{"id":18451,"date":"2024-10-19T12:55:48","date_gmt":"2024-10-19T10:55:48","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/19\/virus-specific-th17-cells-are-induced-by-human-cytomegalovirus-after-renal-transplantation\/"},"modified":"2024-10-19T12:55:48","modified_gmt":"2024-10-19T10:55:48","slug":"virus-specific-th17-cells-are-induced-by-human-cytomegalovirus-after-renal-transplantation","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/19\/virus-specific-th17-cells-are-induced-by-human-cytomegalovirus-after-renal-transplantation\/","title":{"rendered":"Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantation"},"content":{"rendered":"<div>\n<p>J Immunol. 2024 Oct 18:ji2300742. doi: 10.4049\/jimmunol.2300742. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>CMV infection and Th17 cells are independently associated with increased risk for late allograft loss after renal transplantation. Although CMV-specific Th17 cells are detectable in animal models and nontransplant clinical populations, evidence linking CMV and Th17 cells after renal transplantation remains unclear. This prospective observational study evaluated a cohort of renal transplant recipients during 12 mo posttransplant to assess the presence of CMV-specific Th17 cells in peripheral blood and their relationship to pretransplant CMV serostatus and CMV DNAemia. CMV-specific Th17 cells were identified among CMV serostatus donor (D)+ and\/or recipient (R)+ recipients and expanded during both primary (D+\/R-) and reactivated (D+\/R+, D-\/R+) CMV DNAemia. A subset of CMV-specific Th17 cells coexpressed IFN-\u03b3, indicating a Th1\/17 phenotype. These Th17 and Th1\/17 cells expressed CCR6, CCR5, activation and terminal differentiation markers (CD95, OX40, HLA-DR, CD57), and a central\/effector memory phenotype. CMV-specific Th1\/17 cells expressed activating\/inhibitory receptors (CD57, 4-1BB, CD160, CTLA-4, PD-1) at higher frequencies than Th17 cells. In contrast, staphylococcal enterotoxin B-induced Th17 cells did not expand during CMV DNAemia, did not differ between CMV serostatus groups over time, expressed CCR6, predominantly coexpressed TNF-\u03b1, and had lower expression of activating and inhibitory receptors than pp65-specific Th17 and Th1\/17 cells. These data show that CMV-specific Th17 cells expand during episodes of CMV DNAemia among renal transplant recipients, and that these virus-specific Th17 and Th1\/17 cells have distinct phenotypes from global circulating Th(1)\/17 cells. These results suggest a potential proinflammatory pathway by which CMV-induced Th17 cells may contribute to allograft injury, increasing risk for late allograft loss.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39423238\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20241019065547&amp;v=2.18.0.post9+e462414\">39423238<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.4049\/jimmunol.2300742\">10.4049\/jimmunol.2300742<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2024 Oct 18:ji2300742. doi: 10.4049\/jimmunol.2300742. Online ahead of print. ABSTRACT CMV infection and Th17 cells are independently associated with increased risk for late allograft loss after renal transplantation. Although CMV-specific Th17 cells are detectable in animal models and nontransplant clinical populations, evidence linking CMV and Th17 cells after renal transplantation remains unclear. This &#8230; <a title=\"Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantation\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/19\/virus-specific-th17-cells-are-induced-by-human-cytomegalovirus-after-renal-transplantation\/\" aria-label=\"Read more about Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantation\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-18451","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18451"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18451\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18451"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18451"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}