{"id":17767,"date":"2024-10-09T14:50:35","date_gmt":"2024-10-09T12:50:35","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/09\/b-cell-interleukin-1-receptor-1-il1r1-modulates-the-female-adipose-tissue-immune-microenvironment-during-aginganna-carey-on-8-de-october-de-2024-at-1000\/"},"modified":"2024-10-09T14:50:35","modified_gmt":"2024-10-09T12:50:35","slug":"b-cell-interleukin-1-receptor-1-il1r1-modulates-the-female-adipose-tissue-immune-microenvironment-during-aginganna-carey-on-8-de-october-de-2024-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/09\/b-cell-interleukin-1-receptor-1-il1r1-modulates-the-female-adipose-tissue-immune-microenvironment-during-aginganna-carey-on-8-de-october-de-2024-at-1000\/","title":{"rendered":"B-cell Interleukin 1 Receptor 1 (IL1R1) modulates the female adipose tissue immune microenvironment during aging\u200bAnna Carey   on 8 de October de 2024 at 10:00"},"content":{"rendered":"<div>\n<p>J Leukoc Biol. 2024 Oct 8:qiae219. doi: 10.1093\/jleuko\/qiae219. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Myeloid cell production of interleukin-1\u03b2 (IL-1\u03b2) drives inflammaging in visceral adipose tissue (vWAT) and contributes to the expansion of interleukin-1 receptor 1 (Il1r1) positive aged adipose B-cells (AABs). AABs promote metabolic dysfunction and inflammation under inflammatory challenges. However, it is unclear whether IL-1\u03b2 contributes to AAB-associated inflammation during aging. Using a B-cell specific knockout of Il1r1 (BKO mice), we characterized old vWAT in the absence of IL-1\u03b2 &#8211; B-cell signaling. In addition to sex-specific metabolic improvements in females, we identified a reduction in the proportion of B-cells and a sex-specific increase in the B1:B2 B-cell ratio in BKO vWAT. Using single cell RNA-sequencing of vWAT immune cells, we observed that BKO differentially affected inflammatory signaling in vWAT immune cells. These data suggest that IL-1\u03b2 &#8211; B-cell signaling supports the inflammatory response in multiple cell types and provides insight into the complex microenvironment in aged vWAT.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39378334\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20241009085034&amp;v=2.18.0.post9+e462414\">39378334<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiae219\">10.1093\/jleuko\/qiae219<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2024 Oct 8:qiae219. doi: 10.1093\/jleuko\/qiae219. Online ahead of print. ABSTRACT Myeloid cell production of interleukin-1\u03b2 (IL-1\u03b2) drives inflammaging in visceral adipose tissue (vWAT) and contributes to the expansion of interleukin-1 receptor 1 (Il1r1) positive aged adipose B-cells (AABs). AABs promote metabolic dysfunction and inflammation under inflammatory challenges. However, it is unclear whether &#8230; <a title=\"B-cell Interleukin 1 Receptor 1 (IL1R1) modulates the female adipose tissue immune microenvironment during aging\u200bAnna Carey   on 8 de October de 2024 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/09\/b-cell-interleukin-1-receptor-1-il1r1-modulates-the-female-adipose-tissue-immune-microenvironment-during-aginganna-carey-on-8-de-october-de-2024-at-1000\/\" aria-label=\"Read more about B-cell Interleukin 1 Receptor 1 (IL1R1) modulates the female adipose tissue immune microenvironment during aging\u200bAnna Carey   on 8 de October de 2024 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-17767","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=17767"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17767\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=17767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=17767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=17767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}