{"id":16904,"date":"2024-09-29T10:07:00","date_gmt":"2024-09-29T08:07:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/sensory-nerves-unlock-the-toll-7-gate-for-cancer-spread-r-k-subbarao-malireddi\/"},"modified":"2024-09-29T10:07:00","modified_gmt":"2024-09-29T08:07:00","slug":"sensory-nerves-unlock-the-toll-7-gate-for-cancer-spread-r-k-subbarao-malireddi","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/sensory-nerves-unlock-the-toll-7-gate-for-cancer-spread-r-k-subbarao-malireddi\/","title":{"rendered":"Sensory nerves unlock the TOLL-7 gate for cancer spread. R K Subbarao Malireddi"},"content":{"rendered":"<div>\n<p>Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016\/j.it.2024.09.005. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading to single-strand (ss)RNA release and noncanonical Toll-like receptor (TLR)7 signaling that drives metastasis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39327205\/?utm_source=Chrome&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20240929040651&amp;v=2.18.0.post9+e462414\">39327205<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2024.09.005\">10.1016\/j.it.2024.09.005<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2024 Sep 25:S1471-4906(24)00213-8. doi: 10.1016\/j.it.2024.09.005. Online ahead of print. ABSTRACT Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading &#8230; <a title=\"Sensory nerves unlock the TOLL-7 gate for cancer spread. R K Subbarao Malireddi\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/sensory-nerves-unlock-the-toll-7-gate-for-cancer-spread-r-k-subbarao-malireddi\/\" aria-label=\"Read more about Sensory nerves unlock the TOLL-7 gate for cancer spread. R K Subbarao Malireddi\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-16904","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16904","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16904"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16904\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16904"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16904"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16904"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}