{"id":331,"date":"2024-03-03T03:16:53","date_gmt":"2024-03-03T02:16:53","guid":{"rendered":"https:\/\/inmuno.es\/?page_id=331"},"modified":"2025-03-12T11:27:37","modified_gmt":"2025-03-12T10:27:37","slug":"publicaciones","status":"publish","type":"page","link":"https:\/\/inmuno.es\/index.php\/publicaciones\/","title":{"rendered":"Publicaciones"},"content":{"rendered":"<ul class=\"wp-block-latest-posts__list is-grid columns-4 has-dates has-author wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/the-role-of-artificial-intelligence-in-clinical-trials-in-adult-and-pediatric-rheumatology\/\">The role of artificial intelligence in clinical trials in adult and pediatric rheumatology<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-21T00:32:05+02:00\" class=\"wp-block-latest-posts__post-date\">21 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Curr Opin Immunol. 2026 Jul 20;102:102818. doi: 10.1016\/j.coi.2026.102818. Online ahead of print. ABSTRACT The development of clinical trials is limited by high costs and methodological complexities. In this context, artificial intelligence (AI) is emerging as a key instrument for their optimization. In the early phases of study design and recruiting, generative AI systems may help &#8230; <a title=\"The role of artificial intelligence in clinical trials in adult and pediatric rheumatology\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/21\/the-role-of-artificial-intelligence-in-clinical-trials-in-adult-and-pediatric-rheumatology\/\" aria-label=\"Read more about The role of artificial intelligence in clinical trials in adult and pediatric rheumatology\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/7\/e014638?rss=1\">Phase 1\/2 study of IMC-C103C, a T cell receptor bispecific (MAGE-A4xCD3) ImmTAC targeting MAGE-A4-expressing malignancies<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-20T14:34:30+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nPurpose\nIMC-C103C is an ImmTAC bispecific (MAGE-A4xCD3) T cell engager targeting a peptide from the cancer-testis antigen MAGE-A4 presented by HLA-A*02:01. This phase 1\/2 study in advanced solid tumors (IMC-C103C-101; NCT03973333) investigated the saf&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/7\/e015029?rss=1\">Frontline immunotherapy with response-guided subsequent treatment (FIRST) in cutaneous squamous cell carcinoma: a Bayesian causal analysis of dose intensity, early benefit, and treatment de-escalation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-20T14:34:30+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nProgrammed death receptor 1 (PD-1) blockade produces high response rates in resectable and locally advanced cutaneous squamous cell carcinoma (CSCC), but how many doses are needed and whether surgery or radiation after immunotherapy (consol&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/7\/e015122?rss=1\">Safety and efficacy of fecal microbiota transplantation in solid cancers resistant to immune checkpoint inhibitors: results of the MITRIC trial<\/a><div class=\"wp-block-latest-posts__post-author\">by Ullern, A., Garborg, K. K., Chauhan, S. K., Holm, K., Bang, C., Dunn, C., Johnsen, P. H., Hov, J. E. R., Kyte, J. A.<\/div><time datetime=\"2026-07-20T14:34:30+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground\nFecal microbiota transplantation (FMT) has shown promise in overcoming resistance to immune checkpoint inhibitors (ICIs) in early-phase cancer trials. We investigated the safety, feasibility and efficacy of FMT from ICI responders to patien&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1890404\">Case Report: Munc13\u20134 deficiency presenting with autoimmune neuropathy years before FLH: implications for early genetic screening and HSCT timing<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaojing Wei<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundThe UNC13D gene encodes Munc13-4, a critical regulator of cytotoxic granule exocytosis in lymphocytes and the protein responsible for familial hemophagocytic lymphohistiocytosis (FHL). As an essential mediator of perforin release from cytotox&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1867098\">CCR1-mediated monocyte chemotaxis in the immunopathology of primary Sj\u00f6gren\u2019s syndrome: multi-omics integration analysis and computational target prioritization implicating Polygonatum odoratum<\/a><div class=\"wp-block-latest-posts__post-author\">by Jianbin Li<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectivePrimary Sj\u00f6gren\u2019s syndrome (pSS) is a chronic systemic autoimmune disease with no specific etiological treatment. Polygonatum odoratum, a traditional yin-nourishing herb, is used in treating pSS, but its molecular mechanism remains unclear. Th&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1857103\">Conformational bias in SARS-CoV-2 Spike CD4+ T-cell epitope dominance<\/a><div class=\"wp-block-latest-posts__post-author\">by Samuel