{"id":19770,"date":"2024-11-25T07:58:58","date_gmt":"2024-11-25T06:58:58","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/11\/25\/herpes-stromal-keratitis-erodes-the-establishment-of-tissue-resident-memory-t-cell-pool-in-hsv-1-infected-corneas-mizumi-setia\/"},"modified":"2024-11-25T07:58:58","modified_gmt":"2024-11-25T06:58:58","slug":"herpes-stromal-keratitis-erodes-the-establishment-of-tissue-resident-memory-t-cell-pool-in-hsv-1-infected-corneas-mizumi-setia","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/11\/25\/herpes-stromal-keratitis-erodes-the-establishment-of-tissue-resident-memory-t-cell-pool-in-hsv-1-infected-corneas-mizumi-setia\/","title":{"rendered":"Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas. Mizumi Setia"},"content":{"rendered":"<div>\n<p>Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00111-9. doi: 10.1016\/j.mucimm.2024.11.003. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>The recurrent herpes simplex virus-1 (HSV-1) infection of the cornea can cause the development of herpes stromal keratitis (HSK). This chronic immunoinflammatory condition is a major cause of infection-induced vision loss. The previous episodes of HSK increase the risk of future recurrences in the same cornea. However, not all HSV-1 infected corneas that shed infectious virus at the ocular surface develop HSK, suggesting that corneal HSV-1 infection may cause an establishment of protective immunity in HSV-1 infected corneas. However, upon recurrent corneal HSV-1 infection, the established protective immunity can get compromised, resulting in the development of HSK. In this study, we compared the quantity and quality of tissue-resident memory T (TRM) cells in HSV-1 infected corneas that did or did not develop HSK. Our results showed the predominance of TRM cell in the epithelium than in stroma of HSV-1 infected corneas. Furthermore, HSV-1 infected non-HSK corneas exhibited more CD4 and CD8 TRM cells than HSK corneas. The TRM cells in non-HSK than in HSK corneas was more effective in clearing the infectious virus upon secondary corneal HSV-1 infection. Our results demonstrate the differential quantity and quality of TRM cells in HSV-1 infected corneas that did or did not develop HSK.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39581232\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20241125015858&amp;v=2.18.0.post9+e462414\">39581232<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2024.11.003\">10.1016\/j.mucimm.2024.11.003<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00111-9. doi: 10.1016\/j.mucimm.2024.11.003. Online ahead of print. ABSTRACT The recurrent herpes simplex virus-1 (HSV-1) infection of the cornea can cause the development of herpes stromal keratitis (HSK). This chronic immunoinflammatory condition is a major cause of infection-induced vision loss. The previous episodes of HSK increase the risk of future recurrences in &#8230; <a title=\"Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas. Mizumi Setia\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/11\/25\/herpes-stromal-keratitis-erodes-the-establishment-of-tissue-resident-memory-t-cell-pool-in-hsv-1-infected-corneas-mizumi-setia\/\" aria-label=\"Read more about Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas. Mizumi Setia\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-19770","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19770"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19770\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}