{"id":19857,"date":"2024-12-21T22:39:24","date_gmt":"2024-12-21T21:39:24","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/12\/21\/roles-for-siglec-glycan-interactions-in-regulating-immune-cells-sung-yao-lin\/"},"modified":"2024-12-21T22:39:24","modified_gmt":"2024-12-21T21:39:24","slug":"roles-for-siglec-glycan-interactions-in-regulating-immune-cells-sung-yao-lin","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/12\/21\/roles-for-siglec-glycan-interactions-in-regulating-immune-cells-sung-yao-lin\/","title":{"rendered":"Roles for Siglec-glycan interactions in regulating immune cells. Sung-Yao Lin"},"content":{"rendered":"<div>\n<p>Semin Immunol. 2024 Dec 19;77:101925. doi: 10.1016\/j.smim.2024.101925. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of contact between two cells. Indeed, interactions between glycans with glycan-binding can modulate cell-cell interactions. This concept is particularly relevant for immune cells, which use an array of glycan-binding proteins to help in the process of differentiating &#8216;self&#8217; from &#8216;non-self&#8217;. This is exemplified by the sialic acid-binding immunoglobulin-type lectins (Siglecs), which recognize sialic acid. Given that sialic acid is relatively unique to vertebrates, immune cells leverage Siglecs to recognize sialic acid as a marker of &#8216;self&#8217;. Siglecs serve many biological roles, with most of these functions regulated through interactions with their sialoglycan ligands. In this review, we provide a comprehensive update on the ligands of Siglecs and how Siglec-sialoglycan interactions help regulate immune cells in the adaptive and innate immune system.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39706106\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=9009458&amp;ff=20241221163923&amp;v=2.18.0.post9+e462414\">39706106<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.smim.2024.101925\">10.1016\/j.smim.2024.101925<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Semin Immunol. 2024 Dec 19;77:101925. doi: 10.1016\/j.smim.2024.101925. Online ahead of print. ABSTRACT Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of contact between two cells. Indeed, interactions between glycans with glycan-binding can modulate cell-cell interactions. This concept is particularly relevant for immune cells, which use an array of glycan-binding &#8230; <a title=\"Roles for Siglec-glycan interactions in regulating immune cells. Sung-Yao Lin\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/12\/21\/roles-for-siglec-glycan-interactions-in-regulating-immune-cells-sung-yao-lin\/\" aria-label=\"Read more about Roles for Siglec-glycan interactions in regulating immune cells. Sung-Yao Lin\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,110],"tags":[],"class_list":["post-19857","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-seminars-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19857"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19857\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}