{"id":18802,"date":"2024-10-26T15:57:07","date_gmt":"2024-10-26T13:57:07","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/26\/the-marginal-zone-b-cell-compartment-and-t-cell-independent-antibody-responses-are-supported-by-b-cell-intrinsic-expression-of-irf1\/"},"modified":"2024-10-26T15:57:07","modified_gmt":"2024-10-26T13:57:07","slug":"the-marginal-zone-b-cell-compartment-and-t-cell-independent-antibody-responses-are-supported-by-b-cell-intrinsic-expression-of-irf1","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/26\/the-marginal-zone-b-cell-compartment-and-t-cell-independent-antibody-responses-are-supported-by-b-cell-intrinsic-expression-of-irf1\/","title":{"rendered":"The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1"},"content":{"rendered":"<div>\n<p>J Immunol. 2024 Oct 25:ji2300575. doi: 10.4049\/jimmunol.2300575. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>The prototypic IFN-inducible transcription factor, IRF1, not only controls inflammatory gene expression but also regulates T cell and macrophage fate specification and function. Using bone marrow chimeras (80% B6.129S2-Ighmtm1Cgn\/J [\u00b5MT] + 20% B6.129S2-Irf1tm1Mak\/J [Irf1-\/-]), we show that IRF1 expression in B cells is required for marginal zone B (MZB) cell development and T cell-independent Ab responses. Although IFNs can induce IRF1 expression in MZB precursors, deletion of the IFN-\u03b3R (C57BL\/6J [B6], B6.129S7-Ifngr1tm1Agt\/J) or IFN-\u03b1R (B6[Cg]-Ifnar1tm1Agt\/J) did not affect MZB cell development. Instead, BCR and TLR signals promote IRF1 expression and nuclear translocation in MZB cell precursors. In turn, IRF1 is required for Notch2-dependent gene expression in BCR- and TLR-stimulated transitional B cells and development of the MZB cell compartment. Thus, IRF1 regulates MZB-driven T cell-independent Ab responses by regulating Notch programming in MZB precursors and facilitating commitment of these cells to the MZB lineage.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39451043\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20241026095706&amp;v=2.18.0.post9+e462414\">39451043<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.4049\/jimmunol.2300575\">10.4049\/jimmunol.2300575<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2024 Oct 25:ji2300575. doi: 10.4049\/jimmunol.2300575. Online ahead of print. ABSTRACT The prototypic IFN-inducible transcription factor, IRF1, not only controls inflammatory gene expression but also regulates T cell and macrophage fate specification and function. Using bone marrow chimeras (80% B6.129S2-Ighmtm1Cgn\/J [\u00b5MT] + 20% B6.129S2-Irf1tm1Mak\/J [Irf1-\/-]), we show that IRF1 expression in B cells is &#8230; <a title=\"The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/26\/the-marginal-zone-b-cell-compartment-and-t-cell-independent-antibody-responses-are-supported-by-b-cell-intrinsic-expression-of-irf1\/\" aria-label=\"Read more about The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-18802","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18802"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18802\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}