J. Landry<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionEpitope-specific T cells provide significant long-lived protection afforded by adaptive immunity to SARS-CoV-2 spike. CD4+ T-cell epitope peptides that are generated by non-ATP-dependent antigen-processing proteases bind with modest specifi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1850725\">From stasis to systematics: deciphering the pathophysiology of secondary lymphedema through omics<\/a><div class=\"wp-block-latest-posts__post-author\">by Annica R. Stull-Lane<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Secondary lymphedema (LE) can ensue after disruption of lymphatic vasculature, which may be caused by infection, surgery, or cancer treatment. Omics technologies can move the field beyond an anatomic description of lymphatic stasis by defining inflamma&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1805159\">Small extracellular vesicles proteome reveals persistent inflammatory and coagulopathic dysregulation in long-COVID<\/a><div class=\"wp-block-latest-posts__post-author\">by Sivasankar Chandran<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundPost-acute sequelae of SARS-CoV-2 (PASC) or Long-COVID affects millions and remains mechanistically undefined due to its heterogeneous clinical presentation. Identifying robust biological signatures is essential for understanding disease mech&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1864024\">Hormone-dependent immune regulation shapes asthma heterogeneity across the female lifespan<\/a><div class=\"wp-block-latest-posts__post-author\">by Qiaoyu Yang<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Asthma exhibits pronounced sex differences across the human lifespan, shifting from a predominance in males during childhood toward an increased prevalence, severity, and heterogeneity in females following puberty. These epidemiological patterns are no&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1888117\">Fecal microbiota transplantation in ulcerative colitis: mucosal immune mechanisms and precision microbiota therapy<\/a><div class=\"wp-block-latest-posts__post-author\">by Enhui Lu<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Fecal microbiota transplantation (FMT) has emerged as an investigational microbiota-targeted strategy for ulcerative colitis (UC), aiming to restore dysbiotic gut ecosystems and microbiota\u2013host homeostasis. Mechanistic studies suggest that FMT may resh&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1931341\">Correction: New proteomic biomarkers identified in plasma extracellular vesicles in sarcoidosis: a case-control matched study<\/a><div class=\"wp-block-latest-posts__post-author\">by Runzhen Zhao<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1825974\">Case Report: Efgartigimod: a beacon of hope for overlapping stiff-person syndrome and myasthenia gravis following thymoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Jingjing Nie<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The coexistence of stiff person syndrome (SPS) and myasthenia gravis (MG) is exceptionally rare, with fewer than 20 cases reported to date. Thymoma has been identified in a substantial proportion of these patients, suggesting a potential shared autoimm&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1904272\">Comparison of the protective effect of human respiratory syncytial virus Pre-F protein combined with different adjuvants in BALB\/c mice<\/a><div class=\"wp-block-latest-posts__post-author\">by Mengxuan Chu<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionHuman respiratory syncytial virus (HRSV) has a high disease burden in infants and elderly individuals. In this study, the adjuvants AlOH, AlOH+CpG and BFA03 were used to compare the protective effect of HRSV prefusion protein (Pre-F) in BAL&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1779014\">Fibrotic remodeling in the NOD\/ShiLtJ mouse model of Sj\u00f6gren\u2019s disease: insights from single-cell transcriptomics and AI-driven ECM quantification<\/a><div class=\"wp-block-latest-posts__post-author\">by Jennifer M. Morrissey<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionSj\u00f6gren&#8217;s Disease (SjD) is an autoimmune disorder characterized by salivary gland hypofunction and lymphocytic infiltration, yet the contribution of fibrosis to glandular dysfunction remains unclear.MethodsWe evaluated the NOD\/ShiLtJ mouse &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1827602\">Tuberculous meningoencephalitis concurrent with autoimmune glial fibrillary acidic protein astrocytopathy: a case report<\/a><div class=\"wp-block-latest-posts__post-author\">by Yuan Deng<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundTuberculous meningoencephalitis and autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy display similar clinical features, cerebrospinal fluid (CSF) profiles, and neuroimaging patterns, which contribute to a high rate of