{"id":23163,"date":"2025-01-28T06:47:26","date_gmt":"2025-01-28T05:47:26","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/01\/28\/maternal-obesity-associates-with-altered-humoral-immunity-in-blood-and-colostrum-erick-s-sanchez-salguero\/"},"modified":"2025-01-28T06:47:26","modified_gmt":"2025-01-28T05:47:26","slug":"maternal-obesity-associates-with-altered-humoral-immunity-in-blood-and-colostrum-erick-s-sanchez-salguero","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/01\/28\/maternal-obesity-associates-with-altered-humoral-immunity-in-blood-and-colostrum-erick-s-sanchez-salguero\/","title":{"rendered":"Maternal obesity associates with altered humoral immunity in blood and colostrum. Erick S S\u00e1nchez-Salguero"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Jan 25:S1933-0219(25)00007-8. doi: 10.1016\/j.mucimm.2025.01.007. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5-25 or &gt; 30 kg\/m<sup>2<\/sup> (21 and 16 mothers, respectively) were collected 24-48 h postpartum. B lymphocyte subpopulations were investigated using flow cytometry. IgG, IgA, and IgM concentrations, and antibody production from colostrum-resident B cells were quantified. Overall, na\u00efve B lymphocytes were the most abundant subtype in peripheral blood, while CD27<sup>&#8211;<\/sup>IgD<sup>&#8211;<\/sup> double-negative B cells were the most B lymphocyte subtype abundant in colostrum. The colostrum from mothers with BMI &gt; 30 kg\/m<sup>2<\/sup> contained significantly more IgG-secreting colostrum-resident B cells, more IgG, and less IgA. Mothers with BMI &gt; 30 kg\/m<sup>2<\/sup> who had been vaccinated with the Pfizer BioNTech bivalent vaccine during the third trimester of pregnancy (n = 8) did not show higher IgA or IgG antibody responses against SARS-CoV-2 RBD in either tissue types compared to unvaccinated mothers, contrasting with mother of BMI between 18.5-25 kg\/m<sup>2<\/sup> (n = 7). Similar trends were evidenced in colostrum post-Tdap vaccination. This is the first characterization of B lymphocyte subpopulations and antibodies in the colostrum of mothers with obesity. This work uncovers maternal obesity as a possible modifier of humoral immune components in colostrum.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39870213\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250128004725&amp;v=2.18.0.post9+e462414\">39870213<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.01.007\">10.1016\/j.mucimm.2025.01.007<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Jan 25:S1933-0219(25)00007-8. doi: 10.1016\/j.mucimm.2025.01.007. Online ahead of print. ABSTRACT Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5-25 or &gt; 30 kg\/m2 (21 and 16 mothers, &#8230; <a title=\"Maternal obesity associates with altered humoral immunity in blood and colostrum. Erick S S\u00e1nchez-Salguero\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/01\/28\/maternal-obesity-associates-with-altered-humoral-immunity-in-blood-and-colostrum-erick-s-sanchez-salguero\/\" aria-label=\"Read more about Maternal obesity associates with altered humoral immunity in blood and colostrum. Erick S S\u00e1nchez-Salguero\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-23163","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/23163","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=23163"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/23163\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=23163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=23163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=23163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}