{"id":19771,"date":"2024-11-25T07:58:58","date_gmt":"2024-11-25T06:58:58","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/11\/25\/the-c-type-lectin-receptor-mincle-interferes-with-eosinophil-function-and-protective-intestinal-immunity-in-strongyloides-ratti-infected-mice-lara-linnemann\/"},"modified":"2024-11-25T07:58:58","modified_gmt":"2024-11-25T06:58:58","slug":"the-c-type-lectin-receptor-mincle-interferes-with-eosinophil-function-and-protective-intestinal-immunity-in-strongyloides-ratti-infected-mice-lara-linnemann","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/11\/25\/the-c-type-lectin-receptor-mincle-interferes-with-eosinophil-function-and-protective-intestinal-immunity-in-strongyloides-ratti-infected-mice-lara-linnemann\/","title":{"rendered":"The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice. Lara Linnemann"},"content":{"rendered":"<div>\n<p>Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00114-4. doi: 10.1016\/j.mucimm.2024.11.005. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S. ratti infection has not been investigated. Here, we show that S. ratti-derived ligands are recognized by the CLR Macrophage inducible Ca2+-dependent lectin receptor (MINCLE). While MINCLE-deficiency did not affect initiation of a protective anti-S. ratti type 2 immunity, MINCLE-deficient mice had a transient advantage in intestinal immunity. Unravelling the underlying mechanism, we show that next to macrophages, dendritic cells and neutrophils, a fraction of eosinophils express MINCLE and expand during S. ratti infection. MINCLE-deficient eosinophils exhibited a more active phenotype and prolonged expansion in vivo and displayed increased capacity to reduce S. ratti motility and produce reactive oxygen species in vitro, compared to wild-type (WT) eosinophils. Depletion of eosinophils in S. ratti-infected mice after the tissue-migration phase elevated intestinal worm burden in MINCLE-deficient mice to the WT level. Thus, our findings establish a central contribution of eosinophils to parasite ejection from the intestine and suggest that S. ratti-triggered signalling via MINCLE interferes with eosinophil mediated ejection of S. ratti from the intestine.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39581231\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20241125015858&amp;v=2.18.0.post9+e462414\">39581231<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2024.11.005\">10.1016\/j.mucimm.2024.11.005<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00114-4. doi: 10.1016\/j.mucimm.2024.11.005. Online ahead of print. ABSTRACT Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S. ratti infection has not been &#8230; <a title=\"The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice. Lara Linnemann\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/11\/25\/the-c-type-lectin-receptor-mincle-interferes-with-eosinophil-function-and-protective-intestinal-immunity-in-strongyloides-ratti-infected-mice-lara-linnemann\/\" aria-label=\"Read more about The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice. Lara Linnemann\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-19771","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19771"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19771\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19771"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19771"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}