{"id":27828,"date":"2025-03-21T05:47:32","date_gmt":"2025-03-21T04:47:32","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/21\/trained-immunity-based-mucosal-immunotherapies-for-the-prevention-of-respiratory-infections-luna-minute\/"},"modified":"2025-03-21T05:47:32","modified_gmt":"2025-03-21T04:47:32","slug":"trained-immunity-based-mucosal-immunotherapies-for-the-prevention-of-respiratory-infections-luna-minute","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/21\/trained-immunity-based-mucosal-immunotherapies-for-the-prevention-of-respiratory-infections-luna-minute\/","title":{"rendered":"Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections. Luna Minute"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Mar 19:S1471-4906(25)00055-9. doi: 10.1016\/j.it.2025.02.012. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory infections. These immunotherapies can activate a wide spectrum of immunological mechanisms, with trained immunity (TI) being particularly significant. This phenomenon has led to the concept of trained immunity-based vaccines (TIbVs), which represent a novel approach in vaccinology. We discuss examples of TIbVs, including the tuberculosis vaccine Bacille Calmette-Gu\u00e9rin (BCG) and the polybacterial immunotherapy MV130. From our viewpoint, illustrating the mode of action and clinical evidence supports the proposal that TIbVs should be considered as next-generation vaccines to confer protection against a wide range of respiratory infections.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40113536\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250321004731&amp;v=2.18.0.post9+e462414\">40113536<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.02.012\">10.1016\/j.it.2025.02.012<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Mar 19:S1471-4906(25)00055-9. doi: 10.1016\/j.it.2025.02.012. Online ahead of print. ABSTRACT The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory infections. These immunotherapies can activate a wide spectrum of immunological mechanisms, &#8230; <a title=\"Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections. Luna Minute\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/21\/trained-immunity-based-mucosal-immunotherapies-for-the-prevention-of-respiratory-infections-luna-minute\/\" aria-label=\"Read more about Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections. Luna Minute\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-27828","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=27828"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/27828\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=27828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=27828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=27828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}