{"id":27455,"date":"2025-03-15T05:54:19","date_gmt":"2025-03-15T04:54:19","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/15\/afucosylated-broadly-neutralising-antibodies-targeting-hiv-envelope-elicit-enhanced-nk-cell-mediated-cytotoxicity-against-hiv-infected-cd4-t-cell-and-macrophage-targetsolivia-wilhelm-on-14\/"},"modified":"2025-03-15T05:54:19","modified_gmt":"2025-03-15T04:54:19","slug":"afucosylated-broadly-neutralising-antibodies-targeting-hiv-envelope-elicit-enhanced-nk-cell-mediated-cytotoxicity-against-hiv-infected-cd4-t-cell-and-macrophage-targetsolivia-wilhelm-on-14","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/15\/afucosylated-broadly-neutralising-antibodies-targeting-hiv-envelope-elicit-enhanced-nk-cell-mediated-cytotoxicity-against-hiv-infected-cd4-t-cell-and-macrophage-targetsolivia-wilhelm-on-14\/","title":{"rendered":"Afucosylated broadly neutralising antibodies targeting HIV envelope elicit enhanced NK cell-mediated cytotoxicity against HIV-infected CD4+ T cell and macrophage targets\u200bOlivia Wilhelm   on 14 de March de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Mar 15:qiaf033. doi: 10.1093\/jleuko\/qiaf033. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Enhancement of antibody-dependent cellular cytotoxicity (ADCC) is a promising adjunct approach to achieve HIV control in the absence of antiretroviral therapy but requires the development of potent ADCC-eliciting antibodies which can recognise diverse HIV-infected cell types. A panel of broadly neutralising antibodies (bNAbs) targeting HIV envelope were identified which specifically bind both HIV-infected CD4+ T cells and monocyte-derived macrophages (MDM). Afucosylated versions of these bNAbs containing \u224830% less core fucose were generated and elicited a significant increase in ADCC responses from NK cells against HIV-infected T cell and MDM targets. Afucosylation did not alter virus neutralisation or cell-binding activity of these bNAbs. Afucosylation modifications of bNAb Fc regions is thus a promising strategy to enhance Fc-mediated activity against both T cell and macrophage targets in vivo which may be employed to heighten the therapeutic potential of antibody-based immunotherapy approaches for drug-free HIV control.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40086815\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250315005418&amp;v=2.18.0.post9+e462414\">40086815<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf033\">10.1093\/jleuko\/qiaf033<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Mar 15:qiaf033. doi: 10.1093\/jleuko\/qiaf033. Online ahead of print. ABSTRACT Enhancement of antibody-dependent cellular cytotoxicity (ADCC) is a promising adjunct approach to achieve HIV control in the absence of antiretroviral therapy but requires the development of potent ADCC-eliciting antibodies which can recognise diverse HIV-infected cell types. A panel of broadly neutralising antibodies &#8230; <a title=\"Afucosylated broadly neutralising antibodies targeting HIV envelope elicit enhanced NK cell-mediated cytotoxicity against HIV-infected CD4+ T cell and macrophage targets\u200bOlivia Wilhelm   on 14 de March de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/15\/afucosylated-broadly-neutralising-antibodies-targeting-hiv-envelope-elicit-enhanced-nk-cell-mediated-cytotoxicity-against-hiv-infected-cd4-t-cell-and-macrophage-targetsolivia-wilhelm-on-14\/\" aria-label=\"Read more about Afucosylated broadly neutralising antibodies targeting HIV envelope elicit enhanced NK cell-mediated cytotoxicity against HIV-infected CD4+ T cell and macrophage targets\u200bOlivia Wilhelm   on 14 de March de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-27455","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=27455"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27455\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=27455"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=27455"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=27455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}