{"id":16905,"date":"2024-09-29T10:07:00","date_gmt":"2024-09-29T08:07:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/covid-19-thromboinflammation-adding-inflammatory-fibrin-to-the-puzzle-elena-magrini\/"},"modified":"2024-09-29T10:07:00","modified_gmt":"2024-09-29T08:07:00","slug":"covid-19-thromboinflammation-adding-inflammatory-fibrin-to-the-puzzle-elena-magrini","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/covid-19-thromboinflammation-adding-inflammatory-fibrin-to-the-puzzle-elena-magrini\/","title":{"rendered":"COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle. Elena Magrini"},"content":{"rendered":"<div>\n<p>Trends Immunol. 2024 Sep 25:S1471-4906(24)00211-4. doi: 10.1016\/j.it.2024.09.003. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin peptide protected mice from spike-dependent fibrin clotting and neuropathology.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39327204\/?utm_source=Chrome&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20240929040651&amp;v=2.18.0.post9+e462414\">39327204<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2024.09.003\">10.1016\/j.it.2024.09.003<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2024 Sep 25:S1471-4906(24)00211-4. doi: 10.1016\/j.it.2024.09.003. Online ahead of print. ABSTRACT Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin &#8230; <a title=\"COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle. Elena Magrini\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/covid-19-thromboinflammation-adding-inflammatory-fibrin-to-the-puzzle-elena-magrini\/\" aria-label=\"Read more about COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle. Elena Magrini\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-16905","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16905"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16905\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}