misdiagn&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1884158\">Integrated airway epithelial signaling networks linking allergen-driven inflammation to airway remodeling in asthma<\/a><div class=\"wp-block-latest-posts__post-author\">by Shin-Young Park<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Asthma is a chronic inflammatory airway disease characterized by persistent immune activation, airway hyperresponsiveness, and progressive structural remodeling. The airway epithelium functions as the primary sensor of inhaled allergens and actively or&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1879355\">Case Report: Overlapping multiple sclerosis and neuropsychiatric systemic lupus erythematosus with positive MOG-IgG: a case initially misdiagnosed as depression<\/a><div class=\"wp-block-latest-posts__post-author\">by Wan Wei<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">We present a 69-year-old female patient who initially manifested with depression and anhedonia, initially misdiagnosed as primary psychiatric illness. She subsequently developed progressive gait instability and cognitive decline. After comprehensive cl&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1894263\">Immunological heterogeneity in rheumatoid arthritis: challenges in early-stage stratification, non-response to targeted therapy, and the restoration of immune tolerance<\/a><div class=\"wp-block-latest-posts__post-author\">by Yanmei Li<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic erosive synovitis, progressive bone destruction, and marked inter-patient heterogeneity in disease course and treatment response. This review critically examines the me&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1876576\">Multi-omics Mendelian randomization integrating GWAS, eQTL, mQTL and pQTL data prioritizes mitochondrial gene FXN as a hypothesis\u2212generating candidate for nephrolithiasis<\/a><div class=\"wp-block-latest-posts__post-author\">by Yanting Wu<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundMitochondrial dysfunction is linked to urolithiasis, but causal genetic drivers remain unclear. We integrated multi-omics data using Mendelian randomization to identify mitochondrial-related genes causally associated with urolithiasis.Methods&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1830627\">Association of serological markers with endoscopic mucosal healing and disease activity in patients with inflammatory bowel disease: a retrospective study<\/a><div class=\"wp-block-latest-posts__post-author\">by Lu Zhou<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">ObjectiveThis study aimed to examine the link between serological markers and endoscopic mucosal healing and inflammation in diagnosis of inflammatory bowel disease (IBD) patients.MethodsClinical data from 200 IBD patients (91 with ulcerative colitis [&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1878482\">Integrating multi-omics data reveals IL-8 positive cancer-associated fibroblasts as mediators of chemotherapy-induced tumor progression in breast cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by Huifeng Liao<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundRecent studies have shown that while chemotherapy kills tumor cells, it may also induce adaptive changes in cells within the tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), which could paradoxically promote tumor pr&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1892405\">Tumor-associated neutrophils in lung adenocarcinoma: from mechanisms to therapeutic targeting<\/a><div class=\"wp-block-latest-posts__post-author\">by Ruichen Zhang<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Lung adenocarcinoma (LUAD) is the predominant subtype of non-small cell lung cancer (NSCLC), characterized by a complex tumor microenvironment (TME) where tumor-associated neutrophils (TANs) exert dual functions\u2014a concept now well-established in broade&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1859932\">CCL20-CCR6 axis mediates mucosal-associated invariant T-M2 macrophage crosstalk to drive immune dysregulation in liver cirrhosis<\/a><div class=\"wp-block-latest-posts__post-author\">by Bochen Chen<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionCirrhosis is the end-stage of chronic liver disease characterized by progressive hepatic fibrosis and persistent immune dysregulation, yet the mechanisms by which immune cell crosstalk drives disease progression remain poorly understood.Met&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1820802\">Single-cell analysis reveals KLF10-high macrophages induced by glioblastoma cells are associated with tumor progression<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaodong Zhang<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundGlioblastoma (GBM) is the most common and aggressive primary malignant tumor of the adult central nervous system, with nearly 90% of cases recurring within two years despite standard surgery, radiotherapy, and