{"id":18890,"date":"2024-10-29T17:51:12","date_gmt":"2024-10-29T16:51:12","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/10\/29\/il-33-increases-the-magnitude-of-the-tissue-resident-memory-t-cell-response-in-intestinal-tissues-during-local-infection\/"},"modified":"2024-10-29T17:51:12","modified_gmt":"2024-10-29T16:51:12","slug":"il-33-increases-the-magnitude-of-the-tissue-resident-memory-t-cell-response-in-intestinal-tissues-during-local-infection","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/10\/29\/il-33-increases-the-magnitude-of-the-tissue-resident-memory-t-cell-response-in-intestinal-tissues-during-local-infection\/","title":{"rendered":"IL-33 Increases the Magnitude of the Tissue-Resident Memory T Cell Response in Intestinal Tissues during Local Infection"},"content":{"rendered":"<div>\n<p>J Immunol. 2024 Oct 28:ji2400323. doi: 10.4049\/jimmunol.2400323. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>IL-33 plays an important role in the early programming of CD8 T cells; however, its contribution to the differentiation of tissue-resident memory T cells in vivo remains poorly defined. After infection of mice with Yersinia pseudotuberculosis, IL-33 expression was increased in the intestinal tissue, and this coincided with the expression of ST2 on T cells infiltrating the intestinal epithelium and lamina propria. Blocking IL-33 signaling after T cell infiltration of the intestinal tissue did not significantly impact the number or phenotype of tissue-resident memory T cells generated. However, overexpression of ST2 on T cells was able to increase expression of TCF1 and T cell number in the intestine compared with the lymphoid organs during infection. We also observed that enhanced accumulation and maintenance of ST2-overexpressing cells in the intestine postinfection were resolved. This points to a role for IL-33 in increasing the number of T cells that commit to intestinal tissue residency in vivo.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39465972\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20241029125111&amp;v=2.18.0.post9+e462414\">39465972<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.4049\/jimmunol.2400323\">10.4049\/jimmunol.2400323<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2024 Oct 28:ji2400323. doi: 10.4049\/jimmunol.2400323. Online ahead of print. ABSTRACT IL-33 plays an important role in the early programming of CD8 T cells; however, its contribution to the differentiation of tissue-resident memory T cells in vivo remains poorly defined. After infection of mice with Yersinia pseudotuberculosis, IL-33 expression was increased in the intestinal &#8230; <a title=\"IL-33 Increases the Magnitude of the Tissue-Resident Memory T Cell Response in Intestinal Tissues during Local Infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/10\/29\/il-33-increases-the-magnitude-of-the-tissue-resident-memory-t-cell-response-in-intestinal-tissues-during-local-infection\/\" aria-label=\"Read more about IL-33 Increases the Magnitude of the Tissue-Resident Memory T Cell Response in Intestinal Tissues during Local Infection\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-18890","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18890","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=18890"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/18890\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=18890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=18890"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=18890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}