{"id":16938,"date":"2024-09-29T10:20:05","date_gmt":"2024-09-29T08:20:05","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/toolkit-for-mapping-the-clonal-landscape-of-tumor-infiltrating-b-cells-e-o-serebrovskaya\/"},"modified":"2024-09-29T10:20:05","modified_gmt":"2024-09-29T08:20:05","slug":"toolkit-for-mapping-the-clonal-landscape-of-tumor-infiltrating-b-cells-e-o-serebrovskaya","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/toolkit-for-mapping-the-clonal-landscape-of-tumor-infiltrating-b-cells-e-o-serebrovskaya\/","title":{"rendered":"Toolkit for mapping the clonal landscape of tumor-infiltrating B cells. E O Serebrovskaya"},"content":{"rendered":"<div>\n<p>Semin Immunol. 2024 Mar;72:101864. doi: 10.1016\/j.smim.2024.101864. Epub 2024 Jan 31.<\/p>\n<p>ABSTRACT<\/p>\n<p>Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor &#8211; in distinct cancers, subcohorts and individual patients &#8211; is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute to the antitumor response, while others steer the immune response away from the desired mechanics. To step up to a new level of understanding and managing B cell behaviors in the tumor microenvironment, we need to rationally discern these roles, which are cumulatively defined by B cell clonal functional programs, specificities of their B cell receptors, specificities and isotypes of the antibodies they produce, and their spatial interactions within the tumor environment. Comprehensive analysis of these characteristics of clonal B cell populations is now becoming feasible with the development of a whole arsenal of advanced technical approaches, which include (1) methods of single-cell and spatial transcriptomics, genomics, and proteomics; (2) methods of massive identification of B cell specificities; (3) methods of deep error-free profiling of B cell receptor repertoires. Here we overview existing techniques, summarize their current application for B cells studies and propose promising future directions in advancing B cells exploration.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38301345\/?utm_source=Chrome&amp;utm_medium=rss&amp;utm_content=9009458&amp;ff=20240929041955&amp;v=2.18.0.post9+e462414\">38301345<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.smim.2024.101864\">10.1016\/j.smim.2024.101864<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Semin Immunol. 2024 Mar;72:101864. doi: 10.1016\/j.smim.2024.101864. Epub 2024 Jan 31. ABSTRACT Our current understanding of whether B cell involvement in the tumor microenvironment benefits the patient or the tumor &#8211; in distinct cancers, subcohorts and individual patients &#8211; is quite limited. Both statements are probably true in most cases: certain clonal B cell populations contribute &#8230; <a title=\"Toolkit for mapping the clonal landscape of tumor-infiltrating B cells. E O Serebrovskaya\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/29\/toolkit-for-mapping-the-clonal-landscape-of-tumor-infiltrating-b-cells-e-o-serebrovskaya\/\" aria-label=\"Read more about Toolkit for mapping the clonal landscape of tumor-infiltrating B cells. E O Serebrovskaya\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,110],"tags":[],"class_list":["post-16938","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-seminars-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16938","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16938"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16938\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}