{"id":17346,"date":"2024-10-08T14:05:30","date_gmt":"2024-10-08T12:05:30","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/08\/thymic-stromal-lymphopoietin-signaling-in-b-cells-from-progenitors-to-plasma-cellsphillip-p-domeier-on-7-de-october-de-2024-at-1000\/"},"modified":"2024-10-08T14:05:30","modified_gmt":"2024-10-08T12:05:30","slug":"thymic-stromal-lymphopoietin-signaling-in-b-cells-from-progenitors-to-plasma-cellsphillip-p-domeier-on-7-de-october-de-2024-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/08\/thymic-stromal-lymphopoietin-signaling-in-b-cells-from-progenitors-to-plasma-cellsphillip-p-domeier-on-7-de-october-de-2024-at-1000\/","title":{"rendered":"Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells\u200bPhillip P Domeier   on 7 de October de 2024 at 10:00"},"content":{"rendered":"<div>\n<p>J Leukoc Biol. 2024 Oct 7:qiae216. doi: 10.1093\/jleuko\/qiae216. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Thymic stromal lymphopoietin (TSLP) is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings that underpin our limited understanding of the role TSLP in modulating different stages of B cell development. We will also provide an overview of how TSLP drives B cell-mediated immune disease and how novel TSLP-blocking biologics could be used to modulate B cell responses. TSLP is critical for the regulation, diversity, and longevity of humoral immunity.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39373526\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20241008080530&amp;v=2.18.0.post9+e462414\">39373526<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiae216\">10.1093\/jleuko\/qiae216<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2024 Oct 7:qiae216. doi: 10.1093\/jleuko\/qiae216. Online ahead of print. ABSTRACT Thymic stromal lymphopoietin (TSLP) is an established pleotropic alarmin cytokine that is generated at barrier tissues to induce type 2 immune responses, but its role in regulating the diversity of B cells is poorly understood. Here, we will highlight the key findings &#8230; <a title=\"Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells\u200bPhillip P Domeier   on 7 de October de 2024 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/08\/thymic-stromal-lymphopoietin-signaling-in-b-cells-from-progenitors-to-plasma-cellsphillip-p-domeier-on-7-de-october-de-2024-at-1000\/\" aria-label=\"Read more about Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells\u200bPhillip P Domeier   on 7 de October de 2024 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-17346","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=17346"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17346\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=17346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=17346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=17346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}