{"id":27448,"date":"2025-03-14T23:49:17","date_gmt":"2025-03-14T22:49:17","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/hla-e-peptide-complexes-differentially-interact-with-nkg2a-cd94-and-t-cell-receptors\/"},"modified":"2025-03-14T23:49:17","modified_gmt":"2025-03-14T22:49:17","slug":"hla-e-peptide-complexes-differentially-interact-with-nkg2a-cd94-and-t-cell-receptors","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/hla-e-peptide-complexes-differentially-interact-with-nkg2a-cd94-and-t-cell-receptors\/","title":{"rendered":"HLA-E\/peptide complexes differentially interact with NKG2A\/CD94 and T cell receptors"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Mar 14:vkae068. doi: 10.1093\/jimmun\/vkae068. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A\/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cells. HLA-E presents self-peptides to NKG2A\/CD94 to regulate tissue homeostasis, whereas HLA-E restricted T cells mediate regulatory and cytotoxic responses toward pathogen-infected cells. In this study, we directly compared HLA-E\/peptide recognition and signaling between NKG2A\/CD94 and 2 HLA-E restricted TCRs that can recognize self-peptides or identical peptide mimics from the viral UL40 protein of cytomegalovirus using position substituted peptide variants. We show that position 7 is critical for interaction with NKG2A\/CD94, whereas position 8 is important for interaction with the TCRs. The Arginine at position 5 of these peptides is an essential residue for recognition by both receptors. Thus, NKG2A\/CD94 and TCRs have different requirements for recognition of peptides presented in HLA-E.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40085431\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250314184916&amp;v=2.18.0.post9+e462414\">40085431<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkae068\">10.1093\/jimmun\/vkae068<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Mar 14:vkae068. doi: 10.1093\/jimmun\/vkae068. Online ahead of print. ABSTRACT The virtually monomorphic antigen presentation molecule HLA-E can present self- and non-self peptides to the NKG2A\/CD94 co-receptor inhibitory complex expressed on natural killer (NK) cells and to T cell receptors (TCRs) expressed on T cells. HLA-E presents self-peptides to NKG2A\/CD94 to regulate tissue &#8230; <a title=\"HLA-E\/peptide complexes differentially interact with NKG2A\/CD94 and T cell receptors\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/14\/hla-e-peptide-complexes-differentially-interact-with-nkg2a-cd94-and-t-cell-receptors\/\" aria-label=\"Read more about HLA-E\/peptide complexes differentially interact with NKG2A\/CD94 and T cell receptors\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-27448","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=27448"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27448\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=27448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=27448"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=27448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}