phenotype CD8+ T lymphocytes (TMP) develop in immunologically naive hosts in the absence of non-self-antigens (Ag). We discuss the current understanding and controversies on the origin, maintenance and functions of the main populations recognized as TMP, in comparison to naive (TN) and Ag-specific true memory T cells (TTM). ABSTRACT Conventional or &#8230; <a title=\"Going Virtual as a Memory\u2010Phenotype T Lymphocyte. [[{&#8220;value&#8221;:&#8221;Bin Yang, \nBenjamin G. Dewals&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/17\/going-virtual-as-a-memory%e2%80%90phenotype-t-lymphocyte-valuebin-yang-benjamin-g-dewals\/\" aria-label=\"Read more about Going Virtual as a Memory\u2010Phenotype T Lymphocyte. [[{&#8220;value&#8221;:&#8221;Bin Yang, \nBenjamin G. Dewals&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/oleic-acid-promotes-treg-cell-differentiation-via-autophagy-induction-and-ameliorates-dss%e2%80%90induced-colitis-valueminghui-xia-yang-liu-xiujuan-zhao-qiuyang-du-zijie-chen-jing\/\">Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS\u2010Induced Colitis. [[{&#8220;value&#8221;:&#8221;Minghui Xia, \nYang Liu, \nXiujuan Zhao, \nQiuyang Du, \nZijie Chen, \nJing Wang, \nKamran Ghoreschi, \nArian Laurence, \nXinxin Xiong, \nJunyan Zhang, \nMing Zeng, \nXiang\u2010Ping Yang&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-14T08:49:54+01:00\" class=\"wp-block-latest-posts__post-date\">14 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Oleic acid enhances Treg cell differentiation by inducing autophagy via AMPK activation and mTORC1 inhibition. In DSS-induced colitis, oleic acid treatment expands colonic Tregs, reduces inflammatory cytokines, and ameliorates intestinal pathology. ABSTRACT Oleic acid (OA), a monounsaturated fatty acid (FA) prevalent in olive oil and key component of Mediterranean diet, exhibits anti-inflammatory effects in ulcerative &#8230; <a title=\"Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS\u2010Induced Colitis. [[{&#8220;value&#8221;:&#8221;Minghui Xia, \nYang Liu, \nXiujuan Zhao, \nQiuyang Du, \nZijie Chen, \nJing Wang, \nKamran Ghoreschi, \nArian Laurence, \nXinxin Xiong, \nJunyan Zhang, \nMing Zeng, \nXiang\u2010Ping Yang&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/oleic-acid-promotes-treg-cell-differentiation-via-autophagy-induction-and-ameliorates-dss%e2%80%90induced-colitis-valueminghui-xia-yang-liu-xiujuan-zhao-qiuyang-du-zijie-chen-jing\/\" aria-label=\"Read more about Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS\u2010Induced Colitis. [[{&#8220;value&#8221;:&#8221;Minghui Xia, \nYang Liu, \nXiujuan Zhao, \nQiuyang Du, \nZijie Chen, \nJing Wang, \nKamran Ghoreschi, \nArian Laurence, \nXinxin Xiong, \nJunyan Zhang, \nMing Zeng, \nXiang\u2010Ping Yang&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/human-systems-immunology-in-the-omics-era-challenges-methods-and-emerging-directions-valuelennart-riemann-reinhold-forster\/\">Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions. [[{&#8220;value&#8221;:&#8221;Lennart Riemann, \nReinhold F\u00f6rster&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-14T08:49:54+01:00\" class=\"wp-block-latest-posts__post-date\">14 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Systems immunology provides a transformative framework for decoding human immune complexity. This review evaluates high-throughput technologies and provides a roadmap for navigating analytical challenges\u2014such as batch effects and interindividual heterogeneity\u2014to successfully translate multimodal data into meaningful biological insights. ABSTRACT The human immune system is a highly complex, dynamic, and heterogeneous network shaped by genetic, environmental, &#8230; <a title=\"Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions. [[{&#8220;value&#8221;:&#8221;Lennart Riemann, \nReinhold F\u00f6rster&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/14\/human-systems-immunology-in-the-omics-era-challenges-methods-and-emerging-directions-valuelennart-riemann-reinhold-forster\/\" aria-label=\"Read more about Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions. [[{&#8220;value&#8221;:&#8221;Lennart Riemann, \nReinhold F\u00f6rster&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/single%e2%80%90cell-profiling-of-splenic-immune-ageing-and-chronic-stress-adaptations-in-mice-with-natural-microbiota-valuechinna-susan-philip-igor-filippov-uku-haljasorg-part-peterso\/\">Single\u2010Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota. [[{&#8220;value&#8221;:&#8221;Chinna Susan Philip, \nIgor Filippov, \nUku Haljasorg, \nP\u00e4rt Peterson&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mice with natural microbiota show expected ageing spleen trends: na\u00efve T cell loss with effector-memory expansion, mature B cell shifts, Gzmk + CD8+ T cell heterogeneity, diminished NK cytotoxicity and pro-inflammatory macrophages. Chronic stress modestly counteracted these age-related changes. Splenocyte transcriptomic atlas reveals reproducible compositional shifts and defines conserved cell-type-specific ageing signatures. ABSTRACT Immune ageing &#8230; <a title=\"Single\u2010Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota. [[{&#8220;value&#8221;:&#8221;Chinna Susan Philip, \nIgor Filippov, \nUku Haljasorg, \nP\u00e4rt Peterson&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/single%e2%80%90cell-profiling-of-splenic-immune-ageing-and-chronic-stress-adaptations-in-mice-with-natural-microbiota-valuechinna-susan-philip-igor-filippov-uku-haljasorg-part-peterso\/\" aria-label=\"Read more about Single\u2010Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota. [[{&#8220;value&#8221;:&#8221;Chinna Susan Philip, \nIgor Filippov, \nUku Haljasorg, \nP\u00e4rt Peterson&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/non%e2%80%90cognate-cd8-binding-to-mhc-i-promotes-positive-selection-of-an-mhc%e2%80%90e-restricted-cd8-t-cell-population-valuexiaokun-yang-melissa-a-colden-rachel-coombs-kathya-aran\/\">Non\u2010cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC\u2010E Restricted CD8 T Cell Population. [[{&#8220;value&#8221;:&#8221;Xiaokun Yang, \nMelissa A. Colden, \nRachel Coombs, \nKathya Arana, \nDan Tran, \nMichael Manoharan Valerio, \nEllen A. Robey, \nLaurent Coscoy&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mouse Qa1b-restricted T cells show promiscuous requirements for positive selection. Using in vivo tetramer enrichment, in vitro APC engineering, and in vitro thymocyte stimulation, we demonstrate that a Qa1b-restricted T cell population can be selected by both Qa1b and H2-T11, and depends on non-cognate CD8-MHC I binding. ABSTRACT MHC-E-restricted CD8 T cells are emerging as &#8230; <a title=\"Non\u2010cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC\u2010E Restricted CD8 T Cell Population. [[{&#8220;value&#8221;:&#8221;Xiaokun Yang, \nMelissa A. Colden, \nRachel Coombs, \nKathya Arana, \nDan Tran, \nMichael Manoharan Valerio, \nEllen A. Robey, \nLaurent Coscoy&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/non%e2%80%90cognate-cd8-binding-to-mhc-i-promotes-positive-selection-of-an-mhc%e2%80%90e-restricted-cd8-t-cell-population-valuexiaokun-yang-melissa-a-colden-rachel-coombs-kathya-aran\/\" aria-label=\"Read more about Non\u2010cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC\u2010E Restricted CD8 T Cell Population. [[{&#8220;value&#8221;:&#8221;Xiaokun Yang, \nMelissa A. Colden, \nRachel Coombs, \nKathya Arana, \nDan Tran, \nMichael Manoharan Valerio, \nEllen A. Robey, \nLaurent Coscoy&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/heterogeneous-activated-b-cell-compartments-arising-early-and-transiently-after-sars%e2%80%90cov%e2%80%902-vaccination-valuelaura-fernandez-blanco-lisan-h-kuijper-laura-y-l-kummer-n\/\">Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS\u2010CoV\u20102 Vaccination. [[{&#8220;value&#8221;:&#8221;Laura Fernandez Blanco, \nLisan H. Kuijper, \nLaura Y.L. Kummer, \nNiels J.M. Verstegen, \nAm\u00e9lie Bos, \nMathieu Claireaux, \nMari\u00ebl C. Duurland, \nTineke Jorritsma, \nMaurice Steenhuis, \nGius Kerster, \nJuan J. Garcia Vallejo, \nMarit J. van Gils, \nKoos P.J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nLaura Boekel, \nGertjan J. Wolbink, \nSander W. Tas, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nAnja ten Brinke, \nS. Marieke van Ham, \nof T2B! Immunity Against SARS\u2010CoV\u20102 Study Group&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Characterization of the early antigen-specific B cell response post-SARS-CoV-2 vaccination reveals novel activated B cell clusters, showing different phenotypes and contraction dynamics. Some short-lived activated B cells expressed both CD71 and the extrafollicular marker CD11c. These results advance our understanding of B-cell differentiation regulation and biomarker potential. ABSTRACT In humans, the stages and dynamics of &#8230; <a title=\"Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS\u2010CoV\u20102 Vaccination. [[{&#8220;value&#8221;:&#8221;Laura Fernandez Blanco, \nLisan H. Kuijper, \nLaura Y.L. Kummer, \nNiels J.M. Verstegen, \nAm\u00e9lie Bos, \nMathieu Claireaux, \nMari\u00ebl C. Duurland, \nTineke Jorritsma, \nMaurice Steenhuis, \nGius Kerster, \nJuan J. Garcia Vallejo, \nMarit J. van Gils, \nKoos P.J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nLaura Boekel, \nGertjan J. Wolbink, \nSander W. Tas, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nAnja ten Brinke, \nS. Marieke van Ham, \nof T2B! Immunity Against SARS\u2010CoV\u20102 Study Group&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/heterogeneous-activated-b-cell-compartments-arising-early-and-transiently-after-sars%e2%80%90cov%e2%80%902-vaccination-valuelaura-fernandez-blanco-lisan-h-kuijper-laura-y-l-kummer-n\/\" aria-label=\"Read