{"id":17131,"date":"2024-10-03T03:46:56","date_gmt":"2024-10-03T01:46:56","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/03\/fuelling-b-cells-dynamic-regulation-of-b-cell-metabolism\/"},"modified":"2024-10-03T03:46:56","modified_gmt":"2024-10-03T01:46:56","slug":"fuelling-b-cells-dynamic-regulation-of-b-cell-metabolism","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/03\/fuelling-b-cells-dynamic-regulation-of-b-cell-metabolism\/","title":{"rendered":"Fuelling B cells: dynamic regulation of B cell metabolism"},"content":{"rendered":"<div>\n<p>Curr Opin Immunol. 2024 Oct 1;91:102484. doi: 10.1016\/j.coi.2024.102484. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>B cells experience extreme alterations in their metabolism throughout their life cycle, from na\u00efve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the fastest rate of all cells, to long-lived plasma cells with very high levels of protein production that can persist for decades. The underpinning of these transitions remains incompletely understood, and a key question is how utilisation of fuel source supports B cell metabolism. For example, GC B cells, unlike almost all rapidly proliferating cells, mainly use fatty acid oxidation rather than glycolysis. However, following differentiation to plasma cells, their metabolism switches towards a high rate of glucose consumption to aid antibody production. In this review, we discuss the key metabolic pathways in B cells, linking them to cellular signalling events and placing them in the context of disease and therapeutic potential.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39357080\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20241002214656&amp;v=2.18.0.post9+e462414\">39357080<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2024.102484\">10.1016\/j.coi.2024.102484<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2024 Oct 1;91:102484. doi: 10.1016\/j.coi.2024.102484. Online ahead of print. ABSTRACT B cells experience extreme alterations in their metabolism throughout their life cycle, from na\u00efve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the fastest rate of all cells, to long-lived plasma cells with very high &#8230; <a title=\"Fuelling B cells: dynamic regulation of B cell metabolism\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/03\/fuelling-b-cells-dynamic-regulation-of-b-cell-metabolism\/\" aria-label=\"Read more about Fuelling B cells: dynamic regulation of B cell metabolism\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-17131","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=17131"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17131\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=17131"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=17131"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=17131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}