{"id":17999,"date":"2024-10-10T14:51:37","date_gmt":"2024-10-10T12:51:37","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/10\/neutrophil-plasticity-in-liver-diseasesjia-ming-nickolas-teo-on-9-de-october-de-2024-at-1000\/"},"modified":"2024-10-10T14:51:37","modified_gmt":"2024-10-10T12:51:37","slug":"neutrophil-plasticity-in-liver-diseasesjia-ming-nickolas-teo-on-9-de-october-de-2024-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/10\/neutrophil-plasticity-in-liver-diseasesjia-ming-nickolas-teo-on-9-de-october-de-2024-at-1000\/","title":{"rendered":"Neutrophil plasticity in liver diseases\u200bJia Ming Nickolas Teo   on 9 de October de 2024 at 10:00"},"content":{"rendered":"<div>\n<p>J Leukoc Biol. 2024 Oct 9:qiae222. doi: 10.1093\/jleuko\/qiae222. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>The liver has critical digestive, metabolic, and immunosurveillance roles, which get disrupted during liver diseases such as viral hepatitis, fatty liver disease, and hepatocellular carcinoma. While previous research on the pathological development of these diseases has focused on liver-resident immune populations, such as Kupffer cells, infiltrating immune cells responding to pathogens and disease also play crucial roles. Neutrophils are one such key population contributing to hepatic inflammation and disease progression. Belonging to the initial waves of immune response to threats, neutrophils suppress bacterial and viral spread during acute infections, and have homeostasis-restoring functions. Whereas during chronic insults, they display their plastic nature by responding to the inflammatory environment and develop new phenotypes alongside longer lifespans. This review summarizes the diversity in neutrophil function and subpopulations present at steady state, during liver disease, and during liver cancer.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39383213\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20241010085136&amp;v=2.18.0.post9+e462414\">39383213<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiae222\">10.1093\/jleuko\/qiae222<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2024 Oct 9:qiae222. doi: 10.1093\/jleuko\/qiae222. Online ahead of print. ABSTRACT The liver has critical digestive, metabolic, and immunosurveillance roles, which get disrupted during liver diseases such as viral hepatitis, fatty liver disease, and hepatocellular carcinoma. While previous research on the pathological development of these diseases has focused on liver-resident immune populations, such &#8230; <a title=\"Neutrophil plasticity in liver diseases\u200bJia Ming Nickolas Teo   on 9 de October de 2024 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/10\/neutrophil-plasticity-in-liver-diseasesjia-ming-nickolas-teo-on-9-de-october-de-2024-at-1000\/\" aria-label=\"Read more about Neutrophil plasticity in liver diseases\u200bJia Ming Nickolas Teo   on 9 de October de 2024 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-17999","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=17999"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/17999\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=17999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=17999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=17999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}