more about Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS\u2010CoV\u20102 Vaccination. [[{&#8220;value&#8221;:&#8221;Laura Fernandez Blanco, \nLisan H. Kuijper, \nLaura Y.L. Kummer, \nNiels J.M. Verstegen, \nAm\u00e9lie Bos, \nMathieu Claireaux, \nMari\u00ebl C. Duurland, \nTineke Jorritsma, \nMaurice Steenhuis, \nGius Kerster, \nJuan J. Garcia Vallejo, \nMarit J. van Gils, \nKoos P.J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nLaura Boekel, \nGertjan J. Wolbink, \nSander W. Tas, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nAnja ten Brinke, \nS. Marieke van Ham, \nof T2B! Immunity Against SARS\u2010CoV\u20102 Study Group&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/transcriptome-proteome-analysis-of-human-naive-and-memory-b-cell-subsets-reveals-isotype-and-subclass%e2%80%90specific-phenotypes-valuejana-koers-arie-j-hoogendijk-simon-tol\/\">Transcriptome\u2013Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass\u2010Specific Phenotypes. [[{&#8220;value&#8221;:&#8221;Jana Koers, \nArie J. Hoogendijk, \nSimon Tol, \nFloris P.J. Van Alphen, \nNinotska I.L. Derksen, \nMaartje van den Biggelaar, \nTheo Rispens&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We performed combined proteome and transcriptome analysis of human isotype-defined B cell subsets. IgG4-switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. SDR16C5 was identified as uniquely upregulated in IgG4-switched B cells. ABSTRACT Antibodies produced by B cells aid in the recognition and clearance &#8230; <a title=\"Transcriptome\u2013Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass\u2010Specific Phenotypes. [[{&#8220;value&#8221;:&#8221;Jana Koers, \nArie J. Hoogendijk, \nSimon Tol, \nFloris P.J. Van Alphen, \nNinotska I.L. Derksen, \nMaartje van den Biggelaar, \nTheo Rispens&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/transcriptome-proteome-analysis-of-human-naive-and-memory-b-cell-subsets-reveals-isotype-and-subclass%e2%80%90specific-phenotypes-valuejana-koers-arie-j-hoogendijk-simon-tol\/\" aria-label=\"Read more about Transcriptome\u2013Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass\u2010Specific Phenotypes. [[{&#8220;value&#8221;:&#8221;Jana Koers, \nArie J. Hoogendijk, \nSimon Tol, \nFloris P.J. Van Alphen, \nNinotska I.L. Derksen, \nMaartje van den Biggelaar, \nTheo Rispens&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/viral-immunity-in-immunoglobulin-products-global-immunity-debt-and-autoimmunity-in-the-postpandemic-era-valuehannes-lindahl-katy-shaw%e2%80%90saliba-h-benjamin-larman-c-i-edvard-s\/\">Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era. [[{&#8220;value&#8221;:&#8221;Hannes Lindahl, \nKaty Shaw\u2010Saliba, \nH. Benjamin Larman, \nC. I. Edvard Smith, \nPeter Bergman&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Immunoglobulin products derived from pooled global plasma reflect population-level antiviral immunity. Analysis of batches from 2017 to 2023 reveals pandemic-driven shifts in viral antibody profiles and a concurrent rise in autoantibodies, notably against TRIM21\/Ro52, highlighting links between SARS-CoV-2, immunity debt, and autoimmunity. ABSTRACT Immunoglobulin (Ig) replacement therapy is commonly used to prevent infections in individuals &#8230; <a title=\"Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era. [[{&#8220;value&#8221;:&#8221;Hannes Lindahl, \nKaty Shaw\u2010Saliba, \nH. Benjamin Larman, \nC. I. Edvard Smith, \nPeter Bergman&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/viral-immunity-in-immunoglobulin-products-global-immunity-debt-and-autoimmunity-in-the-postpandemic-era-valuehannes-lindahl-katy-shaw%e2%80%90saliba-h-benjamin-larman-c-i-edvard-s\/\" aria-label=\"Read more about Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era. [[{&#8220;value&#8221;:&#8221;Hannes Lindahl, \nKaty Shaw\u2010Saliba, \nH. Benjamin Larman, \nC. I. Edvard Smith, \nPeter Bergman&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/changes-in-adaptive-immunity-in-autoimmune-diseases-and-aging-shared-features-key-differences-and-implications-for-immune-vulnerability-valuebojan-jevtic-milica-lazarevic-dorde-miljk\/\">Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for Immune Vulnerability. [[{&#8220;value&#8221;:&#8221;Bojan Jevti\u0107, \nMilica Lazarevi\u0107, \n\u0110or\u0111e Miljkovi\u0107, \nJanko \u017d. Nikolich&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-13T09:32:55+01:00\" class=\"wp-block-latest-posts__post-date\">13 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Changes in adaptive immunity in autoimmune diseases and aging exhibit both shared and distinct alterations in immune cell compartments. Immune vulnerability is influenced by these alterations, which affect infection susceptibility and vaccination response in these clinically different but immunologically related conditions. ABSTRACT Immunologically vulnerable populations (IVP) are particularly at risk of infection due to dysregulated &#8230; <a title=\"Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for Immune Vulnerability. [[{&#8220;value&#8221;:&#8221;Bojan Jevti\u0107, \nMilica Lazarevi\u0107, \n\u0110or\u0111e Miljkovi\u0107, \nJanko \u017d. Nikolich&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/13\/changes-in-adaptive-immunity-in-autoimmune-diseases-and-aging-shared-features-key-differences-and-implications-for-immune-vulnerability-valuebojan-jevtic-milica-lazarevic-dorde-miljk\/\" aria-label=\"Read more about Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for Immune Vulnerability. [[{&#8220;value&#8221;:&#8221;Bojan Jevti\u0107, \nMilica Lazarevi\u0107, \n\u0110or\u0111e Miljkovi\u0107, \nJanko \u017d. Nikolich&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/02\/38%e2%80%90marker-full%e2%80%90spectrum-flow-cytometry-panel-for-the-comprehensive-profiling-of-%ce%b3%ce%b4-t-cells-in-human-blood-and-lymphoid-tissues-valuemohamed-hamed-daniela-moreno\/\">38\u2010Marker Full\u2010Spectrum Flow Cytometry Panel for the Comprehensive Profiling of \u03b3\u03b4 T Cells in Human Blood and Lymphoid Tissues. [[{&#8220;value&#8221;:&#8221;Mohamed Hamed, \nDaniela Moreno\u2010Vicencio, \nDaniel Arsovski, \nMustafa Farhat, \nRosie Sanders, \nEllen Mann, \nAnnabelle Bennett, \nPriyanka Chevour, \nMartin S. Davey&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-02T10:26:00+01:00\" class=\"wp-block-latest-posts__post-date\">2 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This is an update to the\u00a0Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et\u00a0al. A 38-marker full-spectrum flow cytometry panel enabling high-resolution profiling of human \u03b3\u03b4 T cells across blood and lymphoid tissues, including robust identification of rare, tissue-adapted subsets.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/il%e2%80%9033-elicits-ltc4-synthesis-in-allergic-inflammation-via-st2%e2%80%90mediated-activation-of-eosinophils-valuevitoria-f-rosario%e2%80%90garcia-ericka-guimaraes%e2%80%90ferreira\/\">IL\u201033 Elicits LTC4 Synthesis in Allergic Inflammation via ST2\u2010Mediated Activation of Eosinophils. [[{&#8220;value&#8221;:&#8221;Vit\u00f3ria F. Ros\u00e1rio\u2010Garcia, \nEricka Guimaraes\u2010Ferreira, \nYasmin Brito\u2010Leite, \nJamille F. Oliveira, \nJulia Santos\u2010da\u2010Silva, \nNat\u00e1lia R. T. Amorim, \nValdirene S. Muniz, \nLukas Bolini, \nMiriam B. F. Werneck, \nClaudio Canetti, \nBruno L. Diaz, \nChristianne Bandeira\u2010Melo&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-01T10:06:16+01:00\" class=\"wp-block-latest-posts__post-date\">1 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Allergic reaction-derived IL-33 activates ST2 to trigger selective eosinophil activation. IL-33 in a type 2 immune response environment induces biogenesis of lipid bodies in eosinophils, platforms for the generation of lipid mediators, and selectively triggers LTC4 production. ABSTRACT Like pieces of a puzzle, IL-33, eosinophils, and cysteinyl leukotrienes seem to come together and orchestrate allergic &#8230; <a title=\"IL\u201033 Elicits LTC4 Synthesis in Allergic Inflammation via ST2\u2010Mediated Activation of Eosinophils. [[{&#8220;value&#8221;:&#8221;Vit\u00f3ria F. Ros\u00e1rio\u2010Garcia, \nEricka Guimaraes\u2010Ferreira, \nYasmin Brito\u2010Leite, \nJamille F. Oliveira, \nJulia Santos\u2010da\u2010Silva, \nNat\u00e1lia R. T. Amorim, \nValdirene S. Muniz, \nLukas Bolini, \nMiriam B. F. Werneck, \nClaudio Canetti, \nBruno L. Diaz, \nChristianne Bandeira\u2010Melo&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/il%e2%80%9033-elicits-ltc4-synthesis-in-allergic-inflammation-via-st2%e2%80%90mediated-activation-of-eosinophils-valuevitoria-f-rosario%e2%80%90garcia-ericka-guimaraes%e2%80%90ferreira\/\" aria-label=\"Read more about IL\u201033 Elicits LTC4 Synthesis in Allergic Inflammation via ST2\u2010Mediated Activation of Eosinophils. [[{&#8220;value&#8221;:&#8221;Vit\u00f3ria F. Ros\u00e1rio\u2010Garcia, \nEricka Guimaraes\u2010Ferreira, \nYasmin Brito\u2010Leite, \nJamille F. Oliveira, \nJulia Santos\u2010da\u2010Silva, \nNat\u00e1lia R. T. Amorim, \nValdirene S. Muniz, \nLukas Bolini, \nMiriam B. F. Werneck, \nClaudio Canetti, \nBruno L. Diaz, \nChristianne Bandeira\u2010Melo&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/cover-story-eur-j-immunol-326\/\">Cover Story: Eur. J. Immunol. 3&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-01T10:06:16+01:00\" class=\"wp-block-latest-posts__post-date\">1 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 3&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/cover-story-eur-j-immunol-326\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 3&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/01\/issue-information-eur-j-immunol-326\/\">Issue Information: Eur. J. Immunol. 