{"id":25872,"date":"2025-03-01T00:50:42","date_gmt":"2025-02-28T23:50:42","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/01\/more-xs-more-problems-how-contributions-from-the-x-chromosomes-enhance-female-predisposition-for-autoimmunity\/"},"modified":"2025-03-01T00:50:42","modified_gmt":"2025-02-28T23:50:42","slug":"more-xs-more-problems-how-contributions-from-the-x-chromosomes-enhance-female-predisposition-for-autoimmunity","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/01\/more-xs-more-problems-how-contributions-from-the-x-chromosomes-enhance-female-predisposition-for-autoimmunity\/","title":{"rendered":"More X’s, more problems: how contributions from the X chromosomes enhance female predisposition for autoimmunity"},"content":{"rendered":"
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Curr Opin Immunol<\/b>. 2025 Feb 27;93:102543. doi: 10.1016\/j.coi.2025.102543. Online ahead of print.<\/p>\n

ABSTRACT<\/b><\/p>\n

Many autoimmune diseases exhibit a strong female bias. While sex hormones may influence sex bias in disease, recent studies suggest that the X chromosome itself directly contributes to female-biased susceptibility to autoimmunity. Females with two X chromosomes utilize X Chromosome Inactivation (XCI) to silence gene expression from one X chromosome, equalizing expression between the sexes. The X chromosome is highly enriched with immune-related genes, and recent work indicates that the fidelity of XCI maintenance in lymphocytes from female systemic lupus erythematosus patients is compromised, suggesting that aberrant X-linked gene expression contributes to autoimmune phenotypes. XCI is initiated and maintained by the long noncoding RNA XIST\/Xist through its interactions with the inactive X chromosome and numerous interacting proteins, and recent studies also implicate XIST\/Xist RNA in driving endosomal Toll-like receptor signaling and XIST\/Xist RNA-protein complexes in serving as a source of autoantigens to respectively drive autoimmunity. Here, we will review these three distinct pathways that underscore the significance of X-linked genetics for understanding the origins of the female bias in autoimmune disease.<\/p>\n

PMID:40020257<\/a> | DOI:10.1016\/j.coi.2025.102543<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Curr Opin Immunol. 2025 Feb 27;93:102543. doi: 10.1016\/j.coi.2025.102543. Online ahead of print. ABSTRACT Many autoimmune diseases exhibit a strong female bias. While sex hormones may influence sex bias in disease, recent studies suggest that the X chromosome itself directly contributes to female-biased susceptibility to autoimmunity. Females with two X chromosomes utilize X Chromosome Inactivation (XCI) … Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-25872","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=25872"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25872\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=25872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=25872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=25872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}