{"id":27433,"date":"2025-03-14T16:47:04","date_gmt":"2025-03-14T15:47:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/monoallelic-expression-in-human-immune-cells-linking-genotype-to-phenotype-lennart-hammarstrom\/"},"modified":"2025-03-14T16:47:04","modified_gmt":"2025-03-14T15:47:04","slug":"monoallelic-expression-in-human-immune-cells-linking-genotype-to-phenotype-lennart-hammarstrom","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/monoallelic-expression-in-human-immune-cells-linking-genotype-to-phenotype-lennart-hammarstrom\/","title":{"rendered":"Monoallelic expression in human immune cells: linking genotype to phenotype. Lennart Hammarstr\u00f6m"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Mar 12:S1471-4906(25)00032-8. doi: 10.1016\/j.it.2025.02.005. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was recently and elegantly demonstrated by Stewart et al.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40082159\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250314114703&amp;v=2.18.0.post9+e462414\">40082159<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.02.005\">10.1016\/j.it.2025.02.005<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Mar 12:S1471-4906(25)00032-8. doi: 10.1016\/j.it.2025.02.005. Online ahead of print. ABSTRACT Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was &#8230; <a title=\"Monoallelic expression in human immune cells: linking genotype to phenotype. Lennart Hammarstr\u00f6m\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/monoallelic-expression-in-human-immune-cells-linking-genotype-to-phenotype-lennart-hammarstrom\/\" aria-label=\"Read more about Monoallelic expression in human immune cells: linking genotype to phenotype. Lennart Hammarstr\u00f6m\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-27433","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=27433"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27433\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=27433"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=27433"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=27433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}