3&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-03-01T10:06:16+01:00\" class=\"wp-block-latest-posts__post-date\">1 de March de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 3, March 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/26\/curbing-autoimmunity-a-new-fab-fragment-targeting-cd40%e2%80%90cd40l-halts-b%e2%80%90cell-activation-and-differentiation-valuekathrine-pedersen-kenneth-green-emil-l-kristoffersen-th\/\">Curbing Autoimmunity: A New Fab Fragment Targeting CD40\u2010CD40L Halts B\u2010Cell Activation and Differentiation. [[{&#8220;value&#8221;:&#8221;Kathrine Pedersen, \nKenneth Green, \nEmil L. Kristoffersen, \nThea Schinkel, \nAnnette G. Hansen, \nYaseelan Palarasah, \nAnne B. Rovsing, \nEbbe S. Andersen, \nJuli\u00e1n Valero, \nLaia Civit, \nNick S. Laursen, \nAnne Troldborg, \nS\u00f8ren E. Degn, \nSteffen Thiel&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-26T09:59:27+01:00\" class=\"wp-block-latest-posts__post-date\">26 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The CD40-CD40L pathway is often dysregulated in B-cell-driven autoimmune diseases, making the development of CD40L inhibitors a promising therapeutic approach in managing autoimmune responses. We developed an inhibitory anti-CD40L Fab fragment, Fab20, and demonstrated that Fab20 effectively suppresses B-cell proliferation, differentiation, and antibody production in vitro. Made with Biorender. ABSTRACT Dysregulation of the CD40-CD40L axis &#8230; <a title=\"Curbing Autoimmunity: A New Fab Fragment Targeting CD40\u2010CD40L Halts B\u2010Cell Activation and Differentiation. [[{&#8220;value&#8221;:&#8221;Kathrine Pedersen, \nKenneth Green, \nEmil L. Kristoffersen, \nThea Schinkel, \nAnnette G. Hansen, \nYaseelan Palarasah, \nAnne B. Rovsing, \nEbbe S. Andersen, \nJuli\u00e1n Valero, \nLaia Civit, \nNick S. Laursen, \nAnne Troldborg, \nS\u00f8ren E. Degn, \nSteffen Thiel&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/26\/curbing-autoimmunity-a-new-fab-fragment-targeting-cd40%e2%80%90cd40l-halts-b%e2%80%90cell-activation-and-differentiation-valuekathrine-pedersen-kenneth-green-emil-l-kristoffersen-th\/\" aria-label=\"Read more about Curbing Autoimmunity: A New Fab Fragment Targeting CD40\u2010CD40L Halts B\u2010Cell Activation and Differentiation. [[{&#8220;value&#8221;:&#8221;Kathrine Pedersen, \nKenneth Green, \nEmil L. Kristoffersen, \nThea Schinkel, \nAnnette G. Hansen, \nYaseelan Palarasah, \nAnne B. Rovsing, \nEbbe S. Andersen, \nJuli\u00e1n Valero, \nLaia Civit, \nNick S. Laursen, \nAnne Troldborg, \nS\u00f8ren E. Degn, \nSteffen Thiel&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/25\/spatial-profiling-of-germinal-centers-in-mouse-secondary-lymphoid-organs-using-macsima-imaging-cyclic-staining-technology-valueisabel-san-martin-molina-hanneke-okkenhaug-simon-walker\/\">Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology. [[{&#8220;value&#8221;:&#8221;Isabel San Mart\u00edn Molina, \nHanneke Okkenhaug, \nSimon Walker, \nMichelle Linterman, \nEdith Marcial\u2010Ju\u00e1rez&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-25T09:35:29+01:00\" class=\"wp-block-latest-posts__post-date\">25 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, automated cyclic imaging, image preprocessing, and a new analysis method that detects morphological changes in irregularly shaped stromal cells.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/25\/type-1-and-cd103-type-2-conventional-dendritic-cells-are-decreased-in-active-patients-with-ulcerative-colitis-but-not-with-crohns-disease-valueelisa-arribas%e2%80%90rodriguez-carolina\/\">Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn&#8217;s Disease. [[{&#8220;value&#8221;:&#8221;Elisa Arribas\u2010Rodr\u00edguez, \nCarolina G. de Castro, \nAida Fiz\u2010L\u00f3pez, \n\u00c1ngel De Prado, \n\u00c1lvaro Mart\u00edn\u2010Mu\u00f1oz, \nLuis Fern\u00e1ndez Salazar, \nJes\u00fas Barrio, \nSandra Izquierdo, \nJavier Garc\u00eda Alonso, \nBeatriz de Andr\u00e9s, \nJos\u00e9 Mar\u00eda Garc\u00eda\u2010Abril, \nAlejandro Romero, \nJavier S\u00e1nchez Gonz\u00e1lez, \nCecilio Santander, \nEduardo Arranz, \nMar\u00eda Chaparro, \nJos\u00e9 A. Garrote, \nJavier P. Gisbert, \nDavid Bernardo&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-25T09:35:29+01:00\" class=\"wp-block-latest-posts__post-date\">25 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Human lamina propia mononuclear cells (LPMC) were isolated from intestinal biopsies and resections, as well as peripheral blood mononuclear cells (PBMC) from blood. Using flow cytometry approaches, we characterized cDC subsets and assessed their functional capacity through T-cell coculture assays (after isolation of the different subsets of cDC using sorter cytometry). This approach enabled a &#8230; <a title=\"Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn&#8217;s Disease. [[{&#8220;value&#8221;:&#8221;Elisa Arribas\u2010Rodr\u00edguez, \nCarolina G. de Castro, \nAida Fiz\u2010L\u00f3pez, \n\u00c1ngel De Prado, \n\u00c1lvaro Mart\u00edn\u2010Mu\u00f1oz, \nLuis Fern\u00e1ndez Salazar, \nJes\u00fas Barrio, \nSandra Izquierdo, \nJavier Garc\u00eda Alonso, \nBeatriz de Andr\u00e9s, \nJos\u00e9 Mar\u00eda Garc\u00eda\u2010Abril, \nAlejandro Romero, \nJavier S\u00e1nchez Gonz\u00e1lez, \nCecilio Santander, \nEduardo Arranz, \nMar\u00eda Chaparro, \nJos\u00e9 A. Garrote, \nJavier P. Gisbert, \nDavid Bernardo&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/25\/type-1-and-cd103-type-2-conventional-dendritic-cells-are-decreased-in-active-patients-with-ulcerative-colitis-but-not-with-crohns-disease-valueelisa-arribas%e2%80%90rodriguez-carolina\/\" aria-label=\"Read more about Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn&#8217;s Disease. [[{&#8220;value&#8221;:&#8221;Elisa Arribas\u2010Rodr\u00edguez, \nCarolina G. de Castro, \nAida Fiz\u2010L\u00f3pez, \n\u00c1ngel De Prado, \n\u00c1lvaro Mart\u00edn\u2010Mu\u00f1oz, \nLuis Fern\u00e1ndez Salazar, \nJes\u00fas Barrio, \nSandra Izquierdo, \nJavier Garc\u00eda Alonso, \nBeatriz de Andr\u00e9s, \nJos\u00e9 Mar\u00eda Garc\u00eda\u2010Abril, \nAlejandro Romero, \nJavier S\u00e1nchez Gonz\u00e1lez, \nCecilio Santander, \nEduardo Arranz, \nMar\u00eda Chaparro, \nJos\u00e9 A. Garrote, \nJavier P. Gisbert, \nDavid Bernardo&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/24\/cd4-t%e2%80%90cell%e2%80%90intrinsic-il%e2%80%906-is-critical-for-th17-differentiation-and-dampened-responsiveness-to-cd8-t-cell%e2%80%90mediated-suppression-valuechakrapani-vemulawada\/\">CD4+ T\u2010Cell\u2010Intrinsic IL\u20106 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell\u2010Mediated Suppression. [[{&#8220;value&#8221;:&#8221;Chakrapani Vemulawada, \nKshitija Kale, \nMichael P. Crawford, \nNitin J. Karandikar&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-24T10:15:54+01:00\" class=\"wp-block-latest-posts__post-date\">24 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">1. Normal state: T-cell-endogenous IL-6 stabilizes IL6R and promotes STAT3 activation, functional Th17 differentiation with resistance to immune suppression. 2. Il6-KO: Loss of T-cell endogenous IL-6 destabilizes IL6R expression, leading to suboptimal Th17 and greater susceptibility to suppression, despite availability of exogenous IL-6. 3. IL-21 bypasses the requirement for endogenous IL-6 by restoring STAT3 signaling &#8230; <a title=\"CD4+ T\u2010Cell\u2010Intrinsic IL\u20106 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell\u2010Mediated Suppression. [[{&#8220;value&#8221;:&#8221;Chakrapani Vemulawada, \nKshitija Kale, \nMichael P. Crawford, \nNitin J. Karandikar&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/24\/cd4-t%e2%80%90cell%e2%80%90intrinsic-il%e2%80%906-is-critical-for-th17-differentiation-and-dampened-responsiveness-to-cd8-t-cell%e2%80%90mediated-suppression-valuechakrapani-vemulawada\/\" aria-label=\"Read more about CD4+ T\u2010Cell\u2010Intrinsic IL\u20106 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell\u2010Mediated Suppression. [[{&#8220;value&#8221;:&#8221;Chakrapani Vemulawada, \nKshitija Kale, \nMichael P. Crawford, \nNitin J. Karandikar&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/latent-lytic-and-linked-to-multiple-sclerosis-how-ebv-drives-autoimmunity-valuefabienne-laderach-elena-bremer-christian-munz\/\">Latent, Lytic, and Linked to Multiple Sclerosis\u2014How EBV Drives Autoimmunity. [[{&#8220;value&#8221;:&#8221;Fabienne L\u00e4derach, \nElena Bremer, \nChristian M\u00fcnz&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-23T09:57:17+01:00\" class=\"wp-block-latest-posts__post-date\">23 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B-cell repertoire and promotes the oligoclonal expansion and subsequent CNS infiltration of T-bet+CXCR3+ B cells, resulting in a cascade of immune dysregulation, CNS inflammation, and autoreactive T cell stimulation. Created in BioRender. &#8230; <a title=\"Latent, Lytic, and Linked to Multiple Sclerosis\u2014How EBV Drives Autoimmunity. [[{&#8220;value&#8221;:&#8221;Fabienne L\u00e4derach, \nElena Bremer, \nChristian M\u00fcnz&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/latent-lytic-and-linked-to-multiple-sclerosis-how-ebv-drives-autoimmunity-valuefabienne-laderach-elena-bremer-christian-munz\/\" aria-label=\"Read more about Latent, Lytic, and Linked to Multiple Sclerosis\u2014How EBV Drives Autoimmunity. [[{&#8220;value&#8221;:&#8221;Fabienne L\u00e4derach, \nElena Bremer, \nChristian M\u00fcnz&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/discovery-of-lomitapide-as-a-novel-mast-cell-regulatory-agent-through-chemical-library-screening-valueshiori-mamorita-atsushi-furukawa-yuka-nagata-ryo-suzuki\/\">Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [[{&#8220;value&#8221;:&#8221;Shiori