{"id":18273,"date":"2024-10-15T16:57:46","date_gmt":"2024-10-15T14:57:46","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/15\/polarization-of-the-memory-b-cell-responselizzette-perez-perez-on-14-de-october-de-2024-at-1000\/"},"modified":"2024-10-15T16:57:46","modified_gmt":"2024-10-15T14:57:46","slug":"polarization-of-the-memory-b-cell-responselizzette-perez-perez-on-14-de-october-de-2024-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/15\/polarization-of-the-memory-b-cell-responselizzette-perez-perez-on-14-de-october-de-2024-at-1000\/","title":{"rendered":"Polarization of the memory B cell response\u200bLizzette P\u00e9rez-P\u00e9rez   on 14 de October de 2024 at 10:00"},"content":{"rendered":"<div>\n<p>J Leukoc Biol. 2024 Oct 14:qiae228. doi: 10.1093\/jleuko\/qiae228. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Memory B cells are long-lived cells that are induced following infection or vaccination. Upon antigen re-encounter, memory B cells rapidly differentiate into antibody-secreting or germinal center B cells. While memory B cells are an important component of long-term protective immunity following vaccination, they also contribute to the progression of diseases such as autoimmunity and allergy. Numerous subsets of memory B cells have been identified in mice and humans that possess important phenotypic and functional differences. Here, we review the transcriptional circuitry governing memory B cell differentiation and function. We then summarize emerging evidence that the inflammatory environment in which memory B cells develop has an important role in shaping their phenotype and examine the pathways regulating the development of memory B cells during a type 1-skewed and type-2 skewed immune response.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39401326\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20241015105745&amp;v=2.18.0.post9+e462414\">39401326<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiae228\">10.1093\/jleuko\/qiae228<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2024 Oct 14:qiae228. doi: 10.1093\/jleuko\/qiae228. Online ahead of print. ABSTRACT Memory B cells are long-lived cells that are induced following infection or vaccination. Upon antigen re-encounter, memory B cells rapidly differentiate into antibody-secreting or germinal center B cells. While memory B cells are an important component of long-term protective immunity following vaccination, &#8230; <a title=\"Polarization of the memory B cell response\u200bLizzette P\u00e9rez-P\u00e9rez   on 14 de October de 2024 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/15\/polarization-of-the-memory-b-cell-responselizzette-perez-perez-on-14-de-october-de-2024-at-1000\/\" aria-label=\"Read more about Polarization of the memory B cell response\u200bLizzette P\u00e9rez-P\u00e9rez   on 14 de October de 2024 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-18273","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18273","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18273"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18273\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18273"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}