chemotherapy. Tumor-associated m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1860149\">Explainable machine learning for predicting venous thromboembolism in septic shock patients<\/a><div class=\"wp-block-latest-posts__post-author\">by Yuanyuan Li<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundVenous thromboembolism (VTE) frequently complicates septic shock, yet precise, individualized risk stratification tools remain scarce. This study aimed to develop and externally validate an explainable machine learning (ML) framework to predi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1861781\">Reader-dependent functional duality of FTO: a context-switching node at the intersection of immune evasion and therapeutic resistance<\/a><div class=\"wp-block-latest-posts__post-author\">by WenJie Tian<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The fat mass and obesity-associated protein (FTO), an RNA demethylase acting on both internal m6;A and cap-proximal m6;Am, functions in cancer as a context-dependent epitranscriptomic regulator whose net effect cannot be reduced to an oncogene\u2013tumor-su&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1927032\">Editorial: Metabolite-induced metabolic reprogramming in the immune system<\/a><div class=\"wp-block-latest-posts__post-author\">by Jacqueline Oliva-Ram\u00edrez<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\"><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1899202\">Tea saponin\u2013soybean oil submicron emulsion promotes durable protective immunity against Pasteurella multocida<\/a><div class=\"wp-block-latest-posts__post-author\">by Xuemei Cui<\/div><time datetime=\"2026-07-20T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">20 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">BackgroundInactivated Pasteurella multocida (Pm) vaccines are safe and practical for veterinary use, but their protection is often limited by weak cellular immune activation and insufficient durability of antibody responses. This study investigated whe&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/19\/dysregulated-muc5b-and-muc5ac-impair-epithelial-barrier-function-and-alter-granulocyte-frequency-and-activation-in-the-lung-and-distal-sites-neeraj-patil\/\">Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites. Neeraj Patil<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-19T07:00:50+02:00\" class=\"wp-block-latest-posts__post-date\">19 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mucosal Immunol. 2026 Jul 18:100385. doi: 10.1016\/j.mucimm.2026.100385. Online ahead of print. ABSTRACT BACKGROUND: Mucus obstructs the airways in respiratory diseases where MUC5B is the major gel-forming mucin in COPD and MUC5AC-rich mucus dominates in asthma. Mucin production changes in response to inflammatory signals, but whether mucin dysregulation drives inflammation is less studied. OBJECTIVE: We sought &#8230; <a title=\"Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites. Neeraj Patil\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/19\/dysregulated-muc5b-and-muc5ac-impair-epithelial-barrier-function-and-alter-granulocyte-frequency-and-activation-in-the-lung-and-distal-sites-neeraj-patil\/\" aria-label=\"Read more about Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites. Neeraj Patil\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/accumulation-of-mucosal-and-lymphoid-hypo-functional-granzyme-k-producing-cd8-effector-memory-t-cells-in-idiopathic-pulmonary-fibrosis-jetina-okereke\/\">Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis. Jetina Okereke<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T07:28:15+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mucosal Immunol. 2026 Jul 17:100387. doi: 10.1016\/j.mucimm.2026.100387. Online ahead of print. ABSTRACT Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options are limited; lung transplantation remains the only definitive treatment. The adaptive immune system has been &#8230; <a title=\"Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis. Jetina Okereke\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/accumulation-of-mucosal-and-lymphoid-hypo-functional-granzyme-k-producing-cd8-effector-memory-t-cells-in-idiopathic-pulmonary-fibrosis-jetina-okereke\/\" aria-label=\"Read more about Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis. Jetina Okereke\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/fluorescence-tracking-cd8-t-cells-from-tumor-draining-lymph-nodes-to-irradiated-tumors-and-their-activation-in-the-tumor-environment\/\">Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag142. doi: 10.1093\/jimmun\/vkag142. ABSTRACT Radiation is an effective site-specific cytotoxic therapy for cancer cells. In preclinical models, CD8 T cells are essential for optimum tumor control by radiation therapy, yet CD8 T cells are radiosensitive and depleted within the treatment field. Irradiated tumors can be refilled with T cells that were &#8230; <a title=\"Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/fluorescence-tracking-cd8-t-cells-from-tumor-draining-lymph-nodes-to-irradiated-tumors-and-their-activation-in-the-tumor-environment\/\" aria-label=\"Read more about Fluorescence tracking CD8 T cells from tumor-draining lymph nodes to irradiated tumors and their activation in the tumor environment\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/single-cell-analysis-of-ovarian-immune-cells-reveals-dynamic-changes-in-nk-and-b-cell-populations-after-ovarian-stimulation\/\">Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag153. doi: 10.1093\/jimmun\/vkag153. ABSTRACT The mammalian ovary is the dynamic end-organ of the hypothalamic-pituitary-ovarian axis. In this coordinated system, ovarian cells undergo continuous cycles of apoptosis, proliferation, and differentiation. These changes parallel fluctuations in ovarian hormones such as estradiol; however, the ovarian immune microenvironment during high- and low-estradiol states remains incompletely &#8230; <a title=\"Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/single-cell-analysis-of-ovarian-immune-cells-reveals-dynamic-changes-in-nk-and-b-cell-populations-after-ovarian-stimulation\/\" aria-label=\"Read more about Single-cell analysis of ovarian immune cells reveals dynamic changes in NK and B-cell populations after ovarian stimulation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/the-transcription-factor-srebp2-supports-the-activation-and-homeostasis-of-cd4-foxp3-regulatory-t-cells\/\">The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag181. doi: 10.1093\/jimmun\/vkag181. ABSTRACT Periodic activation of regulatory T cells (Tregs) is necessary to restrict autoreactive T cells and maintain immune homeostasis. IL-2-STAT5 signaling instructs several metabolic processes underlying Treg activation, including the mevalonate pathway, which is crucial for optimal Treg responses. However, direct links between IL-2-STAT5, mevalonate, and Treg function &#8230; <a title=\"The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/the-transcription-factor-srebp2-supports-the-activation-and-homeostasis-of-cd4-foxp3-regulatory-t-cells\/\" aria-label=\"Read more about The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/pari-deficiency-leads-to-increased-somatic-hypermutation\/\">PARI deficiency leads to increased somatic hypermutation<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-18T01:24:41+02:00\" class=\"wp-block-latest-posts__post-date\">18 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag031. doi: 10.1093\/jimmun\/vkag031. ABSTRACT Somatic hypermutation of immunoglobulin (Ig) genes in germinal center B cells is based on the introduction of DNA lesions by activation-induced cytidine deaminase (AID), followed by lesion processing by multiple error-prone DNA repair pathways. Error-free DNA repair by homologous recombination (HR) is required for the repair of &#8230; <a title=\"PARI deficiency leads to increased somatic hypermutation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/18\/pari-deficiency-leads-to-increased-somatic-hypermutation\/\" aria-label=\"Read more about PARI deficiency leads to increased somatic hypermutation\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/t-cell-mir-155-regulates-the-response-to-tumor-specific-mrna-vaccines-in-a-murine-model-of-acute-myeloid-leukemia\/\">T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag184. doi: 10.1093\/jimmun\/vkag184. ABSTRACT Acute myeloid leukemia (AML) is a malignant clonal expansion of myeloid progenitor cells that impedes normal hematopoiesis and culminates in bone marrow failure and death. The development of chemoresistant disease in response to first-line chemotherapies is common and indicates a need for new therapies. Tumor-specific mRNA vaccines &#8230; <a title=\"T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/t-cell-mir-155-regulates-the-response-to-tumor-specific-mrna-vaccines-in-a-murine-model-of-acute-myeloid-leukemia\/\" aria-label=\"Read more about T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/mtecs-and-b-cells-form-a-thymic-microniche-associated-with-b-cell-licensing\/\">mTECs and B cells form a thymic microniche associated with B-cell licensing<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag185. doi: 10.1093\/jimmun\/vkag185. ABSTRACT Thymic B cells rely on T cells and type-III IFN (IFN-\u03bb) signaling for class switch recombination and effective licensing as APCs, a process essential for their role in establishing central T-cell tolerance. IFN-\u03bb is produced exclusively by a subset of medullary thymic epithelial cells (mTECs); however, the &#8230; <a title=\"mTECs and B cells form a thymic microniche associated with B-cell licensing\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/mtecs-and-b-cells-form-a-thymic-microniche-associated-with-b-cell-licensing\/\" aria-label=\"Read more about mTECs and B cells form a thymic microniche associated with B-cell licensing\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/hidden-effects-of-polymyxin-b-its-role-in-activating-tlr2-mediated-inflammatory-responses\/\">Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T13:14:03+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Immunol. 