Mamorita, \nAtsushi Furukawa, \nYuka Nagata, \nRyo Suzuki&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-23T09:57:17+01:00\" class=\"wp-block-latest-posts__post-date\">23 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Chemical library screening identified lomitapide as a novel mast cell (MC) regulatory agent. Lomitapide selectively inhibits IgE\/Ag- or phorbol 12-myristate 13-acetate (PMA)\/ionomycin-mediated MC degranulation by altering plasma membrane dynamics, including endocytosis and membrane fusion. ABSTRACT Allergic diseases are a global health concern, and new molecular insights and therapeutic agents are necessary to support future research &#8230; <a title=\"Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [[{&#8220;value&#8221;:&#8221;Shiori Mamorita, \nAtsushi Furukawa, \nYuka Nagata, \nRyo Suzuki&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/23\/discovery-of-lomitapide-as-a-novel-mast-cell-regulatory-agent-through-chemical-library-screening-valueshiori-mamorita-atsushi-furukawa-yuka-nagata-ryo-suzuki\/\" aria-label=\"Read more about Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. [[{&#8220;value&#8221;:&#8221;Shiori Mamorita, \nAtsushi Furukawa, \nYuka Nagata, \nRyo Suzuki&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/19\/il%e2%80%9021-selectively-augments-cytotoxic-potential-of-antigen%e2%80%90activated-mait-cells-valuelaura-e-wedlock-rajesh-lamichhane-meg-c-webley-selena-c-l-gilmer-andrea-j-ve\/\">IL\u201021 Selectively Augments Cytotoxic Potential of Antigen\u2010Activated MAIT Cells. [[{&#8220;value&#8221;:&#8221;Laura E. Wedlock, \nRajesh Lamichhane, \nMeg C. Webley, \nSelena C. L. Gilmer, \nAndrea J. Vernall, \nJames E. Ussher&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-19T10:22:31+01:00\" class=\"wp-block-latest-posts__post-date\">19 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Using an in vitro PBMC assay, we found that the addition of exogenous IL-21 enhances the cytotoxic potential of MAIT cells activated by 5-OP-RU. IL-21 induces STAT phosphorylation and provides co-stimulation to TCR-activated MAIT cells, selectively augmenting granzyme B and perforin expression without enhancing interferon-gamma or TNF production at 6\u00a0h. ABSTRACT Mucosal-associated invariant T (MAIT) &#8230; <a title=\"IL\u201021 Selectively Augments Cytotoxic Potential of Antigen\u2010Activated MAIT Cells. [[{&#8220;value&#8221;:&#8221;Laura E. Wedlock, \nRajesh Lamichhane, \nMeg C. Webley, \nSelena C. L. Gilmer, \nAndrea J. Vernall, \nJames E. Ussher&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/19\/il%e2%80%9021-selectively-augments-cytotoxic-potential-of-antigen%e2%80%90activated-mait-cells-valuelaura-e-wedlock-rajesh-lamichhane-meg-c-webley-selena-c-l-gilmer-andrea-j-ve\/\" aria-label=\"Read more about IL\u201021 Selectively Augments Cytotoxic Potential of Antigen\u2010Activated MAIT Cells. [[{&#8220;value&#8221;:&#8221;Laura E. Wedlock, \nRajesh Lamichhane, \nMeg C. Webley, \nSelena C. L. Gilmer, \nAndrea J. Vernall, \nJames E. Ussher&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/16\/charting-bird-tregs-valuelingling-wu-jingxia-wu-guoliang-cui\/\">Charting Bird Tregs. [[{&#8220;value&#8221;:&#8221;Lingling Wu, \nJingxia Wu, \nGuoliang Cui&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-16T10:14:01+01:00\" class=\"wp-block-latest-posts__post-date\">16 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">FoxP3, a lineage-defining transcription factor, defines mammalian Tregs together with antibodies against CD25, GITR, and CTLA-4. No valid chicken anti-FoxP3 or surface CTLA-4 antibodies are available to date. Given current experimental tools, the study proposes CD4+CD25+GITR+ as a practical panel for phenotypic characterization and sorting of viable chicken Tregs. ABSTRACT Regulatory T cells (Tregs) are &#8230; <a title=\"Charting Bird Tregs. [[{&#8220;value&#8221;:&#8221;Lingling Wu, \nJingxia Wu, \nGuoliang Cui&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/16\/charting-bird-tregs-valuelingling-wu-jingxia-wu-guoliang-cui\/\" aria-label=\"Read more about Charting Bird Tregs. [[{&#8220;value&#8221;:&#8221;Lingling Wu, \nJingxia Wu, \nGuoliang Cui&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/distinguishing-features-of-ilc2s-during-type-2-immune-responses-valuemanuel-o-jakob-patrycja-m-forster-christoph-s-n-klose\/\">Distinguishing Features of ILC2s During Type 2 Immune Responses. [[{&#8220;value&#8221;:&#8221;Manuel O. Jakob, \nPatrycja M. Forster, \nChristoph S. N. Klose&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-13T09:59:13+01:00\" class=\"wp-block-latest-posts__post-date\">13 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells regulated by diverse signals often emanating from surrounding nonhematopoietic cells at barrier surfaces. Their effector cytokines determine tissue homeostasis at steady state and during type 2 immunity in allergies or worm infections. Redundant and unique functions of ILC2s and T cells are assessed in this context. &#8230; <a title=\"Distinguishing Features of ILC2s During Type 2 Immune Responses. [[{&#8220;value&#8221;:&#8221;Manuel O. Jakob, \nPatrycja M. Forster, \nChristoph S. N. Klose&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/distinguishing-features-of-ilc2s-during-type-2-immune-responses-valuemanuel-o-jakob-patrycja-m-forster-christoph-s-n-klose\/\" aria-label=\"Read more about Distinguishing Features of ILC2s During Type 2 Immune Responses. [[{&#8220;value&#8221;:&#8221;Manuel O. Jakob, \nPatrycja M. Forster, \nChristoph S. N. Klose&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/multi%e2%80%90omics-analysis-reveals-sex%e2%80%90specific-signatures-for-bcg-vaccine-efficacy-valueqiuyao-zhan-liang-zhou-jianbo-fu-xun-jiang-xuan-liu-wenchao-li-simone-j-c-f-m\/\">Multi\u2010Omics Analysis Reveals Sex\u2010Specific Signatures for BCG Vaccine Efficacy. [[{&#8220;value&#8221;:&#8221;Qiuyao Zhan, \nLiang Zhou, \nJianbo Fu, \nXun Jiang, \nXuan Liu, \nWenchao Li, \nSimone J.C.F.M. Moorlag, \nValerie A.C.M. Koeken, \nL. Charlotte J. de Bree, \nVera P. Mourits, \nLeo A.B. Joosten, \nYang Li, \nMihai G. Netea, \nCheng\u2010Jian Xu&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-13T09:59:13+01:00\" class=\"wp-block-latest-posts__post-date\">13 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Sex-specific pre-vaccination immune landscapes associated with effective BCG vaccine responses. Male high responders exhibit a monocyte-enriched, pro-inflammatory innate immune profile, whereas female high responders display immune signatures associated with enhanced adaptive immune responses. ABSTRACT Vaccines are a cornerstone of global public health, but their efficacy can vary significantly among individuals. Bacille Calmette-Gu\u00e9rin (BCG) vaccine against &#8230; <a title=\"Multi\u2010Omics Analysis Reveals Sex\u2010Specific Signatures for BCG Vaccine Efficacy. [[{&#8220;value&#8221;:&#8221;Qiuyao Zhan, \nLiang Zhou, \nJianbo Fu, \nXun Jiang, \nXuan Liu, \nWenchao Li, \nSimone J.C.F.M. Moorlag, \nValerie A.C.M. Koeken, \nL. Charlotte J. de Bree, \nVera P. Mourits, \nLeo A.B. Joosten, \nYang Li, \nMihai G. Netea, \nCheng\u2010Jian Xu&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/13\/multi%e2%80%90omics-analysis-reveals-sex%e2%80%90specific-signatures-for-bcg-vaccine-efficacy-valueqiuyao-zhan-liang-zhou-jianbo-fu-xun-jiang-xuan-liu-wenchao-li-simone-j-c-f-m\/\" aria-label=\"Read more about Multi\u2010Omics Analysis Reveals Sex\u2010Specific Signatures for BCG Vaccine Efficacy. [[{&#8220;value&#8221;:&#8221;Qiuyao Zhan, \nLiang Zhou, \nJianbo Fu, \nXun Jiang, \nXuan Liu, \nWenchao Li, \nSimone J.C.F.M. Moorlag, \nValerie A.C.M. Koeken, \nL. Charlotte J. de Bree, \nVera P. Mourits, \nLeo A.B. Joosten, \nYang Li, \nMihai G. Netea, \nCheng\u2010Jian Xu&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/10\/meningococcal-serogroup-y-meningitis-reveals-inborn-factor-b-deficiency-valuecamille-bougeard-eleonore-eskander-paula-vieira-martins-joan-bitan-julia-roquigny-christele-kyheng-t\/\">Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency. [[{&#8220;value&#8221;:&#8221;Camille Bougeard, \nEl\u00e9onore Eskander, \nPaula Vieira Martins, \nJoan Bitan, \nJulia Roquigny, \nChrist\u00e8le Kyheng, \nTamazoust Guiddir, \nV\u00e9ronique Fr\u00e9meaux\u2010Bacchi, \nC\u00e9cile Gonnin, \nCarine ElSissy&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-10T10:28:22+01:00\" class=\"wp-block-latest-posts__post-date\">10 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and to the clinical use of Factor B &#8230; <a title=\"Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency. [[{&#8220;value&#8221;:&#8221;Camille Bougeard, \nEl\u00e9onore Eskander, \nPaula Vieira Martins, \nJoan Bitan, \nJulia Roquigny, \nChrist\u00e8le Kyheng, \nTamazoust Guiddir, \nV\u00e9ronique Fr\u00e9meaux\u2010Bacchi, \nC\u00e9cile Gonnin, \nCarine ElSissy&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/10\/meningococcal-serogroup-y-meningitis-reveals-inborn-factor-b-deficiency-valuecamille-bougeard-eleonore-eskander-paula-vieira-martins-joan-bitan-julia-roquigny-christele-kyheng-t\/\" aria-label=\"Read more about Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency. [[{&#8220;value&#8221;:&#8221;Camille Bougeard, \nEl\u00e9onore Eskander, \nPaula Vieira Martins, \nJoan Bitan, \nJulia Roquigny, \nChrist\u00e8le Kyheng, \nTamazoust Guiddir, \nV\u00e9ronique Fr\u00e9meaux\u2010Bacchi, \nC\u00e9cile Gonnin, \nCarine ElSissy&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/07\/cytomegalovirus%e2%80%90based-viral-vectors-elicit-robust-systemic-and-tissue%e2%80%90resident-immune-response-against-sars%e2%80%90cov%e2%80%902-antigens-valuemaja-cokaric-brdovcak-jelen\/\">Cytomegalovirus\u2010Based