{"id":331,"date":"2024-03-03T03:16:53","date_gmt":"2024-03-03T02:16:53","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=331"},"modified":"2025-03-12T11:27:37","modified_gmt":"2025-03-12T10:27:37","slug":"publicaciones","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/publicaciones\/","title":{"rendered":"Publicaciones"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/the-role-of-different-apl-subpopulations-in-the-lupus-anticoagulant-phenomenon\/\">The role of different aPL subpopulations in the lupus anticoagulant phenomenon<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T07:30:56+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 May 4;100:102784. doi: 10.1016\/j.coi.2026.102784. Online ahead of print. ABSTRACT The lupus anticoagulant (LA) phenomenon represents a paradoxical prothrombotic state characterised by inhibition of phospholipid-dependent coagulation assays in vitro, despite a strong association with thrombosis and pregnancy morbidity in vivo. LA is a central laboratory criterion for the diagnosis and risk stratification &#8230; <a title=\"The role of different aPL subpopulations in the lupus anticoagulant phenomenon\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/the-role-of-different-apl-subpopulations-in-the-lupus-anticoagulant-phenomenon\/\" aria-label=\"Read more about The role of different aPL subpopulations in the lupus anticoagulant phenomenon\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/chemokine-receptor-expression-defines-a-trajectory-from-monocytes-to-mature-macrophages-in-the-lungheather-mathie-on-5-de-may-de-2026-at-1000\/\">Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung\u200bHeather Mathie   on 5 de May de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T07:30:51+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 May 6:qiag059. doi: 10.1093\/jleuko\/qiag059. Online ahead of print. ABSTRACT CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte\/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Using transcriptomic approaches to examine inflammatory chemokine receptor expression on lung &#8230; <a title=\"Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung\u200bHeather Mathie   on 5 de May de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/chemokine-receptor-expression-defines-a-trajectory-from-monocytes-to-mature-macrophages-in-the-lungheather-mathie-on-5-de-may-de-2026-at-1000\/\" aria-label=\"Read more about Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung\u200bHeather Mathie   on 5 de May de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1852625\">Editorial: Lipid influence on lung immune-structural cell crosstalk: implications for respiratory health<\/a><div class=\"wp-block-latest-posts__post-author\">by Benoit Allard<\/div><time datetime=\"2026-05-06T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1864583\">Editorial: Overcoming resistance to immune checkpoint inhibitors: mechanisms and strategies in cancer therapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Margherita Piccinelli<\/div><time datetime=\"2026-05-06T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1859297\">Editorial: Beyond therapeutic innovation in genitourinary cancers: the unmet need for biologically driven patient selection<\/a><div class=\"wp-block-latest-posts__post-author\">by Brigida Anna Maiorano<\/div><time datetime=\"2026-05-06T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/immune-landscape-of-covid-19-recovery-nucleocapsid-as-a-major-target-of-cd8-t-cell-antiviral-responses-in-convalescent-hla-a2-individuals-from-brazilagata-lopes-ribeiro-on-5-de-may-de-2\/\">Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil\u200b\u00c1gata Lopes-Ribeiro   on 5 de May de 2026 at 10:00<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T01:22:49+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Leukoc Biol. 2026 May 5:qiag050. doi: 10.1093\/jleuko\/qiag050. Online ahead of print. ABSTRACT Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific responses of acute and post-acute COVID-19 patients. Our results indicate that convalescent individuals displayed &#8230; <a title=\"Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil\u200b\u00c1gata Lopes-Ribeiro   on 5 de May de 2026 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/immune-landscape-of-covid-19-recovery-nucleocapsid-as-a-major-target-of-cd8-t-cell-antiviral-responses-in-convalescent-hla-a2-individuals-from-brazilagata-lopes-ribeiro-on-5-de-may-de-2\/\" aria-label=\"Read more about Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil\u200b\u00c1gata Lopes-Ribeiro   on 5 de May de 2026 at 10:00\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/uba2-high-osteosarcoma-suppresses-immune-infiltration-by-autophagy-mediated-mhc-i-degradation\/\">UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-06T01:22:49+02:00\" class=\"wp-block-latest-posts__post-date\">6 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cancer Immunol Res. 2026 May 5. doi: 10.1158\/2326-6066.CIR-25-1321. Online ahead of print. ABSTRACT Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a &#8230; <a title=\"UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/06\/uba2-high-osteosarcoma-suppresses-immune-infiltration-by-autophagy-mediated-mhc-i-degradation\/\" aria-label=\"Read more about UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e012427?rss=1\">Characterization of aberrant alternative splicing landscape in patients with metastatic renal cell carcinoma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T16:00:19+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nPurpose\nAberrant alternative splicing (AS) events have been implicated in cancer progression; however, their role in metastatic renal cell carcinoma (mRCC) remains underexplored. This study aims to identify AS events associated with clinical benefits &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01308-z\">CRISPR screen reveals regulators of age-associated CD8&lt;sup&gt;+&lt;\/sup&gt; T cell dysfunction in cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by Matthew Bianca<\/div><time datetime=\"2026-05-05T12:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 05 May 2026; doi:10.1038\/s41577-026-01308-zA preprint by Chen et al. identifies Dusp5 and Zfp219 as regulators of age-associated T cell dysfunction in the tumour microenvironment.<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/spatial-multiomics-reveal-insights-into-adc-efficacy-valueosman-goni-niklas-klumper-maria-del-mar-muniz-moreno-markus-eckstein-christoph-kuppe\/\">Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Spatial multiomics profiling can reveal how tumor heterogeneity and microenvironment influence ADC efficacy. Combining spatial transcriptomics, proteomics, and AI-based analysis improves the identification of tissue factors influencing therapy response. This integrative approach potentially enables prediction of response, resistance, and optimized patient selection, which we review here. ABSTRACT Antibody\u2013drug conjugates (ADCs) have transformed the therapeutic landscape &#8230; <a title=\"Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/spatial-multiomics-reveal-insights-into-adc-efficacy-valueosman-goni-niklas-klumper-maria-del-mar-muniz-moreno-markus-eckstein-christoph-kuppe\/\" aria-label=\"Read more about Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{&#8220;value&#8221;:&#8221;Osman Goni, \nNiklas Kl\u00fcmper, \nMaria del Mar Mu\u00f1iz Moreno, \nMarkus Eckstein, \nChristoph Kuppe&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/syk-signalling-in-nlrp3-inflammasome%e2%80%90mediated-response-of-murine-microglia-activated-by-immune-complexes-formed-of-viral-proteins-and-specific-igg-valuekristina-masalaite-milda-no\/\">SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IC-mediated inflammatory response\u2014the NLRP3 inflammasome activation, cytokine secretion, and antigen presentation depend on SYK signalling pathways in primary murine microglia. ABSTRACT Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation, but the precise mechanism remains unknown. The NLRP3 inflammasome is a vital component of &#8230; <a title=\"SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/syk-signalling-in-nlrp3-inflammasome%e2%80%90mediated-response-of-murine-microglia-activated-by-immune-complexes-formed-of-viral-proteins-and-specific-igg-valuekristina-masalaite-milda-no\/\" aria-label=\"Read more about SYK Signalling in NLRP3 Inflammasome\u2010Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{&#8220;value&#8221;:&#8221;Kristina Ma\u0161alait\u0117, \nMilda Norkien\u0117, \nAurelija \u017dvirblien\u0117, \nAsta Lu\u010di\u016bnait\u0117&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/borrelia-burgdorferi-sensu-lato-employs-several-escape-mechanisms-to-bypass-the-human-defense-system-valuezara-karami-hadewych-j-m-ter-hofstede-leo-a-b-joosten\/\">Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:05:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva-mediated suppression of innate defenses, TLR2\/NOD2-driven cytokine dysregulation, and interference with JAK\/STAT and CIITA-dependent antigen presentation. Impaired autophagy skews responses toward pathogenic Th17 activity, while disrupted lymph node architecture, persistent IgM, and defective CD4+ T cell function collectively impair &#8230; <a title=\"Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/borrelia-burgdorferi-sensu-lato-employs-several-escape-mechanisms-to-bypass-the-human-defense-system-valuezara-karami-hadewych-j-m-ter-hofstede-leo-a-b-joosten\/\" aria-label=\"Read more about Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{&#8220;value&#8221;:&#8221;Zara Karami, \nHadewych J. M. ter Hofstede, \nLeo A. B. Joosten&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/cover-story-eur-j-immunol-526\/\">Cover Story: Eur. J. Immunol. 5&#8217;26.<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:04:59+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI&#8217;s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared &#8230; <a title=\"Cover Story: Eur. J. Immunol. 5&#8217;26.\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/cover-story-eur-j-immunol-526\/\" aria-label=\"Read more about Cover Story: Eur. J. Immunol. 5&#8217;26.