{"id":16903,"date":"2024-09-29T10:07:00","date_gmt":"2024-09-29T08:07:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/intracellular-c1q-an-unexpected-player-in-neuronal-proteostasis-erin-e-west\/"},"modified":"2024-09-29T10:07:00","modified_gmt":"2024-09-29T08:07:00","slug":"intracellular-c1q-an-unexpected-player-in-neuronal-proteostasis-erin-e-west","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/intracellular-c1q-an-unexpected-player-in-neuronal-proteostasis-erin-e-west\/","title":{"rendered":"Intracellular C1q &#8211; an unexpected player in neuronal proteostasis. Erin E West"},"content":{"rendered":"<div>\n<p>Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016\/j.it.2024.09.006. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Extrahepatic, cell-autonomous, and\/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts protein translation and impairs the extinction of conditioned fear responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39327206\/?utm_source=Chrome&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20240929040651&amp;v=2.18.0.post9+e462414\">39327206<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2024.09.006\">10.1016\/j.it.2024.09.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2024 Sep 25:S1471-4906(24)00214-X. doi: 10.1016\/j.it.2024.09.006. Online ahead of print. ABSTRACT Extrahepatic, cell-autonomous, and\/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts &#8230; <a title=\"Intracellular C1q &#8211; an unexpected player in neuronal proteostasis. Erin E West\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/intracellular-c1q-an-unexpected-player-in-neuronal-proteostasis-erin-e-west\/\" aria-label=\"Read more about Intracellular C1q &#8211; an unexpected player in neuronal proteostasis. Erin E West\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-16903","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16903"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16903\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}