Viral Vectors Elicit Robust Systemic and Tissue\u2010Resident Immune Response Against SARS\u2010CoV\u20102 Antigens. [[{&#8220;value&#8221;:&#8221;Maja Cokari\u0107 Brdov\u010dak, \nJelena Materljan Franki, \nMarko \u0160usti\u0107, \nKarmela Mikli\u0107, \nMagdalena Medved, \nLydia Ga\u0107ina, \nTina Ru\u017ei\u0107, \nStipan Jonji\u0107, \nIlija Brizi\u0107, \nAstrid Krmpoti\u0107&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-07T09:45:38+01:00\" class=\"wp-block-latest-posts__post-date\">7 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We developed murine CMV-based viral vectors expressing SARS-CoV-2 spike antigen and compared immune response following intraperitoneal and intranasal delivery. Route of vaccine administration shaped antibody and CD8+ T cell response magnitude, kinetics, and tissue residency, highlighting the potential of CMV vectors for induction of protective lung immunity. Created in https:\/\/BioRender.com. ABSTRACT Current COVID-19 vaccines face &#8230; <a title=\"Cytomegalovirus\u2010Based Viral Vectors Elicit Robust Systemic and Tissue\u2010Resident Immune Response Against SARS\u2010CoV\u20102 Antigens. [[{&#8220;value&#8221;:&#8221;Maja Cokari\u0107 Brdov\u010dak, \nJelena Materljan Franki, \nMarko \u0160usti\u0107, \nKarmela Mikli\u0107, \nMagdalena Medved, \nLydia Ga\u0107ina, \nTina Ru\u017ei\u0107, \nStipan Jonji\u0107, \nIlija Brizi\u0107, \nAstrid Krmpoti\u0107&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/07\/cytomegalovirus%e2%80%90based-viral-vectors-elicit-robust-systemic-and-tissue%e2%80%90resident-immune-response-against-sars%e2%80%90cov%e2%80%902-antigens-valuemaja-cokaric-brdovcak-jelen\/\" aria-label=\"Read more about Cytomegalovirus\u2010Based Viral Vectors Elicit Robust Systemic and Tissue\u2010Resident Immune Response Against SARS\u2010CoV\u20102 Antigens. [[{&#8220;value&#8221;:&#8221;Maja Cokari\u0107 Brdov\u010dak, \nJelena Materljan Franki, \nMarko \u0160usti\u0107, \nKarmela Mikli\u0107, \nMagdalena Medved, \nLydia Ga\u0107ina, \nTina Ru\u017ei\u0107, \nStipan Jonji\u0107, \nIlija Brizi\u0107, \nAstrid Krmpoti\u0107&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/06\/isolation-of-pure-stable-human-treg-cells-based-on-expression-of-gpa33-valueflorencia-morgana-edith-slot-derk-amsen\/\">Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33. [[{&#8220;value&#8221;:&#8221;Florencia Morgana, \nEdith Slot, \nDerk Amsen&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-06T10:23:24+01:00\" class=\"wp-block-latest-posts__post-date\">6 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">GPA33 identifies stable human regulatory T cells suitable for therapeutic use. GPA33+ Treg subsets expand efficiently, maintain high FOXP3+Helios+ expression, and lack production of IL-2, IFN\u03b3, and IL-17A. GPA33, alone or combined with TIGIT, also enables robust post-expansion isolation of pure, stable Treg cells for adoptive cell therapy. ABSTRACT Adoptive cell therapy (ACT) with regulatory &#8230; <a title=\"Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33. [[{&#8220;value&#8221;:&#8221;Florencia Morgana, \nEdith Slot, \nDerk Amsen&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/06\/isolation-of-pure-stable-human-treg-cells-based-on-expression-of-gpa33-valueflorencia-morgana-edith-slot-derk-amsen\/\" aria-label=\"Read more about Isolation of Pure Stable Human Treg Cells Based on Expression of GPA33. [[{&#8220;value&#8221;:&#8221;Florencia Morgana, \nEdith Slot, \nDerk Amsen&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/ubl3-participates-in-the-early-stages-of-cd83%e2%80%90dependent-cd4-t-cell-selection-valuehuw-morgan-haiyin-liu-jose-a-villadangos-justine-d-mintern\/\">UBL3 Participates in the Early Stages of CD83\u2010Dependent CD4+ T Cell Selection. [[{&#8220;value&#8221;:&#8221;Huw Morgan, \nHaiyin Liu, \nJose A. Villadangos, \nJustine D. Mintern&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-05T09:38:04+01:00\" class=\"wp-block-latest-posts__post-date\">5 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">CD83 and UBL3 are regulators of MHCII surface expression; however, only CD83 has a known role in regulating CD4+ T cell selection. This paper describes a role for UBL3 in regulating MHC II expression on thymic epithelium in a CD83-deficient context, leading to alterations in CD4+ T cell positive selection. ABSTRACT CD83 is critical for &#8230; <a title=\"UBL3 Participates in the Early Stages of CD83\u2010Dependent CD4+ T Cell Selection. [[{&#8220;value&#8221;:&#8221;Huw Morgan, \nHaiyin Liu, \nJose A. Villadangos, \nJustine D. Mintern&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/ubl3-participates-in-the-early-stages-of-cd83%e2%80%90dependent-cd4-t-cell-selection-valuehuw-morgan-haiyin-liu-jose-a-villadangos-justine-d-mintern\/\" aria-label=\"Read more about UBL3 Participates in the Early Stages of CD83\u2010Dependent CD4+ T Cell Selection. [[{&#8220;value&#8221;:&#8221;Huw Morgan, \nHaiyin Liu, \nJose A. Villadangos, \nJustine D. Mintern&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/a-novel-murine-model-of-hemophagocytic-lymphohistiocytosis%e2%80%90like-inflammation-in-znfx1-deficiency-valuediana-tintor-samantha-milanesi-tommaso-marchetti-tiziana-lorenzini-seve\/\">A Novel Murine Model of Hemophagocytic Lymphohistiocytosis\u2010Like Inflammation in ZNFX1 Deficiency. [[{&#8220;value&#8221;:&#8221;Diana Tintor, \nSamantha Milanesi, \nTommaso Marchetti, \nTiziana Lorenzini, \nSeverin Walser, \nJunyi Chen, \nJulius K\u00f6ppen, \nAchim Weber, \nOla Sabet, \nJana Pachlopnik Schmid&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-05T09:38:04+01:00\" class=\"wp-block-latest-posts__post-date\">5 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">LCMV-infected Znfx1-deficient mice develop hemophagocytic lymphohistiocytosis (HLH)-like immune dysregulation, mirroring key aspects of the immunopathology observed in ZNFX1-deficient patients. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages. Recently, deleterious autosomal recessive mutations in ZNFX1 were reported to predispose pediatric patients to HLH-like disease upon viral trigger. &#8230; <a title=\"A Novel Murine Model of Hemophagocytic Lymphohistiocytosis\u2010Like Inflammation in ZNFX1 Deficiency. [[{&#8220;value&#8221;:&#8221;Diana Tintor, \nSamantha Milanesi, \nTommaso Marchetti, \nTiziana Lorenzini, \nSeverin Walser, \nJunyi Chen, \nJulius K\u00f6ppen, \nAchim Weber, \nOla Sabet, \nJana Pachlopnik Schmid&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/a-novel-murine-model-of-hemophagocytic-lymphohistiocytosis%e2%80%90like-inflammation-in-znfx1-deficiency-valuediana-tintor-samantha-milanesi-tommaso-marchetti-tiziana-lorenzini-seve\/\" aria-label=\"Read more about A Novel Murine Model of Hemophagocytic Lymphohistiocytosis\u2010Like Inflammation in ZNFX1 Deficiency. [[{&#8220;value&#8221;:&#8221;Diana Tintor, \nSamantha Milanesi, \nTommaso Marchetti, \nTiziana Lorenzini, \nSeverin Walser, \nJunyi Chen, \nJulius K\u00f6ppen, \nAchim Weber, \nOla Sabet, \nJana Pachlopnik Schmid&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/gene-regulatory-programs-of-nk-cells-show-that-ncam1-cd56-and-kirs-are-controlled-by-genetically-polymorphic-distal-regulatory-elements-valuemariam-a-salem-aditi-varkey-matthew-d-es\/\">Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements. [[{&#8220;value&#8221;:&#8221;Mariam A. Salem, \nAditi Varkey, \nMatthew D. Estrada, \nKruthika Sharma, \nCaprice D. Eisele, \nNitin Chakravarti, \nDean A. Lee, \nAharon G. Freud, \nBethany L. Mundy\u2010Bosse, \nPatrick L. Collins&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-05T09:38:04+01:00\" class=\"wp-block-latest-posts__post-date\">5 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">A deeper understanding of the natural killer cell gene expression regulation driving NK cell maturation and cytotoxicity could provide critical insights into optimizing NK therapies. Our findings reveal novel enhancers governing NK cell genes for NCAM1\/CD56 and cis-regulation for KIR receptors and clarify existing models of NK cell cis-accessibility regulation. ABSTRACT Owing to their immunoprotective &#8230; <a title=\"Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements. [[{&#8220;value&#8221;:&#8221;Mariam A. Salem, \nAditi Varkey, \nMatthew D. Estrada, \nKruthika Sharma, \nCaprice D. Eisele, \nNitin Chakravarti, \nDean A. Lee, \nAharon G. Freud, \nBethany L. Mundy\u2010Bosse, \nPatrick L. Collins&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/05\/gene-regulatory-programs-of-nk-cells-show-that-ncam1-cd56-and-kirs-are-controlled-by-genetically-polymorphic-distal-regulatory-elements-valuemariam-a-salem-aditi-varkey-matthew-d-es\/\" aria-label=\"Read more about Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements. [[{&#8220;value&#8221;:&#8221;Mariam A. Salem, \nAditi Varkey, \nMatthew D. Estrada, \nKruthika Sharma, \nCaprice D. Eisele, \nNitin Chakravarti, \nDean A. Lee, \nAharon G. Freud, \nBethany L. Mundy\u2010Bosse, \nPatrick L. Collins&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/issue-information-eur-j-immunol-226\/\">Issue Information: Eur. J. Immunol. 