2026 Jul 10;215(7):vkag193. doi: 10.1093\/jimmun\/vkag193. ABSTRACT Polymyxins are cyclic cationic lipopeptide antibiotics that disrupt both the outer and inner membranes of Gram-negative bacteria. They also bind to bacterial lipopolysaccharides (LPSs), thereby inhibiting LPS recognition by Toll-like receptor 4 (TLR4) and preventing macrophage activation. However, the immunomodulatory effects of polymyxin B during infection, in &#8230; <a title=\"Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/hidden-effects-of-polymyxin-b-its-role-in-activating-tlr2-mediated-inflammatory-responses\/\" aria-label=\"Read more about Hidden effects of polymyxin B: Its role in activating TLR2-mediated inflammatory responses\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/7\/e015303?rss=1\">Spatial architecture of tertiary lymphoid structures represents an independent prognostic dimension in hepatocellular carcinoma<\/a><div class=\"wp-block-latest-posts__post-author\">by Liu, W., Zhu, C., Cui, Z., Shi, J., Zhang, B., Xiong, A., Wang, L., Gao, Q., Ding, G., Liu, X.<\/div><time datetime=\"2026-07-17T12:44:23+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nBackground and aims\nTertiary lymphoid structures (TLS) are associated with heterogeneous outcomes in hepatocellular carcinoma (HCC), but whether their anatomical context determines clinical impact remains unknown. We hypothesized that spatial compartm&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"http:\/\/jitc.bmj.com\/cgi\/content\/short\/14\/7\/e015274?rss=1\">RAS signaling at the crossroads of radioresistance and tumor immunity<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T12:44:23+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\nRAS mutations are among the most prevalent oncogenic drivers in solid tumors and are consistently associated with suboptimal responses to radiation therapy (RT). Within this family, KRAS is the dominant isoform and a central regulator of tumor stress &#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/igg4-related-hepatic-disease-unmasking-hepatic-actinomycosis\/\">IgG4-Related Hepatic Disease Unmasking Hepatic Actinomycosis<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T12:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">J Clin Immunol. 2026 Jul 18. doi: 10.1007\/s10875-026-02049-3. Online ahead of print. ABSTRACT PURPOSE: Hepatic actinomycosis is a rare granulomatous disease caused by an opportunistic Gram-positive bacillus of the genus Actinomyces. We report an unusual association between hepatic actinomycosis and IgG-4 related disease. CASE DESCRIPTION: A 70-year-old man was admitted to the University Hospital of &#8230; <a title=\"IgG4-Related Hepatic Disease Unmasking Hepatic Actinomycosis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/igg4-related-hepatic-disease-unmasking-hepatic-actinomycosis\/\" aria-label=\"Read more about IgG4-Related Hepatic Disease Unmasking Hepatic Actinomycosis\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41577-026-01334-x\">Macrophages are constitutive architects of tissue integrity<\/a><div class=\"wp-block-latest-posts__post-author\">by Miriam Merad<\/div><time datetime=\"2026-07-17T11:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Nature Reviews Immunology, Published online: 17 July 2026; doi:10.1038\/s41577-026-01334-xThe lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintena&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41423-026-01451-6\">The Parkinson\u2019s disease-linked &lt;i&gt;G2019S&lt;\/i&gt; mutation of &lt;i&gt;LRRK2&lt;\/i&gt; increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections<\/a><div class=\"wp-block-latest-posts__post-author\">by Kate Hurley<\/div><time datetime=\"2026-07-17T10:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Cellular &amp; Molecular Immunology, Published online: 17 July 2026; doi:10.1038\/s41423-026-01451-6The Parkinson\u2019s disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacter&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.nature.com\/articles\/s41423-026-01449-0\">Author Correction: DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury<\/a><div class=\"wp-block-latest-posts__post-author\">by Shisuo Du<\/div><time datetime=\"2026-07-17T10:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">\n                Cellular &amp; Molecular Immunology, Published online: 17 July 2026; doi:10.1038\/s41423-026-01449-0Author Correction: DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciimmunol.aee0990?af=R\">Macrophage-derived oxysterols organize T helper 2 cells to suppress type 1 inflammation during pulmonary fungal infection<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Science