{"id":28237,"date":"2025-03-27T21:50:11","date_gmt":"2025-03-27T20:50:11","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/03\/27\/metabolic-adaptations-driving-innate-immune-memory-mechanisms-and-therapeutic-implicationsdan-hao-on-26-de-march-de-2025-at-1000\/"},"modified":"2025-03-27T21:50:11","modified_gmt":"2025-03-27T20:50:11","slug":"metabolic-adaptations-driving-innate-immune-memory-mechanisms-and-therapeutic-implicationsdan-hao-on-26-de-march-de-2025-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/03\/27\/metabolic-adaptations-driving-innate-immune-memory-mechanisms-and-therapeutic-implicationsdan-hao-on-26-de-march-de-2025-at-1000\/","title":{"rendered":"Metabolic Adaptations Driving Innate Immune Memory: Mechanisms and Therapeutic Implications\u200bDan Hao   on 26 de March de 2025 at 10:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Mar 26:qiaf037. doi: 10.1093\/jleuko\/qiaf037. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Immune memory is a hallmark of the adaptive immune system. However, recent research reveals that innate immune cells also retain memory of prior pathogen exposure that prompts enhanced responses to subsequent infections. This phenomenon is termed &#8220;innate immune memory&#8221; or &#8220;trained immunity.&#8221; Notably, remodeling of cellular metabolism, which closely links to epigenetic reprogramming, is a prominent feature of innate immune memory. Adaptations in glycolysis, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), glutaminolysis, and lipid synthesis pathways are critical for establishing innate immune memory. This review provides an overview of the current understanding of how metabolic adaptations drive innate immune memory. This understanding is fundamental to understanding innate immune system functions and advancing therapies against infectious diseases.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40138361\/?utm_source=WordPress&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20250327165010&amp;v=2.18.0.post9+e462414\">40138361<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf037\">10.1093\/jleuko\/qiaf037<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Mar 26:qiaf037. doi: 10.1093\/jleuko\/qiaf037. Online ahead of print. ABSTRACT Immune memory is a hallmark of the adaptive immune system. However, recent research reveals that innate immune cells also retain memory of prior pathogen exposure that prompts enhanced responses to subsequent infections. This phenomenon is termed &#8220;innate immune memory&#8221; or &#8220;trained immunity.&#8221; &#8230; <a title=\"Metabolic Adaptations Driving Innate Immune Memory: Mechanisms and Therapeutic Implications\u200bDan Hao   on 26 de March de 2025 at 10:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/03\/27\/metabolic-adaptations-driving-innate-immune-memory-mechanisms-and-therapeutic-implicationsdan-hao-on-26-de-march-de-2025-at-1000\/\" aria-label=\"Read more about Metabolic Adaptations Driving Innate Immune Memory: Mechanisms and Therapeutic Implications\u200bDan Hao   on 26 de March de 2025 at 10:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-28237","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/28237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=28237"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/28237\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=28237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=28237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=28237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}