2&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 2, February 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/microbial%e2%80%90immune-interplay-in-cns-autoimmune-diseases-lessons-from-animal-models-and-clinical-studies-valuematteo-ceccon-francesca-ronchi\/\">Microbial\u2010Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies. [[{&#8220;value&#8221;:&#8221;Matteo Ceccon, \nFrancesca Ronchi&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS-resident cells such as microglia and astrocytes, contributing to immune-mediated CNS pathology. Multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), &#8230; <a title=\"Microbial\u2010Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies. [[{&#8220;value&#8221;:&#8221;Matteo Ceccon, \nFrancesca Ronchi&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/microbial%e2%80%90immune-interplay-in-cns-autoimmune-diseases-lessons-from-animal-models-and-clinical-studies-valuematteo-ceccon-francesca-ronchi\/\" aria-label=\"Read more about Microbial\u2010Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies. [[{&#8220;value&#8221;:&#8221;Matteo Ceccon, \nFrancesca Ronchi&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/proteomic-analysis-of-regulated-dendritic-cell-endosomes-reveals-dynamic-adaptation-to-antigen-uptake-and-cross%e2%80%90presentation-valuealice-senni-louise-grumbach-sara-ceccacci-mat\/\">Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross\u2010Presentation. [[{&#8220;value&#8221;:&#8221;Alice Senni, \nLouise Grumbach, \nSara Ceccacci, \nMathieu Frechin, \nNicolas Goudin, \nIda Chiara Guerrera, \nBarbara Bertocci, \nPeter van Endert&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross-presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated. ABSTRACT MHC class I (MHC-I) cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated &#8230; <a title=\"Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross\u2010Presentation. [[{&#8220;value&#8221;:&#8221;Alice Senni, \nLouise Grumbach, \nSara Ceccacci, \nMathieu Frechin, \nNicolas Goudin, \nIda Chiara Guerrera, \nBarbara Bertocci, \nPeter van Endert&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/proteomic-analysis-of-regulated-dendritic-cell-endosomes-reveals-dynamic-adaptation-to-antigen-uptake-and-cross%e2%80%90presentation-valuealice-senni-louise-grumbach-sara-ceccacci-mat\/\" aria-label=\"Read more about Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross\u2010Presentation. [[{&#8220;value&#8221;:&#8221;Alice Senni, \nLouise Grumbach, \nSara Ceccacci, \nMathieu Frechin, \nNicolas Goudin, \nIda Chiara Guerrera, \nBarbara Bertocci, \nPeter van Endert&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/a-cell%e2%80%90intrinsic-role-for-rank-in-regulatory-t-cells-of-the-human-thymus-valuezoe%e2%80%90isabella-junginger-ramona-adameck-alexandre-a-s-f-raposo-pedro-rosmaninho-ana-e\/\">A Cell\u2010Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus. [[{&#8220;value&#8221;:&#8221;Zoe\u2010Isabella Junginger, \nRamona Adameck, \nAlexandre A. S. F. Raposo, \nPedro Rosmaninho, \nAna E. Sousa, \nAfonso R. M. Almeida&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We identified RANK (TNFRSF11a) expression in human thymic FOXP3+ Tregs, revealing a previously unknown role for the RANK-RANKL axis in human tTreg development. We show that IL-2 and IL-15 can drive RANK expression in CD4+ tTregs, which in turn may modulate their maturation and proliferation within the thymic environment. Created in BioRender. Biorender, I. (2026) &#8230; <a title=\"A Cell\u2010Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus. [[{&#8220;value&#8221;:&#8221;Zoe\u2010Isabella Junginger, \nRamona Adameck, \nAlexandre A. S. F. Raposo, \nPedro Rosmaninho, \nAna E. Sousa, \nAfonso R. M. Almeida&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/a-cell%e2%80%90intrinsic-role-for-rank-in-regulatory-t-cells-of-the-human-thymus-valuezoe%e2%80%90isabella-junginger-ramona-adameck-alexandre-a-s-f-raposo-pedro-rosmaninho-ana-e\/\" aria-label=\"Read more about A Cell\u2010Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus. [[{&#8220;value&#8221;:&#8221;Zoe\u2010Isabella Junginger, \nRamona Adameck, \nAlexandre A. S. F. Raposo, \nPedro Rosmaninho, \nAna E. Sousa, \nAfonso R. M. Almeida&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/cover-story-eur-j-immunol-226\/\">Cover Story: Eur. J. Immunol. 2&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 2&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/cover-story-eur-j-immunol-226\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 2&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/stabilization-of-human-cd8-treg-in-inflammatory-environments-through-foxp3-expression-valueseverine-bezie-jenny-greig-sonia-salle-juliette-lasselin-lisa-dugast-laurent-tesson-c\/\">Stabilization of Human CD8+ Treg in Inflammatory Environments Through FOXP3 Expression. [[{&#8220;value&#8221;:&#8221;S\u00e9verine B\u00e9zie, \nJenny Greig, \nSonia Salle, \nJuliette Lasselin, \nLisa Dugast, \nLaurent Tesson, \nC\u00e9line S\u00e9razin, \nNad\u00e8ge Vimond, \nIgnacio Anegon, \nCarole Guillonneau&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-02-03T10:33:54+01:00\" class=\"wp-block-latest-posts__post-date\">3 de February de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Specific pro-inflammatory cytokines destabilize CD8+ Tregs, altering their phenotype and reducing FOXP3 expression. Enforced FOXP3 expression, or the upregulation of its molecular regulators, partially protects CD8+ Tregs from inflammatory disruption, restoring their phenotype and maintaining suppressive function under inflammatory conditions. ABSTRACT Cell therapy using regulatory T cells (Tregs) holds therapeutic promise in immune-mediated diseases, but &#8230; <a title=\"Stabilization of Human CD8+ Treg in Inflammatory Environments Through FOXP3 Expression. [[{&#8220;value&#8221;:&#8221;S\u00e9verine B\u00e9zie, \nJenny Greig, \nSonia Salle, \nJuliette Lasselin, \nLisa Dugast, \nLaurent Tesson, \nC\u00e9line S\u00e9razin, \nNad\u00e8ge Vimond, \nIgnacio Anegon, \nCarole Guillonneau&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/03\/stabilization-of-human-cd8-treg-in-inflammatory-environments-through-foxp3-expression-valueseverine-bezie-jenny-greig-sonia-salle-juliette-lasselin-lisa-dugast-laurent-tesson-c\/\" aria-label=\"Read more about Stabilization of Human CD8+ Treg in Inflammatory Environments Through FOXP3 Expression. [[{&#8220;value&#8221;:&#8221;S\u00e9verine B\u00e9zie, \nJenny Greig, \nSonia Salle, \nJuliette Lasselin, \nLisa Dugast, \nLaurent Tesson, \nC\u00e9line S\u00e9razin, \nNad\u00e8ge Vimond, \nIgnacio Anegon, \nCarole Guillonneau&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/27\/developmental-impact-of-maternal-immune-activation-on-the-fetal-immune-system-and-lung-valuewalaa-jradi-kira-duhm-clarissa-prazeres-da-costa\/\">Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung. [[{&#8220;value&#8221;:&#8221;Walaa Jradi, \nKira Duhm, \nClarissa Prazeres da Costa&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-27T10:26:04+01:00\" class=\"wp-block-latest-posts__post-date\">27 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Maternal immune activation triggers elevated cytokines (IL-6 and IL-17A), disrupting fetal immune system development. This not only alters hematopoietic stem cell balance but also leads to ILC2 hyperactivation in the lung, which could potentially affect susceptibility to allergic diseases in the offspring. ABSTRACT Maternal immune activation (MIA) refers to an immune response triggered in a &#8230; <a title=\"Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung. [[{&#8220;value&#8221;:&#8221;Walaa Jradi, \nKira Duhm, \nClarissa Prazeres da Costa&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/27\/developmental-impact-of-maternal-immune-activation-on-the-fetal-immune-system-and-lung-valuewalaa-jradi-kira-duhm-clarissa-prazeres-da-costa\/\" aria-label=\"Read more about Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung. [[{&#8220;value&#8221;:&#8221;Walaa Jradi, \nKira Duhm, \nClarissa Prazeres da Costa&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/environmental-signals-that-drive-early-life-innate-lymphoid-cell-development-valueemily-n-kulp-colleen-m-lau\/\">Environmental Signals That Drive Early Life Innate Lymphoid Cell Development. [[{&#8220;value&#8221;:&#8221;Emily N. Kulp, \nColleen M. Lau&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-26T10:45:51+01:00\" class=\"wp-block-latest-posts__post-date\">26 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Recent evidence supports a model in which the pool of adult immune cells is actually composed of cells derived from fetal, neonatal, and adult waves of hematopoiesis. In this review, we discuss this evidence in the context of innate lymphoid cells (ILC), with a focus on the environmental signals required for their development during early &#8230; <a title=\"Environmental Signals That Drive Early Life Innate Lymphoid Cell Development. [[{&#8220;value&#8221;:&#8221;Emily N. Kulp, \nColleen M. Lau&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/environmental-signals-that-drive-early-life-innate-lymphoid-cell-development-valueemily-n-kulp-colleen-m-lau\/\" aria-label=\"Read more about Environmental Signals That Drive Early Life Innate Lymphoid Cell Development. [[{&#8220;value&#8221;:&#8221;Emily N. Kulp, \nColleen M. Lau&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/igd%e2%80%90expressing-mature-b-cells-exhibit-enhanced-sensitivity-to-glucocorticoid%e2%80%90induced-cell-death-valuekais-almohammad-marc-young-sabine-vettorazzi-franziska-greulich\/\">IgD\u2010Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid\u2010Induced Cell Death. [[{&#8220;value&#8221;:&#8221;Kais Almohammad, \nMarc Young, \nSabine Vettorazzi, \nFranziska Greulich, \nMahmoud Alkhatib, \nJan Tuckermann, \nHassan Jumaa, \nCorinna S. Setz&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-26T10:45:51+01:00\" class=\"wp-block-latest-posts__post-date\">26 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our study shows that mature B cells expressing IgD exhibit significantly higher sensitivity to glucocorticoid (GC)-induced