Immunology, Volume 11, Issue 121, July 2026. <\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciimmunol.adv1149?af=R\">Mucosal tissue cues shape B cell memory through the IgA BCR<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T09:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Science Immunology, Volume 11, Issue 121, July 2026. <\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/gone-but-not-forgotten-lung-infection-history-shapes-future-respiratory-immunity-alicia-dirlam\/\">Gone but not forgotten: lung infection history shapes future respiratory immunity. Alicia Dirlam<\/a><div class=\"wp-block-latest-posts__post-author\">by inmunoadmin<\/div><time datetime=\"2026-07-17T07:04:50+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Mucosal Immunol. 2026 Jul 16:100386. doi: 10.1016\/j.mucimm.2026.100386. Online ahead of print. ABSTRACT After respiratory infection, the lung does not simply return to the prior baseline but adopts a new distinct post-infection steady state involving durable imprints that can shape tissue responses to subsequent challenges. This review introduces the concept of lung tissue memory, whereby prior &#8230; <a title=\"Gone but not forgotten: lung infection history shapes future respiratory immunity. Alicia Dirlam\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/07\/17\/gone-but-not-forgotten-lung-infection-history-shapes-future-respiratory-immunity-alicia-dirlam\/\" aria-label=\"Read more about Gone but not forgotten: lung infection history shapes future respiratory immunity. Alicia Dirlam\">Read more<\/a><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1901126\">Parasite in cancer therapy: molecular mechanisms and translational potential<\/a><div class=\"wp-block-latest-posts__post-author\">by Juanyan Liao<\/div><time datetime=\"2026-07-17T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Parasite-derived molecules have emerged as a promising source of natural bioactive compounds with immunomodulatory and antitumor properties, attracting increasing attention in cancer research. Derived from both protozoan and helminth parasites, these m&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1855111\">Fetal sex shapes maternal immune adaptation: placental extracellular vesicles differentially reprogram the phenotype, metabolism, and function of circulating monocytes<\/a><div class=\"wp-block-latest-posts__post-author\">by Julieta Avalos<\/div><time datetime=\"2026-07-17T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">IntroductionMaternal immune adaptation during pregnancy is orchestrated by dynamic signals from the uterine microenvironment, including placental extracellular vesicles (pEVs) released into maternal circulation. EVs have emerged as key mediators of thi&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1892750\">Melissa officinalis extract selectively suppresses STAT1 signaling in oral epithelial cells<\/a><div class=\"wp-block-latest-posts__post-author\">by Issam Rasheed<\/div><time datetime=\"2026-07-17T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Oral inflammatory diseases such as oral lichen planus are characterized by dysregulated chemokine production and persistent interferon-associated signaling, with JAK\/STAT pathways playing a central role in epithelial-immune crosstalk. Here, we investig&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1793737\">Latest advances in nanodrug delivery systems for modulating the immune microenvironment in triple-negative breast cancer<\/a><div class=\"wp-block-latest-posts__post-author\">by Xiaoya Dong<\/div><time datetime=\"2026-07-17T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">The tumor immune microenvironment (TIME), composed of tumor cells, immune\/stromal cells, cytokines, and other components, plays a central role in determining tumor immunogenicity and response to therapy. The balance between effector T\/NK cells and immu&#8230;<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1901126\">Parasite in cancer therapy: molecular mechanisms and translational potential<\/a><div class=\"wp-block-latest-posts__post-author\">by Juanyan Liao<\/div><time datetime=\"2026-07-17T02:00:00+02:00\" class=\"wp-block-latest-posts__post-date\">17 de July de 2026<\/time><div class=\"wp-block-latest-posts__post-excerpt\">Parasite-derived molecules have emerged as a promising source of natural bioactive compounds with immunomodulatory and antitumor properties, attracting increasing attention in cancer research. Derived from both protozoan and helminth parasites, these m&#8230;<\/div><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-331","page","type-page","status-publish"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=331"}],"version-history":[{"count":3,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/331\/revisions"}],"predecessor-version":[{"id":27040,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/pages\/331\/revisions\/27040"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}