{"id":27655,"date":"2025-03-19T05:47:26","date_gmt":"2025-03-19T04:47:26","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/19\/cd209d-e-are-required-for-macrophage-mediated-phagocytosis-and-activation-during-methicillin-resistant-staphylococcus-aureus-pulmonary-host-defense\/"},"modified":"2025-03-19T05:47:26","modified_gmt":"2025-03-19T04:47:26","slug":"cd209d-e-are-required-for-macrophage-mediated-phagocytosis-and-activation-during-methicillin-resistant-staphylococcus-aureus-pulmonary-host-defense","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/19\/cd209d-e-are-required-for-macrophage-mediated-phagocytosis-and-activation-during-methicillin-resistant-staphylococcus-aureus-pulmonary-host-defense\/","title":{"rendered":"CD209d\/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Mar 18:vkae061. doi: 10.1093\/jimmun\/vkae061. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) is a pattern-recognition receptor that binds to a broad range of pathogens, promoting phagocytosis. Here we aimed to study the role of mouse homologues of DC-SIGN, CD209d\/e, in a methicillin-resistant S. aureus (MRSA) pulmonary infection model. CD209d\/e-\/- and wild-type C57BL\/6 mice were infected with MRSA and inflammatory parameters were evaluated. CD209d\/e-\/- mice had delayed bacterial burden and mortality together with increased frequency of neutrophils and decreased dendritic cells in the lung compared with control mice. iNOS+ macrophages, and regulatory T cell frequency were decreased in the lungs of CD209d\/e-\/- mice. CD209d\/e-\/- mice had increased levels of inflammatory cytokines in the lungs, but levels of IL-12p40 were decreased. MRSA reduced expression of interferon-\u03b3 and pattern-recognition receptors in CD209d\/e-\/- mice. MRSA uptake by phagocytes was decreased in the lungs of CD209d\/e-\/- versus control mice. CD209d\/e-\/- bone marrow derived macrophages showed impaired MRSA uptake and killing. These data suggest that CD209d\/e are essential receptors to control inflammation by activating macrophages leading to MRSA uptake and killing.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40101753\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250319004725&amp;v=2.18.0.post9+e462414\">40101753<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkae061\">10.1093\/jimmun\/vkae061<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Mar 18:vkae061. doi: 10.1093\/jimmun\/vkae061. Online ahead of print. ABSTRACT Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular patterns through pattern-recognition receptors is crucial for eliminating microorganisms such as S. aureus. DC-SIGN (CD209) is a pattern-recognition receptor that binds to a broad range &#8230; <a title=\"CD209d\/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/19\/cd209d-e-are-required-for-macrophage-mediated-phagocytosis-and-activation-during-methicillin-resistant-staphylococcus-aureus-pulmonary-host-defense\/\" aria-label=\"Read more about CD209d\/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-27655","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=27655"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27655\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=27655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=27655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=27655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}