{"id":18541,"date":"2024-10-22T14:53:48","date_gmt":"2024-10-22T12:53:48","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/22\/skin-resident-t-cells-contribute-to-the-dynamic-disease-manifestations-of-psoriasis\/"},"modified":"2024-10-22T14:53:48","modified_gmt":"2024-10-22T12:53:48","slug":"skin-resident-t-cells-contribute-to-the-dynamic-disease-manifestations-of-psoriasis","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/22\/skin-resident-t-cells-contribute-to-the-dynamic-disease-manifestations-of-psoriasis\/","title":{"rendered":"Skin-resident T Cells Contribute to the Dynamic Disease Manifestations of Psoriasis"},"content":{"rendered":"<div>\n<p>J Immunol. 2024 Nov 1;213(9):1267-1277. doi: 10.4049\/jimmunol.2400020.<\/p>\n<p>ABSTRACT<\/p>\n<p>The human skin forms a dynamic barrier to physical injuries and microbial invasion. Constant interactions between stroma and tissue-confined immune cells maintain skin homeostasis. However, the cellular interactions that maintain skin health also contribute to focal immunopathology. Psoriasis is a common disease that manifests with focal pathology induced by environmental triggers in genetically susceptible individuals. Within psoriasis plaques, cross-talk between skin-resident T cells and stroma cells leads to chronic inflammation. Inflammatory cytokines such as TNF-\u03b1, IL-17, IL-22, and IL-23 amplify the local chronic inflammation and sustain the well-demarcated thick and scaly plaques that characterize the disease. In resolved lesions, T cells remain poised for IL-17 and IL-22 production, and postinflammatory epigenetic modifications lower the threshold for initiation of local relapse. This review focuses on how tissue-resident memory T cells contribute to the onset, maintenance, resolution, and relapse of psoriasis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39432869\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20241022085345&amp;v=2.18.0.post9+e462414\">39432869<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.4049\/jimmunol.2400020\">10.4049\/jimmunol.2400020<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2024 Nov 1;213(9):1267-1277. doi: 10.4049\/jimmunol.2400020. ABSTRACT The human skin forms a dynamic barrier to physical injuries and microbial invasion. Constant interactions between stroma and tissue-confined immune cells maintain skin homeostasis. However, the cellular interactions that maintain skin health also contribute to focal immunopathology. Psoriasis is a common disease that manifests with focal pathology &#8230; <a title=\"Skin-resident T Cells Contribute to the Dynamic Disease Manifestations of Psoriasis\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/22\/skin-resident-t-cells-contribute-to-the-dynamic-disease-manifestations-of-psoriasis\/\" aria-label=\"Read more about Skin-resident T Cells Contribute to the Dynamic Disease Manifestations of Psoriasis\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-18541","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18541"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18541\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}