{"id":18090,"date":"2024-10-11T17:52:13","date_gmt":"2024-10-11T15:52:13","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/11\/a-reappraisal-of-il-9-in-inflammation-and-cancer-fabian-bick\/"},"modified":"2024-10-11T17:52:13","modified_gmt":"2024-10-11T15:52:13","slug":"a-reappraisal-of-il-9-in-inflammation-and-cancer-fabian-bick","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/11\/a-reappraisal-of-il-9-in-inflammation-and-cancer-fabian-bick\/","title":{"rendered":"A reappraisal of IL-9 in inflammation and cancer. Fabian Bick"},"content":{"rendered":"<div>\n<p>Mucosal Immunol. 2024 Oct 8:S1933-0219(24)00106-5. doi: 10.1016\/j.mucimm.2024.10.003. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9. Chronic inflammation seen in allergic diseases, autoimmunity and cancer is however frequently accompanied by overproduction of this elusive type 2 cytokine. Initially identified as a T cell and mast cell growth factor, and later as the hallmark cytokine defining TH9 cells, we now know that IL-9 is produced by multiple innate and adaptive immune cells. Recent evidence suggests that IL-9 controls discrete aspects of the allergic cascade, cellular responses of immune and stromal cells, cancer progression, tolerance and immune escape. Despite functioning as a pleiotropic cytokine in mucosal environments, like the lungs, the direct and indirect cellular targets of IL-9 are still not well characterized. Here, we discuss IL-9&#8217;s cellular senders and receivers, focusing on asthma and cancer. Moreover, we review current research directions and the outlook of targeted therapy centered around the biology of IL-9.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39389468\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20241011115212&amp;v=2.18.0.post9+e462414\">39389468<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2024.10.003\">10.1016\/j.mucimm.2024.10.003<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2024 Oct 8:S1933-0219(24)00106-5. doi: 10.1016\/j.mucimm.2024.10.003. Online ahead of print. ABSTRACT While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9. Chronic inflammation seen in allergic diseases, autoimmunity and cancer is however frequently accompanied by &#8230; <a title=\"A reappraisal of IL-9 in inflammation and cancer. Fabian Bick\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/11\/a-reappraisal-of-il-9-in-inflammation-and-cancer-fabian-bick\/\" aria-label=\"Read more about A reappraisal of IL-9 in inflammation and cancer. Fabian Bick\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-18090","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18090"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18090\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18090"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18090"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}