{"id":16826,"date":"2024-09-29T01:49:42","date_gmt":"2024-09-28T23:49:42","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/developmental-vitamin-d-deficiency-and-the-vitamin-d-receptor-control-hematopoiesis\/"},"modified":"2024-09-29T01:49:42","modified_gmt":"2024-09-28T23:49:42","slug":"developmental-vitamin-d-deficiency-and-the-vitamin-d-receptor-control-hematopoiesis","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/developmental-vitamin-d-deficiency-and-the-vitamin-d-receptor-control-hematopoiesis\/","title":{"rendered":"Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis"},"content":{"rendered":"<div>\n<p>J Immunol. 2024 Sep 25:ji2400292. doi: 10.4049\/jimmunol.2400292. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Vitamin D status, the vitamin D receptor (VDR), and the ability to produce active vitamin D [1,25(OH)2D, regulated by Cyp27b1] regulate fetal and adult hematopoiesis. Transgenic reporter mice that express the tdTomato RFP as an indication of Vdr expression were used to identify immune cells that express the Vdr. Vdr\/tdTomato+ hematopoietic progenitors were identified as early as embryonic day (E)15.5, establishing that these cells have expressed the Vdr and are vitamin D targets. Maternal vitamin D deficiency [D-; serum 25(OH)D &lt; 20 ng\/ml] or Vdr knockout or Cyp27b1 knockout resulted in embryos with fewer fetal progenitors. Vdr\/tdTomato+ expression was found to increase with age in CD8+ T cells and innate lymphoid cells (ILCs)1 and ILC3, suggesting that initial Vdr expression in these cells is dependent on environmental factors immediately postbirth. In adult tissues, the frequencies of mature T cells and ILCs as well as Vdr\/tdTomato expression were reduced by D-. Maternal D- resulted in fewer progenitors that expressed Vdr\/tdTomato+ at E15.5 and fewer Vdr\/tdTomato+ immune cells in the adult spleen than offspring from D+ mice. We challenged D- mice with H1N1 influenza infection and found that D- mice were more susceptible than D+ mice. Treating D- mice with vitamin D restored Vdr\/tdTomato+ expression in splenic T cells and partially restored resistance to H1N1 infection, which shows that developmental D- results in lingering effects on Vdr expression in the adult immune system that compromise the immune response to H1N1 infection. Vitamin D and the Vdr regulate hematopoiesis in both fetal and postnatal phases of immune cell development that impact the immune response to a viral infection.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39320233\/?utm_source=Chrome&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20240928194702&amp;v=2.18.0.post9+e462414\">39320233<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.4049\/jimmunol.2400292\">10.4049\/jimmunol.2400292<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2024 Sep 25:ji2400292. doi: 10.4049\/jimmunol.2400292. Online ahead of print. ABSTRACT Vitamin D status, the vitamin D receptor (VDR), and the ability to produce active vitamin D [1,25(OH)2D, regulated by Cyp27b1] regulate fetal and adult hematopoiesis. Transgenic reporter mice that express the tdTomato RFP as an indication of Vdr expression were used to identify &#8230; <a title=\"Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/developmental-vitamin-d-deficiency-and-the-vitamin-d-receptor-control-hematopoiesis\/\" aria-label=\"Read more about Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[71],"tags":[],"class_list":["post-16826","post","type-post","status-publish","format-standard","hentry","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16826","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16826"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16826\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}