{"id":16931,"date":"2024-09-29T10:20:04","date_gmt":"2024-09-29T08:20:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/durability-of-immune-responses-to-sars-cov-2-infection-and-vaccination-mehul-s-suthar\/"},"modified":"2024-09-29T10:20:04","modified_gmt":"2024-09-29T08:20:04","slug":"durability-of-immune-responses-to-sars-cov-2-infection-and-vaccination-mehul-s-suthar","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/durability-of-immune-responses-to-sars-cov-2-infection-and-vaccination-mehul-s-suthar\/","title":{"rendered":"Durability of immune responses to SARS-CoV-2 infection and vaccination. Mehul S Suthar"},"content":{"rendered":"<div>\n<p>Semin Immunol. 2024 Jun 10;73:101884. doi: 10.1016\/j.smim.2024.101884. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Infection with SARS-CoV-2 in humans has caused a pandemic of unprecedented dimensions. SARS-CoV-2 is primarily transmitted through respiratory droplets and targets ciliated epithelial cells in the nasal cavity, trachea, and lungs by utilizing the cellular receptor angiotensin-converting enzyme 2 (ACE2). The innate immune response, including type I and III interferons, inflammatory cytokines (IL-6, TNF-\u03b1, IL-1\u03b2), innate immune cells (monocytes, DCs, neutrophils, natural killer cells), antibodies (IgG, sIgA, neutralizing antibodies), and adaptive immune cells (B cells, CD8+ and CD4+ T cells) play pivotal roles in mitigating COVID-19 disease. Broad and durable B-cell- and T-cell immunity elicited by infection and vaccination is essential for protection against severe disease, hospitalization and death. However, the emergence of SARS-CoV-2 variants that evade neutralizing antibodies continue to jeopardize vaccine efficacy. In this review, we highlight our understanding the infection- and vaccine-mediated humoral, B and T cell responses, the durability of the immune responses, and how variants continue to threaten the efficacy of SARS-CoV-2 vaccines.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38861769\/?utm_source=Chrome&amp;utm_medium=rss&amp;utm_content=9009458&amp;ff=20240929041955&amp;v=2.18.0.post9+e462414\">38861769<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.smim.2024.101884\">10.1016\/j.smim.2024.101884<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Semin Immunol. 2024 Jun 10;73:101884. doi: 10.1016\/j.smim.2024.101884. Online ahead of print. ABSTRACT Infection with SARS-CoV-2 in humans has caused a pandemic of unprecedented dimensions. SARS-CoV-2 is primarily transmitted through respiratory droplets and targets ciliated epithelial cells in the nasal cavity, trachea, and lungs by utilizing the cellular receptor angiotensin-converting enzyme 2 (ACE2). The innate immune &#8230; <a title=\"Durability of immune responses to SARS-CoV-2 infection and vaccination. Mehul S Suthar\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/durability-of-immune-responses-to-sars-cov-2-infection-and-vaccination-mehul-s-suthar\/\" aria-label=\"Read more about Durability of immune responses to SARS-CoV-2 infection and vaccination. Mehul S Suthar\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,110],"tags":[],"class_list":["post-16931","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-seminars-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16931","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16931"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16931\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}