{"id":19716,"date":"2024-11-13T20:49:47","date_gmt":"2024-11-13T19:49:47","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/11\/13\/pro-inflammatory-nk-like-t-cells-are-expanded-in-the-blood-and-inflamed-intestine-in-crohns-disease-cristina-m-chiarolla\/"},"modified":"2024-11-13T20:49:47","modified_gmt":"2024-11-13T19:49:47","slug":"pro-inflammatory-nk-like-t-cells-are-expanded-in-the-blood-and-inflamed-intestine-in-crohns-disease-cristina-m-chiarolla","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/11\/13\/pro-inflammatory-nk-like-t-cells-are-expanded-in-the-blood-and-inflamed-intestine-in-crohns-disease-cristina-m-chiarolla\/","title":{"rendered":"Pro-inflammatory NK-like T cells are expanded in the blood and inflamed intestine in Croh\u0144s disease. Cristina M Chiarolla"},"content":{"rendered":"<div>\n<p>Mucosal Immunol. 2024 Nov 7:S1933-0219(24)00109-0. doi: 10.1016\/j.mucimm.2024.11.001. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Altered intestinal immune homeostasis leads to chronic inflammation in Crohn&#8217;s disease (CD). To address disease- and tissue-specific alterations, we performed a T cell-centric mass cytometry analysis of peripheral and intestinal lymphocytes from patients with CD and healthy donors&#8217; PBMCs. Chronic intestinal inflammation enforced activation, exhaustion, and terminal differentiation of CD4+ and CD8+ T cells and a relative enrichment of CD4+ regulatory T (Treg) cells. Moreover, enigmatic rare Treg subsets appeared upon inflammation, e.g. CD4+FOXP3+HLA-DR+TIGIT- and CD4+FOXP3+CD56+, expressing pro-inflammatory IFN-\u03b3 upon in vitro stimulation. Some conventional T (Tcon) cells acquired NK-like features. In CD patients&#8217; blood, not well studied CD16+CCR6+CD127+ T cells appeared, being CD4+ or CD8+, a phenotype inducible on healthy T cells by CD blood plasma. Upon CD16-mediated antibody binding, they could attain effector function. These findings suggest an uncommon pro-inflammatory innate-like differentiation of Treg and Tcon cells with acquisition of non-specific cytotoxicity. Most likely, this is both cause and consequence of intestinal inflammation during CD.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39521274\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20241113144946&amp;v=2.18.0.post9+e462414\">39521274<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2024.11.001\">10.1016\/j.mucimm.2024.11.001<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2024 Nov 7:S1933-0219(24)00109-0. doi: 10.1016\/j.mucimm.2024.11.001. Online ahead of print. ABSTRACT Altered intestinal immune homeostasis leads to chronic inflammation in Crohn&#8217;s disease (CD). To address disease- and tissue-specific alterations, we performed a T cell-centric mass cytometry analysis of peripheral and intestinal lymphocytes from patients with CD and healthy donors&#8217; PBMCs. Chronic intestinal inflammation enforced &#8230; <a title=\"Pro-inflammatory NK-like T cells are expanded in the blood and inflamed intestine in Croh\u0144s disease. Cristina M Chiarolla\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/11\/13\/pro-inflammatory-nk-like-t-cells-are-expanded-in-the-blood-and-inflamed-intestine-in-crohns-disease-cristina-m-chiarolla\/\" aria-label=\"Read more about Pro-inflammatory NK-like T cells are expanded in the blood and inflamed intestine in Croh\u0144s disease. Cristina M Chiarolla\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-19716","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19716"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19716\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}