{"id":25275,"date":"2025-02-20T13:04:17","date_gmt":"2025-02-20T12:04:17","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/02\/20\/histones-hist1-genes-and-tumor-infiltrating-lymphocytes-in-a-child-with-gamma-delta-t-cell-acute-lymphoblastic-leukemia-by-single-cell-sequencingxiao-hua-luo-on-20-de-february-de-2025-at-11\/"},"modified":"2025-02-20T13:04:17","modified_gmt":"2025-02-20T12:04:17","slug":"histones-hist1-genes-and-tumor-infiltrating-lymphocytes-in-a-child-with-gamma-delta-t-cell-acute-lymphoblastic-leukemia-by-single-cell-sequencingxiao-hua-luo-on-20-de-february-de-2025-at-11","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/02\/20\/histones-hist1-genes-and-tumor-infiltrating-lymphocytes-in-a-child-with-gamma-delta-t-cell-acute-lymphoblastic-leukemia-by-single-cell-sequencingxiao-hua-luo-on-20-de-february-de-2025-at-11\/","title":{"rendered":"Histones HIST1 genes and tumor infiltrating lymphocytes in a child with gamma delta T cell acute lymphoblastic leukemia by single-cell sequencing\u200bXiao-Hua Luo   on 20 de February de 2025 at 11:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Feb 20:qiaf022. doi: 10.1093\/jleuko\/qiaf022. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Gamma delta T-cell acute lymphoblastic leukemia (\u03b3\u03b4 T-ALL) represents a rare subset of T-ALL and is correlated with high rates of induction failure, relapse and increased mortality. \u03b3\u03b4 T-ALL lacks a biologically-informed framework for guiding its classification and treatment strategies. In this report, we detail a case of child with \u03b3\u03b4 T-ALL who underwent induction chemotherapy and intensification treatment, followed by haploidentical hematopoietic stem cell transplantation. The patient achieved a clinical complete remission and remains minimal residual disease negative with chidamide maintenance post-transplantation. Single-cell RNA sequencing revealed a connection between histones HIST1 genes and gamma delta T-ALL, and identified potential effector functions of \u03b3\u03b4 T cells in combating this leukemia. This case carries significant implications for managing \u03b3\u03b4 T-ALL, highlighting the relationship between histone modification patterns and gamma delta tumor infiltrating lymphocytes in \u03b3\u03b4 T-ALL cells for developing novel therapeutic approaches.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39973604\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250220070416&amp;v=2.18.0.post9+e462414\">39973604<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf022\">10.1093\/jleuko\/qiaf022<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Feb 20:qiaf022. doi: 10.1093\/jleuko\/qiaf022. Online ahead of print. ABSTRACT Gamma delta T-cell acute lymphoblastic leukemia (\u03b3\u03b4 T-ALL) represents a rare subset of T-ALL and is correlated with high rates of induction failure, relapse and increased mortality. \u03b3\u03b4 T-ALL lacks a biologically-informed framework for guiding its classification and treatment strategies. In this &#8230; <a title=\"Histones HIST1 genes and tumor infiltrating lymphocytes in a child with gamma delta T cell acute lymphoblastic leukemia by single-cell sequencing\u200bXiao-Hua Luo   on 20 de February de 2025 at 11:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/02\/20\/histones-hist1-genes-and-tumor-infiltrating-lymphocytes-in-a-child-with-gamma-delta-t-cell-acute-lymphoblastic-leukemia-by-single-cell-sequencingxiao-hua-luo-on-20-de-february-de-2025-at-11\/\" aria-label=\"Read more about Histones HIST1 genes and tumor infiltrating lymphocytes in a child with gamma delta T cell acute lymphoblastic leukemia by single-cell sequencing\u200bXiao-Hua Luo   on 20 de February de 2025 at 11:00\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-25275","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=25275"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25275\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=25275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=25275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=25275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}