\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/adapted-live-sars%e2%80%90cov%e2%80%902-vaccine-elicits-rapid-mucosal-immunity-protects-from-disease-and-reduces-shedding-of-xbb-1-5-valuejana-kochmann-tobias-britzke-nico-joel-halwe\/\">Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-05T11:04:59+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">An attenuated live vaccine (OTS-300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination. Therefore, vaccination with the OTS LAV platform may help to disrupt transmission chains. ABSTRACT The emergence of &#8230; <a title=\"Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/05\/adapted-live-sars%e2%80%90cov%e2%80%902-vaccine-elicits-rapid-mucosal-immunity-protects-from-disease-and-reduces-shedding-of-xbb-1-5-valuejana-kochmann-tobias-britzke-nico-joel-halwe\/\" aria-label=\"Read more about Adapted Live SARS\u2010CoV\u20102 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5. [[{&#8220;value&#8221;:&#8221;Jana Kochmann, \nTobias Britzke, \nNico Jo\u00ebl Halwe, \nLorenz Ulrich, \nAngele Breithaupt, \nG. Tuba Barut, \nNadine Ebert, \nBettina Salome Tr\u00fceb, \nVolker Thiel, \nAnca Dorhoi, \nMartin Beer, \nDonata Hoffmann, \nBj\u00f6rn Corleis, \nJacob Sch\u00f6n&#8221;}]]\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01303-4\">Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by Shokrollah Elahi<\/div><time datetime=\"2026-05-05T10:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 05 May 2026; doi:10.1038\/s41577-026-01303-4This Review from Shokrollah Elahi considers how erythroid cells \u2014 including erythroid progenitors and precursors and mature red blood cells \u2014 can m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1805513\">Immunity beyond borders: non-lethal Plasmodium confers cross-protection against lethal Babesia via macrophage activation<\/a><div class=\"wp-block-latest-posts__post-author\">by Iqra Zafar<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionIn co-endemic regions, hosts are concurrently infected by related apicomplexan hemoparasites, Plasmodium and the zoonotic pathogen Babesia. This study investigates how Plasmodium berghei XAT-Babesia rodhaini co-infection modulates host immu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1811583\">Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis<\/a><div class=\"wp-block-latest-posts__post-author\">by Qingyi Mao<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundNumerous studies indicated inflammatory bowel disease (IBD) patients suffered from sleep disturbances. Although melatonin (MT) exerts positive effects on maintaining circadian rhythms and anti-inflammation, its impact on the gut microbiome an&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1845580\">Obinutuzumab-induced acute thrombocytopenia and leukopenia in ANCA-associated glomerulonephritis: case report and literature review<\/a><div class=\"wp-block-latest-posts__post-author\">by Yiming Jin<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Obinutuzumab is a humanized type II anti-CD20 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity. It is widely used in B-cell malignancies and is increasingly being explored in autoimmune diseases such as lupus nephritis. The ma&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1834595\">Antigen-specific tolerance and control of autoimmunity effected by liver sinusoidal endothelial cells is unimpaired in liver fibrosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Cornelia Gottwick<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Background and aimsLiver sinusoidal endothelial cells (LSECs) have a key role in maintaining organismal homeostasis by scavenging blood-borne molecules and inducing specific immune tolerance to ingested antigens. The scavenger and tolerance function of&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1808890\">Surface-enhanced Raman spectroscopy-based liquid biopsy for diagnosis and classification of lupus nephritis using urine biomarkers<\/a><div class=\"wp-block-latest-posts__post-author\">by Xue Xia<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Background Lupus nephritis (LN) is a leading cause of mortality in patients with systemic lupus erythematosus (SLE), and the accurate classification of renal pathological subtypes is crucial for reducing mortality rates and improving long-term prognosi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1816335\">Immune cells and high-density lipoprotein cholesterol derivative markers mediate the impact of hypertriglyceridemia on hyperuricemia in diabetes mellitus<\/a><div class=\"wp-block-latest-posts__post-author\">by Wei Wang<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundAs markers of inflammation and oxidative stress, immune cells and high-density lipoprotein cholesterol (HDL-c) derivative markers, such as the monocyte to HDL-c ratio (MHR) and lymphocyte to HDL-c ratio (LHR), have been widely utilized in cli&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1787877\">Preclinical evaluation of a multi-epitope mRNA vaccine platform for broad and durable SARS-CoV-2 protection<\/a><div class=\"wp-block-latest-posts__post-author\">by Laura Marcos-Villar<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionThe emergence of immune-evasive SARS-CoV-2 variants has exposed limitations in the breadth and durability of protection conferred by current Spike-based vaccines, highlighting the need for next-generation approaches targeting conserved vira&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1784757\">Ankylosing spondylitis and the gut microbiome: future research hotspots and trends<\/a><div class=\"wp-block-latest-posts__post-author\">by Xingxiao