{"id":16992,"date":"2024-09-30T01:47:12","date_gmt":"2024-09-29T23:47:12","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/09\/30\/b-cell-memory-of-immunoglobulin-e-ige-antibody-responses-in-allergy\/"},"modified":"2024-09-30T01:47:12","modified_gmt":"2024-09-29T23:47:12","slug":"b-cell-memory-of-immunoglobulin-e-ige-antibody-responses-in-allergy","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/09\/30\/b-cell-memory-of-immunoglobulin-e-ige-antibody-responses-in-allergy\/","title":{"rendered":"B cell memory of Immunoglobulin E (IgE) antibody responses in allergy"},"content":{"rendered":"<div>\n<p>Curr Opin Immunol. 2024 Sep 27;91:102488. doi: 10.1016\/j.coi.2024.102488. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Immunoglobulin E (IgE)-mediated allergic diseases are driven by high-affinity allergen-specific IgE antibodies. IgE antibodies bind to Fc epsilon receptors on mast cells, prompting their degranulation and initiating inflammatory reactions upon allergen crosslinking. While most IgE-producing plasma cells have short lifespans, and IgE memory B cells are exceedingly rare, studies have indicated that non-IgE-expressing type 2-polarized IgG memory B cells serve as a reservoir of IgE memory in allergies. This review explores the B cell populations underlying IgE-mediated allergies, including the cellular and molecular processes that drive IgE class switching from non-IgE memory B cells. It highlights emerging evidence from human studies identifying type 2 IgG memory B cells as the source of pathogenic IgE in allergic responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39340881\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20240929194711&amp;v=2.18.0.post9+e462414\">39340881<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2024.102488\">10.1016\/j.coi.2024.102488<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2024 Sep 27;91:102488. doi: 10.1016\/j.coi.2024.102488. Online ahead of print. ABSTRACT Immunoglobulin E (IgE)-mediated allergic diseases are driven by high-affinity allergen-specific IgE antibodies. IgE antibodies bind to Fc epsilon receptors on mast cells, prompting their degranulation and initiating inflammatory reactions upon allergen crosslinking. While most IgE-producing plasma cells have short lifespans, and IgE &#8230; <a title=\"B cell memory of Immunoglobulin E (IgE) antibody responses in allergy\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/09\/30\/b-cell-memory-of-immunoglobulin-e-ige-antibody-responses-in-allergy\/\" aria-label=\"Read more about B cell memory of Immunoglobulin E (IgE) antibody responses in allergy\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-16992","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16992","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=16992"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/16992\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=16992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=16992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=16992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}