{"id":17043,"date":"2024-10-01T02:47:41","date_gmt":"2024-10-01T00:47:41","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/01\/tim-3-is-required-for-regulatory-t-cell-mediated-promotion-of-t-cell-exhaustion-and-viral-persistence-during-chronic-lymphocytic-choriomeningitis-virus-infection\/"},"modified":"2024-10-01T02:47:41","modified_gmt":"2024-10-01T00:47:41","slug":"tim-3-is-required-for-regulatory-t-cell-mediated-promotion-of-t-cell-exhaustion-and-viral-persistence-during-chronic-lymphocytic-choriomeningitis-virus-infection","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/01\/tim-3-is-required-for-regulatory-t-cell-mediated-promotion-of-t-cell-exhaustion-and-viral-persistence-during-chronic-lymphocytic-choriomeningitis-virus-infection\/","title":{"rendered":"Tim-3 Is Required for Regulatory T Cell-Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection"},"content":{"rendered":"<div>\n<p>J Immunol. 2024 Sep 30:ji2400119. doi: 10.4049\/jimmunol.2400119. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Expression of T cell Ig and mucin domain-containing protein 3 (Tim-3) is upregulated on regulatory T cells (Tregs) during chronic viral infections. In several murine and human chronic infections, the expression of Tim-3 is associated with poor control of viral burden and impaired antiviral immune responses. However, the role of Tim-3+ Tregs during persistent viral infections has not been fully defined. We employed an inducible Treg-specific Tim-3 loss-of-function (Tim-3 Treg knockout) murine model to dissect the role of Tim-3 on Tregs during chronic lymphocytic choriomeningitis virus infection. Tim-3 Treg knockout mice exhibited a decrease in morbidity, a more potent virus-specific T cell response, and a significant decrease in viral burden. These mice also had a reduction in the frequency of PD-1+Tim-3+ and PD-1+Tox+ gp33-specific exhausted CD8+ T cells. Our findings demonstrate that modulation of a single surface protein on Tregs can lead to a reduction in viral burden, limit T cell exhaustion, and enhance gp33-specific T cell response. These studies may help to identify Tim-3-directed therapies for the management of persistent infections and cancer.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39345172\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20240930204740&amp;v=2.18.0.post9+e462414\">39345172<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.4049\/jimmunol.2400119\">10.4049\/jimmunol.2400119<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2024 Sep 30:ji2400119. doi: 10.4049\/jimmunol.2400119. Online ahead of print. ABSTRACT Expression of T cell Ig and mucin domain-containing protein 3 (Tim-3) is upregulated on regulatory T cells (Tregs) during chronic viral infections. In several murine and human chronic infections, the expression of Tim-3 is associated with poor control of viral burden and impaired &#8230; <a title=\"Tim-3 Is Required for Regulatory T Cell-Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/01\/tim-3-is-required-for-regulatory-t-cell-mediated-promotion-of-t-cell-exhaustion-and-viral-persistence-during-chronic-lymphocytic-choriomeningitis-virus-infection\/\" aria-label=\"Read more about Tim-3 Is Required for Regulatory T Cell-Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infection\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-17043","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=17043"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17043\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=17043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=17043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=17043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}