{"id":18732,"date":"2024-10-24T21:47:25","date_gmt":"2024-10-24T19:47:25","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/24\/characteristics-of-the-igm-repertoires-in-the-peripheral-blood-of-early-rheumatoid-arthritis-patientsbinbin-hong-on-24-de-october-de-2024-at-1000\/"},"modified":"2024-10-24T21:47:25","modified_gmt":"2024-10-24T19:47:25","slug":"characteristics-of-the-igm-repertoires-in-the-peripheral-blood-of-early-rheumatoid-arthritis-patientsbinbin-hong-on-24-de-october-de-2024-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/24\/characteristics-of-the-igm-repertoires-in-the-peripheral-blood-of-early-rheumatoid-arthritis-patientsbinbin-hong-on-24-de-october-de-2024-at-1000\/","title":{"rendered":"Characteristics of the IgM Repertoires in the Peripheral Blood of Early Rheumatoid Arthritis Patients\u200bBinbin Hong   on 24 de October de 2024 at 10:00"},"content":{"rendered":"<div>\n<p>J Leukoc Biol. 2024 Oct 24:qiae236. doi: 10.1093\/jleuko\/qiae236. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Rheumatoid arthritis is a common autoimmune disease, but little is known about the characteristics of the B cell repertoires in the peripheral blood. In this study, the peripheral IgM repertoires of early rheumatoid arthritis (ERA) patients were analyzed by high-throughput sequencing and bioinformatics analyses. Clonal expansion was observed in IgM repertoires of ERA patients. Interestingly, a subset of the dominant clones in ERA repertoires showed self- and poly-reactivity to several autoantigens. The clones were also present in IgM repertoires of healthy adults but they were not expanded, suggesting that may stem from the natural auto-reactive B cell repertoire. Additionally, the ERA repertoires exhibited a greater extent of somatic hypermutations, particularly in the ERA dominant clones, resulting in an enrichment of amino acids important for antigen-antibody interaction. The in-depth analysis of B-cell repertoires improved our knowledge of the IgM repertoires in early rheumatoid arthritis, offering potential insights into the disease&#8217;s pathogenesis.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39446383\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20241024154724&amp;v=2.18.0.post9+e462414\">39446383<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiae236\">10.1093\/jleuko\/qiae236<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2024 Oct 24:qiae236. doi: 10.1093\/jleuko\/qiae236. Online ahead of print. ABSTRACT Rheumatoid arthritis is a common autoimmune disease, but little is known about the characteristics of the B cell repertoires in the peripheral blood. In this study, the peripheral IgM repertoires of early rheumatoid arthritis (ERA) patients were analyzed by high-throughput sequencing and &#8230; <a title=\"Characteristics of the IgM Repertoires in the Peripheral Blood of Early Rheumatoid Arthritis Patients\u200bBinbin Hong   on 24 de October de 2024 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/24\/characteristics-of-the-igm-repertoires-in-the-peripheral-blood-of-early-rheumatoid-arthritis-patientsbinbin-hong-on-24-de-october-de-2024-at-1000\/\" aria-label=\"Read more about Characteristics of the IgM Repertoires in the Peripheral Blood of Early Rheumatoid Arthritis Patients\u200bBinbin Hong   on 24 de October de 2024 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-18732","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18732","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18732"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18732\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18732"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18732"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}