{"id":27437,"date":"2025-03-14T16:47:09","date_gmt":"2025-03-14T15:47:09","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/there-and-back-again-pd-l1-positivity-as-a-biomarker-for-immune-checkpoint-blockade-in-urothelial-carcinoma\/"},"modified":"2025-03-14T16:47:09","modified_gmt":"2025-03-14T15:47:09","slug":"there-and-back-again-pd-l1-positivity-as-a-biomarker-for-immune-checkpoint-blockade-in-urothelial-carcinoma","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/there-and-back-again-pd-l1-positivity-as-a-biomarker-for-immune-checkpoint-blockade-in-urothelial-carcinoma\/","title":{"rendered":"There and back again: PD-L1 Positivity as a Biomarker for Immune Checkpoint Blockade in Urothelial Carcinoma"},"content":{"rendered":"<div>\n<p><b>Cancer Immunol Res<\/b>. 2025 Mar 14:OF1-OF2. doi: 10.1158\/2326-6066.CIR-25-0202. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Biomarkers of responsiveness to immune checkpoint blockade (ICB) are heavily sought given the breadth and depth of the use of ICB in cancer. PD-L1 expression was among the first biomarkers identified, but multiple factors have precluded more widespread use. In this issue, Galsky and colleagues utilize two separate PD-L1 assays to study urothelial carcinoma specimens and observe that SP142 (relative to 22C3) preferentially stains dendritic cells. These observations may help reconcile the discordant performance of the two PD-L1 assays in ICB-treated urothelial carcinoma while underscoring the role of dendritic cells in orchestrating ICB response. See related article by Galsky et al., p. XX .<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40084809\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=101614637&amp;ff=20250314114707&amp;v=2.18.0.post9+e462414\">40084809<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1158\/2326-6066.CIR-25-0202\">10.1158\/2326-6066.CIR-25-0202<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cancer Immunol Res. 2025 Mar 14:OF1-OF2. doi: 10.1158\/2326-6066.CIR-25-0202. Online ahead of print. ABSTRACT Biomarkers of responsiveness to immune checkpoint blockade (ICB) are heavily sought given the breadth and depth of the use of ICB in cancer. PD-L1 expression was among the first biomarkers identified, but multiple factors have precluded more widespread use. In this issue, &#8230; <a title=\"There and back again: PD-L1 Positivity as a Biomarker for Immune Checkpoint Blockade in Urothelial Carcinoma\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/there-and-back-again-pd-l1-positivity-as-a-biomarker-for-immune-checkpoint-blockade-in-urothelial-carcinoma\/\" aria-label=\"Read more about There and back again: PD-L1 Positivity as a Biomarker for Immune Checkpoint Blockade in Urothelial Carcinoma\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55,42],"tags":[],"class_list":["post-27437","post","type-post","status-publish","format-standard","hentry","category-cancer-immunology-reserch","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=27437"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27437\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=27437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=27437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=27437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}