{"id":25800,"date":"2025-02-28T07:01:35","date_gmt":"2025-02-28T06:01:35","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/02\/28\/extracellular-vesicles-transport-gasdermin-pores-amplifying-inflammatory-cell-death-bhesh-raj-sharma\/"},"modified":"2025-02-28T07:01:35","modified_gmt":"2025-02-28T06:01:35","slug":"extracellular-vesicles-transport-gasdermin-pores-amplifying-inflammatory-cell-death-bhesh-raj-sharma","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/02\/28\/extracellular-vesicles-transport-gasdermin-pores-amplifying-inflammatory-cell-death-bhesh-raj-sharma\/","title":{"rendered":"Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death. Bhesh Raj Sharma"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Feb 26:S1471-4906(25)00031-6. doi: 10.1016\/j.it.2025.02.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the membrane of neighboring cells, driving inflammatory cell death.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40016052\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250228010134&amp;v=2.18.0.post9+e462414\">40016052<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.02.004\">10.1016\/j.it.2025.02.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Feb 26:S1471-4906(25)00031-6. doi: 10.1016\/j.it.2025.02.004. Online ahead of print. ABSTRACT Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the &#8230; <a title=\"Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death. Bhesh Raj Sharma\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/02\/28\/extracellular-vesicles-transport-gasdermin-pores-amplifying-inflammatory-cell-death-bhesh-raj-sharma\/\" aria-label=\"Read more about Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death. Bhesh Raj Sharma\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-25800","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25800","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=25800"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25800\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=25800"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=25800"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=25800"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}