Yin<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundAnkylosing spondylitis (AS) is an autoimmune disease. Its exact cause remains unclear. It is generally believed to result from a combination of genetic and environmental factors, as well as immune disorders. However, growing evidence suggests&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1798542\">NLRP3 inflammasomes at the ARDS-cancer interface: mechanisms and translational hypotheses<\/a><div class=\"wp-block-latest-posts__post-author\">by Salima Shebbo<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Acute respiratory distress syndrome (ARDS) and cancer share common pathogenetic mechanisms that involve immune dysregulation and inflammatory responses. Inflammasomes, part of the initial innate immune response to infection and injury, play a pivotal r&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1792155\">Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation<\/a><div class=\"wp-block-latest-posts__post-author\">by Poorya Foroutan Pajoohian<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study was to assess how vaccine delivery routes (homologous versus heterologous) in mice &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1790014\">Correction: Premature renal epithelial cell senescence promoted by LXN\/Rps3\/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage polarization<\/a><div class=\"wp-block-latest-posts__post-author\">by Maolin Chu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1702830\">Performance of Tai Chi Chuan and NF-\u03baB-driven proinflammatory gene expression (IL-6, IL-1\u03b2, TNF-\u03b1) in adult chronic disease patients: a systematic review and meta-analysis of randomized controlled trials<\/a><div class=\"wp-block-latest-posts__post-author\">by Si-Qi Zhu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveThis systematic review and meta-analysis aims to evaluate the effects of Tai Chi Chuan on the expression of pro-inflammatory genes IL-6, IL-1\u03b2, and TNF-\u03b1\u2014downstream of the NF-\u03baB pathway\u2014in adults with chronic diseases. It further explores pote&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1733373\">Antibiotic use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database<\/a><div class=\"wp-block-latest-posts__post-author\">by Jia Yu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundThe use of antibiotics may influence the efficacy and toxicity of immune checkpoint inhibitors (ICIs) by altering the gut microbiota. However, current evidence on the link between antibiotic use and immune-related adverse events (irAEs) is li&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1778359\">Recurrent spinal IgG4-related hypertrophic pachymeningitis and its management: a case report<\/a><div class=\"wp-block-latest-posts__post-author\">by Gorbachev Jowah<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">AimIn this report, we share a case of recurrent spinal immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis (IgG4-RHP) in a patient who initially achieved near-complete recovery of muscle weakness after decompression surgery and steroid therap&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1726565\">T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype<\/a><div class=\"wp-block-latest-posts__post-author\">by Aaron B. Schultz<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutations of STAT3 are strikingly pre&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1781797\">Immunometabolic control of cytokine production by micronutrients in health, aging, and inflammation<\/a><div class=\"wp-block-latest-posts__post-author\">by Joyeta Ghosh<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Micronutrients serve as critical metabolic sensors and epigenetic regulators that orchestrate cytokine production through multiple overlapping signalling cascades, transcriptional networks, and cellular metabolic states. This comprehensive review synth&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1751523\">Cell death in uveitis: pyroptosis, ferroptosis, apoptosis, and beyond<\/a><div class=\"wp-block-latest-posts__post-author\">by Jianxin Liu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Uveitis is a group of diseases characterized by intraocular inflammation, closely associated with infectious, autoimmune, genetic, or environmental factors. Cell death, a critical biological process involved in development, the maintenance of homeostas&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1772425\">Compositional maturation of the microbiome and adaptive immunity in the postnatal period<\/a><div class=\"wp-block-latest-posts__post-author\">by Miranda Green<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionRecent research has highlighted the role of the gut microbiome in shaping the development and function of the mammalian immune system. Interactions between these complex networks of microbes and host cells serve not only to train major aspe&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1793865\">Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies<\/a><div class=\"wp-block-latest-posts__post-author\">by Xingyu Su<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Non-infectious uveitis encompasses a diverse array of autoimmune ocular disorders marked by the breakdown of