{"id":19787,"date":"2024-11-28T08:10:40","date_gmt":"2024-11-28T07:10:40","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/11\/28\/how-do-autoimmune-cd4-t-cells-handle-exhaustion-astrid-fabri\/"},"modified":"2024-11-28T08:10:40","modified_gmt":"2024-11-28T07:10:40","slug":"how-do-autoimmune-cd4-t-cells-handle-exhaustion-astrid-fabri","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/11\/28\/how-do-autoimmune-cd4-t-cells-handle-exhaustion-astrid-fabri\/","title":{"rendered":"How do autoimmune CD4+ T cells handle exhaustion?. Astrid Fabri"},"content":{"rendered":"<div>\n<p>Trends Immunol. 2024 Nov 27:S1471-4906(24)00275-8. doi: 10.1016\/j.it.2024.11.004. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4+ T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L+ CD4+ T cells seems to sustain the local autoimmune response.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39603888\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20241128021039&amp;v=2.18.0.post9+e462414\">39603888<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2024.11.004\">10.1016\/j.it.2024.11.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2024 Nov 27:S1471-4906(24)00275-8. doi: 10.1016\/j.it.2024.11.004. Online ahead of print. ABSTRACT Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4+ T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L+ CD4+ T &#8230; <a title=\"How do autoimmune CD4+ T cells handle exhaustion?. Astrid Fabri\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/11\/28\/how-do-autoimmune-cd4-t-cells-handle-exhaustion-astrid-fabri\/\" aria-label=\"Read more about How do autoimmune CD4+ T cells handle exhaustion?. Astrid Fabri\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-19787","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19787"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19787\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}