{"id":19860,"date":"2024-12-22T07:25:39","date_gmt":"2024-12-22T06:25:39","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2024\/12\/22\/epstein-barr-virus-hijacks-b-cell-metabolism-to-establish-persistent-infection-and-drive-pathogenesis-bojana-muller-durovic\/"},"modified":"2024-12-22T07:25:39","modified_gmt":"2024-12-22T06:25:39","slug":"epstein-barr-virus-hijacks-b-cell-metabolism-to-establish-persistent-infection-and-drive-pathogenesis-bojana-muller-durovic","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2024\/12\/22\/epstein-barr-virus-hijacks-b-cell-metabolism-to-establish-persistent-infection-and-drive-pathogenesis-bojana-muller-durovic\/","title":{"rendered":"Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis. Bojana M\u00fcller-Durovic"},"content":{"rendered":"<div>\n<p>Trends Immunol. 2024 Dec 20:S1471-4906(24)00296-5. doi: 10.1016\/j.it.2024.11.011. Online ahead of print.<\/p>\n<p>ABSTRACT<\/p>\n<p>When B cells engage in an immune response, metabolic reprogramming is key to meeting cellular energetic and biosynthetic demands. Epstein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the human host&#8217;s lifetime. By hijacking signaling pathways of T cell-dependent humoral immunity, EBV activates B cells in a T cell-independent manner, forcing lymphoblastoid transformation. Interlinked with this coercion of signaling pathways, EBV has also evolved strategies to manipulate B cell metabolism. In this opinion article we integrate recent findings from studies of B cell metabolic reprogramming after EBV infection and during antigen-specific activation, respectively. We hypothesize that defining EBV host-cell metabolic vulnerabilities that differ from pathways required for B cell immunity might uncover novel therapeutic targets against EBV-related diseases.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39709272\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20241222012539&amp;v=2.18.0.post9+e462414\">39709272<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2024.11.011\">10.1016\/j.it.2024.11.011<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2024 Dec 20:S1471-4906(24)00296-5. doi: 10.1016\/j.it.2024.11.011. Online ahead of print. ABSTRACT When B cells engage in an immune response, metabolic reprogramming is key to meeting cellular energetic and biosynthetic demands. Epstein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the human host&#8217;s lifetime. By hijacking signaling pathways of T cell-dependent &#8230; <a title=\"Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis. Bojana M\u00fcller-Durovic\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2024\/12\/22\/epstein-barr-virus-hijacks-b-cell-metabolism-to-establish-persistent-infection-and-drive-pathogenesis-bojana-muller-durovic\/\" aria-label=\"Read more about Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis. Bojana M\u00fcller-Durovic\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-19860","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=19860"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/19860\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=19860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=19860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=19860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}