immune tolerance and recurrent inflammatory episodes. Regulatory T cells (Tregs) are integral to the maintenance of ocular homeostasis in all s&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1818127\">The antimicrobial potential of the secretome from Wharton\u2019s jelly mesenchymal stem cells in the context of regenerative medicine: an in vitro study<\/a><div class=\"wp-block-latest-posts__post-author\">by Filomena Napolitano<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionThe secretome derived from Mesenchymal Stem Cells (MSCs) have received significant attention as a promising tool in regenerative medicine. This \u201ccell-free\u201d strategy offers a promising alternative to stem cell therapies, potentially avoiding&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1823338\">Biomarkers for predicting immunotherapy response and resistance in glioblastoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Samuel Kim<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Glioblastoma is the most common and aggressive primary brain tumor in adults that fails to meet survival endpoint criteria in current immunotherapy Phase III clinical trials. As a small subset of immunotherapy-responsive patients has been identified, b&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1796042\">Qijia Rougan Formula alleviates liver fibrosis by inhibiting NLRP3-mediated pyroptosis and regulating macrophage polarization<\/a><div class=\"wp-block-latest-posts__post-author\">by Xin Ding<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundStage F3 liver fibrosis represents a critical phase for intercepting the progression toward irreversible cirrhosis. Despite its clinical significance, effective interventions remain scarce. Clinical observations indicate that the traditional &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1823240\">STING inhibits viral lytic reactivation and cell growth in primary effusion lymphoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Tiffany S. Nelson<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) is a DNA virus linked to multiple malignancies associated with compromised immunity, such as Kaposi\u2019s sarcoma (KS) and primary effusion lymphoma (PEL). These malignancies are strongly linked to HIV coinfec&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1810985\">Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Gunapati Bhargavi<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">L-arginine (ARG) availability is a critical determinant of macrophage antimicrobial capacity, as it fuels nitric oxide production and other immune effector pathways essential for restricting Mycobacterium tuberculosis (Mtb), the causative agent of tube&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1764099\">Research progress in the inhibitory mechanisms of traditional Chinese medicine therapies against influenza A<\/a><div class=\"wp-block-latest-posts__post-author\">by Mingjiang Liu<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Influenza A, an acute or subacute respiratory infectious disease caused by the influenza A virus (IAV), affects humans and animals, and poses a serious threat to public health. Currently, IAV prevention and treatment rely primarily on antiviral drugs a&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1777564\">Design of the MERCURION-IPF trial \u2013 intravenous immunoglobulin for the treatment of acute exacerbations of idiopathic pulmonary fibrosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Vasilina Sotiropoulou<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionDespite their profound clinical impact and high mortality, acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) still lack any effective or standardized treatment strategies. This manuscript describes the rationale and design of a &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1829051\">CD8 regulatory T cells are a novel type regulatory T cells in the induction of transplantation immune tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Jin-can Huang<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveRegulatory T cells (Tregs) play an essential role in transplantation immune tolerance. Although CD4+ Tregs have been extensively studied, the contribution of CD8+ regulatory T-cell subsets to transplant tolerance remains less well defined. Thi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1789537\">MesenSistem-EB: systemic haploidentical mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa associated with clinical benefits and correlated with MCP1 and sCD40L dynamics<\/a><div class=\"wp-block-latest-posts__post-author\">by Roc\u00edo Maseda<\/div><time datetime=\"2026-05-05T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">5 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundRecessive dystrophic epidermolysis bullosa (RDEB) is a devastating genodermatosis caused by biallelic COL7A1 mutations, where chronic inflammation drives disabling complications affecting quality of life and survival. Effective inflammatory c&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014314?rss=1\">Safety and immunogenicity of a tri-antigen vaccine targeting IGFBP-2, HER2, and IGF-IR in participants with non-metastatic breast cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nDuctal carcinoma in situ (DCIS) is