cell death. This elevated sensitivity is specifically dependent on GC receptor (GR) expression and is accompanied by enhanced activation as well as terminal differentiation of B cells. Our findings elucidate how exogenous GCs affect B cell survival and suggest &#8230; <a title=\"IgD\u2010Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid\u2010Induced Cell Death. [[{&#8220;value&#8221;:&#8221;Kais Almohammad, \nMarc Young, \nSabine Vettorazzi, \nFranziska Greulich, \nMahmoud Alkhatib, \nJan Tuckermann, \nHassan Jumaa, \nCorinna S. Setz&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/26\/igd%e2%80%90expressing-mature-b-cells-exhibit-enhanced-sensitivity-to-glucocorticoid%e2%80%90induced-cell-death-valuekais-almohammad-marc-young-sabine-vettorazzi-franziska-greulich\/\" aria-label=\"Read more about IgD\u2010Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid\u2010Induced Cell Death. [[{&#8220;value&#8221;:&#8221;Kais Almohammad, \nMarc Young, \nSabine Vettorazzi, \nFranziska Greulich, \nMahmoud Alkhatib, \nJan Tuckermann, \nHassan Jumaa, \nCorinna S. Setz&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/tissue-immunometabolism-in-autoimmunity-matteo-villa\/\">Tissue Immunometabolism in Autoimmunity. Matteo Villa<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-25T10:23:19+01:00\" class=\"wp-block-latest-posts__post-date\">25 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The tissue metabolic environment in autoimmunity influences immune and nonimmune cells via fuelling cellular metabolism or through metabolic signalling. Intracellular metabolic sensors combine several environmental cues to control transcription, metabolism, and cell function. The function of each cell contributes to the concerted dysfunctional behaviour of a tissue in autoimmunity. ABSTRACT Autoimmunity causes damage to organs &#8230; <a title=\"Tissue Immunometabolism in Autoimmunity. Matteo Villa\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/tissue-immunometabolism-in-autoimmunity-matteo-villa\/\" aria-label=\"Read more about Tissue Immunometabolism in Autoimmunity. Matteo Villa\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/restoring-immunological-tolerance-via-dendritic-cells-in-rheumatoid-arthritis-valuehannah-costello-andrea-woodcock-mary-canavan\/\">Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Hannah Costello, \nAndrea Woodcock, \nMary Canavan&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-25T10:23:19+01:00\" class=\"wp-block-latest-posts__post-date\">25 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">This review examines the failure of peripheral immune tolerance as the initiating factor in rheumatoid arthritis (RA), focusing on the role of dendritic cells. It discusses strategies to convert these cells from immunogenic to tolerogenic states, while also exploring emerging research on the anatomical sites where this critical loss of tolerance occurs. ABSTRACT Rheumatoid arthritis &#8230; <a title=\"Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Hannah Costello, \nAndrea Woodcock, \nMary Canavan&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/25\/restoring-immunological-tolerance-via-dendritic-cells-in-rheumatoid-arthritis-valuehannah-costello-andrea-woodcock-mary-canavan\/\" aria-label=\"Read more about Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Hannah Costello, \nAndrea Woodcock, \nMary Canavan&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/23\/downregulation-of-cd19-expression-associates-with-mantle-cell-lymphoma-relapse-following-car%e2%80%90t-cell-therapy-valuebenedetta-peruzzi-alessio-mazzoni-ilaria-cutini-francesca-mata\/\">Downregulation of CD19 Expression Associates With Mantle Cell Lymphoma Relapse Following CAR\u2010T Cell Therapy. [[{&#8220;value&#8221;:&#8221;Benedetta Peruzzi, \nAlessio Mazzoni, \nIlaria Cutini, \nFrancesca Matani, \nRoberto Caporale, \nSara Bencini, \nSara Pratesi, \nLaura Maggi, \nManuela Capone, \nAnna Vanni, \nGiulia Lamacchia, \nLucia Bartoli, \nFrancesco Liotta, \nLorenzo Cosmi, \nBenedetta Puccini, \nLuca Nassi, \nBenedetta Sordi, \nChiara Camerini, \nAlessandro Maria Vannucchi, \nChiara Nozzoli, \nFrancesco Annunziato&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-23T10:18:36+01:00\" class=\"wp-block-latest-posts__post-date\">23 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. However, downregulation of CD19 expression on malignant B cells led to sudden therapy failure.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/fam83h-regulates-postnatal-t-cell-development-through-thymic-stroma-organization-valuebetul-melike-ogan-veronika-forstlova-laura-jane-dowling-michaela-simova-kristina-vicikova-ven\/\">FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{&#8220;value&#8221;:&#8221;Betul Melike Ogan, \nVeronika Forstlova, \nLaura Jane Dowling, \nMichaela Simova, \nKristina Vicikova, \nVendula Novosadova, \nFrantisek Spoutil, \nSylvie Cervenkova, \nMichaela Proch\u00e1zkov\u00e1, \nJolana Tureckova, \nOlha Fedosieieva, \nJuraj Labaj, \nPetr Nickl, \nKamila Krizova, \nJan Prochazka, \nJana Balounova, \nRadislav Sedlacek&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-17T09:55:03+01:00\" class=\"wp-block-latest-posts__post-date\">17 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Loss of the casein kinase 1 scaffolding protein FAM83H compromises bone marrow lymphopoiesis, reduces Foxn1 expression in cortical thymic epithelial cells (TEC), disrupts thymic architecture and TEC identity, and ultimately impairs double-negative thymocyte proliferation and T-cell production. ABSTRACT Family of Sequence Similarity 83H (FAM83H\/SACK1H) is primarily expressed in epithelial cells, where it interacts with casein &#8230; <a title=\"FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{&#8220;value&#8221;:&#8221;Betul Melike Ogan, \nVeronika Forstlova, \nLaura Jane Dowling, \nMichaela Simova, \nKristina Vicikova, \nVendula Novosadova, \nFrantisek Spoutil, \nSylvie Cervenkova, \nMichaela Proch\u00e1zkov\u00e1, \nJolana Tureckova, \nOlha Fedosieieva, \nJuraj Labaj, \nPetr Nickl, \nKamila Krizova, \nJan Prochazka, \nJana Balounova, \nRadislav Sedlacek&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/fam83h-regulates-postnatal-t-cell-development-through-thymic-stroma-organization-valuebetul-melike-ogan-veronika-forstlova-laura-jane-dowling-michaela-simova-kristina-vicikova-ven\/\" aria-label=\"Read more about FAM83H Regulates Postnatal T Cell Development Through Thymic Stroma Organization. [[{&#8220;value&#8221;:&#8221;Betul Melike Ogan, \nVeronika Forstlova, \nLaura Jane Dowling, \nMichaela Simova, \nKristina Vicikova, \nVendula Novosadova, \nFrantisek Spoutil, \nSylvie Cervenkova, \nMichaela Proch\u00e1zkov\u00e1, \nJolana Tureckova, \nOlha Fedosieieva, \nJuraj Labaj, \nPetr Nickl, \nKamila Krizova, \nJan Prochazka, \nJana Balounova, \nRadislav Sedlacek&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/shared-hla%e2%80%90e-and-mamu%e2%80%90e-peptide-repertoires-with-subtle-peptide-binding-differences-revealed-by-combined-ndsf%e2%80%90-and-fluorescence-polarisation%e2%80%90based-methods-value\/\">Shared HLA\u2010E and Mamu\u2010E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF\u2010 and Fluorescence Polarisation\u2010Based Methods. [[{&#8220;value&#8221;:&#8221;Max N. Quastel, \nSashini A. Ranawana, \nBas W. A. Peeters, \nAndy van Hateren, \nAndrew J. McMichael, \nGeraldine M. Gillespie&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-17T09:55:03+01:00\" class=\"wp-block-latest-posts__post-date\">17 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The MHC-E peptide binding methods described here\u2014nano-differential scanning fluorimetry and fluorescence polarisation\u2014demonstrate shared peptide binding repertoires with subtle binding hierarchy differences for the tested HLA-E and Mamu-E allotypes. When combined, these methods illustrate how minor MHC-E-peptide thermal stability changes equate to significant binding strength differences. ABSTRACT The primary function of MHC-E\u2014human leukocyte antigen (HLA)-E in &#8230; <a title=\"Shared HLA\u2010E and Mamu\u2010E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF\u2010 and Fluorescence Polarisation\u2010Based Methods. [[{&#8220;value&#8221;:&#8221;Max N. Quastel, \nSashini A. Ranawana, \nBas W. A. Peeters, \nAndy van Hateren, \nAndrew J. McMichael, \nGeraldine M. Gillespie&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/17\/shared-hla%e2%80%90e-and-mamu%e2%80%90e-peptide-repertoires-with-subtle-peptide-binding-differences-revealed-by-combined-ndsf%e2%80%90-and-fluorescence-polarisation%e2%80%90based-methods-value\/\" aria-label=\"Read more about Shared HLA\u2010E and Mamu\u2010E Peptide Repertoires With Subtle Peptide Binding Differences Revealed by Combined nDSF\u2010 and Fluorescence Polarisation\u2010Based Methods. [[{&#8220;value&#8221;:&#8221;Max N. Quastel, \nSashini A. Ranawana, \nBas W. A. Peeters, \nAndy van Hateren, \nAndrew J. McMichael, \nGeraldine M. Gillespie&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/13\/correction-to-immunological-impact-of-oncolytic-adenoviruses-on-cancer-therapy-clinical-insights-2\/\">Correction to \u201cImmunological Impact of Oncolytic Adenoviruses on Cancer Therapy: Clinical Insights\u201d.