{"id":16906,"date":"2024-09-29T10:07:01","date_gmt":"2024-09-29T08:07:01","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/apoe4-affects-neutrophil-microglia-crosstalk-in-alzheimers-disease-eleonora-terrabuio\/"},"modified":"2024-09-29T10:07:01","modified_gmt":"2024-09-29T08:07:01","slug":"apoe4-affects-neutrophil-microglia-crosstalk-in-alzheimers-disease-eleonora-terrabuio","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/apoe4-affects-neutrophil-microglia-crosstalk-in-alzheimers-disease-eleonora-terrabuio\/","title":{"rendered":"APOE4 affects neutrophil-microglia crosstalk in Alzheimer&#8217;s disease. Eleonora Terrabuio"},"content":{"rendered":"<div>\n<p>Trends Immunol. 2024 Sep 24:S1471-4906(24)00210-2. doi: 10.1016\/j.it.2024.09.002. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Circulating immune cells contribute to the pathogenesis of Alzheimer&#8217;s disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17+ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion in neutrophils restored microglial responses and reduced murine amyloid pathology.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39322476\/?utm_source=Chrome&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20240929040651&amp;v=2.18.0.post9+e462414\">39322476<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2024.09.002\">10.1016\/j.it.2024.09.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2024 Sep 24:S1471-4906(24)00210-2. doi: 10.1016\/j.it.2024.09.002. Online ahead of print. ABSTRACT Circulating immune cells contribute to the pathogenesis of Alzheimer&#8217;s disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17+ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion &#8230; <a title=\"APOE4 affects neutrophil-microglia crosstalk in Alzheimer&#8217;s disease. Eleonora Terrabuio\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/apoe4-affects-neutrophil-microglia-crosstalk-in-alzheimers-disease-eleonora-terrabuio\/\" aria-label=\"Read more about APOE4 affects neutrophil-microglia crosstalk in Alzheimer&#8217;s disease. Eleonora Terrabuio\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-16906","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16906"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16906\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16906"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16906"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}