a preinvasive form of breast cancer. Current treatment consists of surgery, radiation, and often systemic therapy exposing patients to unnecessary health risks. Vaccines targeting DCIS may be a way to inte&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e013906?rss=1\">Phase II trial of combination radiation, hormone, and immunotherapy in grade group 5 prostate cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nGrade group 5 (GG5) prostate cancer (PCa) carries a less favorable prognosis after standard-of-care (SOC) therapy, necessitating novel therapeutic approaches. High-dose rate brachytherapy (HDRBT) and androgen deprivation therapy (ADT) may m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e009702?rss=1\">Cancer-associated fibroblast targeting therapies as a tool to enhance responses to radiotherapy and immunotherapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Garate-Soraluze, E., Martinez-Zubiaurre, I., Rodriguez-Ruiz, M. E.<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nCancer-associated fibroblasts (CAFs) are one of the main components of the tumor microenvironment (TME) of solid tumors. They have several functions, which all contribute to tumor growth and immune evasion. CAF presence is associated with poor clinica&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014592?rss=1\">CAR-engineering of innate and innate-like immune cells: a new horizon in adoptive cell therapy for solid tumors<\/a><div class=\"wp-block-latest-posts__post-author\">by Nardo, G., Putti, F., Indini, A., Del Vecchio, M., De Braud, F., Di Nicola, M., De Santis, F.<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nChimeric antigen receptor (CAR) therapies have revolutionized cancer immunotherapy, particularly in hematologic malignancies, but their efficacy in solid tumors remains limited. Key barriers include tumor antigen heterogeneity, on-target\/of&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e015063?rss=1\">Discontinuation of combo immunotherapy and outcome of patients with melanoma brain metastases<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nNivolumab plus ipilimumab (COMBO) is the standard treatment for asymptomatic melanoma brain metastases (MBM), but current guidelines do not provide specific recommendations for treatment discontinuation in responding patients. This study ai&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014555?rss=1\">Patient-derived organotypic tumor spheroids as a functional platform for predicting immunotherapeutic responses and guiding precision treatment for hepatocellular carcinoma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nHepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide. While immune checkpoint blockade has revolutionized the treatment of many cancers, responses in HCC remain limited. Robust functional platforms capable of&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/5\/e014346?rss=1\">Phase 2 study of palbociclib plus retifanlimab in patients with advanced dedifferentiated liposarcoma<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T17:49:10+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nThe cyclin-dependent kinase 4 and 6 (CDK4\/6) inhibitor palbociclib delays disease progression in dedifferentiated liposarcoma (DDLPS) by inducing tumor cell quiescence or senescence, though most tumors ultimately progress. Preclinical data &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/a-sampling-of-highlights-from-the-literature-article-recommendations-from-our-deputy-and-senior-editors-12\/\">A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T12:41:35+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Cancer Immunol Res. 2026 May 4;14(5):715. doi: 10.1158\/2326-6066.CIR-14-5-WWR. NO ABSTRACT PMID:42076931 | DOI:10.1158\/2326-6066.CIR-14-5-WWR<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king\/\">Cytokine networks driving eosinophil functional heterogeneity. James I King<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-05-04T06:37:14+02:00\" class=\"wp-block-latest-posts__post-date\">4 de May de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mucosal Immunol. 2026 May 1:100347. doi: 10.1016\/j.mucimm.2026.100347. Online ahead of print. ABSTRACT Eosinophils have traditionally been viewed as terminally differentiated type 2 effector cells involved in anti-helminth immunity and allergic inflammation. Recent advances in single-cell transcriptomics have refined this view, revealing substantial developmental and functional heterogeneity across tissues and inflammatory settings. Eosinophil development in the &#8230; <a title=\"Cytokine networks driving eosinophil functional heterogeneity. James I King\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/05\/04\/cytokine-networks-driving-eosinophil-functional-heterogeneity-james-i-king\/\" aria-label=\"Read more about Cytokine networks driving eosinophil functional heterogeneity. James I King\">Read more<\/a><\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-331","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=331"}],"version-history":[{"count":3,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/331\/revisions"}],"predecessor-version":[{"id":27040,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/331\/revisions\/27040"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}