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-13T10:40:32+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 1, January 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/13\/the-increased-secretion-of-lactate-observed-in-obesity-and-aging-leads-to-the-generation-of-pathogenic-b-cells-valuemaria-romero-amanda-virtue-kate-miller-andrew-gelsomini-dhananjay\/\">The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{&#8220;value&#8221;:&#8221;Maria Romero, \nAmanda Virtue, \nKate Miller, \nAndrew Gelsomini, \nDhananjay Suresh, \nSophie LaPointe, \nSuresh Pallikkuth, \nDaniela Frasca&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-13T10:40:32+01:00\" class=\"wp-block-latest-posts__post-date\">13 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The increased lactate secretion by B cells from people with obesity and aging is a stimulus for pathogenic autoimmune anti-dsDNA antibodies. The effects of lactate are mediated by phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and inhibited by a neutralizing antibody that blocks the lactate transporter SLC5A12, responsible for lactate uptake and activation &#8230; <a title=\"The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{&#8220;value&#8221;:&#8221;Maria Romero, \nAmanda Virtue, \nKate Miller, \nAndrew Gelsomini, \nDhananjay Suresh, \nSophie LaPointe, \nSuresh Pallikkuth, \nDaniela Frasca&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/13\/the-increased-secretion-of-lactate-observed-in-obesity-and-aging-leads-to-the-generation-of-pathogenic-b-cells-valuemaria-romero-amanda-virtue-kate-miller-andrew-gelsomini-dhananjay\/\" aria-label=\"Read more about The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells. [[{&#8220;value&#8221;:&#8221;Maria Romero, \nAmanda Virtue, \nKate Miller, \nAndrew Gelsomini, \nDhananjay Suresh, \nSophie LaPointe, \nSuresh Pallikkuth, \nDaniela Frasca&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/11\/a-transcriptional-map-of-human-tonsil-architecture-beyond-the-sum-of-single-cell-parts-valuehelena-l-crowell-laura-llao%e2%80%90cid-gerard-frigola-samuel-gunz-irene-ruano-patr\/\">A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{&#8220;value&#8221;:&#8221;Helena L. Crowell, \nLaura Lla\u00f3\u2010Cid, \nGerard Frigola, \nSamuel Gunz, \nIrene Ruano, \nPatricia Lorden, \nMax Ruiz, \nMarta Kulis, \nJos\u00e9 Ignacio Martin\u2010Subero, \nHolger Heyn, \nElias Campo, \nAnna Pascual\u2010Reguant&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-11T09:59:32+01:00\" class=\"wp-block-latest-posts__post-date\">11 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Picture-book compartmentalization makes tonsillar tissue an ideal model to study spatial immunology. Using single-molecule imaging (SMI) of whole-tissue sections, we showcase many an alternative view on tissue composition and architecture that these data and concomitant analyses provide\u2014at the level of single cells, cellular neighborhoods, and anatomical units such as germinal centers and epithelial\u00a0substructures. ABSTRACT The &#8230; <a title=\"A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{&#8220;value&#8221;:&#8221;Helena L. Crowell, \nLaura Lla\u00f3\u2010Cid, \nGerard Frigola, \nSamuel Gunz, \nIrene Ruano, \nPatricia Lorden, \nMax Ruiz, \nMarta Kulis, \nJos\u00e9 Ignacio Martin\u2010Subero, \nHolger Heyn, \nElias Campo, \nAnna Pascual\u2010Reguant&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/11\/a-transcriptional-map-of-human-tonsil-architecture-beyond-the-sum-of-single-cell-parts-valuehelena-l-crowell-laura-llao%e2%80%90cid-gerard-frigola-samuel-gunz-irene-ruano-patr\/\" aria-label=\"Read more about A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. [[{&#8220;value&#8221;:&#8221;Helena L. Crowell, \nLaura Lla\u00f3\u2010Cid, \nGerard Frigola, \nSamuel Gunz, \nIrene Ruano, \nPatricia Lorden, \nMax Ruiz, \nMarta Kulis, \nJos\u00e9 Ignacio Martin\u2010Subero, \nHolger Heyn, \nElias Campo, \nAnna Pascual\u2010Reguant&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/09\/correction-to-immunological-impact-of-oncolytic-adenoviruses-on-cancer-therapy-clinical-insights\/\">Correction to \u201cImmunological Impact of Oncolytic Adenoviruses on Cancer Therapy: Clinical Insights\u201d.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-09T10:25:14+01:00\" class=\"wp-block-latest-posts__post-date\">9 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 1, January 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/08\/sars%e2%80%90cov%e2%80%902-mrna-vaccination-leads-to-transient-humoral-and-b-cell-bystander-responses-in-adults-valuelisan-h-kuijper-laura-y-l-kummer-laura-fernandez-blanco-karlijn\/\">SARS\u2010CoV\u20102 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{&#8220;value&#8221;:&#8221;Lisan H. Kuijper, \nLaura Y. L. Kummer, \nLaura Fernandez Blanco, \nKarlijn van der Straten, \nMathieu A. F. Claireaux, \nAm\u00e9lie V. Bos, \nMiranda C. Dieker\u2010Meijer, \nTineke Jorritsma, \nMari\u00ebl C. Duurland, \nMaurice Steenhuis, \nJuan J. Garcia Vallejo, \nKoos P. J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nSander W. Tas, \nLaura Boekel, \nGert\u2010Jan Wolbink, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nMarit J. van Gils, \nAnja ten Brinke, \nS. Marieke van Ham, \nT2B! immunity against SARS\u2010CoV\u20102 study group&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-08T10:07:24+01:00\" class=\"wp-block-latest-posts__post-date\">8 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">SARS-CoV-2 mRNA vaccination triggers bystander activation of B cells, transiently increasing antibody levels after the first vaccination against influenza, RSV, and tetanus. Reactivation of B cell responses also occurred, where (CD11c+) MBC and DN3 are expanded after SARS-CoV-2 mRNA vaccination, independent of antigen exposure. ABSTRACT After antigen encounter, long-lived antibody-secreting cells (ASC) secrete high-affinity circulating &#8230; <a title=\"SARS\u2010CoV\u20102 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{&#8220;value&#8221;:&#8221;Lisan H. Kuijper, \nLaura Y. L. Kummer, \nLaura Fernandez Blanco, \nKarlijn van der Straten, \nMathieu A. F. Claireaux, \nAm\u00e9lie V. Bos, \nMiranda C. Dieker\u2010Meijer, \nTineke Jorritsma, \nMari\u00ebl C. Duurland, \nMaurice Steenhuis, \nJuan J. Garcia Vallejo, \nKoos P. J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nSander W. Tas, \nLaura Boekel, \nGert\u2010Jan Wolbink, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nMarit J. van Gils, \nAnja ten Brinke, \nS. Marieke van Ham, \nT2B! immunity against SARS\u2010CoV\u20102 study group&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/08\/sars%e2%80%90cov%e2%80%902-mrna-vaccination-leads-to-transient-humoral-and-b-cell-bystander-responses-in-adults-valuelisan-h-kuijper-laura-y-l-kummer-laura-fernandez-blanco-karlijn\/\" aria-label=\"Read more about SARS\u2010CoV\u20102 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults. [[{&#8220;value&#8221;:&#8221;Lisan H. Kuijper, \nLaura Y. L. Kummer, \nLaura Fernandez Blanco, \nKarlijn van der Straten, \nMathieu A. F. Claireaux, \nAm\u00e9lie V. Bos, \nMiranda C. Dieker\u2010Meijer, \nTineke Jorritsma, \nMari\u00ebl C. Duurland, \nMaurice Steenhuis, \nJuan J. Garcia Vallejo, \nKoos P. J. van Dam, \nEileen W. Stalman, \nLuuk Wieske, \nSander W. Tas, \nLaura Boekel, \nGert\u2010Jan Wolbink, \nTheo Rispens, \nTaco W. Kuijpers, \nFilip Eftimov, \nMarit J. van Gils, \nAnja ten Brinke, \nS. Marieke van Ham, \nT2B! immunity against SARS\u2010CoV\u20102 study group&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/issue-information-eur-j-immunol-126\/\">Issue Information: Eur. J. Immunol. 1&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-06T09:37:17+01:00\" class=\"wp-block-latest-posts__post-date\">6 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">European Journal of Immunology, Volume 56, Issue 1, January 2026.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/synovial-tissue-macrophage-heterogeneity-in-rheumatoid-arthritis-valuemegan-m-hanlon-ursula-fearon-ellen-m-gravallese\/\">Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Megan M. Hanlon, \nUrsula Fearon, \nEllen M. Gravallese&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-06T09:37:16+01:00\" class=\"wp-block-latest-posts__post-date\">6 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Synovial tissue macrophages are essential coordinators of joint homeostasis and inflammatory responses in rheumatoid arthritis. Here, we highlight recent advances that have enabled a deeper characterization of synovial tissue macrophages and their distinct phenotypes and functions in health and disease. ABSTRACT Synovial tissue macrophages are critical orchestrators in the pathogenesis of rheumatoid arthritis, comprising a &#8230; <a title=\"Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Megan M. Hanlon, \nUrsula Fearon, \nEllen M. Gravallese&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/synovial-tissue-macrophage-heterogeneity-in-rheumatoid-arthritis-valuemegan-m-hanlon-ursula-fearon-ellen-m-gravallese\/\" aria-label=\"Read more about Synovial Tissue Macrophage Heterogeneity in Rheumatoid Arthritis. [[{&#8220;value&#8221;:&#8221;Megan M. Hanlon, \nUrsula Fearon, \nEllen M. Gravallese&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/cover-story-eur-j-immunol-126\/\">Cover Story: Eur. J. Immunol. 1&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-01-06T09:37:16+01:00\" class=\"wp-block-latest-posts__post-date\">6 de January de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 1&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/06\/cover-story-eur-j-immunol-126\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 1&#8217;26.\">Read more<\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16986","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16986","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16986"}],"version-history":[{"count":1,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16986\/revisions"}],"predecessor-version":[{"id":16987,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/16986\/revisions\/16987"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16986"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}