{"id":18710,"date":"2024-10-23T12:00:00","date_gmt":"2024-10-23T10:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/23\/dissecting-secondary-immunodeficiency-identification-of-primary-immunodeficiency-within-b-cell-lymphoproliferative-disorders\/"},"modified":"2024-10-23T12:00:00","modified_gmt":"2024-10-23T10:00:00","slug":"dissecting-secondary-immunodeficiency-identification-of-primary-immunodeficiency-within-b-cell-lymphoproliferative-disorders","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/23\/dissecting-secondary-immunodeficiency-identification-of-primary-immunodeficiency-within-b-cell-lymphoproliferative-disorders\/","title":{"rendered":"Dissecting Secondary Immunodeficiency: Identification of Primary Immunodeficiency within B-Cell Lymphoproliferative Disorders"},"content":{"rendered":"<div>\n<p>J Clin Immunol. 2024 Oct 23;45(1):32. doi: 10.1007\/s10875-024-01818-2.<\/p>\n<p>ABSTRACT<\/p>\n<p>Distinguishing between primary (PID) and secondary (SID) immunodeficiencies, particularly in relation to hematological B-cell lymphoproliferative disorders (B-CLPD), poses a major clinical challenge. We aimed to analyze and define the clinical and laboratory variables in SID patients associated with B-CLPD, identifying overlaps with late-onset PIDs, which could potentially improve diagnostic precision and prognostic assessment. We studied 37 clinical\/laboratory variables in 151 SID patients with B-CLPD. Patients were classified as &#8220;Suspected PID Group&#8221; when having recurrent-severe infections prior to the B-CLPD and\/or hypogammaglobulinemia according to key ESID criteria for PID. Bivariate association analyses showed significant statistical differences between &#8220;Suspected PID&#8221;- and &#8220;SID&#8221;-groups in 10 out of 37 variables analyzed, with &#8220;Suspected PID&#8221; showing higher frequencies of childhood recurrent-severe infections, family history of B-CLPD, significantly lower serum Free Light Chain (sFLC), immunoglobulin concentrations, lower total leukocyte, and switch-memory B-cell counts at baseline. Rpart machine learning algorithm was performed to potentially create a model to differentiate both groups. The model developed a decision tree with two major variables in order of relevance: sum \u03ba + \u03bb and history of severe-recurrent infections in childhood, with high sensitivity 89.5%, specificity 100%, and accuracy 91.8% for PID prediction. Identifying significant clinical and immunological variables can aid in the difficult task of recognizing late-onset PIDs among SID patients, emphasizing the value of a comprehensive immunological evaluation. The differences between &#8220;Suspected PID&#8221; and SID groups, highlight the need of early, tailored diagnostic and treatment strategies for personalized patient management and follow up.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39441407\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20241024094706&amp;v=2.18.0.post9+e462414\">39441407<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-024-01818-2\">10.1007\/s10875-024-01818-2<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2024 Oct 23;45(1):32. doi: 10.1007\/s10875-024-01818-2. ABSTRACT Distinguishing between primary (PID) and secondary (SID) immunodeficiencies, particularly in relation to hematological B-cell lymphoproliferative disorders (B-CLPD), poses a major clinical challenge. We aimed to analyze and define the clinical and laboratory variables in SID patients associated with B-CLPD, identifying overlaps with late-onset PIDs, which could &#8230; <a title=\"Dissecting Secondary Immunodeficiency: Identification of Primary Immunodeficiency within B-Cell Lymphoproliferative Disorders\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/23\/dissecting-secondary-immunodeficiency-identification-of-primary-immunodeficiency-within-b-cell-lymphoproliferative-disorders\/\" aria-label=\"Read more about Dissecting Secondary Immunodeficiency: Identification of Primary Immunodeficiency within B-Cell Lymphoproliferative Disorders\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-18710","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18710"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18710\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}