{"id":25875,"date":"2025-03-01T00:50:42","date_gmt":"2025-02-28T23:50:42","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/01\/t-cell-b-cell-interactions-in-human-autoimmune-diseases\/"},"modified":"2025-03-01T00:50:42","modified_gmt":"2025-02-28T23:50:42","slug":"t-cell-b-cell-interactions-in-human-autoimmune-diseases","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/01\/t-cell-b-cell-interactions-in-human-autoimmune-diseases\/","title":{"rendered":"T cell-B cell interactions in human autoimmune diseases"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Feb 27;93:102539. doi: 10.1016\/j.coi.2025.102539. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Activation of autoreactive B cells and production of specific autoantibodies are hallmark features of many autoimmune diseases. B cell differentiation into antibody-secreting cells typically requires help from cognate T cells, which provide both cytokines and cell surface signals in an intricate intercellular interaction. A range of T cells can provide this help to B cells, including T follicular helper cells in follicles of secondary lymphoid organs, as well as T peripheral helper cells, which accumulate within inflamed target tissues in autoimmune diseases. Here, we discuss recent observations about the phenotypes of B cell-helper T cells that accumulate in inflamed tissues and in circulation of patients with autoimmune diseases, the correlations between B cell-helper T cells and B cells in these tissues, and key mediators of productive T cell-B cell interactions, with a focus on mediators that are being targeted therapeutically. Understanding the scope of B cell-helper T cells and their functions will improve our ability to quantify and track pathologic T cell-B cell interactions in human autoimmune diseases and may highlight critical mediators that can be targeted to suppress these interactions therapeutically.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40020254\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250228185041&amp;v=2.18.0.post9+e462414\">40020254<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102539\">10.1016\/j.coi.2025.102539<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Feb 27;93:102539. doi: 10.1016\/j.coi.2025.102539. Online ahead of print. ABSTRACT Activation of autoreactive B cells and production of specific autoantibodies are hallmark features of many autoimmune diseases. B cell differentiation into antibody-secreting cells typically requires help from cognate T cells, which provide both cytokines and cell surface signals in an intricate intercellular &#8230; <a title=\"T cell-B cell interactions in human autoimmune diseases\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/01\/t-cell-b-cell-interactions-in-human-autoimmune-diseases\/\" aria-label=\"Read more about T cell-B cell interactions in human autoimmune diseases\">Read more<\/a><\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-25875","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=25875"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/25875\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=25875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=25875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=25875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}