{"id":19152,"date":"2024-11-05T01:48:06","date_gmt":"2024-11-05T00:48:06","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/11\/05\/piezo1-restrains-proinflammatory-response-but-is-essential-in-t-cell-mediated-immunopathologysung-hee-choi-on-4-de-november-de-2024-at-1100\/"},"modified":"2024-11-05T01:48:06","modified_gmt":"2024-11-05T00:48:06","slug":"piezo1-restrains-proinflammatory-response-but-is-essential-in-t-cell-mediated-immunopathologysung-hee-choi-on-4-de-november-de-2024-at-1100","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/11\/05\/piezo1-restrains-proinflammatory-response-but-is-essential-in-t-cell-mediated-immunopathologysung-hee-choi-on-4-de-november-de-2024-at-1100\/","title":{"rendered":"Piezo1 restrains proinflammatory response but is essential in T cell-mediated immunopathology\u200bSung Hee Choi   on 4 de November de 2024 at 11:00"},"content":{"rendered":"<div>\n<p>J Leukoc Biol. 2024 Nov 4:qiae242. doi: 10.1093\/jleuko\/qiae242. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Piezo1 is a mechanosensitive, nonselective Ca2+ channel which is broadly expressed in CD4+ T cells. Using lineage-specific Piezo1 knockout mice (Piezo1cKO), we show that loss of Piezo1 in CD4+ T cells significantly increased IFN\u03b3 and IL-17 production in vitro under TH1 and TH17 polarizing conditions, respectively. Despite their intrinsic proinflammatory phenotype, Piezo1cKO T cells are incapable of establishing disease in vivo in three separate adoptive transfer (AT) T cell-mediated inflammatory mouse models, including experimental autoimmune encephalomyelitis, inflammatory bowel disease (IBD), and graft versus-host disease. These phenomena coincided with a decreased effector memory (CD44hiCD62Llo) CD4+ T cell pool derived from donor Piezo1cKO T cells, an observation that is related to intrinsic T-cell fitness, as co-transfer IBD mouse model revealed a deficiency in the CD4+ effector memory population derived only from the na\u00efve Piezo1cKO but not co-infused Piezo1WT CD4+ T cell source. Taken together, our results support Piezo1 as restraining proinflammatory T cell differentiation while contributing to the generation and persistence of the effector memory pool during CD4+ T cell-mediated immunopathology.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39492686\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20241104194805&amp;v=2.18.0.post9+e462414\">39492686<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiae242\">10.1093\/jleuko\/qiae242<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2024 Nov 4:qiae242. doi: 10.1093\/jleuko\/qiae242. Online ahead of print. ABSTRACT Piezo1 is a mechanosensitive, nonselective Ca2+ channel which is broadly expressed in CD4+ T cells. Using lineage-specific Piezo1 knockout mice (Piezo1cKO), we show that loss of Piezo1 in CD4+ T cells significantly increased IFN\u03b3 and IL-17 production in vitro under TH1 and &#8230; <a title=\"Piezo1 restrains proinflammatory response but is essential in T cell-mediated immunopathology\u200bSung Hee Choi   on 4 de November de 2024 at 11:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/11\/05\/piezo1-restrains-proinflammatory-response-but-is-essential-in-t-cell-mediated-immunopathologysung-hee-choi-on-4-de-november-de-2024-at-1100\/\" aria-label=\"Read more about Piezo1 restrains proinflammatory response but is essential in T cell-mediated immunopathology\u200bSung Hee Choi   on 4 de November de 2024 at 11:00\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-19152","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19152"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19152\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}