{"id":19793,"date":"2024-11-29T12:00:00","date_gmt":"2024-11-29T11:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/11\/29\/nationwide-survey-of-multisystem-inflammatory-syndrome-in-children-associated-with-coronavirus-disease-2019-in-japan\/"},"modified":"2024-11-29T12:00:00","modified_gmt":"2024-11-29T11:00:00","slug":"nationwide-survey-of-multisystem-inflammatory-syndrome-in-children-associated-with-coronavirus-disease-2019-in-japan","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/11\/29\/nationwide-survey-of-multisystem-inflammatory-syndrome-in-children-associated-with-coronavirus-disease-2019-in-japan\/","title":{"rendered":"Nationwide Survey of Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in Japan"},"content":{"rendered":"<div>\n<p>J Clin Immunol. 2024 Nov 30;45(1):51. doi: 10.1007\/s10875-024-01845-z.<\/p>\n<p>ABSTRACT<\/p>\n<p>BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) presents some clinical overlap with Kawasaki disease (KD). Although KD is common in Japan, the clinical characteristics of MIS-C in Japan remain unknown. Therefore, we aimed to determine the epidemiological and clinical features of MIS-C in Japan.<\/p>\n<p>METHODS: Using a case reporting form, a nationwide registry was created between November 2020 and March 2023, involving 2,080 facilities throughout Japan. We prospectively and retrospectively enrolled patients with MIS-C. The primary outcomes were the number and incidence rates of children with MIS-C. The secondary outcomes included clinical features, such as KD phenotype, organ involvement, shock, intensive care unit admission, and coronary artery lesions.<\/p>\n<p>RESULTS: Among 398 patients registered, central review identified 129 MIS-C cases (mean age: 8\u00b78 \u00b1 3\u00b77 years). The overall incidence rate was estimated to be 1\u00b75 per 100,000 COVID-19 cases, exhibiting a decline as the COVID-19 pandemic progressed, from 12\u00b73 cases (Pre-Delta) to 1\u00b73 cases (Omicron); 80% of MIS-C cases occurred during the Omicron variant predominant period, and 72% of children with MIS-C met the KD criteria. Cardiovascular (88%) and gastrointestinal (90%) involvement were frequent. In Japan, MIS-C cases showed comparatively less severe clinical features, with shock in 29% and admission to the intensive care unit in 12% of cases. Coronary artery lesions were identified in 15 cases (11\u00b76%), irrespective of the presence of shock. No fatalities were reported.<\/p>\n<p>CONCLUSION: The incidence of MIS-C was low in Japan. The clinical features distinctively exhibited a more KD-like phenotype, with less severe clinical features.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39613902\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20241130114822&amp;v=2.18.0.post9+e462414\">39613902<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-024-01845-z\">10.1007\/s10875-024-01845-z<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2024 Nov 30;45(1):51. doi: 10.1007\/s10875-024-01845-z. ABSTRACT BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) presents some clinical overlap with Kawasaki disease (KD). Although KD is common in Japan, the clinical characteristics of MIS-C in Japan remain unknown. Therefore, we aimed to determine the epidemiological and clinical features of MIS-C in Japan. METHODS: Using &#8230; <a title=\"Nationwide Survey of Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in Japan\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/11\/29\/nationwide-survey-of-multisystem-inflammatory-syndrome-in-children-associated-with-coronavirus-disease-2019-in-japan\/\" aria-label=\"Read more about Nationwide Survey of Multisystem Inflammatory Syndrome in Children Associated with Coronavirus Disease 2019 in Japan\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-19793","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19793","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19793"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19793\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19793"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19793"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19793"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}